3-Dimensional morphological characterization of neuroretinal microglia in Alzheimer’s disease via machine learning

Authors: Wissam B. Nassrallah, Hao Ran Li, Lyden Irani, Printha Wijesinghe, Peter William Hogg, Lucy Hui, Jean Oh, Ian R. Mackenzie, Veronica Hirsch-Reinshagen, Ging-Yuek Robin Hsiung, Wellington Pham, Sieun Lee, Joanne A. Matsubara

Source: Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-16 (2024)

Subject Terms: Alzheimer’s disease, Neuroretinal microglia, 3-Dimensional morphology, Microglia morphology, Microglia count, Microglia size, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/2051-5960

Access URL: https://doaj.org/article/c6a57b91b95d4fec8e0d192eefaf6c30

TDP-43 as a potential retinal biomarker for neurodegenerative diseases

Authors: Margit Glashutter, Printha Wijesinghe, Joanne A. Matsubara

Source: Frontiers in Neuroscience, Vol 19 (2025)

Subject Terms: TDP-43 proteinopathy, neurodegenerative disease, biomarker, retina, eye, brain, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fnins.2025.1533045/full; https://doaj.org/toc/1662-453X

Access URL: https://doaj.org/article/c8992ee46c1942a7a7ae7fb33a641872

Targeting soluble amyloid-beta oligomers with a novel nanobody

Authors: Justin R. Haynes, Clayton A. Whitmore, William J. Behof, Charlotte A. Landman, Henry H. Ong, Andrew P. Feld, Isabelle C. Suero, Celeste B. Greer, John C. Gore, Printha Wijesinghe, Joanne A. Matsubara, Brian E. Wadzinski, Benjamin W. Spiller, Wellington Pham

Source: Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/c762f9905491477abe67360110002bce

Apolipoprotein E dysfunction in Alzheimer’s disease: a study on miRNA regulation, glial markers, and amyloid pathology

Authors: Printha Wijesinghe, Hao Ran Li, Zhengyuan Ai, Matthew Campbell, Si Xuan Chen, Jeanne Xi, Wellington Pham, Joanne A. Matsubara

Source: Frontiers in Aging Neuroscience, Vol 16 (2024)

Subject Terms: apolipoprotein E, Alzheimer’s disease, microRNAs, amyloid peptide, astroglia, microglia, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fnagi.2024.1495615/full; https://doaj.org/toc/1663-4365

Access URL: https://doaj.org/article/b251b0c230534f85b9f9f580c90c7c46

Exploring the role of granzyme B in subretinal fibrosis of age-related macular degeneration

Authors: Karanvir Gill, Hyung-Suk Yoo, Harshini Chakravarthy, David J. Granville, Joanne A. Matsubara

Source: Frontiers in Immunology, Vol 15 (2024)

Subject Terms: age-related macular degeneration (AMD), subretinal fibrosis, choroidal neovascularization, inflammation, immunology, granzyme B, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2024.1421175/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/056aa4a011d84cbb818a71abb891ea97

Müller cell degeneration and microglial dysfunction in the Alzheimer’s retina

Authors: Qinyuan Alis Xu, Pierre Boerkoel, Veronica Hirsch-Reinshagen, Ian R. Mackenzie, Ging-Yuek Robin Hsiung, Geoffrey Charm, Elliott F. To, Alice Q. Liu, Katerina Schwab, Kailun Jiang, Marinko Sarunic, Mirza Faisal Beg, Wellington Pham, Jing Cui, Eleanor To, Sieun Lee, Joanne A. Matsubara

Source: Acta Neuropathologica Communications, Vol 10, Iss 1, Pp 1-19 (2022)

Subject Terms: Retina, Amyloid-β, Alzheimer’s disease, Biomarker, Macroglia, Microglia, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/2051-5960

Access URL: https://doaj.org/article/ba3b05c1e6ed405c896afaf90c90c798

Purinergic signaling via P2X receptors and mechanisms of unregulated ATP release in the outer retina and age-related macular degeneration

Authors: Haydn Molcak, Kailun Jiang, Christopher J. Campbell, Joanne A. Matsubara

Source: Frontiers in Neuroscience, Vol 17 (2023)

Subject Terms: purinergic signaling, age-related macular degeneration, ATP, complement, inflammasome, P2X, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fnins.2023.1216489/full; https://doaj.org/toc/1662-453X

Access URL: https://doaj.org/article/7cd0c2f6e5a54010807acda3dbb35ab5

Ergothioneine, a dietary antioxidant improves amyloid beta clearance in the neuroretina of a mouse model of Alzheimer’s disease

