Immunohistochemistry of p53 surrogates TP53 mutation as an accurate predictor for early-relapse of surgically resected stage I-III lung adenocarcinomaCentral MessagePerspective

Authors: Yasuyuki Kurihara, MD, Takayuki Honda, MD, PhD, Akira Takemoto, MD, PhD, Katsutoshi Seto, MD, PhD, Satoshi Endo, MD, Kousuke Tanimoto, MD, PhD, Susumu Kirimura, MD, PhD, Masashi Kobayashi, MD, PhD, Shunichi Baba, MD, PhD, Yasuhiro Nakashima, MD, PhD, Ryo Wakejima, MD, PhD, Rie Sakakibara, MD, PhD, Hironori Ishibashi, MD, PhD, Johji Inazawa, MD, PhD, Toshihiro Tanaka, MD, PhD, Yasunari Miyazaki, MD, PhD, Kenichi Okubo, MD, PhD

Source: JTCVS Open, Vol 20, Iss , Pp 183-193 (2024)

Subject Terms: lung adenocarcinoma, TP53, immunohistochemistry, early relapse, Diseases of the circulatory (Cardiovascular) system, RC666-701, Surgery, RD1-811

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2666273624001633; https://doaj.org/toc/2666-2736

Access URL: https://doaj.org/article/4102ee1106d24518a153130f60139603

Identification of telomere maintenance gene variations related to lung adenocarcinoma risk by genome‐wide association and whole genome sequencing analyses

Authors: Kouya Shiraishi, Atsushi Takahashi, Yukihide Momozawa, Yataro Daigo, Syuzo Kaneko, Takahisa Kawaguchi, Hideo Kunitoh, Shingo Matsumoto, Hidehito Horinouchi, Akiteru Goto, Takayuki Honda, Kimihiro Shimizu, Masahiro Torasawa, Daisuke Takayanagi, Motonobu Saito, Akira Saito, Yuichiro Ohe, Shun‐ichi Watanabe, Koichi Goto, Masahiro Tsuboi, Katsuya Tsuchihara, Sadaaki Takata, Tomomi Aoi, Atsushi Takano, Masashi Kobayashi, Yohei Miyagi, Kazumi Tanaka, Hiroyuki Suzuki, Daichi Maeda, Takumi Yamaura, Maiko Matsuda, Yoko Shimada, Takaaki Mizuno, Hiromi Sakamoto, Teruhiko Yoshida, Yasushi Goto, Tatsuya Yoshida, Taiki Yamaji, Makoto Sonobe, Shinichi Toyooka, Kazue Yoneda, Katsuhiro Masago, Fumihiro Tanaka, Megumi Hara, Nobuo Fuse, Satoshi S. Nishizuka, Noriko Motoi, Norie Sawada, Yuichiro Nishida, Kazuki Kumada, Kenji Takeuchi, Kozo Tanno, Yasushi Yatabe, Kuniko Sunami, Tomoyuki Hishida, Yasunari Miyazaki, Hidemi Ito, Mitsuhiro Amemiya, Hirohiko Totsuka, Haruhiko Nakayama, Tomoyuki Yokose, Kazuyoshi Ishigaki, Toshiteru Nagashima, Yoichi Ohtaki, Kazuhiro Imai, Ken Takasawa, Yoshihiro Minamiya, Kazuma Kobayashi, Kenichi Okubo, Kenji Wakai, Atsushi Shimizu, Masayuki Yamamoto, Motoki Iwasaki, Koichi Matsuda, Johji Inazawa, Yuichi Shiraishi, Hiroyoshi Nishikawa, Yoshinori Murakami, Michiaki Kubo, Fumihiko Matsuda, Yoichiro Kamatani, Ryuji Hamamoto, Keitaro Matsuo, Takashi Kohno

Source: Cancer Communications, Vol 44, Iss 2, Pp 287-293 (2024)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2523-3548

Access URL: https://doaj.org/article/a4b8ea6db19942899046a4b6375483b8

The possibility of mutations of RAS signaling genes and/or TP53 in combination as a negative prognostic impact on pathological stage I non‐small cell lung cancer

Authors: Takayuki Honda, Katsutoshi Seto, Satoshi Endo, Akira Takemoto, Kousuke Tanimoto, Masashi Kobayashi, Masatake Kitano, Rie Sakakibara, Takahiro Mitsumura, Hironori Ishibashi, Johji Inazawa, Toshihiro Tanaka, Yasunari Miyazaki, Kenichi Okubo

