Analysis of CRISPR‐Cas9 screens identifies genetic dependencies in melanoma

Authors: Christodoulou, Eirini, Rashid, Mamunur, Pacini, Clare, Droop, Alastair, Robertson, Holly, Groningen, Tim van, Teunisse, Amina F. A. S., Iorio, Francesco, Jochemsen, Aart G., Adams, David J., Doorn, Remco van

Source: Pigment cell & melanoma research. 34(1):122-131

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100114367208.0x000001&indx=1&recIds=ETOCvdc_100114367208.0x000001

Phosphorylation of Hdmx Mediates Its Hdm2- and ATM-Dependent Degradation in Response to DNA Damage

Authors: Pereg, Yaron, Shkedy, Dganit, de Graaf, Petra, Meulmeester, Erik, Edelson-Averbukh, Marina, Salek, Mogjiborahman, Biton, Sharon, Lehmann, Wolf D., Jochemsen, Aart G., Shiloh, Yosef, Elledge, Stephen J.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2005 Apr 01. 102(14), 5056-5061.

Access URL: https://www.jstor.org/stable/3375178

Functional analyses of a human vascular tumor FOS variant identify a novel degradation mechanism and a link to tumorigenesis

Alternate Title: ACCELERATED COMMUNICATION: Human vascular tumor FOS analyses (English)

Authors: van IJzendoorn, David G.P., Forghany, Zary, Liebelt, Frauke, Vertegaal, Alfred C., Jochemsen, Aart G., Bovée, Judith V.M.G., Szuhai, Karoly, Baker, David A.

Source: In Journal of Biological Chemistry 29 December 2017 292(52):21282-21290

Mutational Analysis of Fibrillarin and Its Mobility in Living Human Cells

Authors: Snaar, Sabine, Wiesmeijer, Karien, Jochemsen, Aart G., Tanke, Hans J., Dirks, Roeland W.

Source: The Journal of Cell Biology, 2000 Oct . 151(3), 653-662.

Access URL: https://www.jstor.org/stable/1620222

Microarray-based identification of age-dependent differences in gene expression of human dermal fibroblasts

Authors: Dekker, Pim, Gunn, David, McBryan, Tony, Dirks, Roeland W., van Heemst, Diana, Lim, Fei-Ling, Jochemsen, Aart G., Verlaan-de Vries, Matty, Nagel, Julia, Adams, Peter D., Tanke, Hans J., Westendorp, Rudi G.J., Maier, Andrea B.

Source: In Mechanisms of Ageing and Development July 2012 133(7):498-507

Activation of cAMP Signaling Interferes with Stress-Induced p53 Accumulation in ALL-Derived Cells by Promoting the Interaction between p53 and HDM2

Authors: Naderi, Elin Hallan, Jochemsen, Aart G, Blomhoff, Heidi Kiil, Naderi, Soheil

Source: In Neoplasia July 2011 13(7):653

Patient-derived zebrafish xenografts of uveal melanoma reveal ferroptosis as a drug target.

Authors: Groenewoud, Arwin, Yin, Jie, Gelmi, Maria Chiara, Alsafadi, Samar, Nemati, Fariba, Decaudin, Didier, Roman-Roman, Sergio, Kalirai, Helen, Coupland, Sarah E., Jochemsen, Aart G., Jager, Martine J., Engel, Felix B., Snaar-Jagalska, B. E.

Source: Cell Death Discovery; 6/16/2023, Vol. 9 Issue 1, p1-11, 11p

FAK Inhibitor-Based Combinations with MEK or PKC Inhibitors Trigger Synergistic Antitumor Effects in Uveal Melanoma.

Authors: Tarin, Malcy, Némati, Fariba, Decaudin, Didier, Canbezdi, Christine, Marande, Benjamin, Silva, Lisseth, Derrien, Héloïse, Jochemsen, Aart G., Gardrat, Sophie, Piperno-Neumann, Sophie, Rodrigues, Manuel, Mariani, Pascale, Cassoux, Nathalie, Stern, Marc-Henri, Roman-Roman, Sergio, Alsafadi, Samar

Source: Cancers; Apr2023, Vol. 15 Issue 8, p2280, 13p

Subject Terms: PROTEIN kinase inhibitors, IN vitro studies, RESEARCH funding, PROTEIN-tyrosine kinase inhibitors, ANTINEOPLASTIC agents, APOPTOSIS, UVEAL melanoma, IN vivo studies, XENOGRAFTS, METASTASIS, MICE, CELL lines, ANIMAL experimentation, GENETIC mutation, CELL survival, DRUG synergism, PHARMACODYNAMICS

Zebrafish Patient-Derived Xenograft Model as a Preclinical Platform for Uveal Melanoma Drug Discovery.

Authors: Yin, Jie, Zhao, Gangyin, Kalirai, Helen, Coupland, Sarah E., Jochemsen, Aart G., Forn-Cuní, Gabriel, Wierenga, Annemijn P. A., Jager, Martine J., Snaar-Jagalska, B. Ewa, Groenewoud, Arwin

Source: Pharmaceuticals (14248247); Apr2023, Vol. 16 Issue 4, p598, 16p

Subject Terms: BRACHYDANIO, DRUG discovery, ANIMAL models in research, EYE cancer, EVEROLIMUS, MELANOMA, INTRAVENOUS injections

HDMX-L Is Expressed from a Functional p53-responsive Promoter in the First Intron of the HDMX Gene and Participates in an Autoregulatory Feedback Loop to Control p53 Activity

Authors: Phillips, Anna, Teunisse, Amina, Lam, Suzanne, Lodder, Kirsten, Darley, Matthew, Emaduddin, Muhammad, Wolf, Anja, Richter, Julia, de Lange, Job, Verlaan-de Vries, Matty, Lenos, Kristiaan, Böhnke, Anja, Bartel, Frank, Blaydes, Jeremy P., Jochemsen, Aart G.

