Tertiary lymphoid structures and B cells determine clinically relevant T cell phenotypes in ovarian cancer

Authors: Lenka Kasikova, Jana Rakova, Michal Hensler, Tereza Lanickova, Jana Tomankova, Josef Pasulka, Jana Drozenova, Katerina Mojzisova, Anna Fialova, Sarka Vosahlikova, Jan Laco, Ales Ryska, Pavel Dundr, Roman Kocian, Tomas Brtnicky, Petr Skapa, Linda Capkova, Marek Kovar, Jan Prochazka, Ivan Praznovec, Vladimir Koblizek, Alice Taskova, Hisashi Tanaka, Robert Lischke, Fernando Casas Mendez, Jiri Vachtenheim, Viola Heinzelmann-Schwarz, Francis Jacob, Iain A. McNeish, Michal J. Halaska, Lukas Rob, David Cibula, Sandra Orsulic, Lorenzo Galluzzi, Radek Spisek, Jitka Fucikova

Source: Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/51ecc26da57243349eb37f9d6e8d150d

Type I interferon signaling in malignant blasts contributes to treatment efficacy in AML patients

Authors: Peter Holicek, Iva Truxova, Jana Rakova, Cyril Salek, Michal Hensler, Marek Kovar, Milan Reinis, Romana Mikyskova, Josef Pasulka, Sarka Vosahlikova, Hana Remesova, Iva Valentova, Daniel Lysak, Monika Holubova, Petr Kaspar, Jan Prochazka, Lenka Kasikova, Radek Spisek, Lorenzo Galluzzi, Jitka Fucikova

Source: Cell Death and Disease, Vol 14, Iss 3, Pp 1-12 (2023)

Subject Terms: Cytology, QH573-671

File Description: electronic resource

Relation: https://doaj.org/toc/2041-4889

Access URL: https://doaj.org/article/f8edc52886a84c80a88c6cee32d03c15

Targeting tumor-associated macrophages for successful immunotherapy of ovarian carcinoma

Authors: David Cibula, Iva Truxova, Radek Špíšek, Jitka Fucikova

Source: Journal for ImmunoTherapy of Cancer, Vol 11, Iss 2 (2023)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://jitc.bmj.com/content/11/2/e005968.full; https://doaj.org/toc/2051-1426

Access URL: https://doaj.org/article/5d1af7e923c740d184ae5041edf54a5b

Peripheral gene signatures reveal distinct cancer patient immunotypes with therapeutic implications for autologous DC-based vaccines

Authors: Michal Hensler, Jana Rakova, Lenka Kasikova, Tereza Lanickova, Josef Pasulka, Peter Holicek, Marek Hraska, Tereza Hrnciarova, Pavla Kadlecova, Andreu Schoenenberger, Klara Sochorova, Daniela Rozkova, Ludek Sojka, Jana Drozenova, Jan Laco, Rudolf Horvath, Michal Podrazil, Guo Hongyan, Tomas Brtnicky, Michal J. Halaska, Lukas Rob, Ales Ryska, An Coosemans, Ignace Vergote, Abhishek D. Garg, David Cibula, Jirina Bartunkova, Radek Spisek, Jitka Fucikova

Source: OncoImmunology, Vol 11, Iss 1 (2022)

Subject Terms: Cancer immunotherapy, metastatic castrate-resistant prostate cancer, non-small cell lung carcinoma, epithelial ovarian carcinoma, circulating biomarkers, anti-PD-1, Immunologic diseases. Allergy, RC581-607, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2162-402X

Access URL: https://doaj.org/article/8aa6cc35d16f49fbb0529e5fcefe2e0f

Detection of immunogenic cell death and its relevance for cancer therapy

Authors: Jitka Fucikova, Oliver Kepp, Lenka Kasikova, Giulia Petroni, Takahiro Yamazaki, Peng Liu, Liwei Zhao, Radek Spisek, Guido Kroemer, Lorenzo Galluzzi

Source: Cell Death and Disease, Vol 11, Iss 11, Pp 1-13 (2020)

Subject Terms: Cytology, QH573-671

File Description: electronic resource

Relation: https://doaj.org/toc/2041-4889

Access URL: https://doaj.org/article/95b8b33719bf44f78dd950d978c8d58c

Immunoprophylactic and immunotherapeutic control of hormone receptor-positive breast cancer