Source: Cancer Medicine, Vol 12, Iss 19, Pp 19406-19413 (2023)

Subject Terms: non‐small cell lung cancer, pathological stage I, RAS signaling genes, TP53, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2045-7634

Access URL: https://doaj.org/article/6ba7b431ba7f44a4957e152056f0c6c6

Large-scale animal model study uncovers altered brain pH and lactate levels as a transdiagnostic endophenotype of neuropsychiatric disorders involving cognitive impairment

Authors: Hideo Hagihara, Hirotaka Shoji, Satoko Hattori, Giovanni Sala, Yoshihiro Takamiya, Mika Tanaka, Masafumi Ihara, Mihiro Shibutani, Izuho Hatada, Kei Hori, Mikio Hoshino, Akito Nakao, Yasuo Mori, Shigeo Okabe, Masayuki Matsushita, Anja Urbach, Yuta Katayama, Akinobu Matsumoto, Keiichi I Nakayama, Shota Katori, Takuya Sato, Takuji Iwasato, Haruko Nakamura, Yoshio Goshima, Matthieu Raveau, Tetsuya Tatsukawa, Kazuhiro Yamakawa, Noriko Takahashi, Haruo Kasai, Johji Inazawa, Ikuo Nobuhisa, Tetsushi Kagawa, Tetsuya Taga, Mohamed Darwish, Hirofumi Nishizono, Keizo Takao, Kiran Sapkota, Kazutoshi Nakazawa, Tsuyoshi Takagi, Haruki Fujisawa, Yoshihisa Sugimura, Kyosuke Yamanishi, Lakshmi Rajagopal, Nanette Deneen Hannah, Herbert Y Meltzer, Tohru Yamamoto, Shuji Wakatsuki, Toshiyuki Araki, Katsuhiko Tabuchi, Tadahiro Numakawa, Hiroshi Kunugi, Freesia L Huang, Atsuko Hayata-Takano, Hitoshi Hashimoto, Kota Tamada, Toru Takumi, Takaoki Kasahara, Tadafumi Kato, Isabella A Graef, Gerald R Crabtree, Nozomi Asaoka, Hikari Hatakama, Shuji Kaneko, Takao Kohno, Mitsuharu Hattori, Yoshio Hoshiba, Ryuhei Miyake, Kisho Obi-Nagata, Akiko Hayashi-Takagi, Léa J Becker, Ipek Yalcin, Yoko Hagino, Hiroko Kotajima-Murakami, Yuki Moriya, Kazutaka Ikeda, Hyopil Kim, Bong-Kiun Kaang, Hikari Otabi, Yuta Yoshida, Atsushi Toyoda, Noboru H Komiyama, Seth GN Grant, Michiru Ida-Eto, Masaaki Narita, Ken-ichi Matsumoto, Emiko Okuda-Ashitaka, Iori Ohmori, Tadayuki Shimada, Kanato Yamagata, Hiroshi Ageta, Kunihiro Tsuchida, Kaoru Inokuchi, Takayuki Sassa, Akio Kihara, Motoaki Fukasawa, Nobuteru Usuda, Tayo Katano, Teruyuki Tanaka, Yoshihiro Yoshihara, Michihiro Igarashi, Takashi Hayashi, Kaori Ishikawa, Satoshi Yamamoto, Naoya Nishimura, Kazuto Nakada, Shinji Hirotsune, Kiyoshi Egawa, Kazuma Higashisaka, Yasuo Tsutsumi, Shoko Nishihara, Noriyuki Sugo, Takeshi Yagi, Naoto Ueno, Tomomi Yamamoto, Yoshihiro Kubo, Rie Ohashi, Nobuyuki Shiina, Kimiko Shimizu, Sayaka Higo-Yamamoto, Katsutaka Oishi, Hisashi Mori, Tamio Furuse, Masaru Tamura, Hisashi Shirakawa, Daiki X Sato, Yukiko U Inoue, Takayoshi Inoue, Yuriko Komine, Tetsuo Yamamori, Kenji Sakimura, Tsuyoshi Miyakawa

Source: eLife, Vol 12 (2024)

Subject Terms: brain pH, lactate, metabolism, neuropsychiatric disorders, animal models, working memory, Medicine, Science, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://elifesciences.org/articles/89376; https://doaj.org/toc/2050-084X

