Amelioration of a von Willebrand disease type 2B phenotype in vivo upon treatment with allele-selective siRNAs

Authors: Linthorst, Noa A. ¹, Jongejan, Yvonne K. ¹, Dirven, Richard J. ¹, Laan, Sebastiaan N. J. ^{1, 2}, Bierings, Ruben ², Casari, Caterina ³, Cordfunke, Robert A. ⁴, Dahlman, James E. ⁵, Dolezal, Natasja ⁴, Drijfhout, Jan Wouter ⁴, Leebeek, Frank W. G. ², Ruhaak, L. Renee ⁶, Schrader Echeverri, Elisa ⁵, Voorberg, Jan ⁷, van Vlijmen, Bart J. M. ¹, Denis, Cécile V. ³, Eikenboom, Jeroen C. J. ^{1, ∗}

Source: In Blood Advances 28 January 2025 9(2):310-320

Silencing of the von Willebrand factor gene in proatherothrombotic APOE∗3-Leiden.CETP transgenic mice

Authors: Jongejan, Yvonne K. ¹, Dirven, Richard J. ¹, Schrader Echeverri, Elisa ², de Jong, Anke J.L. ¹, Pronk, Amanda C.M. ³, Kooijman, Sander ³, Rensen, Patrick C.N. ³, Dahlman, James E. ², Eikenboom, Jeroen C.J. ¹, van Vlijmen, Bart J.M. ^{1, ∗}

Source: In Research and Practice in Thrombosis and Haemostasis January 2025 9(1)

Impact of allele-selective silencing of von Willebrand factor in mice based on a single nucleotide allelic difference in von Willebrand factor

Authors: Jongejan, Yvonne K., Linthorst, Noa A., Schrader Echeverri, Elisa, Laan, Sebastiaan N.J., Dirven, Richard J., Dahlman, James E., van Vlijmen, Bart J.M., Denis, Cécile V., Eikenboom, Jeroen C.J.

Source: In Thrombosis Research April 2024 236:201-208

Small interfering RNA–mediated allele-selective silencing of von Willebrand factor in vitro and in vivo

Authors: Jongejan, Yvonne K., Schrader Echeverri, Elisa, Dirven, Richard J., Paunovska, Kalina, Linthorst, Noa A., de Jong, Annika, Wellershoff, Johannes C., van der Gouw, Kim D., van Vlijmen, Bart J. M., Dahlman, James E., Eikenboom, Jeroen C. J.

Source: In Blood Advances 24 October 2023 7(20):6108-6119

Atherothrombosis model by silencing of protein C in APOE*3-Leiden.CETP transgenic mice.

Authors: Jongejan, Yvonne K., Eikenboom, Jeroen C. J., Gijbels, Marion J. J., Berbée, Jimmy F. P., van Vlijmen, Bart J. M.

Source: Journal of Thrombosis & Thrombolysis; Oct2021, Vol. 52 Issue 3, p715-719, 5p