A neuronal circuit driven by GLP-1 in the olfactory bulb regulates insulin secretion

Authors: Mireia Montaner, Jessica Denom, Vincent Simon, Wanqing Jiang, Marie K. Holt, Daniel I. Brierley, Claude Rouch, Ewout Foppen, Nadim Kassis, David Jarriault, Dawood Khan, Louise Eygret, Francois Mifsud, David J. Hodson, Johannes Broichhagen, Lukas Van Oudenhove, Xavier Fioramonti, Victor Gault, Daniela Cota, Frank Reimann, Fiona M. Gribble, Stephanie Migrenne-Li, Stefan Trapp, Hirac Gurden, Christophe Magnan

Source: Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/cb3515a89fa242b4a3b002d0b2c03c19

Purification of time-resolved insulin granules reveals proteomic and lipidomic changes during granule aging

Authors: Martin Neukam, Pia Sala, Andreas-David Brunner, Katharina Ganß, Alessandra Palladini, Michal Grzybek, Oleksandra Topcheva, Jovana Vasiljević, Johannes Broichhagen, Kai Johnsson, Thomas Kurth, Matthias Mann, Ünal Coskun, Michele Solimena

Source: Cell Reports, Vol 43, Iss 3, Pp 113836- (2024)

Subject Terms: CP: Cell biology, CP: Metabolism, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124724001645; https://doaj.org/toc/2211-1247

Access URL: https://doaj.org/article/cf40f14830104848b5ec1c5564f0aa0e

A versatile Halo- and SNAP-tagged BMP/TGFβ receptor library for quantification of cell surface ligand binding

Authors: Jerome Jatzlau, Wiktor Burdzinski, Michael Trumpp, Leon Obendorf, Kilian Roßmann, Katharina Ravn, Marko Hyvönen, Francesca Bottanelli, Johannes Broichhagen, Petra Knaus

Source: Communications Biology, Vol 6, Iss 1, Pp 1-15 (2023)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/2399-3642

Access URL: https://doaj.org/article/ecd9aa0c06c24813a2ac0f64c9f2cd06

Revealing the tissue-level complexity of endogenous glucagon-like peptide-1 receptor expression and signaling

Authors: Julia Ast, Daniela Nasteska, Nicholas H. F. Fine, Daniel J. Nieves, Zsombor Koszegi, Yann Lanoiselée, Federica Cuozzo, Katrina Viloria, Andrea Bacon, Nguyet T. Luu, Philip N. Newsome, Davide Calebiro, Dylan M. Owen, Johannes Broichhagen, David J. Hodson

Source: Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/a1c114f010cf4dc7bafcaf994b474beb

Hypothalamic and brainstem glucose-dependent insulinotropic polypeptide receptor neurons employ distinct mechanisms to affect feeding

Authors: Alice Adriaenssens, Johannes Broichhagen, Anne de Bray, Julia Ast, Annie Hasib, Ben Jones, Alejandra Tomas, Natalie Figueredo Burgos, Orla Woodward, Jo Lewis, Elisabeth O’Flaherty, Kimberley El, Canqi Cui, Norio Harada, Nobuya Inagaki, Jonathan Campbell, Daniel Brierley, David J. Hodson, Ricardo Samms, Fiona Gribble, Frank Reimann

Source: JCI Insight, Vol 8, Iss 10 (2023)

Subject Terms: Metabolism, Neuroscience, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/2379-3708

Access URL: https://doaj.org/article/98622c9a195d4352900a24be2e5b4bd3

Unusual mode of dimerization of retinitis pigmentosa-associated F220C rhodopsin

Authors: George Khelashvili, Anoop Narayana Pillai, Joon Lee, Kalpana Pandey, Alexander M. Payne, Zarek Siegel, Michel A. Cuendet, Tylor R. Lewis, Vadim Y. Arshavsky, Johannes Broichhagen, Joshua Levitz, Anant K. Menon

Source: Scientific Reports, Vol 11, Iss 1, Pp 1-20 (2021)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/dd6f556860b34a2ea32087d0f5c5847f

14-3-3ζ Constrains insulin secretion by regulating mitochondrial function in pancreatic β cells

Authors: Yves Mugabo, Cheng Zhao, Ju Jing Tan, Anindya Ghosh, Scott A. Campbell, Evgenia Fadzeyeva, Frédéric Paré, Siew Siew Pan, Maria Galipeau, Julia Ast, Johannes Broichhagen, David J. Hodson, Erin E. Mulvihill, Sophie Petropoulos, Gareth E. Lim

