IER5, a DNA damage response gene, is required for Notch-mediated induction of squamous cell differentiation

Authors: Li Pan, Madeleine E Lemieux, Tom Thomas, Julia M Rogers, Colin H Lipper, Winston Lee, Carl Johnson, Lynette M Sholl, Andrew P South, Jarrod A Marto, Guillaume O Adelmant, Stephen C Blacklow, Jon C Aster

Source: eLife, Vol 9 (2020)

Subject Terms: Notch, PP2A, DNA damage response, squamous cell carcinoma, Medicine, Science, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://elifesciences.org/articles/58081; https://doaj.org/toc/2050-084X

Access URL: https://doaj.org/article/ae52c805774448d4bf9d92c9ea73aab9

Loss of atrx cooperates with p53-deficiency to promote the development of sarcomas and other malignancies.

Authors: Felix Oppel, Ting Tao, Hui Shi, Kenneth N Ross, Mark W Zimmerman, Shuning He, Guangxiang Tong, Jon C Aster, A Thomas Look

Source: PLoS Genetics, Vol 15, Iss 4, p e1008039 (2019)

Subject Terms: Genetics, QH426-470

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC6476535?pdf=render; https://doaj.org/toc/1553-7390; https://doaj.org/toc/1553-7404

Access URL: https://doaj.org/article/a406772986bc4045b55fe8516df75a33

Gene expression profiling distinguishes prefibrotic from overtly fibrotic myeloproliferative neoplasms and identifies disease subsets with distinct inflammatory signatures.

Authors: Waihay J Wong, Michele Baltay, Annaliese Getz, Kit Fuhrman, Jon C Aster, Robert P Hasserjian, Olga Pozdnyakova

Source: PLoS ONE, Vol 14, Iss 5, p e0216810 (2019)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/740c883a418840dfa02e252bb5c27d2c

The common oncogenomic program of NOTCH1 and NOTCH3 signaling in T-cell acute lymphoblastic leukemia.

Authors: Sung Hee Choi, Eric Severson, Warren S Pear, Xiaole S Liu, Jon C Aster, Stephen C Blacklow

Source: PLoS ONE, Vol 12, Iss 10, p e0185762 (2017)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC5638296?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/f25c922d9e91461cb195fc3a77c47642

Angiopoietin-like proteins stimulate HSPC development through interaction with notch receptor signaling

Authors: Michelle I Lin, Emily N Price, Sonja Boatman, Elliott J Hagedorn, Eirini Trompouki, Sruthi Satishchandran, Charles W Carspecken, Audrey Uong, Anthony DiBiase, Song Yang, Matthew C Canver, Ann Dahlberg, Zhigang Lu, Cheng Cheng Zhang, Stuart H Orkin, Irwin D Bernstein, Jon C Aster, Richard M White, Leonard I Zon

Source: eLife, Vol 4 (2015)

Subject Terms: angiopoietin-like protein, notch, hematopoietic stem, LILRB2, myc, progenitor cells, Medicine, Science, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://elifesciences.org/articles/05544; https://doaj.org/toc/2050-084X

Access URL: https://doaj.org/article/d413b0fa911d41d19654119779f21716

Gauging NOTCH1 Activation in Cancer Using Immunohistochemistry.

Authors: Michael J Kluk, Todd Ashworth, Hongfang Wang, Birgit Knoechel, Emily F Mason, Elizabeth A Morgan, David Dorfman, Geraldine Pinkus, Oliver Weigert, Jason L Hornick, Lucian R Chirieac, Michelle Hirsch, David J Oh, Andrew P South, Irene M Leigh, Celine Pourreyron, Andrew J Cassidy, Daniel J Deangelo, David M Weinstock, Ian E Krop, Deborah Dillon, Jane E Brock, Alexander J F Lazar, Myron Peto, Raymond J Cho, Alexander Stoeck, Brian B Haines, Sriram Sathayanrayanan, Scott Rodig, Jon C Aster

Source: PLoS ONE, Vol 8, Iss 6, p e67306 (2013)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3688991?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/32604a8825f6402bb5ed46051a8c0b7c

Notch ankyrin repeat domain variation influences leukemogenesis and Myc transactivation.

Authors: Jon C Aster, Nick Bodnar, Lanwei Xu, Fredrick Karnell, John M Milholland, Ivan Maillard, Gavin Histen, Yunsun Nam, Stephen C Blacklow, Warren S Pear

Source: PLoS ONE, Vol 6, Iss 10, p e25645 (2011)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3192765?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/3613db6e838241a1a8c60558210c4dbf

Characterization of Notch1 antibodies that inhibit signaling of both normal and mutated Notch1 receptors.