Authors: Aitziber Buqué, Norma Bloy, Maria Perez-Lanzón, Kristina Iribarren, Juliette Humeau, Jonathan G. Pol, Sarah Levesque, Laura Mondragon, Takahiro Yamazaki, Ai Sato, Fernando Aranda, Sylvère Durand, Alexandre Boissonnas, Jitka Fucikova, Laura Senovilla, David Enot, Michal Hensler, Margerie Kremer, Gautier Stoll, Yang Hu, Chiara Massa, Silvia C. Formenti, Barbara Seliger, Olivier Elemento, Radek Spisek, Fabrice André, Laurence Zitvogel, Suzette Delaloge, Guido Kroemer, Lorenzo Galluzzi

Source: Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/a7e37a6ac2cb4091b97dc956fd1c341a

Safety and efficacy of dendritic cell-based immunotherapy DCVAC/OvCa added to first-line chemotherapy (carboplatin plus paclitaxel) for epithelial ovarian cancer: a phase 2, open-label, multicenter, randomized trial

Authors: David Cibula, Pawel Knapp, Bohuslav Melichar, Jiřina Bartůňková, Radek Špíšek, Lukas Rob, Jitka Fucikova, Peter Mallmann, Lubos Minar, Marek Pluta, Jaroslav Klát, Jirí Špacek, Pavel Bartos, Josef Chovanec, Petr Valha, Zdenek Novotny, Dariusz Kieszko, Tereza Hrnciarova, Roman Pawel Korolkiewicz, Marek Hraska

Source: Journal for ImmunoTherapy of Cancer, Vol 10, Iss 1 (2022)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://jitc.bmj.com/content/10/1/e003190.full; https://doaj.org/toc/2051-1426

Access URL: https://doaj.org/article/54582ca5443540829196267e9ec3d8e8

560 Immunotherapeutic and antimetastatic activity of LTX-315 in preclinical models of ICI-resistant breast cancer

Authors: Xi Zhou, Sandra Demaria, Baldur Sveinbjörnsson, Öystein Rekdal, Erik Wennerberg, Lorenzo Galluzzi, Takahiro Yamazaki, Michal Hensler, Jitka Fucikova, Aitziber Buqué Martinez, Jeffrey Kraynak

Source: Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2051-1426

Access URL: https://doaj.org/article/1b44ce167572402abc4aa806a1f5f6eb

Immunological configuration of ovarian carcinoma: features and impact on disease outcome

Authors: Lorenzo Galluzzi, Radek Špíšek, Jitka Fucikova, Sandra Orsulic

Source: Journal for ImmunoTherapy of Cancer, Vol 9, Iss 10 (2021)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://jitc.bmj.com/content/9/10/e002873.full; https://doaj.org/toc/2051-1426

Access URL: https://doaj.org/article/41a6a6f4be294017adab9289b598177b

Calreticulin exposure correlates with robust adaptive antitumor immunity and favorable prognosis in ovarian carcinoma patients

Authors: Lenka Kasikova, Michal Hensler, Iva Truxova, Petr Skapa, Jan Laco, Lucie Belicova, Ivan Praznovec, Sarka Vosahlikova, Michael J. Halaska, Tomas Brtnicky, Lukas Rob, Jiri Presl, Jan Kostun, Isabelle Cremer, Ales Ryska, Guido Kroemer, Lorenzo Galluzzi, Radek Spisek, Jitka Fucikova

Source: Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-12 (2019)

Subject Terms: B cells, Cancer immunotherapy, CD20, DC-LAMP, Dendritic cells, Immunogenic cell death, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s40425-019-0781-z; https://doaj.org/toc/2051-1426

Access URL: https://doaj.org/article/dd34c6ab408e4a95a1f9593ae45f4fa1

TIM-3 levels correlate with enhanced NK cell cytotoxicity and improved clinical outcome in AML patients

Authors: Jana Rakova, Iva Truxova, Peter Holicek, Cyril Salek, Michal Hensler, Lenka Kasikova, Josef Pasulka, Monika Holubova, Marek Kovar, Daniel Lysak, Justin P. Kline, Zdenek Racil, Lorenzo Galluzzi, Radek Spisek, Jitka Fucikova