Source: JCI Insight, Vol 7, Iss 8 (2022)

Subject Terms: Endocrinology, Metabolism, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/2379-3708

Access URL: https://doaj.org/article/a212201235ad4383a3067ba2c4ddbc78

Reagents and models for detecting endogenous GLP1R and GIPR

Authors: Julia Ast, Johannes Broichhagen, David J. Hodson

Source: EBioMedicine, Vol 74, Iss , Pp 103739- (2021)

Subject Terms: GLP1R, GIPR, GLP1, GIP, incretin-mimetics, diabetes, Medicine, Medicine (General), R5-920

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352396421005338; https://doaj.org/toc/2352-3964

Access URL: https://doaj.org/article/4f9f3d625c02446798ea39e83450f1bf

SNAP-tag-enabled super-resolution imaging reveals constitutive and agonist-dependent trafficking of GPR56 in pancreatic β-cells

Authors: Oladapo E. Olaniru, Jordan Cheng, Julia Ast, Anastasia Arvaniti, Patricio Atanes, Guo C. Huang, Aileen J.F. King, Peter M. Jones, Johannes Broichhagen, David J. Hodson, Shanta J. Persaud

Source: Molecular Metabolism, Vol 53, Iss , Pp 101285- (2021)

Subject Terms: GPR56, SNAP-tag, Trafficking, Islets, Apoptosis, CRISPR-Cas9, Internal medicine, RC31-1245

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2212877821001307; https://doaj.org/toc/2212-8778

Access URL: https://doaj.org/article/3df09aa019eb4776af546b1d54def1df

Super-resolution microscopy compatible fluorescent probes reveal endogenous glucagon-like peptide-1 receptor distribution and dynamics

Authors: Julia Ast, Anastasia Arvaniti, Nicholas H. F. Fine, Daniela Nasteska, Fiona B. Ashford, Zania Stamataki, Zsombor Koszegi, Andrea Bacon, Ben J. Jones, Maria A. Lucey, Shugo Sasaki, Daniel I. Brierley, Benoit Hastoy, Alejandra Tomas, Giuseppe D’Agostino, Frank Reimann, Francis C. Lynn, Christopher A. Reissaus, Amelia K. Linnemann, Elisa D’Este, Davide Calebiro, Stefan Trapp, Kai Johnsson, Tom Podewin, Johannes Broichhagen, David J. Hodson

Source: Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/1bec881e08194ff3b4ad84658e067529

Differences in interactions between transmembrane domains tune the activation of metabotropic glutamate receptors

Authors: Jordana K Thibado, Jean-Yves Tano, Joon Lee, Leslie Salas-Estrada, Davide Provasi, Alexa Strauss, Joao Marcelo Lamim Ribeiro, Guoqing Xiang, Johannes Broichhagen, Marta Filizola, Martin J Lohse, Joshua Levitz

Source: eLife, Vol 10 (2021)

Subject Terms: GPCR, single molecule fluorescence, conformational dynamics, dimerization, metabotropic glutamate receptor, molecular dynamics, Medicine, Science, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://elifesciences.org/articles/67027; https://doaj.org/toc/2050-084X

Access URL: https://doaj.org/article/6412386b702045d99bea060cfa1c8959

Conditional and Reversible Activation of Class A and B G Protein-Coupled Receptors Using Tethered Pharmacology

Authors: Tom Podewin, Julia Ast, Johannes Broichhagen, Nicholas H. F. Fine, Daniela Nasteska, Philipp Leippe, Manuel Gailer, Teresa Buenaventura, Nisha Kanda, Ben J. Jones, Celine M’Kadmi, Jean-Louis Baneres, Jacky Marie, Alejandra Tomas, Dirk Trauner, Anja Hoffmann-Röder, David J. Hodson

Source: ACS Central Science, Vol 4, Iss 2, Pp 166-179 (2018)

Subject Terms: Chemistry, QD1-999

File Description: electronic resource

Relation: https://doaj.org/toc/2374-7951

Access URL: https://doaj.org/article/f8c0f33ccd2442baa687d32ec11cefda

Restoration of patterned vision with an engineered photoactivatable G protein-coupled receptor

Authors: Michael H. Berry, Amy Holt, Joshua Levitz, Johannes Broichhagen, Benjamin M. Gaub, Meike Visel, Cherise Stanley, Krishan Aghi, Yang Joon Kim, Kevin Cao, Richard H. Kramer, Dirk Trauner, John Flannery, Ehud Y. Isacoff

Source: Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/633814130c744076adf5b920ac4c46b7

