Nanobodies targeting the tumor microenvironment and their formulation as nanomedicines

Authors: Liudmyla Maksymova, Yannick A. Pilger, Lutz Nuhn, Jo A. Van Ginderachter

Source: Molecular Cancer, Vol 24, Iss 1, Pp 1-33 (2025)

Subject Terms: Nanobody, Nanoparticle, Tumor microenvironment, Immunotherapy, Conjugational chemistry, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1476-4598

Access URL: https://doaj.org/article/f6f04786fd1d443da4d2aafd8b38ddf7

Development and evaluation of a single domain antibody targeting folate receptor alpha for radioligand therapy

Authors: Jonatan Dewulf, Sam Massa, Laurent Navarro, Yana Dekempeneer, Francis Santens, Hannelore Ceuppens, Karine Breckpot, Jo A. Van Ginderachter, Tony Lahoutte, Matthias D’Huyvetter, Nick Devoogdt

Source: Journal of Nanobiotechnology, Vol 22, Iss 1, Pp 1-13 (2024)

Subject Terms: Single domain antibodies, Radioligand therapy, Folate receptor alpha, Oncology, Biotechnology, TP248.13-248.65, Medical technology, R855-855.5

File Description: electronic resource

Relation: https://doaj.org/toc/1477-3155

Access URL: https://doaj.org/article/bf979be2ad584411beb4ce981ae39b12

The role of RNA modifications in disease-associated macrophages

Authors: Camille Huart, Mayuk Saibal Gupta, Jo A. Van Ginderachter

Source: Molecular Therapy: Nucleic Acids, Vol 35, Iss 4, Pp 102315- (2024)

Subject Terms: MT: RNA and epigenetic editing Special Issue, macrophages, RNA modification, epitranscriptomics, m6A, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2162253124002026; https://doaj.org/toc/2162-2531

Access URL: https://doaj.org/article/4e35d5dce5f44133b08832cf66b83428

Q586B2 is a crucial virulence factor during the early stages of Trypanosoma brucei infection that is conserved amongst trypanosomatids

Authors: Benoit Stijlemans, Patrick De Baetselier, Inge Van Molle, Laurence Lecordier, Erika Hendrickx, Ema Romão, Cécile Vincke, Wendy Baetens, Steve Schoonooghe, Gholamreza Hassanzadeh-Ghassabeh, Hannelie Korf, Marie Wallays, Joar E. Pinto Torres, David Perez-Morga, Lea Brys, Oscar Campetella, María S. Leguizamón, Mathieu Claes, Sarah Hendrickx, Dorien Mabille, Guy Caljon, Han Remaut, Kim Roelants, Stefan Magez, Jo A. Van Ginderachter, Carl De Trez

Source: Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/246f0d22755a498bb72fe9a96e853695

Peroxiredoxin-1 is an H2O2 safe-guard antioxidant and signalling enzyme in M1 macrophages

Authors: Daria Ezeriņa, Trung Nghia Vo, Ting Luo, Yvon Elkrim, Anna Escoda Suarez, Gaëtan Herinckx, Didier Vertommen, Damya Laoui, Jo A. Van Ginderachter, Joris Messens

Source: Advances in Redox Research, Vol 9, Iss , Pp 100083- (2023)

Subject Terms: Peroxiredoxins, Peroxiredoxin-1, M1 macrophages, M2 macrophages, ASK1, ROS, Biochemistry, QD415-436

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2667137923000231; https://doaj.org/toc/2667-1379

Access URL: https://doaj.org/article/d752ac01d1864c7fab4934724cfc6004

Flt3L therapy increases the abundance of Treg-promoting CCR7+ cDCs in preclinical cancer models

Authors: Emile J. Clappaert, Daliya Kancheva, Jan Brughmans, Ayla Debraekeleer, Pauline M. R. Bardet, Yvon Elkrim, Dagmar Lacroix, Maida Živalj, Ahmed E.I. Hamouda, Jo A. Van Ginderachter, Sofie Deschoemaeker, Damya Laoui

Source: Frontiers in Immunology, Vol 14 (2023)

Subject Terms: dendritic cell, immunotherapy, breast cancer, Flt3L, combination therapies, lung cancer, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2023.1166180/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/ad19eef033c8482bbb80dc7e46ef2740

Ontogeny, functions and reprogramming of Kupffer cells upon infectious disease

Authors: Mohamed Amer Musrati, Patrick De Baetselier, Kiavash Movahedi, Jo A. Van Ginderachter

Source: Frontiers in Immunology, Vol 14 (2023)

Subject Terms: liver, Kupffer cell, liver macrophages, infectious diseases, macrophage ontogeny, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2023.1238452/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/e6f8df39d33f46b4b0ff6328db380988

Junctional adhesion molecule-A is dispensable for myeloid cell recruitment and diversification in the tumor microenvironment

Authors: Máté Kiss, Els Lebegge, Aleksandar Murgaski, Helena Van Damme, Daliya Kancheva, Jan Brughmans, Isabelle Scheyltjens, Ali Talebi, Robin Maximilian Awad, Yvon Elkrim, Pauline M. R. Bardet, Sana M. Arnouk, Cleo Goyvaerts, Johan Swinnen, Frank Aboubakar Nana, Jo A. Van Ginderachter, Damya Laoui

