A Practical Approach to Quantitatively Assessing Equilibrium-Constant Accuracy from a Single Binding Isotherm

Authors: Tong Ye Wang, Jessica Latimer, Jean-Luc Rukundo, Isaac Kogan, Svetlana M. Krylova, Sebastian Schreiber, Philip Kohlmann, Joachim Jose, Sergey N. Krylov

Source: Precision Chemistry, Vol 3, Iss 2, Pp 89-104 (2024)

Subject Terms: Chemistry, QD1-999

File Description: electronic resource

Relation: https://doaj.org/toc/2771-9316

Access URL: https://doaj.org/article/e095b50e98164f2bb2a8c3e393c405f8

A novel fluorescent labeling compound for GluN2A containing N-methyl-d-aspartate receptors identified by autodisplay-based screening

Authors: Alexander Dombovski, Ruben Steigerwald, Nadine Ritter, Paul Disse, Gunnar Goerges, Jana Osthues, Isabel Aymanns, Carina Dilkaute, Julian Schreiber, Martina Düfer, Guiscard Seebohm, Bernhard Wünsch, Joachim Jose

Source: Journal of Pharmaceutical Analysis, Vol 14, Iss 7, Pp 100945- (2024)

Subject Terms: Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2095177924000327; https://doaj.org/toc/2095-1779

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Structure–Activity Relationship Studies of Tetracyclic Pyrrolocarbazoles Inhibiting Heterotetrameric Protein Kinase CK2

Authors: Lukas Kröger, Sebastian Borgert, Miriam Lauwers, Michaela Steinkrüger, Joachim Jose, Markus Pietsch, Bernhard Wünsch

Source: Molecules, Vol 30, Iss 1, p 63 (2024)

Subject Terms: CK2, protein kinase, heterotetrameric enzyme, protein–protein interaction, enzyme inhibition, Levy reaction, Organic chemistry, QD241-441

File Description: electronic resource

Relation: https://www.mdpi.com/1420-3049/30/1/63; https://doaj.org/toc/1420-3049

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Förster Resonance Energy Transfer Measurements in Living Bacteria for Interaction Studies of BamA with BamD and Inhibitor Identification

Authors: Sebastian Schreiber, Joachim Jose

Source: Cells, Vol 13, Iss 22, p 1858 (2024)

Subject Terms: BAM complex, FRET, flow cytometry, protein–protein interaction, antibacterial, dissociation constant, Cytology, QH573-671

File Description: electronic resource

Relation: https://www.mdpi.com/2073-4409/13/22/1858; https://doaj.org/toc/2073-4409

Access URL: https://doaj.org/article/49422dfaede949bfb9f4250734a55289

Identification of a potent PCNA‐p15‐interaction inhibitor by autodisplay‐based peptide library screening

Authors: Sarah Hardebeck, Natalie Jácobo Goebbels, Caroline Michalski, Sebastian Schreiber, Joachim Jose

Source: Microbial Biotechnology, Vol 17, Iss 4, Pp n/a-n/a (2024)

Subject Terms: Biotechnology, TP248.13-248.65

File Description: electronic resource

Relation: https://doaj.org/toc/1751-7915

Access URL: https://doaj.org/article/751b1cc78de646c393f0c5afc8348859

Analyzing the interactome of human CK2β in prostate carcinoma cells reveals HSP70‐1 and Rho guanin nucleotide exchange factor 12 as novel interaction partners

Authors: Anna Nickelsen, Claudia Götz, Florian Lenz, Karsten Niefind, Simone König, Joachim Jose

Source: FASEB BioAdvances, Vol 5, Iss 3, Pp 114-130 (2023)

Subject Terms: HSP70‐1, photo‐crosslinking mass spectrometry, prostate cancer, protein kinase CK2, Rho guanin nucleotide exchange factor 12, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/2573-9832

Access URL: https://doaj.org/article/adeb9892a74a4988956a459ad6021031

Synthesis and biological evaluation of anthracene-9,10 dione derivatives as CK2 inhibitors

Authors: Priscila López-Rojas, Samer Haidar, Franziska M. Jürgens, Dagmar Aichele, Ángel Amesty, Ana Estévez-Braun, Joachim Jose

Source: Results in Chemistry, Vol 6, Iss , Pp 100997- (2023)

Subject Terms: Anthracene-9,10-dione, CK2, Cancer, Emodin, Endocrocin, Chemistry, QD1-999

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211715623002369; https://doaj.org/toc/2211-7156

Access URL: https://doaj.org/article/edbe43404e6b4e7a8f8a8da04a8ee2f6

FRET Assays for the Identification of C. albicans HSP90-Sba1 and Human HSP90α-p23 Binding Inhibitors