Authors: Printha Wijesinghe, Clayton A. Whitmore, Matthew Campbell, Charles Li, Miranda Tsuyuki, Eleanor To, Justin Haynes, Wellington Pham, Joanne A. Matsubara

Source: Frontiers in Neuroscience, Vol 17 (2023)

Subject Terms: ergothioneine, Alzheimer’s disease, neuroretina, amyloid beta (Aβ), microglia, astrocytes, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fnins.2023.1107436/full; https://doaj.org/toc/1662-453X

Access URL: https://doaj.org/article/0779f6bc2f6f4b919ed9fe12418178cc

Potential role of extracellular granzyme B in wet age-related macular degeneration and fuchs endothelial corneal dystrophy

Authors: Eden Dubchak, Gideon Obasanmi, Matthew R. Zeglinski, David J. Granville, Sonia N. Yeung, Joanne A. Matsubara

Source: Frontiers in Pharmacology, Vol 13 (2022)

Subject Terms: extracellular matrix, corneal endothelium, retinal pigment epithelium, serine protease, Descemet’s membrane, Bruch’s membrane, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2022.980742/full; https://doaj.org/toc/1663-9812

Access URL: https://doaj.org/article/49aec5773a9341299829b0061ba29bcb

Targeting Pyroptotic Cell Death Pathways in Retinal Disease

Authors: Mary Zhao, Siqi Li, Joanne A. Matsubara

Source: Frontiers in Medicine, Vol 8 (2022)

Subject Terms: pyroptosis, cell death, NLRP3, caspase-1, GSDMD, age-related macular degeneration, Medicine (General), R5-920

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fmed.2021.802063/full; https://doaj.org/toc/2296-858X

Access URL: https://doaj.org/article/12dabad640b54f9dad55d079263d7588

The reduction of XIAP is associated with inflammasome activation in RPE: implications for AMD pathogenesis

Authors: Jiangyuan Gao, Jing Z. Cui, Aikun Wang, Hao Hang Rachel Chen, Alison Fong, Joanne A. Matsubara

Source: Journal of Neuroinflammation, Vol 16, Iss 1, Pp 1-13 (2019)

Subject Terms: Age-related macular degeneration, XIAP, Caspase-1, Inflammasome, Pyroptosis, And retinal pigment epithelium, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s12974-019-1558-5; https://doaj.org/toc/1742-2094

Access URL: https://doaj.org/article/a0d01a927da1404ba5e82c201d325483

Substantially thinner internal granular layer and reduced molecular layer surface in the cerebellar cortex of the Tc1 mouse model of down syndrome – a comprehensive morphometric analysis with active staining contrast-enhanced MRI

Authors: Da Ma, Manuel J. Cardoso, Maria A. Zuluaga, Marc Modat, Nick M. Powell, Frances K. Wiseman, Jon O. Cleary, Benjamin Sinclair, Ian F. Harrison, Bernard Siow, Karteek Popuri, Sieun Lee, Joanne A. Matsubara, Marinko V. Sarunic, Mirza Faisal Beg, Victor L.J. Tybulewicz, Elizabeth M.C. Fisher, Mark F. Lythgoe, Sebastien Ourselin

Source: NeuroImage, Vol 223, Iss , Pp 117271- (2020)

Subject Terms: Cerebellar cortical laminar structure, Down syndrome, Cortical volume, Cortical thickness, Cortical surface area, Active staining, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1053811920307576; https://doaj.org/toc/1095-9572

Access URL: https://doaj.org/article/11d3cf7d4fa743c7b2d3061b08f2b512

Amyloid Beta Immunoreactivity in the Retinal Ganglion Cell Layer of the Alzheimer’s Eye

Authors: Sieun Lee, Kailun Jiang, Brandon McIlmoyle, Eleanor To, Qinyuan (Alis) Xu, Veronica Hirsch-Reinshagen, Ian R. Mackenzie, Ging-Yuek R. Hsiung, Brennan D. Eadie, Marinko V. Sarunic, Mirza Faisal Beg, Jing Z. Cui, Joanne A. Matsubara

Source: Frontiers in Neuroscience, Vol 14 (2020)

Subject Terms: Alzheimer’s disease, retina, amyloid-beta, Temporal retina, Neuritic plaques, ophthalmic imaging, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fnins.2020.00758/full; https://doaj.org/toc/1662-453X

Access URL: https://doaj.org/article/215fa0d53a1740628040aebabed8db97

In vivo Retinal Fluorescence Imaging With Curcumin in an Alzheimer Mouse Model

Authors: Ahmad Sidiqi, Daniel Wahl, Sieun Lee, Da Ma, Elliott To, Jing Cui, Eleanor To, Mirza Faisal Beg, Marinko Sarunic, Joanne A. Matsubara