Source: Frontiers in Immunology, Vol 13 (2022)

Subject Terms: junctional adhesion molecule-A, JAM-A, JAM-1, F11R, monocyte, extravasation, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2022.1003975/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/0086750d30a3451f83ac10075611fcc7

GBM tumors are heterogeneous in their fatty acid metabolism and modulating fatty acid metabolism sensitizes cancer cells derived from recurring GBM tumors to temozolomide

Authors: Sweta Parik, Juan Fernández-García, Francesca Lodi, Karen De Vlaminck, Marleen Derweduwe, Steven De Vleeschouwer, Raf Sciot, Wietse Geens, Linqian Weng, Francesca Maria Bosisio, Gabriele Bergers, Johnny Duerinck, Frederick De Smet, Diether Lambrechts, Jo A. Van Ginderachter, Sarah-Maria Fendt

Source: Frontiers in Oncology, Vol 12 (2022)

Subject Terms: glioblastoma, fatty acid metabolism, lipotoxicity, SCD1, FADS2, tumor heterogeneity, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fonc.2022.988872/full; https://doaj.org/toc/2234-943X

Access URL: https://doaj.org/article/9b367757c6e54473af57787cad0920a8

Imaging of Glioblastoma Tumor-Associated Myeloid Cells Using Nanobodies Targeting Signal Regulatory Protein Alpha

Authors: Karen De Vlaminck, Ema Romão, Janik Puttemans, Ana Rita Pombo Antunes, Daliya Kancheva, Isabelle Scheyltjens, Jo A. Van Ginderachter, Serge Muyldermans, Nick Devoogdt, Kiavash Movahedi, Geert Raes

Source: Frontiers in Immunology, Vol 12 (2021)

Subject Terms: signal regulatory protein alpha, glioblastoma, nanobodies (VHH), imaging, myeloid cell, SIRP alpha, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2021.777524/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/22816153b4a84f9e978050703b2fef79

Validation of miR-20a as a Tumor Suppressor Gene in Liver Carcinoma Using Hepatocyte-Specific Hyperactive piggyBac Transposons

Authors: Jaitip Tipanee, Mario Di Matteo, Warut Tulalamba, Ermira Samara-Kuko, Jiri Keirsse, Jo A. Van Ginderachter, Marinee Khim Chuah, Thierry VandenDriessche

Source: Molecular Therapy: Nucleic Acids, Vol 19, Iss , Pp 1309-1329 (2020)

Subject Terms: Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2162253120300500; https://doaj.org/toc/2162-2531

Access URL: https://doaj.org/article/892c893b67c94af681db97ef39bae16c

Immune microenvironment modulation unmasks therapeutic benefit of radiotherapy and checkpoint inhibition

Authors: Jared M. Newton, Aurelie Hanoteau, Hsuan-Chen Liu, Angelina Gaspero, Falguni Parikh, Robyn D. Gartrell-Corrado, Thomas D. Hart, Damya Laoui, Jo A. Van Ginderachter, Neeraja Dharmaraj, William C. Spanos, Yvonne Saenger, Simon Young, Andrew G. Sikora

Source: Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-21 (2019)

Subject Terms: Immunotherapy, Tumor immune microenvironment, Immune checkpoint inhibitors, Programmed cell death protein-1 (PD-1), Cytotoxic T lymphocyte associated antigen-4 (CTLA-4), Cyclophosphamide (CTX), Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s40425-019-0698-6; https://doaj.org/toc/2051-1426

Access URL: https://doaj.org/article/5865ba33af83434c8d59aa844ab92960

The Interface of Tumour-Associated Macrophages with Dying Cancer Cells in Immuno-Oncology

Authors: Isaure Vanmeerbeek, Jannes Govaerts, Raquel S. Laureano, Jenny Sprooten, Stefan Naulaerts, Daniel M. Borras, Damya Laoui, Massimiliano Mazzone, Jo A. Van Ginderachter, Abhishek D. Garg

Source: Cells, Vol 11, Iss 23, p 3890 (2022)

Subject Terms: macrophages, cancer therapy, tumour microenvironment, radiotherapy, chemotherapy, immunotherapy, Cytology, QH573-671

File Description: electronic resource

Relation: https://www.mdpi.com/2073-4409/11/23/3890; https://doaj.org/toc/2073-4409

Access URL: https://doaj.org/article/8915dc7290e54dc2a42fb2582c530c49

Targeted Repolarization of Tumor‐Associated Macrophages via Imidazoquinoline‐Linked Nanobodies

Authors: Evangelia Bolli, Maximilian Scherger, Sana M. Arnouk, Ana Rita Pombo Antunes, David Straßburger, Moritz Urschbach, Judith Stickdorn, Karen De Vlaminck, Kiavash Movahedi, Hans Joachim Räder, Sophie Hernot, Pol Besenius, Jo A. Van Ginderachter, Lutz Nuhn

