Somatic mutations and DNA methylation identify a subgroup of poor prognosis within lower‐risk myelodysplastic syndromes

Authors: David Rombaut, Sarah Sandmann, Tobias Tekath, Simon Crouch, Aniek O. deGraaf, Alexandra Smith, Daniel Painter, Olivier Kosmider, Magnus Tobiasson, Andreas Lennartsson, Bert A. van derReijden, Sophie Park, Maud D'Aveni, Borhane Slama, Emmanuelle Clappier, Pierre Fenaux, Lionel Adès, Arjan van deLoosdrecht, Saskia Langemeijer, Argiris Symeonidis, Jaroslav Čermák, Claude Preudhomme, Aleksandar Savic, Ulrich Germing, Reinhard Stauder, David Bowen, Corine vanMarrewijk, Elsa Bernard, Theo deWitte, Julian Varghese, Eva Hellström‐Lindberg, Martin Dugas, Joost Martens, Luca Malcovati, Joop H. Jansen, Michaela Fontenay, MDS‐RIGHT consortium

Source: HemaSphere, Vol 9, Iss 1, Pp n/a-n/a (2025)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://doaj.org/toc/2572-9241

Access URL: https://doaj.org/article/0de63b5bc83940d491a74eb6f7347741

High levels of global hydroxymethylation predict worse overall survival in MDS patients treated with azacitidine

Authors: Francesca Tiso, Florentien E. M. in 't Hout, Ruth Knops, Leonie I. Kroeze, Arno vanRooij, Arjan A. van deLoosdrecht, Theresia M. Westers, Saskia M. C. Langemeijer, Claude Preudhomme, Nicolas Duployez, Pierre Fenaux, Olivier Kosmider, Didier Bouscary, Aniek O. deGraaf, Joost H. A. Martens, Bert A. van derReijden, Lionel Adès, Michaela Fontenay, Joop H. Jansen

Source: HemaSphere, Vol 9, Iss 1, Pp n/a-n/a (2025)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://doaj.org/toc/2572-9241

Access URL: https://doaj.org/article/97257d595ad94e539528299336b20916

Expression levels of genes implicated in the working mechanism of lenalidomide predict treatment response in lower risk myelodysplastic syndrome patients

Authors: Florentien E.M. in’t Hout, Thessa N. Scheele, Theresia M. Westers, Canan Alhan, Carolien Duetz, Eline M.P. Cremers, Heleen A. Visser-Wisselaar, Annelies Verbrugge, Dana A. Chitu, Bert A. van der Reijden, Aniek O. de Graaf, Arjan A. van de Loosdrecht, Joop H. Jansen

Source: Haematologica, Vol 999, Iss 1 (2024)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://haematologica.org/article/view/11783; https://doaj.org/toc/0390-6078; https://doaj.org/toc/1592-8721

Access URL: https://doaj.org/article/221b1543b73046578bac22fb1d056c18

Increased peritoneal TGF-β1 is associated with ascites-induced NK-cell dysfunction and reduced survival in high-grade epithelial ovarian cancer

Authors: Ralph J. A. Maas, Janneke S. Hoogstad-van Evert, Iris M. Hagemans, Jolanda Brummelman, Diede van Ens, Paul K. J. D. de Jonge, Laura Hooijmaijers, Shweta Mahajan, Anniek B. van der Waart, Charlotte K. J. C. Hermans, Janne de Klein, Rob Woestenenk, Antonius E. van Herwaarden, Nicolaas P. M. Schaap, Somayeh Rezaeifard, Daniele V. F. Tauriello, Petra L. M. Zusterzeel, Nelleke Ottevanger, Joop H. Jansen, Willemijn Hobo, Harry Dolstra

Source: Frontiers in Immunology, Vol 15 (2024)

Subject Terms: ovarian cancer, ascites, natural killer (NK) cells, TGF-β, tumor microenvironment, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2024.1448041/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/fba2485f4f604077a2047c69ad71b92f

GFI1B and LSD1 repress myeloid traits during megakaryocyte differentiation

Authors: Jeron Venhuizen, Maaike G. J. M. van Bergen, Saskia M. Bergevoet, Daan Gilissen, Cornelia G. Spruijt, Laura Wingens, Emile van den Akker, Michiel Vermeulen, Joop H. Jansen, Joost H. A. Martens, Bert A. van der Reijden

