Inhibition of GSK3β is synthetic lethal with FHIT loss in lung cancer by blocking homologous recombination repair

Authors: Shishi Tao, Yue Pu, Eun Ju Yang, Guowen Ren, Changxiang Shi, Li-Jie Chen, Liang Chen, Joong Sup Shim

Source: Experimental and Molecular Medicine, Vol 57, Iss 1, Pp 167-183 (2025)

Subject Terms: Medicine, Biochemistry, QD415-436

File Description: electronic resource

Relation: https://doaj.org/toc/2092-6413

Access URL: https://doaj.org/article/94991c53bc334479a04ce58ce2b760de

Aurora A kinase inhibition compromises its antitumor efficacy by elevating PD-L1 expression

Authors: Xiaobo Wang, Jing Huang, Fenglin Liu, Qian Yu, Ruina Wang, Jiaqi Wang, Zewen Zhu, Juan Yu, Jun Hou, Joong Sup Shim, Wei Jiang, Zengxia Li, Yuanyuan Zhang, Yongjun Dang

Source: The Journal of Clinical Investigation, Vol 133, Iss 9 (2023)

Subject Terms: Oncology, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/1558-8238

Access URL: https://doaj.org/article/69d0aa58c0c34253814529e277855a41

Molecular landscape and subtype-specific therapeutic response of nasopharyngeal carcinoma revealed by integrative pharmacogenomics

Authors: Ren-Bo Ding, Ping Chen, Barani Kumar Rajendran, Xueying Lyu, Haitao Wang, Jiaolin Bao, Jianming Zeng, Wenhui Hao, Heng Sun, Ada Hang-Heng Wong, Monica Vishnu Valecha, Eun Ju Yang, Sek Man Su, Tak Kan Choi, Shuiming Liu, Kin Iong Chan, Ling-Lin Yang, Jingbo Wu, Kai Miao, Qiang Chen, Joong Sup Shim, Xiaoling Xu, Chu-Xia Deng

Source: Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/87f829886bef4facb841e43c9c543db3

Small Activating RNA Modulation of the G Protein‐Coupled Receptor for Cancer Treatment

Authors: Yunfang Xiong, Ran Ke, Qingyu Zhang, Wenjun Lan, Wanjun Yuan, Karol Nga Ieng Chan, Tom Roussel, Yifan Jiang, Jing Wu, Shuai Liu, Alice Sze Tsai Wong, Joong Sup Shim, Xuanjun Zhang, Ruiyu Xie, Nelson Dusetti, Juan Iovanna, Nagy Habib, Ling Peng, Leo Tsz On Lee

Source: Advanced Science, Vol 9, Iss 26, Pp n/a-n/a (2022)

Subject Terms: cancer therapies, dendrimer vectors, G protein‐coupled receptors, Mas receptors (MAS1s), small activating RNA, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2198-3844

Access URL: https://doaj.org/article/2eda5b61827140be8560c3e34fd77ae2

TRIM family proteins: roles in proteostasis and neurodegenerative diseases

Authors: Yan Zhu, Lukman O. Afolabi, Xiaochun Wan, Joong Sup Shim, Liang Chen

Source: Open Biology, Vol 12, Iss 8 (2022)

Subject Terms: neurodegenerative diseases, trim proteins, protein aggregation, proteostasis, ubiquitin–proteasome system, chaperone, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/2046-2441

Access URL: https://doaj.org/article/667d13a9ae3d4df6ae483c1d6c5ce5eb

Synthetic lethality of RB1 and aurora A is driven by stathmin-mediated disruption of microtubule dynamics

Authors: Junfang Lyu, Eun Ju Yang, Baoyuan Zhang, Changjie Wu, Lakhansing Pardeshi, Changxiang Shi, Pui Kei Mou, Yifan Liu, Kaeling Tan, Joong Sup Shim

Source: Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/c27f425a63c3424e81e7e45850e9e42c

Class I histone deacetylase inhibition is synthetic lethal with BRCA1 deficiency in breast cancer cells

Authors: Baoyuan Zhang, Junfang Lyu, Eun Ju Yang, Yifan Liu, Changjie Wu, Lakhansing Pardeshi, Kaeling Tan, Qiang Chen, Xiaoling Xu, Chu-Xia Deng, Joong Sup Shim

Source: Acta Pharmaceutica Sinica B, Vol 10, Iss 4, Pp 615-627 (2020)