Remote control of glucose homeostasis in vivo using photopharmacology

Authors: Zenobia B. Mehta, Natalie R. Johnston, Marie-Sophie Nguyen-Tu, Johannes Broichhagen, Peter Schultz, Dean P. Larner, Isabelle Leclerc, Dirk Trauner, Guy A. Rutter, David J. Hodson

Source: Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/3ef948b53454487d84dd10b347df1987

Author Correction: Super-resolution microscopy compatible fluorescent probes reveal endogenous glucagon-like peptide-1 receptor distribution and dynamics

Authors: Julia Ast, Anastasia Arvaniti, Nicholas H. F. Fine, Daniela Nasteska, Fiona B. Ashford, Zania Stamataki, Zsombor Koszegi, Andrea Bacon, Ben J. Jones, Maria A. Lucey, Shugo Sasaki, Daniel I. Brierley, Benoit Hastoy, Alejandra Tomas, Giuseppe D’Agostino, Frank Reimann, Francis C. Lynn, Christopher A. Reissaus, Amelia K. Linnemann, Elisa D’Este, Davide Calebiro, Stefan Trapp, Kai Johnsson, Tom Podewin, Johannes Broichhagen, David J. Hodson

Source: Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/ec33e8108ee44445a3672afb9f0516cc

Orthogonal Optical Control of a G Protein-Coupled Receptor with a SNAP-Tethered Photochromic Ligand

Authors: Johannes Broichhagen, Arunas Damijonaitis, Joshua Levitz, Kevin R. Sokol, Philipp Leippe, David Konrad, Ehud Y. Isacoff, Dirk Trauner

Source: ACS Central Science, Vol 1, Iss 7, Pp 383-393 (2015)

Subject Terms: Chemistry, QD1-999

File Description: electronic resource

Relation: https://doaj.org/toc/2374-7943; https://doaj.org/toc/2374-7951

Access URL: https://doaj.org/article/5790bcb39b94428ab7da13d91bc40087

Azobenzene-based inhibitors of human carbonic anhydrase II

Authors: Leander Simon Runtsch, David Michael Barber, Peter Mayer, Michael Groll, Dirk Trauner, Johannes Broichhagen

Source: Beilstein Journal of Organic Chemistry, Vol 11, Iss 1, Pp 1129-1135 (2015)

Subject Terms: azobenzene chemistry, enzyme inhibitors, human carbonic anhydrase II, sulfonamide, X-ray crystallography, Science, Organic chemistry, QD241-441

File Description: electronic resource

Relation: https://doaj.org/toc/1860-5397

Access URL: https://doaj.org/article/4d79e92b18a24f6382952093d4e44b97

6-[6-(Pyridin-2-yl)-1,2,4,5-tetrazin-3-yl]pyridin-3-amine monohydrate

Authors: Johannes Broichhagen, Yvonne E. Klingl, Dirk Trauner, Peter Mayer

Source: Acta Crystallographica Section E: Crystallographic Communications, Vol 72, Iss 2, Pp 238-240 (2016)

Subject Terms: crystal structure, hydrogen bonding, graph sets, asymmetric tetrazines, Crystallography, QD901-999

File Description: electronic resource

Relation: http://scripts.iucr.org/cgi-bin/paper?S2056989016000608; https://doaj.org/toc/2056-9890

Access URL: https://doaj.org/article/6fe27a142c2b40008ba7778e71ae6222

Crystal structure of (E)-1,2-bis(4-bromo-2,6-difluorophenyl)diazene

Authors: Johannes Broichhagen, David H. Woodmansee, Dirk Trauner, Peter Mayer

Source: Acta Crystallographica Section E: Crystallographic Communications, Vol 71, Iss 7, Pp o459-o460 (2015)

Subject Terms: crystal structure, Crystallography, QD901-999

File Description: electronic resource

Relation: http://scripts.iucr.org/cgi-bin/paper?S2056989015010622; https://doaj.org/toc/2056-9890

Access URL: https://doaj.org/article/4551d33a722e4df286983355441bb2c5

Author Correction: Restoration of patterned vision with an engineered photoactivatable G protein-coupled receptor

Authors: Michael H. Berry, Amy Holt, Joshua Levitz, Johannes Broichhagen, Benjamin M. Gaub, Meike Visel, Cherise Stanley, Krishan Aghi, Yang Joon Kim, Kevin Cao, Richard H Kramer, Dirk Trauner, John Flannery, Ehud Y. Isacoff

Source: Nature Communications, Vol 9, Iss 1, Pp 1-1 (2018)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/de7d54f1165c4ef790a4083b2544a8eb