Source: Communications Biology, Vol 7, Iss 1, Pp 1-9 (2024)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/2399-3642

Access URL: https://doaj.org/article/558fcbd9db0c4afb9f0c4bb2090de2b9

The spectrum of neutralizing and non-neutralizing anti-FVIII antibodies in a nationwide cohort of 788 persons with hemophilia A

Authors: Ilja Oomen, Marieke Verhagen, Mariarosaria Miranda, Peter Allacher, Erik A. M. Beckers, Nicole M. A. Blijlevens, Johanna G. van der Bom, Michiel Coppens, Mariëtte Driessens, Jeroen C. J. Eikenboom, Karin Fijnvandraat, Shermarke Hassan, Waander L. van Heerde, H. Louise Hooimeijer, Joop H. Jansen, Paul Kaijen, Frank W. G. Leebeek, Daniëlle Meijer, Helmut Paul, Sanna R. Rijpma, Frits R. Rosendaal, Cees Smit, Lize F. D. van Vulpen, Jan Voorberg, Saskia E. M. Schols, Samantha C. Gouw

Source: Frontiers in Immunology, Vol 15 (2024)

Subject Terms: antibody, ELISA, factor VIII, hemophilia A, immunoglobulin A, immunoglobulin G, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2024.1355813/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/597ab8aa3a9e45e5a577ea5c89256fc0

Evolution of clonal hematopoiesis

Authors: Isabelle A. van Zeventer, Aniek O. de Graaf, Joop H. Jansen, Gerwin Huls

Source: Clinical and Translational Medicine, Vol 13, Iss 10, Pp n/a-n/a (2023)

Subject Terms: Medicine (General), R5-920

File Description: electronic resource

Relation: https://doaj.org/toc/2001-1326

Access URL: https://doaj.org/article/3653626ead6f476187270d72379e0044

Clonal Hematopoiesis Defined by Somatic Mutations Infrequently Co-occurs With Mosaic Loss of the Y Chromosome in a Population-based Cohort

Authors: Priscilla Kamphuis, Isabelle A. van Zeventer, Aniek O. de Graaf, Giulio Genovese, Jonas B. Salzbrunn, Avinash G. Dinmohamed, Bert A. van der Reijden, Jan Jacob Schuringa, Joop H. Jansen, Gerwin Huls

Source: HemaSphere, Vol 7, Iss 10, p e956 (2023)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: http://journals.lww.com/10.1097/HS9.0000000000000956; https://doaj.org/toc/2572-9241

Access URL: https://doaj.org/article/afcc11b0a3ec490a80013e9d69a25b7e

Effect of Eculizumab on Iron Metabolism in Transfusion-independent Patients With Paroxysmal Nocturnal Hemoglobinuria

Authors: Charlotte C.M. Schaap, Saskia E.M. Schols, Frank W.M.B. Preijers, Emiel de Jonge, Coby M.M. Laarakkers, Joop H. Jansen, Nicole M.A. Blijlevens, Dorine W. Swinkels, Saskia M.C. Langemeijer

Source: HemaSphere, Vol 7, Iss 5, p e878 (2023)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: http://journals.lww.com/10.1097/HS9.0000000000000878; https://doaj.org/toc/2572-9241

Access URL: https://doaj.org/article/754f500cf2ed4334972e0ec4c968a5b5

Sex Differences in the Spectrum of Clonal Hematopoiesis

Authors: Priscilla Kamphuis, Isabelle A. van Zeventer, Aniek O. de Graaf, Jonas B. Salzbrunn, Maaike G. J. M. van Bergen, Avinash G. Dinmohamed, Bert A. van der Reijden, Jan Jacob Schuringa, Joop H. Jansen, Gerwin Huls

Source: HemaSphere, Vol 7, Iss 2, p e832 (2023)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: http://journals.lww.com/10.1097/HS9.0000000000000832; https://doaj.org/toc/2572-9241