Subject Terms: Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211383519307208; https://doaj.org/toc/2211-3835

Access URL: https://doaj.org/article/93de3f74397b48339fd123aba8de5335

Large-scale phenotypic drug screen identifies neuroprotectants in zebrafish and mouse models of retinitis pigmentosa

Authors: Liyun Zhang, Conan Chen, Jie Fu, Brendan Lilley, Cynthia Berlinicke, Baranda Hansen, Ding Ding, Guohua Wang, Tao Wang, Daniel Shou, Ying Ye, Timothy Mulligan, Kevin Emmerich, Meera T Saxena, Kelsi R Hall, Abigail V Sharrock, Carlene Brandon, Hyejin Park, Tae-In Kam, Valina L Dawson, Ted M Dawson, Joong Sup Shim, Justin Hanes, Hongkai Ji, Jun O Liu, Jiang Qian, David F Ackerley, Baerbel Rohrer, Donald J Zack, Jeff S Mumm

Source: eLife, Vol 10 (2021)

Subject Terms: neuroprotectants, rod photoreceptors, retinitis pigmentosa, Medicine, Science, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://elifesciences.org/articles/57245; https://doaj.org/toc/2050-084X

Access URL: https://doaj.org/article/ae361e62a3fd4acc8161a7ed3eae9011

Targeting AURKA-CDC25C axis to induce synthetic lethality in ARID1A-deficient colorectal cancer cells

Authors: Changjie Wu, Junfang Lyu, Eun Ju Yang, Yifan Liu, Baoyuan Zhang, Joong Sup Shim

Source: Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/df2b605cb3254b96835e03cc52650794

Cholesterol Trafficking: An Emerging Therapeutic Target for Angiogenesis and Cancer

Authors: Junfang Lyu, Eun Ju Yang, Joong Sup Shim

Source: Cells, Vol 8, Iss 5, p 389 (2019)

Subject Terms: cholesterol trafficking, angiogenesis, lysosome, NPC1, mTOR, Cytology, QH573-671

File Description: electronic resource

Relation: https://www.mdpi.com/2073-4409/8/5/389; https://doaj.org/toc/2073-4409

Access URL: https://doaj.org/article/3271bd06ebd8441a981645e3b632f458

Targeting Epithelial–Mesenchymal Transition (EMT) to Overcome Drug Resistance in Cancer

Authors: Bowen Du, Joong Sup Shim

Source: Molecules, Vol 21, Iss 7, p 965 (2016)

Subject Terms: epithelial–mesenchymal transition, drug resistance, chemotherapy, cancer stem cells, Organic chemistry, QD241-441

File Description: electronic resource

Relation: http://www.mdpi.com/1420-3049/21/7/965; https://doaj.org/toc/1420-3049

Access URL: https://doaj.org/article/eaca730b0c214e50b290021bb6ef7748

BET inhibition induces synthetic lethality in PTEN deficient colorectal cancers via dual action on p21^CIP1/WAF1.

Authors: Guowen Ren, Jinghong Chen, Yue Pu, Eun Ju Yang, Shishi Tao, Pui Kei Mou, Li-Jie Chen, Wenli Zhu, Kin Long Chan, Guanghui Luo, Chuxia Deng, Joong Sup Shim

Source: International Journal of Biological Sciences; 2024, Vol. 20 Issue 6, p1978-1991, 14p

ER translocon inhibitor ipomoeassin F inhibits triple-negative breast cancer growth via blocking ER molecular chaperones.

Authors: Shishi Tao, Eun Ju Yang, Guanghui Zong, Pui Kei Mou, Guowen Ren, Yue Pu, Liang Chen, Ho Jeong Kwon, Jianhong Zhou, Zhijian Hu, Khosravi, Arman, Qingyang Zhang, Yuchun Du, Shi, Wei Q., Joong Sup Shim

Source: International Journal of Biological Sciences; 2023, Vol. 19 Issue 13, p4020-4035, 16p

MDM2 inhibition is synthetic lethal with PTEN loss in colorectal cancer cells via the p53-dependent mechanism.

Authors: Guowen Ren, Eun Ju Yang, Shishi Tao, Pui Kei Mou, Yue Pu, Li-Jie Chen, Joong Sup Shim

Source: International Journal of Biological Sciences; 2023, Vol. 19 Issue 11, p3544-3557, 14p

Plakoglobin is a new target gene of histone deacetylase in human fibrosarcoma HT1080 cells.