Authors: Philip Kohlmann, Sergey N. Krylov, Pascal Marchand, Joachim Jose

Source: Pharmaceuticals, Vol 17, Iss 4, p 516 (2024)

Subject Terms: HSP90, Sba1, p23, drug discovery, accuracy assessment of Kd, fungal infections, Medicine, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://www.mdpi.com/1424-8247/17/4/516; https://doaj.org/toc/1424-8247

Access URL: https://doaj.org/article/c1fb5628e29d4878908c511c00118092

Vector redesign and in‐droplet cell‐growth improves enrichment and recovery in live Escherichia coli

Authors: Bernard D. G. Eenink, Tomasz S. Kaminski, Erich Bornberg‐Bauer, Joachim Jose, Florian Hollfelder, Bert vanLoo

Source: Microbial Biotechnology, Vol 15, Iss 11, Pp 2845-2853 (2022)

Subject Terms: Biotechnology, TP248.13-248.65

File Description: electronic resource

Relation: https://doaj.org/toc/1751-7915

Access URL: https://doaj.org/article/c4f747cc27c4473aa52f5ceedc1452df

Enzyme cascade converting cyclohexanol into ε‐caprolactone coupled with NADPH recycling using surface displayed alcohol dehydrogenase and cyclohexanone monooxygenase on E. coli

Authors: Haijin Tian, Christoph Furtmann, Florian Lenz, Vishnu Srinivasamurthy, Uwe T. Bornscheuer, Joachim Jose

Source: Microbial Biotechnology, Vol 15, Iss 8, Pp 2235-2249 (2022)

Subject Terms: Biotechnology, TP248.13-248.65

File Description: electronic resource

Relation: https://doaj.org/toc/1751-7915

Access URL: https://doaj.org/article/e3f63865c91e45089c502a0e53f047fe

4,5,7‐Trisubstituted indeno[1,2‐b]indole inhibits CK2 activity in tumor cells equivalent to CX‐4945 and shows strong anti‐migratory effects

Authors: Robin Birus, Ehab El‐Awaad, Laurens Ballentin, Faten Alchab, Dagmar Aichele, Laurent Ettouati, Claudia Götz, Marc Le Borgne, Joachim Jose

Source: FEBS Open Bio, Vol 12, Iss 2, Pp 394-411 (2022)

Subject Terms: CK2, HPLC‐MS/MS, indeno[1,2‐b]indole, live‐cell imaging, pharmacokinetics, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/2211-5463

Access URL: https://doaj.org/article/15575243169d4b53b3bcf241add65617

In Silico and In Vitro Search for Dual Inhibitors of the Trypanosoma brucei and Leishmania major Pteridine Reductase 1 and Dihydrofolate Reductase

Authors: Katharina Possart, Fabian C. Herrmann, Joachim Jose, Thomas J. Schmidt

Source: Molecules, Vol 28, Iss 22, p 7526 (2023)

Subject Terms: Trypanosoma brucei, Leishmania major, human African trypanosomiasis, cutaneous leishmaniasis, pteridine reductase 1 inhibitor, dihydrofolate reductase inhibitor, Organic chemistry, QD241-441

File Description: electronic resource

Relation: https://www.mdpi.com/1420-3049/28/22/7526; https://doaj.org/toc/1420-3049

Access URL: https://doaj.org/article/cbaacb37f326440b8709319782792014

De novo variants of CSNK2B cause a new intellectual disability-craniodigital syndrome by disrupting the canonical Wnt signaling pathway

Authors: Maria Asif, Emrah Kaygusuz, Marwan Shinawi, Anna Nickelsen, Tzung-Chien Hsieh, Prerana Wagle, Birgit S. Budde, Jennifer Hochscherf, Uzma Abdullah, Stefan Höning, Christian Nienberg, Dirk Lindenblatt, Angelika A. Noegel, Janine Altmüller, Holger Thiele, Susanne Motameny, Nicole Fleischer, Idan Segal, Lynn Pais, Sigrid Tinschert, Nadra Nasser Samra, Juliann M. Savatt, Natasha L. Rudy, Chiara De Luca, Paola Fortugno, Susan M. White, Peter Krawitz, Anna C.E. Hurst, Karsten Niefind, Joachim Jose, Francesco Brancati, Peter Nürnberg, Muhammad Sajid Hussain

Source: HGG Advances, Vol 3, Iss 3, Pp 100111- (2022)

Subject Terms: intellectual disability-craniodigital syndrome, CSNK2B, CK2β, CK2, Wnt signaling, β-catenin, Genetics, QH426-470

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2666247722000276; https://doaj.org/toc/2666-2477