Access URL: https://doaj.org/article/5fdc205471794171a7c560a811ddcabd

Abnormal Platelet Counts and Clonal Hematopoiesis in the General Population

Authors: Priscilla Kamphuis, Maaike G.J.M. van Bergen, Isabelle A. van Zeventer, Aniek O. de Graaf, Avinash G. Dinmohamed, Jonas B. Salzbrunn, Jan Jacob Schuringa, Bert A. van der Reijden, Gerwin Huls, Joop H. Jansen

Source: HemaSphere, Vol 7, Iss 1, p e821 (2023)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: http://journals.lww.com/10.1097/HS9.0000000000000821; https://doaj.org/toc/2572-9241

Access URL: https://doaj.org/article/7ac6b58cd0d6499e879bd5e536edeca0

Ring sideroblasts in AML are associated with adverse risk characteristics and have a distinct gene expression pattern

Authors: Gerbrig Berger, Mylene Gerritsen, Guoqiang Yi, Theresia N. Koorenhof-Scheele, Leonie I. Kroeze, Marian Stevens-Kroef, Kenichi Yoshida, Yuichi Shiraishi, Eva van den Berg, Hein Schepers, Geert Huls, André B. Mulder, Seishi Ogawa, Joost H.A. Martens, Joop H. Jansen, Edo Vellenga

Source: Blood Advances, Vol 3, Iss 20, Pp 3111-3122 (2019)

Subject Terms: Specialties of internal medicine, RC581-951

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2473952920318310; https://doaj.org/toc/2473-9529

Access URL: https://doaj.org/article/fdda625962e64cb881226474942522a5

CD34+ progenitor-derived NK cell and gemcitabine combination therapy increases killing of ovarian cancer cells in NOD/SCID/IL2Rgnull mice

Authors: Jolien M.R. Van der Meer, Paul K.J.D. de Jonge, Anniek B. van der Waart, Alexander C. Geerlings, Jurgen P. Moonen, Jolanda Brummelman, Janne de Klein, Malou C. Vermeulen, Ralph J.A. Maas, Nicolaas P.M. Schaap, Janneke S. Hoogstad-van Evert, Petronella B. Ottevanger, Joop H. Jansen, Willemijn Hobo, Harry Dolstra

Source: OncoImmunology, Vol 10, Iss 1 (2021)

Subject Terms: natural killer cells, ovarian cancer, gemcitabine, cancer immunotherapy, Immunologic diseases. Allergy, RC581-607, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2162-402X

Access URL: https://doaj.org/article/619acac2e57b40f7a452e2426b67db92

The Effect of SF3B1 Mutation on the DNA Damage Response and Nonsense-Mediated mRNA Decay in Cancer

Authors: Alexander C. Leeksma, Ingrid A. M. Derks, M. Haidar Kasem, Emine Kilic, Annelies de Klein, Martine J. Jager, Arjan A. van de Loosdrecht, Joop H. Jansen, Veronika Navrkalova, Laura M. Faber, Nadja Zaborsky, Alexander Egle, Thorsten Zenz, Sarka Pospisilova, Omar Abdel-Wahab, Arnon P. Kater, Eric Eldering

Source: Frontiers in Oncology, Vol 10 (2021)

Subject Terms: SF3B1, DNA damage response, splicing, nonsense-mediated mRNA decay, apoptosis, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fonc.2020.609409/full; https://doaj.org/toc/2234-943X

Access URL: https://doaj.org/article/91502537fb6b4b8b844b64388f53fc8a

Malignant Transformation Involving CXXC4 Mutations Identified in a Leukemic Progression Model of Severe Congenital Neutropenia

Authors: Patricia A. Olofsen, Szabolcs Fatrai, Paulina M.H. van Strien, Julia C. Obenauer, Hans W.J. de Looper, Remco M. Hoogenboezem, Claudia A.J. Erpelinck-Verschueren, Michael P.W.M. Vermeulen, Onno Roovers, Torsten Haferlach, Joop H. Jansen, Mehrnaz Ghazvini, Eric M.J. Bindels, Rebekka K. Schneider, Emma M. de Pater, Ivo P. Touw

Source: Cell Reports Medicine, Vol 1, Iss 5, Pp 100074- (2020)

Subject Terms: severe congenital neutropenia, AML, CSF3R, RUNX1, CXXC4, TET2, Medicine (General), R5-920

