Combined deletion of cytosolic 5′-nucleotidases IA and II lowers glycemia by improving skeletal muscle insulin action and lowering hepatic glucose production

Authors: Jacobs, Roxane ¹, Herinckx, Gaëtan ¹, Galland, Noémie ², Balty, Clémence ¹, Vertommen, Didier ¹, Rider, Mark H. ¹, Johanns, Manuel ^{1, ∗}

Source: In Journal of Biological Chemistry March 2025 301(3)

Time-of-day-dependent variation of the human liver transcriptome and metabolome is disrupted in MASLD

Authors: Johanns, Manuel, Haas, Joel T., Raverdy, Violetta, Vandel, Jimmy, Chevalier-Dubois, Julie, Guille, Loic, Derudas, Bruno, Legendre, Benjamin, Caiazzo, Robert, Verkindt, Helene, Gnemmi, Viviane, Leteurtre, Emmanuelle, Derhourhi, Mehdi, Bonnefond, Amélie, Froguel, Philippe, Eeckhoute, Jérôme, Lassailly, Guillaume, Mathurin, Philippe, Pattou, François, Staels, Bart, Lefebvre, Philippe

Source: In JHEP Reports January 2024 6(1)

PPARs in liver physiology

Authors: Berthier, Alexandre, Johanns, Manuel, Zummo, Francesco Paolo, Lefebvre, Philippe, Staels, Bart

Source: In BBA - Molecular Basis of Disease 1 May 2021 1867(5)

How mass spectrometry can be exploited to study AMPK.

Authors: Rider, Mark H., Vertommen, Didier, Johanns, Manuel

Source: Essays in Biochemistry; Nov2024, Vol. 68 Issue 3, p283-294, 12p

Genetic deletion of soluble 5′-nucleotidase II reduces body weight gain and insulin resistance induced by a high-fat diet

Authors: Johanns, Manuel, Kviklyte, Samanta, Chuang, Sheng-Ju, Corbeels, Katrien, Jacobs, Roxane, Herinckx, Gaëtan, Vertommen, Didier, Schakman, Olivier, Duparc, Thibaut, Cani, Patrice D., Bouzin, Caroline, Andersén, Harriet, Bohlooly-Y, Mohammad, Van der Schueren, Bart, Oscarsson, Jan, Rider, Mark H.

Source: In Molecular Genetics and Metabolism April 2019 126(4):377-387

HBP1 phosphorylation by AKT regulates its transcriptional activity and glioblastoma cell proliferation

Authors: Bollaert, Emeline, Johanns, Manuel, Herinckx, Gaëtan, de Rocca Serra, Audrey, Vandewalle, Virginie A., Havelange, Violaine, Rider, Mark H., Vertommen, Didier, Demoulin, Jean-Baptiste

Source: In Cellular Signalling April 2018 44:158-170

Role of Akt/PKB and PFKFB isoenzymes in the control of glycolysis, cell proliferation and protein synthesis in mitogen-stimulated thymocytes

Authors: Houddane, Amina, Bultot, Laurent, Novellasdemunt, Laura, Johanns, Manuel, Gueuning, Marie-Agnès, Vertommen, Didier, Coulie, Pierre G., Bartrons, Ramon, Hue, Louis, Rider, Mark H.

Source: In Cellular Signalling June 2017 34:23-37

O-GlcNAcylation controls pro-fibrotic transcriptional regulatory signaling in myofibroblasts.

Authors: Very, Ninon, Boulet, Clémence, Gheeraert, Céline, Berthier, Alexandre, Johanns, Manuel, Bou Saleh, Mohamed, Guille, Loïc, Bray, Fabrice, Strub, Jean-Marc, Bobowski-Gerard, Marie, Zummo, Francesco P., Vallez, Emmanuelle, Molendi-Coste, Olivier, Woitrain, Eloise, Cianférani, Sarah, Montaigne, David, Ntandja-Wandji, Line Carolle, Dubuquoy, Laurent, Dubois-Chevalier, Julie, Staels, Bart

Source: Cell Death & Disease; Jun2024, Vol. 15 Issue 6, p1-22, 22p

The Molecular Circadian Clock Is a Target of Anti-cancer Translation Inhibitors.

Authors: Berthier, Alexandre, Gheeraert, Céline, Johanns, Manuel, Vinod, Manjula, Staels, Bart, Eeckhoute, Jérôme, Lefebvre, Philippe

Source: Journal of Biological Rhythms; Feb2024, Vol. 39 Issue 1, p20-34, 15p

Subject Terms: CIRCADIAN rhythms, MOLECULAR clock, PROTEIN synthesis, TRANSCRIPTION factors, VIRUS diseases, RIBOSOMAL DNA, PUROMYCIN

Specific post-translational modifications of soluble tau protein distinguishes Alzheimer's disease and primary tauopathies.

Authors: Kyalu Ngoie Zola, Nathalie, Balty, Clémence, Pyr dit Ruys, Sébastien, Vanparys, Axelle A. T., Huyghe, Nicolas D. G., Herinckx, Gaëtan, Johanns, Manuel, Boyer, Emilien, Kienlen-Campard, Pascal, Rider, Mark H., Vertommen, Didier, Hanseeuw, Bernard J.

Source: Nature Communications; 6/22/2023, Vol. 14 Issue 1, p1-17, 17p

Subject Terms: TAU proteins, TAUOPATHIES, ALZHEIMER'S disease, NEUROFIBRILLARY tangles, POST-translational modification, ALZHEIMER'S patients, NEURODEGENERATION

Comparison of Different Ex-Vivo Preservation Strategies on Cardiac Metabolism in an Animal Model of Donation after Circulatory Death.