Access URL: https://doaj.org/article/15de117935204a21a8487997042e8094

Genome-wide assessment of genetic risk loci for childhood acute lymphoblastic leukemia in Japanese patients

Authors: Mayumi Hangai, Takahisa Kawaguchi, Masatoshi Takagi, Keitaro Matsuo, Soyoung Jeon, Charleston W.K. Chiang, Andrew T. Dewan, Adam J. de Smith, Toshihiko Imamura, Yasuhiro Okamoto, Akiko M. Saito, Takao Deguchi, Michiaki Kubo, Yoichi Tanaka, Yoko Ayukawa, Toshinari Hori, Kentaro Ohki, Nobutaka Kiyokawa, Takeshi Inukai, Yuki Arakawa, Makiko Mori, Daisuke Hasegawa, Daisuke Tomizawa, Hiroko Fukushima, Yuki Yuza, Yasushi Noguchi, Yuichi Taneyama, Setsuo Ota, Hiroaki Goto, Masakatsu Yanagimachi, Dai Keino, Kazutoshi Koike, Daisuke Toyama, Yozo Nakazawa, Kozue Nakamura, Koichi Moriwaki, Yujin Sekinaka, Daisuke Morita, Shinsuke Hirabayashi, Yosuke Hosoya, Yuri Yoshimoto, Hiroki Yoshihara, Miwa Ozawa, Shinobu Kobayashi, Naho Morisaki, Tshewang Gyeltshen, Osamu Takahashi, Yukinori Okada, Makiko Matsuda, Toshihiro Tanaka, Johji Inazawa, Junko Takita, Yasushi Ishida, Akira Ohara, Catherine Metayer, Joseph L. Wiemels, Xiaomei Ma, Shuki Mizutani, Katsuyoshi Koh, Yukihide Momozawa, Keizo Horibe, Fumihiko Matsuda, Motohiro Kato, Atsushi Manabe, Kevin Y. Urayama

Source: Haematologica, Vol 109, Iss 4 (2023)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://haematologica.org/article/view/11318; https://doaj.org/toc/0390-6078; https://doaj.org/toc/1592-8721

Access URL: https://doaj.org/article/33c9fce9f6da4bfcb04af4388d1b3ffd

Identification of a Biallelic Missense Variant in Gasdermin D (c.823G > C, p.Asp275His) in a Patient of Atypical Gorham‐Stout Disease in a Consanguineous Family

Authors: Daniela Tiaki Uehara, Tomoki Muramatsu, Senichi Ishii, Hidetsugu Suzuki, Kazuyuki Fukushima, Yasuhiro Arasaki, Tadayoshi Hayata, Johji Inazawa, Yoichi Ezura

Source: JBMR Plus, Vol 7, Iss 9, Pp n/a-n/a (2023)

Subject Terms: BONE RESORPTION, GASDERMIN D, INFLAMMATION, MACROPHAGE, OSTEOLYSIS, Orthopedic surgery, RD701-811, Diseases of the musculoskeletal system, RC925-935

File Description: electronic resource

Relation: https://doaj.org/toc/2473-4039

Access URL: https://doaj.org/article/9e734213f4424fd696591ff7e90ae61b

Concurrent targeting of MAP3K3 and BRD4 by miR-3140-3p overcomes acquired resistance to BET inhibitors in neuroblastoma cells

Authors: Chang Liu, Yasuyuki Gen, Kousuke Tanimoto, Tomoki Muramatsu, Jun Inoue, Johji Inazawa

Source: Molecular Therapy: Nucleic Acids, Vol 25, Iss , Pp 83-92 (2021)

Subject Terms: neuroblastoma, BET inhibitor, drug resistance, BRD4, MAP3K3, MYCN, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2162253121001177; https://doaj.org/toc/2162-2531

Access URL: https://doaj.org/article/5c52b700abb940eb83fcf4f444ce6981

Isolation and characterisation of lymphatic endothelial cells from lung tissues affected by lymphangioleiomyomatosis

Authors: Koichi Nishino, Yasuhiro Yoshimatsu, Tomoki Muramatsu, Yasuhito Sekimoto, Keiko Mitani, Etsuko Kobayashi, Shouichi Okamoto, Hiroki Ebana, Yoshinori Okada, Masatoshi Kurihara, Kenji Suzuki, Johji Inazawa, Kazuhisa Takahashi, Tetsuro Watabe, Kuniaki Seyama

Source: Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/2ab2d6be5e714483911e6f086b4389fc