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S266637912030094X; https://doaj.org/toc/2666-3791

Access URL: https://doaj.org/article/a0e7d0f08d2e4c29ae248feba801718a

Transcription factor 4 (TCF4) expression predicts clinical outcome in RUNX1 mutated and translocated acute myeloid leukemia

Authors: Florentien E.M. in't Hout, Mylène Gerritsen, Lars Bullinger, Bert A. van der Reijden, Gerwin Huls, Edo Vellenga, Joop H. Jansen

Source: Haematologica, Vol 105, Iss 9 (2020)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://haematologica.org/article/view/9873; https://doaj.org/toc/0390-6078; https://doaj.org/toc/1592-8721

Access URL: https://doaj.org/article/5fb284159979416e92c6edf245e73918

Clonal evolution in myelodysplastic syndromes

Authors: Pedro da Silva-Coelho, Leonie I. Kroeze, Kenichi Yoshida, Theresia N. Koorenhof-Scheele, Ruth Knops, Louis T. van de Locht, Aniek O. de Graaf, Marion Massop, Sarah Sandmann, Martin Dugas, Marian J. Stevens-Kroef, Jaroslav Cermak, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Satoru Miyano, Theo de Witte, Nicole M. A. Blijlevens, Petra Muus, Gerwin Huls, Bert A. van der Reijden, Seishi Ogawa, Joop H. Jansen

Source: Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/15e723d7aa454140a35f949fbaeac555

Molecular mechanisms of bleeding disorderassociated GFI1BQ287* mutation and its affected pathways in megakaryocytes and platelets

Authors: Rinske van Oorschot, Marten Hansen, Johanna M. Koornneef, Anna E. Marneth, Saskia M. Bergevoet, Maaike G.J.M. van Bergen, Floris P.J. van Alphen, Carmen van der Zwaan, Joost H.A. Martens, Michiel Vermeulen, Pascal W.T.C. Jansen, Marijke P.A. Baltissen, Britta A.P. Laros-van Gorkom, Hans Janssen, Joop H. Jansen, Marieke von Lindern, Alexander B. Meijer, Emile van den Akker, Bert A. van der Reijden

Source: Haematologica, Vol 104, Iss 7 (2019)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://haematologica.org/article/view/8976; https://doaj.org/toc/0390-6078; https://doaj.org/toc/1592-8721

Access URL: https://doaj.org/article/fa460826edfb42dbb79b809d6ce5fa66

Inherited missense variants that affect GFI1B function do not necessarily cause bleeding diatheses

Authors: Rinske van Oorschot, Anna E. Marneth, Saskia M. Bergevoet, Maaike G.J.M. van Bergen, Kathelijne Peerlinck, Claire E. Lentaigne, Carolyn M. Millar, Sarah K. Westbury, Remi Favier, Wendy N. Erber, Ernest Turro, Joop H. Jansen, Willem H. Ouwehand, Harriet L. McKinney, NIHR BioResource Collaborative Group, Kate Downes, Kathleen Freson, Bert A. van der Reijden

Source: Haematologica, Vol 104, Iss 6 (2019)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://haematologica.org/article/view/8951; https://doaj.org/toc/0390-6078; https://doaj.org/toc/1592-8721

Access URL: https://doaj.org/article/ba74c617cb2949d7a1ed47cbed35c732

Impact of induction regimen and allogeneic hematopoietic cell transplantation on outcome in younger adults with acute myeloid leukemia with a monosomal karyotype

Authors: Frédéric Baron, Marian Stevens-Kroef, Michal Kicinski, Giovanna Meloni, Petra Muus, Jean-Pierre Marie, Constantijn J.M. Halkes, Xavier Thomas, Radovan Vrhovac, Francesco Albano, François Lefrère, Simona Sica, Marco Mancini, Adriano Venditti, Anne Hagemeijer, Joop H. Jansen, Sergio Amadori, Theo de Witte, Roelof Willemze, Stefan Suciu

Source: Haematologica, Vol 104, Iss 6 (2019)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://haematologica.org/article/view/8931; https://doaj.org/toc/0390-6078; https://doaj.org/toc/1592-8721

Access URL: https://doaj.org/article/8ddb669aef6d4e8f9d776631211d4876