Authors: Miguel Aste-Amézaga, Ningyan Zhang, Janet E Lineberger, Beth A Arnold, Timothy J Toner, Mingcheng Gu, Lingyi Huang, Salvatore Vitelli, Kim T Vo, Peter Haytko, Jing Zhang Zhao, Frederic Baleydier, Sarah L'Heureux, Hongfang Wang, Wendy R Gordon, Elizabeth Thoryk, Marie Blanke Andrawes, Kittichoat Tiyanont, Kimberly Stegmaier, Giovanni Roti, Kenneth N Ross, Laura L Franlin, Hui Wang, Fubao Wang, Michael Chastain, Andrew J Bett, Laurent P Audoly, Jon C Aster, Stephen C Blacklow, Hans E Huber

Source: PLoS ONE, Vol 5, Iss 2, p e9094 (2010)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC2817004?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/b4ac98e727c04ff3ad08212b68b47d08

Effects of S1 cleavage on the structure, surface export, and signaling activity of human Notch1 and Notch2.

Authors: Wendy R Gordon, Didem Vardar-Ulu, Sarah L'Heureux, Todd Ashworth, Michael J Malecki, Cheryll Sanchez-Irizarry, Debbie G McArthur, Gavin Histen, Jennifer L Mitchell, Jon C Aster, Stephen C Blacklow

Source: PLoS ONE, Vol 4, Iss 8, p e6613 (2009)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC2726630?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/bd8fa4227a984c5fb57219385262de3b

IGH rearrangement in myeloid neoplasms

Authors: Amy W. Xiao, Yuyan Jia, Linda B. Baughn, Kathryn E. Pearce, Beth A. Pitel, Jon C. Aster, Paola Dal Cin, Sheng Xiao

Source: Haematologica, Vol 105, Iss 6 (2020)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://haematologica.org/article/view/9464; https://doaj.org/toc/0390-6078; https://doaj.org/toc/1592-8721

Access URL: https://doaj.org/article/e0d1d24e2730486b9c012e669ace18fc

Systematic STAT3 sequencing in patients with unexplained cytopenias identifies unsuspected large granular lymphocytic leukemia

Authors: Elizabeth A. Morgan, Mark N. Lee, Daniel J. DeAngelo, David P. Steensma, Richard M. Stone, Frank C. Kuo, Jon C. Aster, Christopher J. Gibson, R. Coleman Lindsley

Source: Blood Advances, Vol 1, Iss 21, Pp 1786-1789 (2017)

Subject Terms: Specialties of internal medicine, RC581-951

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2473952920303207; https://doaj.org/toc/2473-9529

Access URL: https://doaj.org/article/bcef717a2e1043c680d555f35ee36358

Pre-diagnosis plasma immune markers and risk of non-Hodgkin lymphoma in two prospective cohort studies

Authors: Mara M. Epstein, Bernard Rosner, Elizabeth C. Breen, Julie L. Batista, Edward L. Giovannucci, Larry Magpantay, Jon C. Aster, Scott J. Rodig, Kimberly A. Bertrand, Francine Laden, Otoniel Martínez-Maza, Brenda M. Birmann

Source: Haematologica, Vol 103, Iss 10 (2018)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://haematologica.org/article/view/8625; https://doaj.org/toc/0390-6078; https://doaj.org/toc/1592-8721

Access URL: https://doaj.org/article/27ed02d80029462c950f85c78c31c87e

T cell acute lymphoblastic leukemia/lymphoma: a human cancer commonly associated with aberrant NOTCH1 signaling.

Authors: Warren S Pear, Jon C Aster

Source: Current Opinion in Hematology; Nov2004, Vol. 11 Issue 6, p426-433, 8p

Integrative cytogenetic and molecular studies unmask 'chromosomal mimicry' in hematologic malignancies

Authors: Melissa Zhao, Scott Ryall, Samuel J. Brody, Amyah C. Harris, Kristin Cabral, Catherine Brownstein, Jaeseung C. Kim, Adam C. Smith, Paola Dal Cin, Rupa Narayan, Kristin Sikkink, Anthony Schmitt, Gabriela S. Hobbs, Amir T. Fathi, Gabriel K. Griffin, Sheila N. J. Sait, Anthony J. Iafrate, Jon C. Aster, Timothy A. Graubert, Valentina Nardi, Adrian M. Dubuc

Source: Blood Advances, Vol 9, Iss 5, Pp 1003-1012 (2025)

Subject Terms: Specialties of internal medicine, RC581-951

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S247395292400689X; https://doaj.org/toc/2473-9529

Access URL: https://doaj.org/article/0a7ad132a269454bb0d47fe6d30ed32a

AL101, a gamma-secretase inhibitor, has potent antitumor activity against adenoid cystic carcinoma with activated NOTCH signaling