Source: Advanced Science, Vol 8, Iss 10, Pp n/a-n/a (2021)

Subject Terms: cancer immunotherapy, drug delivery, M2 macrophages, nanobodies, repolarization, TLR 7/8 agonist, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2198-3844

Access URL: https://doaj.org/article/cac8fa4c5d6f47508fc134a4bcd703ea

Innate Immune Defense Mechanisms by Myeloid Cells That Hamper Cancer Immunotherapy

Authors: Els Lebegge, Sana M. Arnouk, Pauline M. R. Bardet, Máté Kiss, Geert Raes, Jo A. Van Ginderachter

Source: Frontiers in Immunology, Vol 11 (2020)

Subject Terms: cancer immunotherapy, tumor-associated myeloid cells, tumor microenvironment, innate immune response, immune suppression, immunotherapy resistance, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fimmu.2020.01395/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/e7bef2429bcf49b48de6b85b1e93e993

A Critical Blimp-1-Dependent IL-10 Regulatory Pathway in T Cells Protects From a Lethal Pro-inflammatory Cytokine Storm During Acute Experimental Trypanosoma brucei Infection

Authors: Carl De Trez, Benoit Stijlemans, Viki Bockstal, Jennifer Cnops, Hannelie Korf, Jacques Van Snick, Guy Caljon, Eric Muraille, Ian R. Humphreys, Louis Boon, Jo A. Van Ginderachter, Stefan Magez

Source: Frontiers in Immunology, Vol 11 (2020)

Subject Terms: T. brucei, IL-10, inflammation, T cells, IL-27, Blimp-1, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fimmu.2020.01085/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/2c88432ad857445596159ccb25ccec62

Tumor microenvironment modulation enhances immunologic benefit of chemoradiotherapy

Authors: Aurelie Hanoteau, Jared M. Newton, Rosemarie Krupar, Chen Huang, Hsuan-Chen Liu, Angelina Gaspero, Robyn D. Gartrell, Yvonne M. Saenger, Thomas D. Hart, Saskia J. Santegoets, Damya Laoui, Chad Spanos, Falguni Parikh, Padmini Jayaraman, Bing Zhang, Sjoerd H. Van der Burg, Jo A. Van Ginderachter, Cornelis J. M. Melief, Andrew G. Sikora

Source: Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-19 (2019)

Subject Terms: Immunotherapy, Tumor microenvironment, Inducible nitric oxide synthase (iNOS), Cyclophosphamide, L-n6-(1-iminoethyl)-lysine (L-NIL), Chemoradiotherapy, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s40425-018-0485-9; https://doaj.org/toc/2051-1426

Access URL: https://doaj.org/article/529ee5858b424de6b4b551d4e3d1d450

High Salt Inhibits Tumor Growth by Enhancing Anti-tumor Immunity

Authors: Ralf Willebrand, Ibrahim Hamad, Lauren Van Zeebroeck, Máté Kiss, Kirsten Bruderek, Anneleen Geuzens, Dries Swinnen, Beatriz Fernandes Côrte-Real, Lajos Markó, Els Lebegge, Damya Laoui, Josephine Kemna, Thomas Kammertoens, Sven Brandau, Jo A. Van Ginderachter, Markus Kleinewietfeld

Source: Frontiers in Immunology, Vol 10 (2019)

Subject Terms: cancer, dietary factor, MDSC, cancer immunotherapy, sodium chloride (dietary), Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fimmu.2019.01141/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/bfe4fc0328934a64ba739cb53f48cf52

The tumour microenvironment harbours ontogenically distinct dendritic cell populations with opposing effects on tumour immunity

Authors: Damya Laoui, Jiri Keirsse, Yannick Morias, Eva Van Overmeire, Xenia Geeraerts, Yvon Elkrim, Mate Kiss, Evangelia Bolli, Qods Lahmar, Dorine Sichien, Jens Serneels, Charlotte L. Scott, Louis Boon, Patrick De Baetselier, Massimiliano Mazzone, Martin Guilliams, Jo A. Van Ginderachter

Source: Nature Communications, Vol 7, Iss 1, Pp 1-17 (2016)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/a203b2adbb4344c7be80bcf4c68f425a

Transient Multivalent Nanobody Targeting to CD206-Expressing Cells via PH-Degradable Nanogels

Authors: Maximilian Scherger, Evangelia Bolli, Ana Rita Pombo Antunes, Sana Arnouk, Judith Stickdorn, Alexandra Van Driessche, Hansjörg Schild, Stephan Grabbe, Bruno G. De Geest, Jo A. Van Ginderachter, Lutz Nuhn

Source: Cells, Vol 9, Iss 10, p 2222 (2020)

Subject Terms: nanogel, nanobody, targeting, RAFT polymerization, click chemistry, CD206, Cytology, QH573-671

File Description: electronic resource

Relation: https://www.mdpi.com/2073-4409/9/10/2222; https://doaj.org/toc/2073-4409

Access URL: https://doaj.org/article/da8008b0c0bf450e8efd7d18830ad2da