Source: In Journal of Biological Chemistry September 2010 285(38):29111-29127

Identification and Characterization of the First Small Molecule Inhibitor of MDMX

Authors: Reed, Damon, Shen, Ying, Shelat, Anang A., Arnold, Leggy A., Ferreira, Antonio M., Zhu, Fangyi, Mills, Nicholas, Smithson, David C., Regni, Catherine A., Bashford, Donald, Cicero, Samantha A., Schulman, Brenda A., Jochemsen, Aart G. ^**, Guy, R. Kiplin, Dyer, Michael A.

Source: In Journal of Biological Chemistry 2 April 2010 285(14):10786-10796

USP10: Friend and Foe

Authors: Jochemsen, Aart G., Shiloh, Yosef

Source: In Cell 2010 140(3):308-310

c-Abl Phosphorylates Hdmx and Regulates Its Interaction with p53

Authors: Zuckerman, Valentina, Lenos, Kristiaan, Popowicz, Grzegorz M., Silberman, Isabelle, Grossman, Tamar, Marine, Jean-Christophe, Holak, Tad A., Jochemsen, Aart G., Haupt, Ygal

Source: In Journal of Biological Chemistry 6 February 2009 284(6):4031-4039

Increased Radioresistance and Accelerated B Cell Lymphomas in Mice with Mdmx Mutations that Prevent Modifications by DNA-Damage-Activated Kinases

Authors: Wang, Yunyuan V., Leblanc, Mathias, Wade, Mark, Jochemsen, Aart G., Wahl, Geoffrey M.

Source: In Cancer Cell 2009 16(1):33-43

Macrophage p53 controls macrophage death in atherosclerotic lesions of apolipoprotein E deficient mice

Authors: Boesten, Lianne S.M., Zadelaar, A. Susanne M., van Nieuwkoop, Anita, Hu, Lihui, Teunisse, Amina F.A.S., Jochemsen, Aart G., Evers, Bastiaan, van de Water, Bob, Gijbels, Marion J.J., van Vlijmen, Bart J.M., Havekes, Louis M., de Winther, Menno P.J.

Source: In Atherosclerosis 2009 207(2):399-404

MDMX Regulates Transcriptional Activity of p53 and FOXO Proteins to Stimulate Proliferation of Melanoma Cells.

Authors: Heijkants, Renier C., Teunisse, Amina F. A. S., de Jong, Danielle, Glinkina, Kseniya, Mei, Hailiang, Kielbasa, Szymon M., Szuhai, Karoly, Jochemsen, Aart G.

Source: Cancers; Sep2022, Vol. 14 Issue 18, pN.PAG-N.PAG, 22p

Subject Terms: RNA analysis, PROTEIN metabolism, REVERSE transcriptase polymerase chain reaction, SEQUENCE analysis, ANALYSIS of variance, ONCOGENES, MELANOMA, WESTERN immunoblotting, UVEA cancer, PROTEOLYTIC enzymes, SKIN tumors, GENE expression, CELL cycle, T-test (Statistics), CELL proliferation, GENES, GENE expression profiling, TUMOR suppressor genes, DESCRIPTIVE statistics, TRANSCRIPTION factors, CELL lines, DATA analysis software, CELL death

Targeting MDM4 as a Novel Therapeutic Approach in Prostate Cancer Independent of p53 Status.

Authors: Mejía-Hernández, Javier Octavio, Raghu, Dinesh, Caramia, Franco, Clemons, Nicholas, Fujihara, Kenji, Riseborough, Thomas, Teunisse, Amina, Jochemsen, Aart G., Abrahmsén, Lars, Blandino, Giovanni, Russo, Andrea, Gamell, Cristina, Fox, Stephen B., Mitchell, Catherine, Takano, Elena A., Byrne, David, Miranda, Panimaya Jeffreena, Saleh, Reem, Thorne, Heather, Sandhu, Shahneen

Source: Cancers; Aug2022, Vol. 14 Issue 16, p3947, 27p

Subject Terms: PROTEIN metabolism, THERAPEUTIC use of proteins, GENETIC mutation, ANIMAL experimentation, METASTASIS, APOPTOSIS, OXIDATIVE stress, CHALONES, PROSTATE tumors, MICE

Novel Treatments of Uveal Melanoma Identified with a Synthetic Lethal CRISPR/Cas9 Screen.

Authors: Glinkina, Kseniya, Groenewoud, Arwin, Teunisse, Amina F. A. S., Snaar-Jagalska, B. Ewa, Jochemsen, Aart G.

Source: Cancers; Jul2022, Vol. 14 Issue 13, pN.PAG-N.PAG, 18p

Subject Terms: SOMATOMEDIN, IN vivo studies, MELANOMA, ONCOGENES, UVEA cancer, METASTASIS, CELL receptors, EVEROLIMUS, DRUG synergism, CRISPRS, CELL lines

Loss of HAUSP-Mediated Deubiquitination Contributes to DNA Damage-Induced Destabilization of Hdmx and Hdm2

Authors: Meulmeester, Erik, Maurice, Madelon M., Boutell, Chris, Teunisse, Amina F.A.S., Ovaa, Huib, Abraham, Tsion E., Dirks, Roeland W., Jochemsen, Aart G. ^*

Source: In Molecular Cell 2005 18(5):565-576

Mdmx as an essential regulator of p53 activity

Authors: Marine, Jean-Christophe, Jochemsen, Aart G.

Source: In Biochemical and Biophysical Research Communications 2005 331(3):750-760