Design and validation of a GMP stem cell manufacturing protocol for MPSII hematopoietic stem cell gene therapy

Authors: Stuart Ellison, Karen Buckland, Yuko Learmonth, Victoria Day, Spandan Kalra, Lauren Howe, Francisco José Roman-Rodriguez, Jose Bonafont, Laura Booth, Rebecca Holley, Jon Smythe, Simon Jones, Adrian Thrasher, Claire Booth, Brian W. Bigger

Source: Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 2, Pp 101271- (2024)

Subject Terms: hematopoietic stem cell gene therapy, MPSII, mucopolysaccharidosis, GMP cell manufacturing, transduction enhancers, cleanroom validation studies, Genetics, QH426-470, Cytology, QH573-671

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2329050124000871; https://doaj.org/toc/2329-0501

Access URL: https://doaj.org/article/c6d56cc1cb214a2393e79a6e7acc9046

Repair of acute respiratory distress syndrome by stromal cell administration (REALIST): a structured study protocol for an open-label dose-escalation phase 1 trial followed by a randomised, triple-blind, allocation concealed, placebo-controlled phase 2 trial

Authors: Ellen Gorman, Manu Shankar-Hari, Phil Hopkins, William S. Tunnicliffe, Gavin D. Perkins, Jonathan Silversides, Peter McGuigan, Colette Jackson, Roisin Boyle, Jamie McFerran, Cliona McDowell, Christina Campbell, Margaret McFarland, Jon Smythe, Jacqui Thompson, Barry Williams, Gerard Curley, John G. Laffey, Mike Clarke, Daniel F. McAuley, Cecilia O’Kane

Source: Trials, Vol 23, Iss 1, Pp 1-15 (2022)

Subject Terms: Acute respiratory distress syndrome, Mesenchymal stromal cells, MSCs, Mesenchymal stem cells, Clinical trial, Protocol, Medicine (General), R5-920

File Description: electronic resource

Relation: https://doaj.org/toc/1745-6215

Access URL: https://doaj.org/article/b39f86b9bd8d43d5a0df92ee016b7c98

Repair of acute respiratory distress syndrome by stromal cell administration (REALIST) trial: A phase 1 trial

Authors: Ellen Gorman, Manu Shankar-Hari, Phil Hopkins, William S. Tunnicliffe, Gavin D. Perkins, Jonathan Silversides, Peter McGuigan, Anna Krasnodembskaya, Colette Jackson, Roisin Boyle, Jamie McFerran, Cliona McDowell, Christina Campbell, Margaret McFarland, Jon Smythe, Jacqui Thompson, Barry Williams, Gerard Curley, John G. Laffey, Mike Clarke, Daniel F. McAuley, Cecilia M. O'Kane

Source: EClinicalMedicine, Vol 41, Iss , Pp 101167- (2021)

Subject Terms: Medicine (General), R5-920

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2589537021004478; https://doaj.org/toc/2589-5370

Access URL: https://doaj.org/article/5d8040571d894196b436d7a7f05aab42

Repair of Acute Respiratory Distress Syndrome by Stromal Cell Administration in COVID-19 (REALIST-COVID-19): A structured summary of a study protocol for a randomised, controlled trial

Authors: Ellen Gorman, Manu Shankar-Hari, Phil Hopkins, William S. Tunnicliffe, Gavin D. Perkins, Jonathan Silversides, Peter McGuigan, Colette Jackson, Roisin Boyle, Jamie McFerran, Cliona McDowell, Christina Campbell, Margaret McFarland, Jon Smythe, Jacqui Thompson, Barry Williams, Gerard Curley, John G. Laffey, Mike Clarke, Cecilia O’Kane, Daniel F. McAuley

Source: Trials, Vol 21, Iss 1, Pp 1-3 (2020)

Subject Terms: COVID-19, Randomised controlled trial, protocol, Mesenchymal Stromal Cells, Mesenchymal Stem Cells, MSCs, Medicine (General), R5-920

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s13063-020-04416-w; https://doaj.org/toc/1745-6215

Access URL: https://doaj.org/article/523540fd733840fda8dfc370803163c3

Non-invasive imaging reveals conditions that impact distribution and persistence of cells after in vivo administration

Authors: Lauren Scarfe, Arthur Taylor, Jack Sharkey, Rachel Harwood, Michael Barrow, Joan Comenge, Lydia Beeken, Cai Astley, Ilaria Santeramo, Claire Hutchinson, Lorenzo Ressel, Jon Smythe, Eric Austin, Raphael Levy, Matthew J. Rosseinsky, Dave J. Adams, Harish Poptani, Brian K. Park, Patricia Murray, Bettina Wilm

Source: Stem Cell Research & Therapy, Vol 9, Iss 1, Pp 1-17 (2018)

Subject Terms: Cell therapies, Mesenchymal stem/stromal cells, Safety, Preclinical models, Cell tracking, Multi-modal imaging, Medicine (General), R5-920, Biochemistry, QD415-436

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s13287-018-1076-x; https://doaj.org/toc/1757-6512

Access URL: https://doaj.org/article/90b861852cd94ace8b91583c61cbdcce

The Impact of Proliferative Potential of Umbilical Cord–Derived Endothelial Progenitor Cells and Hypoxia on Vascular Tubule Formation In Vitro.

Authors: Youyi Zhang, Nita Fisher, Sarah E. Newey, Jon Smythe, Louise Tatton, Grigorios Tsaknakis, Sinead P. Forde, Lee Carpenter, Thanassi Athanassopoulos, Sarah J. Hale, David J.P. Ferguson, Michael P. Tyler, Suzanne M. Watt

Source: Stem Cells & Development; Mar2009, Vol. 18 Issue 2, p359-376, 18p