Authors: Mastrobuoni, Stefano^1,2 (AUTHOR) alain.poncelet@saintluc.uclouvain.be, Johanns, Manuel³ (AUTHOR) manuel.johanns@uclouvain.be, Vergauwen, Martial² (AUTHOR) gwen.beaurin@uclouvain.be, Beaurin, Gwen² (AUTHOR) pierre.gianello@uclouvain.be, Rider, Mark³ (AUTHOR), Gianello, Pierre² (AUTHOR) olivier.vancaenegem@saintluc.uclouvain.be, Poncelet, Alain^1,2 (AUTHOR), Van Caenegem, Olivier^2,4 (AUTHOR)

Source: Journal of Clinical Medicine. May2023, Vol. 12 Issue 10, p3569. 11p.

Subject Terms: *HEART metabolism, *METABOLIC models, *ANIMAL models in research, *HEART transplantation, *REPERFUSION

AMPK inhibits liver gluconeogenesis: fact or fiction?

Authors: Johanns, Manuel¹, Hue, Louis¹, Rider, Mark H.¹ mark.rider@uclouvain.be

Source: Biochemical Journal. Jan2023, Vol. 480 Issue 1, p105-125. 21p.

Subject Terms: *AMP-activated protein kinases, *GLUCONEOGENESIS, *TYPE 2 diabetes, *INSULIN sensitivity, *LIVER

Inhibition of basal and glucagon-induced hepatic glucose production by 991 and other pharmacological AMPK activators.

Authors: Johanns, Manuel¹, Corbet, Cyril², Jacobs, Roxane¹, Drappier, Melissa¹, Bommer, Guido T.¹, Herinckx, Gaëtan¹, Vertommen, Didier¹, Tajeddine, Nicolas³, Young, David⁴, Messens, Joris⁴, Feron, Olivier², Steinberg, Gregory R.⁵, Hue, Louis¹, Rider, Mark H.¹ mark.rider@uclouvain.be

Source: Biochemical Journal. 6/15/2022, Vol. 479 Issue 12, p1317-1336. 20p.

Subject Terms: *AMP-activated protein kinases, *GLUCOSE, *TYPE 2 diabetes, *INSULIN, *PYRUVATES

AMPK activation by SC4 inhibits noradrenaline-induced lipolysis and insulin-stimulated lipogenesis in white adipose tissue.

Authors: Sheng-Ju Chuang¹, Johanns, Manuel¹, Ruys, Sébastien Pyr dit¹, Steinberg, Gregory R.², Kemp, Bruce E.^3,4, Viollet, Benoît⁵, Rider, Mark H.¹

Source: Biochemical Journal. Nov2021, Vol. 478 Issue 21, p3869-3889. 21p.

Subject Terms: *WHITE adipose tissue, *LIPOLYSIS, *FAT cells, *LIPID synthesis, *ADIPOSE tissues, *ACETYL-CoA carboxylase, *PROTEIN kinases, *PHOSPHORYLATION

Effects of PKB/Akt inhibitors on insulin-stimulated lipogenesis and phosphorylation state of lipogenic enzymes in white adipose tissue.

Authors: Hussain, Nusrat, Sheng-Ju Chuang, Johanns, Manuel, Vertommen, Didier, Steinberg, Gregory R., Kemp, Bruce E., Rider, Mark H.

Source: Biochemical Journal; Apr2020, Vol. 477 Issue 8, p1378-1369, 17p

Subject Terms: WHITE adipose tissue, ALLOSTERIC proteins, PROTEIN kinase B, LIPID synthesis, PHOSPHORYLATION, FAT cells, FRUCTOSE

TLR9 and beclin 1 crosstalk regulates muscle AMPK activation in exercise.

Authors: Liu, Yang, Nguyen, Phong T., Wang, Xun, Zhao, Yuting, Meacham, Corbin E., Zou, Zhongju, Bordieanu, Bogdan, Johanns, Manuel, Vertommen, Didier, Wijshake, Tobias, May, Herman, Xiao, Guanghua, Shoji-Kawata, Sanae, Rider, Mark H., Morrison, Sean J., Mishra, Prashant, Levine, Beth

Source: Nature; 2/27/2020, Vol. 578 Issue 7796, p605-609, 5p, 13 Graphs

Two isoprenylated flavonoids from Dorstenia psilurus activate AMPK, stimulate glucose uptake, inhibit glucose production and lower glycemia.

Authors: Choumessi, Aphrodite T.¹, Johanns, Manuel¹, Beaufay, Claire², Herent, Marie-France², Stroobant, Vincent³, Vertommen, Didier¹, Corbet, Cyril⁴, Jacobs, Roxane¹, Herinckx, Gaëtan¹, Steinberg, Gregory R.^5,6, Feron, Olivier⁴, Quetin-Leclercq, Joëlle², Rider, Mark H.¹ mark.rider@uclouvain.be

Source: Biochemical Journal. Dec2019, Vol. 476 Issue 24, p3687-3704. 18p.

Subject Terms: *ELECTROSPRAY ionization mass spectrometry, *CANCER cell culture, *HUMAN cell culture, *LIVER mitochondria, *GLUCOSE, *ISOMERS, *FLAVONOID glycosides

Geographic Terms: CAMEROON

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