Source: OncoImmunology, Vol 10, Iss 1 (2021)

Subject Terms: co-inhibitory receptor, innate lymphoid cells, lag-3, tigit, vista, Immunologic diseases. Allergy, RC581-607, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2162-402X

Access URL: https://doaj.org/article/7aa2896ab527498bac5610f866169e29

LTX-315-enabled, radiotherapy-boosted immunotherapeutic control of breast cancer by NK cells

Authors: Takahiro Yamazaki, Erik Wennerberg, Michal Hensler, Aitziber Buqué, Jeffrey Kraynak, Jitka Fucikova, Xi Kathy Zhou, Baldur Sveinbjørnsson, Øystein Rekdal, Sandra Demaria, Lorenzo Galluzzi

Source: OncoImmunology, Vol 10, Iss 1 (2021)

Subject Terms: cdc1s, ctla4, immune checkpoint inhibitors, mpa/dmba-driven mammary carcinomas, pd-1, ts/a cells, Immunologic diseases. Allergy, RC581-607, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2162-402X

Access URL: https://doaj.org/article/26e51e80d5d54275a28570327a2e04cd

M2-like macrophages dictate clinically relevant immunosuppression in metastatic ovarian cancer

Authors: Vladimir Benes, Ladislav Pecen, Jelena Pistolic, Lorenzo Galluzzi, Iva Truxova, Radek Špíšek, Lenka Kasikova, Michal Hensler, Petr Skapa, Jan Laco, Ivan Praznovec, Tomas Brtnicky, Lukas Rob, Catherine Sautes-Fridman, Ales Ryska, Jitka Fucikova, Wolf Herve Fridman, Vít Drochýtek, Sarka Vosahlikova, Karel Fiser, Jana Rakova, Tereza Lanickova, Irena Moserova, Martina Rehackova, Ludek Sojka

Source: Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://jitc.bmj.com/content/8/2/e000979.full; https://doaj.org/toc/2051-1426

Access URL: https://doaj.org/article/0c6e706e32b54f77a1056e1dbd1de54b

Calreticulin exposure on malignant blasts correlates with improved natural killer cell-mediated cytotoxicity in acute myeloid leukemia patients

Authors: Iva Truxova, Lenka Kasikova, Cyril Salek, Michal Hensler, Daniel Lysak, Peter Holicek, Pavla Bilkova, Monika Holubova, Xiufen Chen, Romana Mikyskova, Milan Reinis, Marek Kovar, Barbora Tomalova, Justin P. Kline, Lorenzo Galluzzi, Radek Spisek, Jitka Fucikova

Source: Haematologica, Vol 105, Iss 7 (2020)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://haematologica.org/article/view/9938; https://doaj.org/toc/0390-6078; https://doaj.org/toc/1592-8721

Access URL: https://doaj.org/article/d4f009b05a7b49c99d90bd4cbfda5580

Consensus guidelines for the definition, detection and interpretation of immunogenic cell death

Authors: Udo S Gaipl, Dmitriy Zamarin, Felipe Prosper, Francesco M Marincola, Alessandra Cesano, Howard L Kaufman, Laurence Zitvogel, Tim Illidge, Taha Merghoub, Sandra Demaria, Abhishek D Garg, Patrizia Agostinis, James W Hodge, George Coukos, Akseli Hemminki, Öystein Rekdal, Jian Han, John Stagg, Sarah Warren, Lorenzo Galluzzi, Dobrin Draganov, Silvia C Formenti, Mark J Smyth, Radek Špíšek, Michael T Lotze, Takahiro Yamazaki, Guido Kroemer, Daolin Tang, Eric Deutsch, Jitka Fucikova, Sofia R Gameiro, Ilio Vitale, Sandy Adjemian, Aitziber Buqué Martinez, Timothy A Chan, Richard L Edelson, Lucia Gabriele, Encouse Golden, Kevin J Harrington, Dewan Md Sakib Hossain, Michael Karin, Oliver Kepp, Juan Jose Lasarte, Sherene Loi, Gwenola Manic, Alan A Melcher, Karen L Mossman, Maria Rescigno, Chiara Riganti, Antonella Sistigu, Bryan E Strauss, Kazuki Tatsuno, Stefaan W van Gool, Peter Vandenabeele

