Immune responses to SARS-CoV-2 in sub-Saharan Africa and western Europe: a retrospective, population-based, cross-sectional study

Authors: Arbous, M. Sesmu, van den Berg, Bernard M., van der Brand, Jurriaan J., de Bruin-Versteeg, Sandra, Cannegieter, Suzanne, Canté, Kirsten, Cobbaert, Christa M., Coenen - van Vroonhoven, Esther J.C., van der Does, Anne M., van Dongen, Jacques J.M., Eikenboom, Jeroen, Feltkamp, Mariet C.W., Geluk, Annemieke, Goeman, Jelle J., Giera, Martin, Groenland, Rick J., Hankemeier, Thomas, Heemskerk, Mirjam H.M., Hiemstra, Pieter S., Hokke, Cornelis H., van der Holst, Rosalie, Janse, Jacqueline J., Jochems, Simon P., Joosten, Simone A., Kikkert, Marjolein, Flores, Stefanie Klaver, Lamont, Lieke, Manniën, Judith, de Mooij, Bas, Ottenhoff, Tom H.M., Pike-Overzet, Karin, Pongrácz, Tamás, del Prado, Michael R., Rosinach, Núria Queralt, Roestenberg, Meta, Roos, Marco, Roukens, Anna H.E., Schrevel, Marlies, van der Sluijs-Gelling, Alita J., Smits, Hermelijn H., Snijder, Eric J., Staal, Frank J.T., Stradmeijer, Marloes D., Strik, Alouette P., Trouw, Leendert A., Tsonaka, Roula, Verhoeven, Aswin, Visser, Leo G., de Vries, Jutte J.C., van Westerloo, David J., Wigbers, Jeanette, van der Wijk, Henk J., van Wissen, Robin C., Wuhrer, Manfred, Yazdanbakhsh, Maria, Zlei, Mihaela, de Zwart-Slats, Diane, Oud, Josine A., Baysan, Meryem, van Heurn, Lieke J., ter Haar, Susan B., Toppenberg, Alexandra G.L., van IJlzinga Veenstra, Annekee A., Heerdink, Laura, Eikenboom, Anna M., Wubbolts, Julia M., Uzorka, Jonathan, Lijfering, Willem, Meier, Romy, de Jonge, Ingeborg, Arbous, Sesmu M., de Boer, Mark G.J., van der Bom, Johanna G., Dekkers, Olaf M., Rosendaal, Frits R., Mbow, Moustapha ^{a, b, ∗}, Hoving, Dennis ^{c, ∗}, Cisse, Marouba ^{a, c, †}, Diallo, Ibrahima ^{a, c, †}, Honkpehedji, Yabo J ^{c, g, †}, Huisman, Wesley ^c, Pothast, Cilia R ^d, Jongsma, Marlieke L M ^e, König, Marion H ^c, de Kroon, Alicia C ^c, Linh, Le Thi Kieu ^{h, j}, Azimi, Shohreh ^c, Tak, Tamar ^c, Kruize, Yvonne C M ^c, Kurniawan, Farid ^{c, k}, Dia, Yacine Amet ^b, Zhang, Jaimie L H ^c, Prins, Corine ^c, Roukens, Anna H E ^c, de Vries, Jutte J C ^c, Wammes, Linda J ^c, Smits, Hermelijn H ^c, Adegnika, Ayola A ^{c, g, h, i}, Kuijpers, Taco W ^m, Wieske, Luuk ⁿ, Dieye, Alioune ^a, Mboup, Souleymane ^b, Kremsner, Peter G ^{g, h, i}, Eftimov, Filip ⁿ, Velavan, Thirumalaisamy P ^{h, i, j, o}, Berlin, Ilana ^e, Heemskerk, Mirjam H M ^d, Jochems, Simon P ^{c, ∗, ‡}

Source: In The Lancet Microbe February 2025 6(2)

Lifestyle score is associated with cellular immune profiles in healthy Tanzanian adults

Authors: Pyuza, Jeremia J., van Dorst, Marloes M.A.R., Stam, Koen, Wammes, Linda, König, Marion, Kullaya, Vesla I., Kruize, Yvonne, Huisman, Wesley, Andongolile, Nikuntufya, Ngowi, Anastazia, Shao, Elichilia R., Mremi, Alex, Hogendoorn, Pancras C.W., Msuya, Sia E., Jochems, Simon P., de Steenhuijsen Piters, Wouter A.A., Yazdanbakhsh, Maria

Source: In Brain, Behavior, & Immunity - Health November 2024 41

Inflammation of the nasal mucosa is associated with susceptibility to experimental pneumococcal challenge in older adults

Authors: Urban, Britta C., Gonçalves, André N.A., Loukov, Dessi, Passos, Fernando M., Reiné, Jesús, Gonzalez-Dias, Patrícia, Solórzano, Carla, Mitsi, Elena, Nikolaou, Elissavet, O’Connor, Daniel, Collins, Andrea M., Adler, Hugh, Pollard, Andrew, Rylance, Jamie, Gordon, Stephen B., Jochems, Simon P., Nakaya, Helder I., Ferreira, Daniela M.

