Longitudinal changes in DNA methylation associated with clozapine use in treatment-resistant schizophrenia from two international cohorts

Authors: Amy L. Gillespie, Emma M. Walker, Eilis Hannon, Grant A. McQueen, Kyra-Verena Sendt, Alessia Avila, John Lally, Cynthia Okhuijsen-Pfeifer, Marte van der Horst, Alkomiet Hasan, Emma L. Dempster, Joe Burrage, Jan Bogers, Dan Cohen, Marco P. Boks, David A. Collier, Alice Egerton, Jurjen J. Luykx, Jonathan Mill, James H. MacCabe

Source: Translational Psychiatry, Vol 14, Iss 1, Pp 1-11 (2024)

Subject Terms: Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: https://doaj.org/toc/2158-3188

Access URL: https://doaj.org/article/10cc9b0526224bc0a4cf3fb043bfa0a3

Developmentally dynamic changes in DNA methylation in the human pancreas

Authors: Ailsa MacCalman, Elisa De Franco, Alice Franklin, Christine S. Flaxman, Sarah J. Richardson, Kathryn Murrall, Joe Burrage, Barts Pancreas Tissue Bank (BPTB), Emma M. Walker, Noel G. Morgan, Andrew T. Hattersley, Emma L. Dempster, Eilis Hannon, Aaron R. Jeffries, Nick D. L. Owens, Jonathan Mill

Source: BMC Genomics, Vol 25, Iss 1, Pp 1-18 (2024)

Subject Terms: Pancreas, DNA methylation, Development, Sex differences, Fetal, Monogenic diabetes, Biotechnology, TP248.13-248.65, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1471-2164

Access URL: https://doaj.org/article/ea742da1a75a4ea5b89b8681cb5b5745

Quantifying the proportion of different cell types in the human cortex using DNA methylation profiles

Authors: Eilis Hannon, Emma L. Dempster, Jonathan P. Davies, Barry Chioza, Georgina E. T. Blake, Joe Burrage, Stefania Policicchio, Alice Franklin, Emma M. Walker, Rosemary A. Bamford, Leonard C. Schalkwyk, Jonathan Mill

Source: BMC Biology, Vol 22, Iss 1, Pp 1-19 (2024)

Subject Terms: DNA methylation, Brain, Neurons, Glia, Cellular heterogeneity, Alzheimer’s disease, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/1741-7007

Access URL: https://doaj.org/article/3d312550f3bb4808b28fa6884c2ceea6

Uncertainty quantification of reference-based cellular deconvolution algorithms

Authors: Dorothea Seiler Vellame, Gemma Shireby, Ailsa MacCalman, Emma L Dempster, Joe Burrage, Tyler Gorrie-Stone, Leonard S Schalkwyk, Jonathan Mill, Eilis Hannon

Source: Epigenetics, Vol 18, Iss 1 (2023)

Subject Terms: dna methylation, epigenetic epidemiology, illumina 450k array, illumina epic array, cellular heterogeneity, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1559-2294; https://doaj.org/toc/1559-2308

Access URL: https://doaj.org/article/cb633a02d20b4edcbfb594a164f011e5

Social mobility across the lifecourse and DNA methylation age acceleration in adults in the UK

Authors: Yanchun Bao, Tyler Gorrie-Stone, Eilis Hannon, Amanda Hughes, Alexandria Andrayas, Grant Neilson, Joe Burrage, Jonathon Mill, Leonard Schalkwyk, Meena Kumari

Source: Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/03710914b56c4bc7a1d676ae8395efa3

DNA methylation signatures of Alzheimer’s disease neuropathology in the cortex are primarily driven by variation in non-neuronal cell-types

Authors: Gemma Shireby, Emma L. Dempster, Stefania Policicchio, Rebecca G. Smith, Ehsan Pishva, Barry Chioza, Jonathan P. Davies, Joe Burrage, Katie Lunnon, Dorothea Seiler Vellame, Seth Love, Alan Thomas, Keeley Brookes, Kevin Morgan, Paul Francis, Eilis Hannon, Jonathan Mill

Source: Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/4898751694c340419ac1ca01ad423bfa

Genome-wide characterization of mitochondrial DNA methylation in human brain

Authors: Matthew Devall, Darren M. Soanes, Adam R. Smith, Emma L. Dempster, Rebecca G. Smith, Joe Burrage, Artemis Iatrou, Eilis Hannon, Claire Troakes, Karen Moore, Paul O’Neill, Safa Al-Sarraj, Leonard Schalkwyk, Jonathan Mill, Michael Weedon, Katie Lunnon

Source: Frontiers in Endocrinology, Vol 13 (2023)

Subject Terms: 5-Methylcytosine (5mC), Brain, DNA Methylation, epigenetics, Mitochondria, mtDNA, Diseases of the endocrine glands. Clinical endocrinology, RC648-665