Improving the Efficacy of EGFR Inhibitors by Topical Treatment of Cutaneous Squamous Cell Carcinoma with miR-634 Ointment

Authors: Jun Inoue, Kyoko Fujiwara, Hidetoshi Hamamoto, Katsunori Kobayashi, Johji Inazawa

Source: Molecular Therapy: Oncolytics, Vol 19, Iss , Pp 294-307 (2020)

Subject Terms: miRNA therapeutics, skin cancer, EGFR-TKI, glutaminolysis, topical treatment, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2372770520301601; https://doaj.org/toc/2372-7705

Access URL: https://doaj.org/article/7fe27f8daceb40538d6a9fd561077a75

Massive computational identification of somatic variants in exonic splicing enhancers using The Cancer Genome Atlas

Authors: Kousuke Tanimoto, Tomoki Muramatsu, Johji Inazawa

Source: Cancer Medicine, Vol 8, Iss 17, Pp 7372-7384 (2019)

Subject Terms: exonic splicing enhancer, nonsense‐mediated decay, somatic variants, splicing variants, TCGA, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2045-7634

Access URL: https://doaj.org/article/7aa99a7373d04b289ca3272019b133fc

12 new susceptibility loci for prostate cancer identified by genome-wide association study in Japanese population

Authors: Ryo Takata, Atsushi Takahashi, Masashi Fujita, Yukihide Momozawa, Edward J. Saunders, Hiroki Yamada, Kazuhiro Maejima, Kaoru Nakano, Yuichiro Nishida, Asahi Hishida, Keitaro Matsuo, Kenji Wakai, Taiki Yamaji, Norie Sawada, Motoki Iwasaki, Shoichiro Tsugane, Makoto Sasaki, Atsushi Shimizu, Kozo Tanno, Naoko Minegishi, Kichiya Suzuki, Koichi Matsuda, Michiaki Kubo, Johji Inazawa, Shin Egawa, Christopher A. Haiman, Osamu Ogawa, Wataru Obara, Yoichiro Kamatani, Shusuke Akamatsu, Hidewaki Nakagawa

Source: Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/d4f4dad7d5aa4e5bbd57fba6d53b94a6

Fibroblast growth factor signals regulate transforming growth factor‐β‐induced endothelial‐to‐myofibroblast transition of tumor endothelial cells via Elk1

Authors: Yuichi Akatsu, Naoya Takahashi, Yasuhiro Yoshimatsu, Shiori Kimuro, Tomoki Muramatsu, Akihiro Katsura, Nako Maishi, Hiroshi I. Suzuki, Johji Inazawa, Kyoko Hida, Kohei Miyazono, Tetsuro Watabe

Source: Molecular Oncology, Vol 13, Iss 8, Pp 1706-1724 (2019)

Subject Terms: Elk1, EndMT, End‐MyoT, End‐N‐MyoT, FGF2, TGF‐β2, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1574-7891; https://doaj.org/toc/1878-0261

Access URL: https://doaj.org/article/961ecaeac4f34ea69f38d197dd762e8c

Array comparative genomic hybridization analysis discloses chromosome copy number alterations as indicators of patient outcome in lymph node-negative breast cancer

Authors: Ryoko Kikuchi-Koike, Kazunori Nagasaka, Hitoshi Tsuda, Yasuyuki Ishii, Masaru Sakamoto, Yoshihiro Kikuchi, Shiho Fukui, Yuko Miyagawa, Haruko Hiraike, Takayuki Kobayashi, Takayuki Kinoshita, Yae Kanai, Tatsuhiro Shibata, Issei Imoto, Johji Inazawa, Osamu Matsubara, Takuya Ayabe

Source: BMC Cancer, Vol 19, Iss 1, Pp 1-12 (2019)

Subject Terms: pN0 invasive breast cancer, Array-CGH, TNFRSF1A, NR2F1, ABCA3, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s12885-019-5737-7; https://doaj.org/toc/1471-2407

Access URL: https://doaj.org/article/b82b45aa7a8a479c951b0e090e9d6d1e

Augmentation of lenvatinib efficacy by topical treatment of miR-634 ointment in anaplastic thyroid cancer

Authors: Masahiro Kishikawa, Jun Inoue, Hidetoshi Hamamoto, Katsunori Kobayashi, Takahiro Asakage, Johji Inazawa

Source: Biochemistry and Biophysics Reports, Vol 26, Iss , Pp 101009- (2021)