Source: In Mucosal Immunology October 2024 17(5):973-989

Protective efficacy of short-term infection with Necator americanus hookworm larvae in healthy volunteers in the Netherlands: a single-centre, placebo-controlled, randomised, controlled, phase 1 trial

Authors: Hoogerwerf, Marie-Astrid, Janse, Jacqueline J, Kuiper, Vincent P, van Schuijlenburg, Roos, Kruize, Yvonne CM, Sijtsma, Jeroen C, Nosoh, Beckley A, Koopman, Jan-Pieter R, Verbeek-Menken, Petra H, Westra, Inge M, Meij, Pauline, Brienen, Eric AT, Visser, Leo G, van Lieshout, Lisette, Jochems, Simon P, Yazdanbakhsh, Maria, Roestenberg, Meta ^*

Source: In The Lancet Microbe December 2023 4(12):e1024-e1034

Safety and infectivity of female cercariae in Schistosoma-naïve, healthy participants: a controlled human Schistosoma mansoni infection study

Authors: Koopman, Jan Pieter R., Houlder, Emma L., Janse, Jacqueline J., Casacuberta-Partal, Miriam, Lamers, Olivia A.C., Sijtsma, Jeroen C., de Dood, Claudia, Hilt, Stan T., Ozir-Fazalalikhan, Arifa, Kuiper, Vincent P., Roozen, Geert V.T., de Bes-Roeleveld, Laura M., Kruize, Yvonne C.M., Wammes, Linda J., Smits, Hermelijn H., van Lieshout, Lisette, van Dam, Govert J., van Amerongen-Westra, Inge M., Meij, Pauline, Corstjens, Paul L.A.M., Jochems, Simon P., van Diepen, Angela, Yazdanbakhsh, Maria, Hokke, Cornelis H., Roestenberg, Meta

Source: In eBioMedicine November 2023 97

Quality of antibody responses by adults and young children to 13-valent pneumococcal conjugate vaccination and Streptococcus pneumoniae colonisation

Authors: Wolf, Asia-Sophia, Mitsi, Elena, Jones, Scott, Jochems, Simon P., Roalfe, Lucy, Thindwa, Deus, Meiring, James E., Msefula, Jacquline, Bonomali, Farouck, Makhaza Jere, Tikhala, Mbewe, Maurice, Collins, Andrea M., Gordon, Stephen B., Gordon, Melita A., Ferreira, Daniela M., French, Neil, Goldblatt, David, Heyderman, Robert S., Swarthout, Todd D.

Source: Vaccine. 40(50):7201-7210

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100179204199.0x000001&indx=1&recIds=ETOCvdc_100179204199.0x000001

Differences in Bacterial Colonization and Mucosal Responses Between High and Low SES Children in Indonesia

Authors: van Dorst, Marloes M.A.R., Azimi, Shohreh, Wahyuni, Sitti, Amaruddin, Aldian I., Sartono, Erliyani, Wammes, Linda J., Yazdanbakhsh, Maria, Jochems, Simon P.

Source: Pediatric infectious disease journal. 41(6):496-506

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100155499299.0x000001&indx=1&recIds=ETOCvdc_100155499299.0x000001

Comparison of air-liquid interface transwell and airway organoid models for human respiratory virus infection studies.

Authors: Ekanger, Camilla T., Dinesh Kumar, Nilima, Koutstaal, Rosanne W., Zhou, Fan, Beukema, Martin, Waldock, Joanna, Jochems, Simon P., Mulder, Noa, van Els, Cécile A. C. M., Engelhardt, Othmar G., Mantel, Nathalie, Buno, Kevin P., Brokstad, Karl Albert, Engelsen, Agnete S. T., Cox, Rebecca J., Melgert, Barbro N., Huckriede, Anke L. W., van Kasteren, Puck B.