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fendo.2022.1059120/full; https://doaj.org/toc/1664-2392

Access URL: https://doaj.org/article/76c6f9056010427380458856bb8a4059

DNA methylation signatures of adolescent victimization: analysis of a longitudinal monozygotic twin sample

Authors: Radhika Kandaswamy, Eilis Hannon, Louise Arseneault, Georgina Mansell, Karen Sugden, Benjamin Williams, Joe Burrage, James R Staley, Ehsan Pishva, Aisha Dahir, Susanna Roberts, Andrea Danese, Jonathan Mill, Helen L Fisher, Chloe C. Y. Wong

Source: Epigenetics, Vol 16, Iss 11, Pp 1169-1186 (2021)

Subject Terms: adolescence, adversity, dna methylation, epigenetics, longitudinal, twins, victimization, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1559-2294; https://doaj.org/toc/1559-2308

Access URL: https://doaj.org/article/c24e922fd7bc4d3991b7688caaddd685

Novel epigenetic clock for fetal brain development predicts prenatal age for cellular stem cell models and derived neurons

Authors: Leonard C. Steg, Gemma L. Shireby, Jennifer Imm, Jonathan P. Davies, Alice Franklin, Robert Flynn, Seema C. Namboori, Akshay Bhinge, Aaron R. Jeffries, Joe Burrage, Grant W. A. Neilson, Emma M. Walker, Leo W. Perfect, Jack Price, Grainne McAlonan, Deepak P. Srivastava, Nicholas J. Bray, Emma L. Cope, Kimberley M. Jones, Nicholas D. Allen, Ehsan Pishva, Emma L. Dempster, Katie Lunnon, Jonathan Mill, Eilis Hannon

Source: Molecular Brain, Vol 14, Iss 1, Pp 1-11 (2021)

Subject Terms: Epigenetic clock, DNA methylation, Fetal, Neurodevelopment, Induced pluripotent stem cells, iPSC-derived neurons, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/1756-6606

Access URL: https://doaj.org/article/18efbbb134be4d4aa4a20747dc35b350

Systematic underestimation of the epigenetic clock and age acceleration in older subjects

Authors: Louis Y. El Khoury, Tyler Gorrie-Stone, Melissa Smart, Amanda Hughes, Yanchun Bao, Alexandria Andrayas, Joe Burrage, Eilis Hannon, Meena Kumari, Jonathan Mill, Leonard C. Schalkwyk

Source: Genome Biology, Vol 20, Iss 1, Pp 1-10 (2019)

Subject Terms: DNA methylation, Epigenetic clock, Age acceleration, Biology (General), QH301-705.5, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1474-760X

Access URL: https://doaj.org/article/e6858c0976d94ec39b1624f1fc0daea6

Characterization of DNA Methylomic Signatures in Induced Pluripotent Stem Cells During Neuronal Differentiation

Authors: Jennifer Imm, Ehsan Pishva, Muhammadd Ali, Talitha L. Kerrigan, Aaron Jeffries, Joe Burrage, Enrico Glaab, Emma L. Cope, Kimberley M. Jones, Nicholas D. Allen, Katie Lunnon

Source: Frontiers in Cell and Developmental Biology, Vol 9 (2021)

Subject Terms: aging, DNA methylation, EPIC array, epigenetics, epigenome-wide association study, induced pluripotent stem cells, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcell.2021.647981/full; https://doaj.org/toc/2296-634X

Access URL: https://doaj.org/article/74e3d6a630b7493ab30116c44663fb95

The histone modification H3K4me3 is altered at the ANK1 locus in Alzheimer's disease brain

Authors: Adam R Smith, Rebecca G Smith, Ruby Macdonald, Sarah J Marzi, Joe Burrage, Claire Troakes, Safa Al-Sarraj, Jonathan Mill, Katie Lunnon

Source: Future Science OA, Vol 7, Iss 4 (2021)

Subject Terms: Alzheimer's disease, ANK1, brain, chromatin modifications, DNA methylation, Epigenetics, Medicine, Medicine (General), R5-920

File Description: electronic resource

Relation: https://doaj.org/toc/2056-5623

Access URL: https://doaj.org/article/e8edfd606bbb46548e6a839ae3c45883

Assessing the co-variability of DNA methylation across peripheral cells and tissues: Implications for the interpretation of findings in epigenetic epidemiology.