Authors: Joong Sup Shim¹, Dong Hoon Kim¹, Ho Jeong Kwon¹ kwonhj@sejong.ac.kr

Source: Oncogene. 3/4/2004, Vol. 23 Issue 9, p1704-1711. 8p. 4 Black and White Photographs, 1 Chart, 2 Graphs.

Subject Terms: *HISTONE deacetylase, *GENE expression, *ONCOGENES, *DNA microarrays, *SARCOMA, *PRECIPITIN reaction, *GENETIC transcription

Antifungal drug itraconazole targets VDAC1 to modulate the AMPK/mTOR signaling axis in endothelial cells.

Authors: Head, Sarah A., Wei Shi, Liang Zhao, Gorshkov, Kirill, Pasunooti, Kalyan, Yue Chen, Zhiyou Deng, Ruo-jing Li, Joong Sup Shim, Wenzhi Tan, Hartung, Thomas, Jin Zhang, Yingming Zhao, Colombini, Marco, Liu, Jun O.

Source: Proceedings of the National Academy of Sciences of the United States of America; 12/29/2015, Vol. 112 Issue 52, pE7276-E7285, 10p

Subject Terms: ANTIFUNGAL agents, ITRACONAZOLE, MTOR protein, CELLULAR signal transduction, MITOCHONDRIAL proteins, TARGETED drug delivery, ENDOTHELIAL cells

Purpurin inhibits adipocyte-derived leucine aminopeptidase and angiogenesis in a zebrafish model.

Authors: Hyomi Park¹, Joong Sup Shim², Beom Seok Kim¹, Hye Jin Jung³, Tae-Lin Huh⁴, Ho Jeong Kwon^1,5 kwonhj@yonsei.ac.kr

Source: Biochemical & Biophysical Research Communications. Jul2014, Vol. 450 Issue 1, p561-567. 7p.

Subject Terms: *ANTHRAQUINONES, *FAT cells, *LEUCINE aminopeptidase, *NEOVASCULARIZATION inhibitors, *LABORATORY zebrafish, *VASCULAR endothelial growth factors

Selective Inhibition of HER2-Positive Breast Cancer Cells by the HIV Protease Inhibitor Nelfinavir.

Authors: Joong Sup Shim¹, Rao, Rajini², Beebe, Kristin, Neckers, Len³, Hart, Inkyu⁴, Nahta, Rita⁵, Liu, Jun O.^1,6 liu@jhu.edu

Source: JNCI: Journal of the National Cancer Institute. 10/17/2012, Vol. 104 Issue 20, p1576-1590. 15p. 1 Color Photograph, 3 Black and White Photographs, 1 Diagram, 1 Chart, 2 Graphs.

Subject Terms: *HER2 protein, *BREAST cancer diagnosis, *TARGETED drug delivery, *NELFINAVIR, *XENOGRAFTS, *CANCER cells

Chemical screen identifies FDA-approved drugs and target pathways that induce precocious pancreatic endocrine differentiation.

Authors: Rovira, Meritxell, Wei Huang, Yusuff, Shamila, Joong Sup Shim, Ferrante, Anthony A., Liu, Jun O., Parsons, Michael J.

Source: Proceedings of the National Academy of Sciences of the United States of America; 11/29/2011, Vol. 108 Issue 48, p19264-19269, 6p

Subject Terms: HYPOGLYCEMIC agents, TYPE 1 diabetes, AUTOIMMUNITY, PANCREATIC secretions, TRETINOIN, BIOCHEMISTRY

Effect of Nitroxoline on Angiogenesis and Growth of Human Bladder Cancer.

Authors: Joong Sup Shim¹, Matsui, Yoshiyuki², Bhat, Shridhar¹, Nacev, Benjamin A.^1,3, Jing Xu¹, Bhang, Hyo-eun C.¹, Dhara, Surajit⁴, Kee Chung Han¹, Chong, Curtis R.^1,3, Pomper, Martin G.^1,4, So, Alan², Liu, Jun O.^1,5 joliu@jhu.edu

Source: JNCI: Journal of the National Cancer Institute. Dec2010, Vol. 102 Issue 24, p1855-1873. 19p. 1 Black and White Photograph, 7 Graphs.

Subject Terms: *NEOVASCULARIZATION, *BLADDER cancer, *TUMOR growth, *METASTASIS, *ANTINEOPLASTIC agents