Source: Frontiers in Neuroscience, Vol 14 (2020)

Subject Terms: amyloid beta, plaques, Alzheimer’s Disease, APP/PS1, fluorescence, scanning laser ophthalmoscopy, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fnins.2020.00713/full; https://doaj.org/toc/1662-453X

Access URL: https://doaj.org/article/c1c69abd5058410798feaa57763ea3be

Retinal Distribution and Extracellular Activity of Granzyme B: A Serine Protease That Degrades Retinal Pigment Epithelial Tight Junctions and Extracellular Matrix Proteins

Authors: Joanne A. Matsubara, Yuan Tian, Jing Z. Cui, Matthew R. Zeglinski, Sho Hiroyasu, Christopher T. Turner, David J. Granville

Source: Frontiers in Immunology, Vol 11 (2020)

Subject Terms: ZO-1, blood-eye barrier, Bruch's membrane, geographic atrophy, soft drusen, choroidal neovascularization, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fimmu.2020.00574/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/6bb5f337ed3f418b95dedea95750c015

Longitudinal Consumption of Ergothioneine Reduces Oxidative Stress and Amyloid Plaques and Restores Glucose Metabolism in the 5XFAD Mouse Model of Alzheimer’s Disease

Authors: Clayton A. Whitmore, Justin R. Haynes, William J. Behof, Adam J. Rosenberg, Mohammed N. Tantawy, Brian C. Hachey, Brian E. Wadzinski, Benjamin W. Spiller, Todd E. Peterson, Krista C. Paffenroth, Fiona E. Harrison, Robert B. Beelman, Printha Wijesinghe, Joanne A. Matsubara, Wellington Pham

Source: Pharmaceuticals, Vol 15, Iss 6, p 742 (2022)

Subject Terms: ergothioneine, ROS, PET, Alzheimer, oxidative stress, 5XFAD, Medicine, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://www.mdpi.com/1424-8247/15/6/742; https://doaj.org/toc/1424-8247

Access URL: https://doaj.org/article/882ef7134def4279bbf43586617325cc

Understanding AMD by analogy: systematic review of lipid-related common pathogenic mechanisms in AMD, AD, AS and GN

Authors: Qinyuan Xu, Sijia Cao, Sanjeeva Rajapakse, Joanne A. Matsubara

Source: Lipids in Health and Disease, Vol 17, Iss 1, Pp 1-13 (2018)

Subject Terms: Lipids/oxidation, Cholesterol, Apolipoproteins, Inflammation, Complement, Macrophages, Nutritional diseases. Deficiency diseases, RC620-627

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s12944-017-0647-7; https://doaj.org/toc/1476-511X

Access URL: https://doaj.org/article/33a172e44f3943e29776ad9bee14372d

Evidence for the activation of pyroptotic and apoptotic pathways in RPE cells associated with NLRP3 inflammasome in the rodent eye

Authors: Jiangyuan Gao, Jing Z. Cui, Eleanor To, Sijia Cao, Joanne A. Matsubara

Source: Journal of Neuroinflammation, Vol 15, Iss 1, Pp 1-12 (2018)

Subject Terms: Age-related macular degeneration, Retinal pigment epithelium, NLRP3 inflammasome, Cell death, Amyloid beta, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s12974-018-1062-3; https://doaj.org/toc/1742-2094

Access URL: https://doaj.org/article/7514c38d97ff41a38b94a3dab2844539

Inhalable Thioflavin S for the Detection of Amyloid Beta Deposits in the Retina

Authors: Shawn M. Barton, Eleanor To, Baxter P. Rogers, Clayton Whitmore, Manjosh Uppal, Joanne A. Matsubara, Wellington Pham

Source: Molecules, Vol 26, Iss 4, p 835 (2021)

Subject Terms: Alzheimer, molecular imaging, retinal imaging, probes, Organic chemistry, QD241-441

File Description: electronic resource

Relation: https://www.mdpi.com/1420-3049/26/4/835; https://doaj.org/toc/1420-3049

Access URL: https://doaj.org/article/8219219e34d74fe9a9eac0c70f61f7f4

NLRP3 Inflammasome: Activation and Regulation in Age-Related Macular Degeneration

Authors: Jiangyuan Gao, Ruozhou Tom Liu, Sijia Cao, Jing Z. Cui, Aikun Wang, Eleanor To, Joanne A. Matsubara

Source: Mediators of Inflammation, Vol 2015 (2015)

Subject Terms: Pathology, RB1-214

File Description: electronic resource

Relation: https://doaj.org/toc/0962-9351; https://doaj.org/toc/1466-1861

Access URL: https://doaj.org/article/0d2d3063c364495e8f69ca9beeda1bf5