Authors: Renata Ferrarotto, Vasudha Mishra, Elad Herz, Adar Yaacov, Oz Solomon, Rami Rauch, Adi Mondshine, Maria Motin, Tal Leibovich-Rivkin, Matti Davis, Joel Kaye, Christopher R. Weber, Le Shen, Alexander T. Pearson, Ari J. Rosenberg, Xiangying Chen, Alka Singh, Jon C. Aster, Nishant Agrawal, Evgeny Izumchenko

Source: Cell Death and Disease, Vol 13, Iss 8, Pp 1-11 (2022)

Subject Terms: Cytology, QH573-671

File Description: electronic resource

Relation: https://doaj.org/toc/2041-4889

Access URL: https://doaj.org/article/56e0238430084912a4c2eb44ee06b45b

FcγR engagement reprograms neutrophils into antigen cross-presenting cells that elicit acquired anti-tumor immunity

Authors: Vijayashree Mysore, Xavier Cullere, Joseph Mears, Florencia Rosetti, Koshu Okubo, Pei X. Liew, Fan Zhang, Iris Madera-Salcedo, Frank Rosenbauer, Richard M. Stone, Jon C. Aster, Ulrich H. von Andrian, Andrew H. Lichtman, Soumya Raychaudhuri, Tanya N. Mayadas

Source: Nature Communications, Vol 12, Iss 1, Pp 1-23 (2021)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/86a5a1c6c18f436081a1927c18c8de2d

Shortwave-infrared meso-patterned imaging enables label-free mapping of tissue water and lipid content

Authors: Yanyu Zhao, Anahita Pilvar, Anup Tank, Hannah Peterson, John Jiang, Jon C. Aster, John Paul Dumas, Mark C. Pierce, Darren Roblyer

Source: Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/35eb329c1dd3420fba184c8ac9282a99

A Novel SEC22B-NOTCH2 Fusion in Chronic Lymphocytic Leukemia

Authors: Rory Crotty, Dora Dias-Santagata, Jon C. Aster, Valentina Nardi

Source: Human Pathology: Case Reports, Vol 21, Iss , Pp 200408- (2020)

Subject Terms: Chronic lymphocytic leukemia, Molecular alteration, Gene rearrangement, Gamma-secretase inhibitors, Breast carcinoma, Pathology, RB1-214

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2214330020300572; https://doaj.org/toc/2214-3300

Access URL: https://doaj.org/article/ae7cbcaef36c4536b2133d4275ae3d5a

suz12 inactivation in p53- and nf1-deficient zebrafish accelerates the onset of malignant peripheral nerve sheath tumors and expands the spectrum of tumor types

Authors: Felix Oppel, Dong H. Ki, Mark W. Zimmerman, Kenneth N. Ross, Ting Tao, Hui Shi, Shuning He, Jon C. Aster, A. Thomas Look

Source: Disease Models & Mechanisms, Vol 13, Iss 8 (2020)

Subject Terms: mpnst, leukemia, suz12, p53, nf1, ras signaling, Medicine, Pathology, RB1-214

File Description: electronic resource

Relation: http://dmm.biologists.org/content/13/8/dmm042341; https://doaj.org/toc/1754-8403; https://doaj.org/toc/1754-8411

Access URL: https://doaj.org/article/9652420fb6814c8ab9af147d0275ee95

Targetable vulnerabilities in T- and NK-cell lymphomas identified through preclinical models

Authors: Samuel Y. Ng, Noriaki Yoshida, Amanda L. Christie, Mahmoud Ghandi, Neekesh V. Dharia, Joshua Dempster, Mark Murakami, Kay Shigemori, Sara N. Morrow, Alexandria Van Scoyk, Nicolas A. Cordero, Kristen E. Stevenson, Maneka Puligandla, Brian Haas, Christopher Lo, Robin Meyers, Galen Gao, Andrew Cherniack, Abner Louissaint, Valentina Nardi, Aaron R. Thorner, Henry Long, Xintao Qiu, Elizabeth A. Morgan, David M. Dorfman, Danilo Fiore, Julie Jang, Alan L. Epstein, Ahmet Dogan, Yanming Zhang, Steven M. Horwitz, Eric D. Jacobsen, Solimar Santiago, Jian-Guo Ren, Vincent Guerlavais, D. Allen Annis, Manuel Aivado, Mansoor N. Saleh, Amitkumar Mehta, Aviad Tsherniak, David Root, Francisca Vazquez, William C. Hahn, Giorgio Inghirami, Jon C. Aster, David M. Weinstock, Raphael Koch

Source: Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/ecc83cf960564bd2938fc055d45d8a01