Comprehensive Synthetic Route Redesign of AZD5991: A High-Complexity Atropisomeric Macrocycle.

Authors: Howell, Gareth P., Agnew, Lauren R., Bauer, Christoph, Bell, Fiona J., Campbell, Andrew D., Dai, Kuangchu, Dave, David, Ellis, Sam R., Foulkes, Matthew J., Gall, Malcolm A. Y., Garrec, Kilian, Ge, Huajun, Hayter, Barry R., Jones, Martin F., Karageorgis, George, Littleson, Mairi, Lloyd-Hughes, Thomas W., McNicholl, Harriet C., Mooney, David T., Moore, Bethany J.

Source: Organic Process Research & Development; 3/21/2025, Vol. 29 Issue 3, p804-827, 24p

Deactivation mechanisms of iodo-iridium catalysts in chiral amine racemization

Authors: Kwan, Maria H.T., Pokar, Nisha P.B., Good, Catherine, Jones, Martin F., Munday, Rachel, Screen, Thomas, Blacker, A. John

Source: In Tetrahedron 29 January 2021 80

Cediranib Maleate—From Crystal Structure Toward Materials Control

Authors: Black, Simon N., Wheatcroft, Helen P., Roberts, Ron, Jones, Martin F., McFarlane, Ian, Pettersen, Anna

Source: In Journal of Pharmaceutical Sciences April 2020 109(4):1509-1518

Behavioural activation for people in custody with depression: A protocol for a feasibility randomised controlled study.

Authors: Walsh, Sandra M., Muyambi, Kuda, Dennis, Shaun, Hutchinson, Steven, Turnbull, Tom, Tan, Kuan Liung, Dettwiller, Pascale, Bressington, Daniel, Gray, Richard, Howard, Lucy, Andrews, Joanne, Muthuramalingam, Shyamsundar, Versace, Vincent L., Jones, Martin F.

Source: PLoS ONE; 6/13/2024, Vol. 19 Issue 6, p1-16, 16p

Subject Terms: COGNITIVE therapy, MENTAL health personnel, PSYCHOTHERAPY, MEDICAL care, RANDOMIZED controlled trials, JUVENILE offenders

Geographic Terms: NEW Zealand

Company/Entity: UNIVERSITY of South Australia

Metal-Catalyzed C–N Bond Forming Reaction Selection and Process Development for the Manufacture of AZD7594

Authors: Aydin, Gulsevim, Ball, Matthew, Bishop, Thomas George, Burns, Matthew, Campbell, Andrew D., Cox, Robert J., Dai, Kuangchu, Dave, David, Fisk, Heidi, Hamilton, Laura, Heffernan, Claire, Henry, Jean-Marc, Holman, Stephen W., Jones, Martin F., Noonan, Gary, Patel, Bharti, Streather, David, Tomasi, Simone

Source: Organic Process Research & Development; February 2024, Vol. 28 Issue: 2 p559-576, 18p

Exploiting the Physical Properties of Diethanolamine Boronic Esters for Process Improvements in AZD5718.

Authors: Henry, Jean-Marc, Milne, David, Perkins, Dave, Hicks, William, Hose, David R. J., Campbell, Andrew D., Mullen, Alexander K., Inglesby, Phillip A., Raw, Steven A., Jones, Martin F.

Source: Organic Process Research & Development; 3/17/2023, Vol. 27 Issue 3, p488-495, 8p

Bayesian Self‐Optimization for Telescoped Continuous Flow Synthesis.

Authors: Clayton, Adam D., Pyzer‐Knapp, Edward O., Purdie, Mark, Jones, Martin F., Barthelme, Alexandre, Pavey, John, Kapur, Nikil, Chamberlain, Thomas W., Blacker, A. John, Bourne, Richard A.

Source: Angewandte Chemie; 1/16/2023, Vol. 135 Issue 3, p1-5, 5p

Subject Terms: CHEMICAL synthesis, MATHEMATICAL optimization, SUSTAINABLE chemistry, HIGH performance liquid chromatography, PHARMACEUTICAL chemistry

Process Development, Manufacture, and Understanding of the Atropisomerism and Polymorphism of Verinurad.