Access URL: https://doaj.org/article/9ab8572fe2874d66a9f70e678cec119a

Mechanistic basis of breast cancer resistance protein inhibition by new indeno[1,2-b]indoles

Authors: Diogo Henrique Kita, Nathalie Guragossian, Ingrid Fatima Zattoni, Vivian Rotuno Moure, Fabiane Gomes de Moraes Rego, Sabrina Lusvarghi, Thomas Moulenat, Billel Belhani, Geraldo Picheth, Sofiane Bouacida, Zouhair Bouaziz, Christelle Marminon, Malika Berredjem, Joachim Jose, Marcos Brown Gonçalves, Suresh V. Ambudkar, Glaucio Valdameri, Marc Le Borgne

Source: Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/9507ff384b6a431cbbe3c2b6d3bf058b

Structural and Enzymological Evidence for an Altered Substrate Specificity in Okur-Chung Neurodevelopmental Syndrome Mutant CK2αLys198Arg

Authors: Christian Werner, Alexander Gast, Dirk Lindenblatt, Anna Nickelsen, Karsten Niefind, Joachim Jose, Jennifer Hochscherf

Source: Frontiers in Molecular Biosciences, Vol 9 (2022)

Subject Terms: okur-chung neurodevelopmental syndrome (OCNDS), protein kinase CK2, casein kinase 2, CSNK2A1 gene, acidophilic substrate specificity, substrate recognition, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fmolb.2022.831693/full; https://doaj.org/toc/2296-889X

Access URL: https://doaj.org/article/18550c73c84b43ea989010813692759f

A Novel Flow Cytometry-Based Assay for the Identification of HCN4 CNBD Ligands

Authors: Magdalena N. Wojciechowski, Sebastian Schreiber, Joachim Jose

Source: Pharmaceuticals, Vol 16, Iss 5, p 710 (2023)

Subject Terms: autodisplay, HCN channels, CNBD, ligand binding, Medicine, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://www.mdpi.com/1424-8247/16/5/710; https://doaj.org/toc/1424-8247

Access URL: https://doaj.org/article/cf0a365dc46544ceb7d12d6a0f0b5377

Improving the autotransporter‐based surface display of enzymes in Pseudomonas putida KT2440

Authors: Iasson E. P. Tozakidis, Lena M. Lüken, Alina Üffing, Annika Meyers, Joachim Jose

Source: Microbial Biotechnology, Vol 13, Iss 1, Pp 176-184 (2020)

Subject Terms: Biotechnology, TP248.13-248.65

File Description: electronic resource

Relation: https://doaj.org/toc/1751-7915

Access URL: https://doaj.org/article/c5bc430de16043bc8602151f3a7ed306

Cell density‐dependent auto‐inducible promoters for expression of recombinant proteins in Pseudomonas putida

Authors: Annika Meyers, Christoph Furtmann, Katrin Gesing, Iasson E. P. Tozakidis, Joachim Jose

Source: Microbial Biotechnology, Vol 12, Iss 5, Pp 1003-1013 (2019)

Subject Terms: Biotechnology, TP248.13-248.65

File Description: electronic resource

Relation: https://doaj.org/toc/1751-7915

Access URL: https://doaj.org/article/406420eebb3c49bcbc5f85200b7f3577

Diacritic Binding of an Indenoindole Inhibitor by CK2α Paralogs Explored by a Reliable Path to Atomic Resolution CK2α′ Structures

Authors: Dirk Lindenblatt, Anna Nickelsen, Violetta M. Applegate, Jennifer Hochscherf, Benedict Witulski, Zouhair Bouaziz, Christelle Marminon, Maria Bretner, Marc Le Borgne, Joachim Jose, Karsten Niefind

Source: ACS Omega, Vol 4, Iss 3, Pp 5471-5478 (2019)

Subject Terms: Chemistry, QD1-999

File Description: electronic resource

Relation: https://doaj.org/toc/2470-1343

Access URL: https://doaj.org/article/6c5bcdc4d49e447faba4e5a030c89f66

Root Extracts From Ononis spinosa Inhibit IL-8 Release via Interactions With Toll-Like Receptor 4 and Lipopolysaccharide

Authors: Verena Spiegler, Barbara Gierlikowska, Thorsten Saenger, John N. Addotey, Jandirk Sendker, Joachim Jose, Anna K. Kiss, Andreas Hensel

Source: Frontiers in Pharmacology, Vol 11 (2020)

Subject Terms: Ononis spinosa, restharrow root, inflammation, Toll-like receptor-4, clitorienolactone B, CD11b/CD18, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fphar.2020.00889/full; https://doaj.org/toc/1663-9812

Access URL: https://doaj.org/article/dbaca7bb1cdf4f879403a7f22c893d4b