Authors: Eilis Hannon, Georgina Mansell, Emma Walker, Marta F Nabais, Joe Burrage, Agnieszka Kepa, Janis Best-Lane, Anna Rose, Suzanne Heck, Terrie E Moffitt, Avshalom Caspi, Louise Arseneault, Jonathan Mill

Source: PLoS Genetics, Vol 17, Iss 3, p e1009443 (2021)

Subject Terms: Genetics, QH426-470

File Description: electronic resource

Relation: https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1009443&type=printable; https://doaj.org/toc/1553-7390; https://doaj.org/toc/1553-7404

Access URL: https://doaj.org/article/50a178cec0884582985504eb05029264

DNA methylation meta-analysis reveals cellular alterations in psychosis and markers of treatment-resistant schizophrenia

Authors: Eilis Hannon, Emma L Dempster, Georgina Mansell, Joe Burrage, Nick Bass, Marc M Bohlken, Aiden Corvin, Charles J Curtis, David Dempster, Marta Di Forti, Timothy G Dinan, Gary Donohoe, Fiona Gaughran, Michael Gill, Amy Gillespie, Cerisse Gunasinghe, Hilleke E Hulshoff, Christina M Hultman, Viktoria Johansson, René S Kahn, Jaakko Kaprio, Gunter Kenis, Kaarina Kowalec, James MacCabe, Colm McDonald, Andrew McQuillin, Derek W Morris, Kieran C Murphy, Colette J Mustard, Igor Nenadic, Michael C O'Donovan, Diego Quattrone, Alexander L Richards, Bart PF Rutten, David St Clair, Sebastian Therman, Timothea Toulopoulou, Jim Van Os, John L Waddington, Wellcome Trust Case Control Consortium (WTCCC), CRESTAR consortium, Patrick Sullivan, Evangelos Vassos, Gerome Breen, David Andrew Collier, Robin M Murray, Leonard S Schalkwyk, Jonathan Mill

Source: eLife, Vol 10 (2021)

Subject Terms: epigenetics, DNA methylation, psychosis, schizophrenia, clozapine, Medicine, Science, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://elifesciences.org/articles/58430; https://doaj.org/toc/2050-084X

Access URL: https://doaj.org/article/999721787b59406784bbb6d4b382c82f

Parallel profiling of DNA methylation and hydroxymethylation highlights neuropathology-associated epigenetic variation in Alzheimer’s disease

Authors: Adam R. Smith, Rebecca G. Smith, Ehsan Pishva, Eilis Hannon, Janou A. Y. Roubroeks, Joe Burrage, Claire Troakes, Safa Al-Sarraj, Carolyn Sloan, Jonathan Mill, Daniel L. van den Hove, Katie Lunnon

Source: Clinical Epigenetics, Vol 11, Iss 1, Pp 1-13 (2019)

Subject Terms: Alzheimer’s disease (AD), Brain, Ankyrin 1 (ANK1), DNA methylation (5mC), DNA hydroxymethylation (5hmC), Entorhinal cortex (EC), Medicine, Genetics, QH426-470

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s13148-019-0636-y; https://doaj.org/toc/1868-7075; https://doaj.org/toc/1868-7083

Access URL: https://doaj.org/article/a2d864d64def4e4f9da5378cdfdff5c4

Genome-wide methylomic analysis in individuals with HNF1B intragenic mutation and 17q12 microdeletion

Authors: Rhian L. Clissold, Beth Ashfield, Joe Burrage, Eilis Hannon, Coralie Bingham, Jonathan Mill, Andrew Hattersley, Emma L. Dempster

Source: Clinical Epigenetics, Vol 10, Iss 1, Pp 1-11 (2018)

Subject Terms: Epigenetics, DNA methylation, HNF1B, CNV, 17q12 deletion, Renal disease, Medicine, Genetics, QH426-470

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s13148-018-0530-z; https://doaj.org/toc/1868-7075; https://doaj.org/toc/1868-7083

Access URL: https://doaj.org/article/4fd6e271d90c4a3ab620a37ca4c96694

Characterizing genetic and environmental influences on variable DNA methylation using monozygotic and dizygotic twins.

Authors: Eilis Hannon, Olivia Knox, Karen Sugden, Joe Burrage, Chloe C Y Wong, Daniel W Belsky, David L Corcoran, Louise Arseneault, Terrie E Moffitt, Avshalom Caspi, Jonathan Mill

Source: PLoS Genetics, Vol 14, Iss 8, p e1007544 (2018)

Subject Terms: Genetics, QH426-470

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC6084815?pdf=render; https://doaj.org/toc/1553-7390; https://doaj.org/toc/1553-7404

Access URL: https://doaj.org/article/6809e2304b544180b9d0ec8e454447ef

A comparison of mitochondrial DNA isolation methods in frozen post-mortem human brain tissue—applications for studies of mitochondrial genetics in brain disorders

Authors: Matthew Devall, Joe Burrage, Richard Caswell, Matthew Johnson, Claire Troakes, Safa Al-Sarraj, Aaron R Jeffries, Jonathan Mill, Katie Lunnon

Source: BioTechniques, Vol 59, Iss 4, Pp 241-246 (2015)

Subject Terms: mitochondria, genetics, epigenetics, isolation, DNA, mtDNA, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/0736-6205; https://doaj.org/toc/1940-9818

Access URL: https://doaj.org/article/db2d141b423a44a585d81507be83d570

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