Authors: Ring, Oliver T., Hayter, Barry R., Ronson, Thomas O., Agnew, Lauren R., Ashworth, Ian W., Cherryman, Janette, Gall, Malcolm A. Y., Hamilton, Peter R., Inglesby, Phillip A., Jones, Martin F., Lamacraft, Alex L., Leahy, Adam J., McKinney, David, Miller-Potucka, Lucie, Powell, Lyn, Putra, Okky D., Robbins, Andrew J., Tomasi, Simone, Wordsworth, Rosemary A.

Source: Organic Process Research & Development; 3/18/2022, Vol. 26 Issue 3, p936-948, 13p

Sequential decarboxylative azomethine ylide cycloaddition—palladium catalysed hydrostannylation–cyclisation-anion capture processes

Authors: Grigg, Ronald, Jones, Martin F, McTiernan, Michelle, Sridharan, Visuvanathar

Source: In Tetrahedron 2001 57(37):7979-7989

Route Design to Manufacture: Synthesis of the Heterocyclic Fragment of AZD5718 Using a Non-cryogenic Lithiation-Alkoxycarbonylation Reaction.

Authors: Burns, Matthew, Perkins, Dave, Chan, Lai C., Pilling, Michael J., Jawor-Baczynska, Anna, Mullen, Alexander K., Steven, Alan, Wimsey, Chris, Elmekawy, Ahmed, Lamacraft, Alex, Dobson, Benjamin C., McMillan, Angus E., Hose, David R. J., Inglesby, Phillip A., Raw, Steven A., Jones, Martin F.

Source: Organic Process Research & Development; 4/16/2021, Vol. 25 Issue 4, p858-870, 13p

Continuous Flow Chiral Amine Racemization Applied to Continuously Recirculating Dynamic Diastereomeric Crystallizations.

Authors: Kwan, Maria H. T., Breen, Jessica, Bowden, Martin, Conway, Louis, Crossley, Ben, Jones, Martin F., Munday, Rachel, Pokar, Nisha P. B., Screen, Thomas, Blacker, A. John

Source: Journal of Organic Chemistry; 2/5/2021, Vol. 86 Issue 3, p2458-2473, 16p

Development and Scale-Up of an Improved Manufacturing Route to the ATR Inhibitor Ceralasertib.

Authors: Graham, Mark A., Askey, Hannah, Campbell, Andrew D., Chan, Lai, Cooper, Katie G., Cui, Zhaoshan, Dalgleish, Andrew, Dave, David, Ensor, Gareth, Galan Espinosa, Maria Rita, Hamilton, Peter, Heffernan, Claire, Jackson, Lucinda V., Jing, Dajiang, Jones, Martin F., Liu, Pengpeng, Mulholland, Keith R., Pervez, Mohammed, Popadynec, Michael, Randles, Emma

Source: Organic Process Research & Development; 1/15/2021, Vol. 25 Issue 1, p43-56, 14p

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Interesting stereoselectivity of intramolecular Diels-Alder reactions leading to 5-carbomethoxy yohimbine systems

Authors: Leonard, John, Hague, Andrew B., Harms, Guido, Jones, Martin F.

Source: In Tetrahedron Letters 1999 40(46):8141-8145

Self-optimising reactive extractions: towards the efficient development of multi-step continuous flow processes.

Authors: Clayton, Adam D., Power, Luke A., Reynolds, William R., Ainsworth, Caroline, Hose, David R. J., Jones, Martin F., Chamberlain, Thomas W., Blacker, A. John, Bourne, Richard A.

Source: Journal of Flow Chemistry; Mar2020, Vol. 10 Issue 1, p199-206, 8p

Subject Terms: CONTINUOUS processing, INTERMEDIATE goods, CONTINUOUS flow reactors, LIQUID-liquid extraction, AMINES

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Stereoretentive Etherification of an α‑Aryl-β-amino Alcohol Using a Selective Aziridinium Ring Opening for the Synthesis of AZD7594.

Authors: McMillan, Angus E., Steven, Alan, Ashworth, Ian W., Mullen, Alexander K., Chan, Lai C., Galan Espinosa, Maria Rita, Pilling, Michael J., Raw, Steven A., Jones, Martin F.

Source: Journal of Organic Chemistry; 4/19/2019, Vol. 84 Issue 8, p4629-4638, 10p

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Efficient synthesis of the selective COX-2 inhibitor GW406381X

Authors: Whitehead, Andrew J., Ward, Richard A., Jones, Martin F.

Source: In Tetrahedron Letters 2007 48(6):911-913