P-selectin-dependent leukocyte adhesion is governed by endolysosomal two-pore channel 2

Authors: Jonas Goretzko, Inga Pauels, Nicole Heitzig, Katharina Thomas, Marina Kardell, Johannes Naß, Einar Kleinhans Krogsaeter, Sebastian Schloer, Barbara Spix, Anna Lívia Linard Matos, Charlotte Leser, Tristan Wegner, Frank Glorius, Franz Bracher, Volker Gerke, Jan Rossaint, Christian Grimm, Ursula Rescher

Source: Cell Reports, Vol 42, Iss 12, Pp 113501- (2023)

Subject Terms: CP: Immunology, CP: Cell biology, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124723015139; https://doaj.org/toc/2211-1247

Access URL: https://doaj.org/article/743e166b584b4ba9a9ee505a123e92b3

Pharmacologically induced endolysosomal cholesterol imbalance through clinically licensed drugs itraconazole and fluoxetine impairs Ebola virus infection in vitro

Authors: Susann Kummer, Angelika Lander, Jonas Goretzko, Norman Kirchoff, Ursula Rescher, Sebastian Schloer

Source: Emerging Microbes and Infections, Vol 11, Iss 1, Pp 195-207 (2022)

Subject Terms: ebola virus, niemann-pick c1, itraconazole, fiasma, fluoxetine, viral entry, endolysosomal interference, Infectious and parasitic diseases, RC109-216, Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/2222-1751

Access URL: https://doaj.org/article/673fa9eaf29b4e8e97536ec71e50e379

Targeting the endolysosomal host-SARS-CoV-2 interface by clinically licensed functional inhibitors of acid sphingomyelinase (FIASMA) including the antidepressant fluoxetine

Authors: Sebastian Schloer, Linda Brunotte, Jonas Goretzko, Angeles Mecate-Zambrano, Nadia Korthals, Volker Gerke, Stephan Ludwig, Ursula Rescher

Source: Emerging Microbes and Infections, Vol 9, Iss 1, Pp 2245-2255 (2020)

Subject Terms: SARS-CoV-2, IAV, FIASMA, fluoxetine, viral entry, endolysosomal interference, Infectious and parasitic diseases, RC109-216, Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/2222-1751

Access URL: https://doaj.org/article/bcf82b4bf73a42dcb504646c60eb279b

The clinically licensed antifungal drug itraconazole inhibits influenza virus in vitro and in vivo

Authors: Sebastian Schloer, Jonas Goretzko, Alexander Kühnl, Linda Brunotte, Stephan Ludwig, Ursula Rescher

Source: Emerging Microbes and Infections, Vol 8, Iss 1, Pp 80-93 (2019)

Subject Terms: Influenza A virus, posaconazole, itraconazole, interferon response, cellular cholesterol, host cell factors, Infectious and parasitic diseases, RC109-216, Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/2222-1751

Access URL: https://doaj.org/article/30def7bef94a4af185c7a339cd4abadd

Repurposing Antifungals for Host-Directed Antiviral Therapy?

Authors: Sebastian Schloer, Jonas Goretzko, Ursula Rescher

Source: Pharmaceuticals, Vol 15, Iss 2, p 212 (2022)

Subject Terms: antifungals, host-directed drug therapy, drug repurposing, azoles, polyenes, echinocandins, Medicine, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://www.mdpi.com/1424-8247/15/2/212; https://doaj.org/toc/1424-8247

Access URL: https://doaj.org/article/d4d37ee2f94a41cc83fe5b372f987012

High Nuclease Activity of Long Persisting Staphylococcus aureus Isolates Within the Airways of Cystic Fibrosis Patients Protects Against NET-Mediated Killing

Authors: Susann Herzog, Felix Dach, Nicole de Buhr, Silke Niemann, Jannik Schlagowski, Diego Chaves-Moreno, Claudia Neumann, Jonas Goretzko, Vera Schwierzeck, Alexander Mellmann, Angelika Dübbers, Peter Küster, Holger Schültingkemper, Ursula Rescher, Dietmar H. Pieper, Maren von Köckritz-Blickwede, Barbara C. Kahl

Source: Frontiers in Immunology, Vol 10 (2019)

Subject Terms: Cystic fibrosis, Staphylococcus aureus, neutrophil extracellular traps, nuclease, adaptation, NET-mediated killing, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fimmu.2019.02552/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/d2bcd5f29662432aad134ee62a51d8fe

Combinatory Treatment with Oseltamivir and Itraconazole Targeting Both Virus and Host Factors in Influenza A Virus Infection

Authors: Sebastian Schloer, Jonas Goretzko, Stephan Pleschka, Stephan Ludwig, Ursula Rescher

Source: Viruses, Vol 12, Iss 7, p 703 (2020)

Subject Terms: influenza A virus, oseltamivir, itraconazole, host-directed therapy, drug repurposing, combination therapy, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.mdpi.com/1999-4915/12/7/703; https://doaj.org/toc/1999-4915

Access URL: https://doaj.org/article/62f9580c45304b9bbf68cacee7b704da