Source: Journal for ImmunoTherapy of Cancer, Vol 8, Iss 1 (2020)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://jitc.bmj.com/content/8/1/e000337.full; https://doaj.org/toc/2051-1426

Access URL: https://doaj.org/article/a9d90895f1e544d9989ad2cde51f79c0

Mature dendritic cells correlate with favorable immune infiltrate and improved prognosis in ovarian carcinoma patients

Authors: Iva Truxova, Lenka Kasikova, Michal Hensler, Petr Skapa, Jan Laco, Ladislav Pecen, Lucie Belicova, Ivan Praznovec, Michael J. Halaska, Tomas Brtnicky, Eva Salkova, Lukas Rob, Roman Kodet, Jeremy Goc, Catherine Sautes-Fridman, Wolf Herman Fridman, Ales Ryska, Lorenzo Galluzzi, Radek Spisek, Jitka Fucikova

Source: Journal for ImmunoTherapy of Cancer, Vol 6, Iss 1, Pp 1-13 (2018)

Subject Terms: Dendritic cells, DC-LAMP, CD8+ cytotoxic T lymphocytes, Natural killer cells, Tertiary lymphoid structures, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s40425-018-0446-3; https://doaj.org/toc/2051-1426

Access URL: https://doaj.org/article/0ee748c3b81c416998552dbbd4280c8a

Trial watch: chemotherapy-induced immunogenic cell death in immuno-oncology

Authors: Isaure Vanmeerbeek, Jenny Sprooten, Dirk De Ruysscher, Sabine Tejpar, Peter Vandenberghe, Jitka Fucikova, Radek Spisek, Laurence Zitvogel, Guido Kroemer, Lorenzo Galluzzi, Abhishek D. Garg

Source: OncoImmunology, Vol 9, Iss 1 (2020)

Subject Terms: antigen-presenting cell, autophagy, cytotoxic t lymphocyte, endoplasmic reticulum stress, car t cells, cytokines, chemokines, dendritic cell, immune checkpoint blocker, type i interferon, Immunologic diseases. Allergy, RC581-607, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2162-402X

Access URL: https://doaj.org/article/430f227a2bff4708a263f3d1cd73a5de

Calreticulin arms NK cells against leukemia

Authors: Jitka Fucikova, Justin P. Kline, Lorenzo Galluzzi, Radek Spisek

Source: OncoImmunology, Vol 9, Iss 1 (2020)

Subject Terms: anticancer immunity, cd80, ccr7, il15, immunogenic cell death, mhc class ii, type i ifn, Immunologic diseases. Allergy, RC581-607, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2162-402X

Access URL: https://doaj.org/article/26a70ffa3ff6410c91d79bb9550202d5

Converging focal radiation and immunotherapy in a preclinical model of triple negative breast cancer: contribution of VISTA blockade

Authors: Karsten A. Pilones, Michal Hensler, Camille Daviaud, Jeffrey Kraynak, Jitka Fucikova, Lorenzo Galluzzi, Sandra Demaria, Silvia C. Formenti

Source: OncoImmunology, Vol 9, Iss 1 (2020)

Subject Terms: c10orf54, cd8+ t cells, cyclophosphamide, 4t1 cells, focal radiotherapy, immunological checkpoints, immunosurveillance, mdscs, myeloid cells, pd-1, tcga, vsir, Immunologic diseases. Allergy, RC581-607, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2162-402X

Access URL: https://doaj.org/article/d9003a3121a04a3e8b47ad5eee7ef96c

Apoptotic caspases inhibit abscopal responses to radiation and identify a new prognostic biomarker for breast cancer patients

Authors: Maria Esperanza Rodriguez-Ruiz, Aitziber Buqué, Michal Hensler, Jonathan Chen, Norma Bloy, Giulia Petroni, Ai Sato, Takahiro Yamazaki, Jitka Fucikova, Lorenzo Galluzzi

Source: OncoImmunology, Vol 8, Iss 11 (2019)

Subject Terms: agr3, apaf1, bcl2, casp9, stc2, sting, susd3, Immunologic diseases. Allergy, RC581-607, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2162-402X

Access URL: https://doaj.org/article/d5d155fc51d74b22b14d6a824e4ff118