Source: Frontiers in Immunology; 2025, p1-16, 16p

Subject Terms: VIRUS diseases, AIRWAY (Anatomy), INFLUENZA A virus, RESPIRATORY infections, VIRAL replication

Symptoms associated with influenza vaccination and experimental human pneumococcal colonisation of the nasopharynx

Authors: Hales, Caz, Jochems, Simon P., Robinson, Rachel, Solórzano, Carla, Carniel, Beatriz, Pojar, Sherin, Reiné, Jesús, German, Esther L., Nikolaou, Elissavet, Mitsi, Elena, Hyder-Wright, Angela D., Hill, Helen, Adler, Hugh, Connor, Victoria, Zaidi, Seher, Lowe, Catherine, Fan, Xiaojing, Wang, Duolao, Gordon, Stephen B., Rylance, Jamie, Ferreira, Daniela M.

Source: Vaccine. 38(10):2298-2306

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100098830979.0x000001&indx=1&recIds=ETOCvdc_100098830979.0x000001

Early expansion of allergen‐responsive LAP⁺ B regulatory cells in allergic rhinitis but not in allergic asthma subjects during allergen immunotherapy.

Authors: Voskamp, Astrid L., de Jong, Nicolette W., Jochems, Simon P., Ozir‐Fazalalikhan, Arifa, van Hengel, Oscar R. J., van der Vlugt, Luciën E. P. M., Stam, Koen Alexander, van den Berge, Maarten, Nawijn, Martijn C., Braunstahl, Gert‐Jan, Möller, Gertrude M., van Wijk, Roy Gerth, Smits, Hermelijn H.

Source: Allergy; Apr2024, Vol. 79 Issue 4, p1060-1064, 5p

Subject Terms: REGULATORY B cells, ALLERGY desensitization, ALLERGIC rhinitis, PLASMA cells, ASTHMA, MILK allergy

Immunogenicity and reactogenicity of intradermal mRNA-1273 SARS-CoV-2 vaccination: a non-inferiority, randomized-controlled trial.

Authors: Prins, Manon L. M., Roozen, Geert V. T., Pothast, Cilia. R., Huisman, Wesley, van Binnendijk, Rob, den Hartog, Gerco, Kuiper, Vincent P., Prins, Corine, Janse, Jacqueline J., Lamers, Olivia. A. C., Koopman, Jan Pieter R., Kruithof, Annelieke C., Kamerling, Ingrid M. C., Dijkland, Romy C., de Kroon, Alicia. C., Azimi, Shohreh, Feltkamp, Mariet C. W., Kuijer, Marjan, Jochems, Simon P., Heemskerk, Mirjam H. M.

Source: NPJ Vaccines; 1/2/2024, Vol. 9 Issue 1, p1-10, 10p

Subject Terms: COVID-19 vaccines, IMMUNE response, VACCINATION, SARS-CoV-2, IMMUNOGLOBULINS, HERD immunity

Geographic Terms: NETHERLANDS

Inflammatory and tolerogenic myeloid cells determine outcome following human allergen challenge

Authors: Voskamp, Astrid L., Tak, Tamar, Gerdes, Maarten L., Menafra, Roberta, Duijster, Ellen, Jochems, Simon P., Kielbasa, Szymon M., Kormelink, Tom Groot, Stam, Koen A., van Hengel, Oscar R. J.

Source: Journal of experimental medicine. 220(9):e20221111-e20221111

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN633494949&indx=1&recIds=ETOCRN633494949

Combinatorial multimer staining and spectral flow cytometry facilitate quantification and characterization of polysaccharide-specific B cell immunity.

Authors: Hoving, Dennis, Marques, Alexandre H. C., Huisman, Wesley, Nosoh, Beckley A., de Kroon, Alicia C., van Hengel, Oscar R. J., Wu, Bing-Ru, Steenbergen, Rosanne A. M., van Helden, Pauline M., Urban, Britta C., Dhar, Nisha, Ferreira, Daniela M., Kwatra, Gaurav, Hokke, Cornelis H., Jochems, Simon P.

Source: Communications Biology; 10/28/2023, Vol. 6 Issue 1, p1-12, 12p

Subject Terms: B cells, FLOW cytometry, IMMUNOLOGIC memory, STREPTOCOCCUS pneumoniae, STREPTOCOCCUS agalactiae, VACCINATION status

Geographic Terms: SOUTH Africa

A Randomized Controlled Clinical Trial of Nasal Immunization with Live Virulence Attenuated Streptococcus pneumoniae Strains Using Human Infection Challenge.