Subject Terms: miRNA therapeutics, Anaplastic thyroid cancer, Lenvatinib, Topical treatment, Biology (General), QH301-705.5, Biochemistry, QD415-436

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2405580821001035; https://doaj.org/toc/2405-5808

Access URL: https://doaj.org/article/99c42b063efc48c8b701f212359f48fc

miR-509-5p and miR-1243 increase the sensitivity to gemcitabine by inhibiting epithelial-mesenchymal transition in pancreatic cancer

Authors: Hidekazu Hiramoto, Tomoki Muramatsu, Daisuke Ichikawa, Kousuke Tanimoto, Satoru Yasukawa, Eigo Otsuji, Johji Inazawa

Source: Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/4339122529b842ef8da00f3593f1db2e

Association of variations in HLA class II and other loci with susceptibility to EGFR-mutated lung adenocarcinoma

Authors: Kouya Shiraishi, Yukinori Okada, Atsushi Takahashi, Yoichiro Kamatani, Yukihide Momozawa, Kyota Ashikawa, Hideo Kunitoh, Shingo Matsumoto, Atsushi Takano, Kimihiro Shimizu, Akiteru Goto, Koji Tsuta, Shun-ichi Watanabe, Yuichiro Ohe, Yukio Watanabe, Yasushi Goto, Hiroshi Nokihara, Koh Furuta, Akihiko Yoshida, Koichi Goto, Tomoyuki Hishida, Masahiro Tsuboi, Katsuya Tsuchihara, Yohei Miyagi, Haruhiko Nakayama, Tomoyuki Yokose, Kazumi Tanaka, Toshiteru Nagashima, Yoichi Ohtaki, Daichi Maeda, Kazuhiro Imai, Yoshihiro Minamiya, Hiromi Sakamoto, Akira Saito, Yoko Shimada, Kuniko Sunami, Motonobu Saito, Johji Inazawa, Yusuke Nakamura, Teruhiko Yoshida, Jun Yokota, Fumihiko Matsuda, Keitaro Matsuo, Yataro Daigo, Michiaki Kubo, Takashi Kohno

Source: Nature Communications, Vol 7, Iss 1, Pp 1-7 (2016)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/06abe374e88a4c0f861cb8193ced8a5f

Comprehensive investigation of CASK mutations and other genetic etiologies in 41 patients with intellectual disability and microcephaly with pontine and cerebellar hypoplasia (MICPCH).

Authors: Shin Hayashi, Daniela Tiaki Uehara, Kousuke Tanimoto, Seiji Mizuno, Yasutsugu Chinen, Shinobu Fukumura, Jun-Ichi Takanashi, Hitoshi Osaka, Nobuhiko Okamoto, Johji Inazawa

Source: PLoS ONE, Vol 12, Iss 8, p e0181791 (2017)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC5546575?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/361ca232e09d4b4c9d6b9d2bc565142d

Simultaneous Detection of Both Single Nucleotide Variations and Copy Number Alterations by Next-Generation Sequencing in Gorlin Syndrome.

Authors: Kei-ichi Morita, Takuya Naruto, Kousuke Tanimoto, Chisato Yasukawa, Yu Oikawa, Kiyoshi Masuda, Issei Imoto, Johji Inazawa, Ken Omura, Hiroyuki Harada

Source: PLoS ONE, Vol 10, Iss 11, p e0140480 (2015)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC4636311?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/d8231e1ecccc401b8d8fe230d74edf6c

NF-κB inducing kinase, a central signaling component of the non-canonical pathway of NF-κB, contributes to ovarian cancer progression.

Authors: Masaya Uno, Yasunori Saitoh, Kanako Mochida, Eri Tsuruyama, Tohru Kiyono, Issei Imoto, Johji Inazawa, Yasuhito Yuasa, Toshiro Kubota, Shoji Yamaoka

Source: PLoS ONE, Vol 9, Iss 2, p e88347 (2014)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3922808?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/8acbe37e396548beb62051f13509af93

miR-655 Is an EMT-suppressive microRNA targeting ZEB1 and TGFBR2.

Authors: Yosuke Harazono, Tomoki Muramatsu, Hironori Endo, Narikazu Uzawa, Tatsuyuki Kawano, Kiyoshi Harada, Johji Inazawa, Ken-ichi Kozaki

Source: PLoS ONE, Vol 8, Iss 5, p e62757 (2013)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3653886?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/af99dc9122054cf2a36a5ead2be3d69e