Authors: Hill, Helen, Mitsi, Elena, Nikolaou, Elissavet, Blizard, Annie, Pojar, Sherin, Howard, Ashleigh, Hyder-Wright, Angela, Devin, Jack, Reiné, Jesus, Robinson, Ryan, Solórzano, Carla, Jochems, Simon P., Kenny-Nyazika, Tinashe, Ramos-Sevillano, Elisa, Weight, Caroline M., Myerscough, Chris, McLenaghan, Daniella, Morton, Ben, Gibbons, Emily, Farrar, Madlen

Source: American Journal of Respiratory & Critical Care Medicine; 10/15/2023, Vol. 208 Issue 8, p868-878, 11p

Subject Terms: STREPTOCOCCUS pneumoniae, CLINICAL trials, INTRANASAL administration, RANDOMIZED controlled trials, PNEUMOCOCCAL pneumonia, KLEBSIELLA pneumoniae

Immunological factors linked to geographical variation in vaccine responses

Authors: van Dorst, Marloes M. A. R., Pyuza, Jeremia J., Nkurunungi, Gyaviira, Kullaya, Vesla I., Smits, Hermelijn H., Hogendoorn, Pancras C. W., Wammes, Linda J., Everts, Bart, Elliott, Alison M., Jochems, Simon P., Yazdanbakhsh, Maria

Source: Nature Reviews Immunology; 20240101, Issue: Preprints p1-14, 14p

DNA methylation changes in metabolic and immune-regulatory pathways in blood and lymph node CD4 + T cells in response to SIV infections

Authors: Jochems, Simon P. [and others]

Source: Clinical epigenetics. 12(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100190469776.0x000001&indx=1&recIds=ETOCvdc_100190469776.0x000001

Interaction between the nasal microbiota and S. pneumoniae in the context of live-attenuated influenza vaccine

Authors: de Steenhuijsen Piters, Wouter A. A., Jochems, Simon P., Mitsi, Elena, Rylance, Jamie, Pojar, Sherin, Nikolaou, Elissavet, German, Esther L., Holloway, Mark, Carniel, Beatriz F., Chu, Mei Ling J. N., Arp, Kayleigh, Sanders, Elisabeth A. M., Ferreira, Daniela M., Bogaert, Debby

Source: Nature communications. 10(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100130636858.0x000001&indx=1&recIds=ETOCvdc_100130636858.0x000001

Microinvasion by Streptococcus pneumoniae induces epithelial innate immunity during colonisation at the human mucosal surface

Authors: Weight, Caroline M., Venturini, Cristina, Pojar, Sherin, Jochems, Simon P., Reiné, Jesús, Nikolaou, Elissavet, Solórzano, Carla, Noursadeghi, Mahdad, Brown, Jeremy S., Ferreira, Daniela M., Heyderman, Robert S.

Source: Nature communications. 10(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100130635877.0x000001&indx=1&recIds=ETOCvdc_100130635877.0x000001

Immunogenicity of an additional mRNA-1273 SARS-CoV-2 vaccination in people with HIV with hyporesponse after primary vaccination.

Authors: Jongkees, Marlou J, Geers, Daryl, Hensley, Kathryn S, Huisman, Wesley, GeurtsvanKessel, Corine H, Bogers, Susanne, Gommers, Lennert, Papageorgiou, Grigorios, Jochems, Simon P, Hollander, Jan G den, Schippers, Emile F, Ammerlaan, Heidi S M, Bierman, Wouter F W, van der Valk, Marc, Berrevoets, Marvin A H, Soetekouw, Robert, Langebeek, Nienke, Bruns, Anke H W, Leyten, Eliane M S, Sigaloff, Kim C E

Source: Journal of Infectious Diseases; 3/1/2023, Vol. 227 Issue 5, p651-662, 12p

Subject Terms: AIDS vaccines, IMMUNE response, COVID-19, HIV-positive persons, COVID-19 vaccines

The immunological mechanisms that control pneumococcal carriage.

Authors: Jochems, Simon P.¹ simon.jochems@lstmed.ac.uk, Weiser, Jeffrey N.², Malley, Richard³, Ferreira, Daniela M.¹ Daniela.ferreira@lstmed.ac.uk

Source: PLoS Pathogens. 12/21/2017, Vol. 13 Issue 12, p1-14. 14p.

Subject Terms: *STREPTOCOCCUS pneumoniae, *IMMUNE system, *NASOPHARYNX diseases, *IMMUNODEFICIENCY, *IMMUNOSUPPRESSION, *GENETICS