The CCR4-NOT complex is a tumor suppressor in Drosophila melanogaster eye cancer models

Authors: Carmen Vicente, Rocco Stirparo, Sofie Demeyer, Charles E. de Bock, Olga Gielen, Mardelle Atkins, Jiekun Yan, Georg Halder, Bassem A. Hassan, Jan Cools

Source: Journal of Hematology & Oncology, Vol 11, Iss 1, Pp 1-16 (2018)

Subject Terms: CCR4-NOT, Leukemia, mRNA stability, Tumor suppressor, Drosophila melanogaster, Diseases of the blood and blood-forming organs, RC633-647.5, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s13045-018-0650-0; https://doaj.org/toc/1756-8722

Access URL: https://doaj.org/article/d2b4f3970332452b81f7d13001aa3d14

A Fat-Facets-Dscam1-JNK Pathway Enhances Axonal Growth in Development and after Injury

Authors: Marta Koch, Maya Nicolas, Marlen Zschaetzsch, Natalie de Geest, Annelies Claeys, Jiekun Yan, Matthew J. Morgan, Maria-Luise Erfurth, Matthew Holt, Dietmar Schmucker, Bassem A. Hassan

Source: Frontiers in Cellular Neuroscience, Vol 11 (2018)

Subject Terms: axonal growth, axonal injury, post-transcriptional reguylatiopn, Central nervous system, Drosophila melanogaster, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: http://journal.frontiersin.org/article/10.3389/fncel.2017.00416/full; https://doaj.org/toc/1662-5102

Access URL: https://doaj.org/article/8cf8885497d447a4a2c78e569f59525b

A novel fragile X syndrome mutation reveals a conserved role for the carboxy‐terminus in FMRP localization and function

Authors: Zeynep Okray, Celine EF de Esch, Hilde Van Esch, Koen Devriendt, Annelies Claeys, Jiekun Yan, Jelle Verbeeck, Guy Froyen, Rob Willemsen, Femke MS de Vrij, Bassem A Hassan

Source: EMBO Molecular Medicine, Vol 7, Iss 4, Pp 423-437 (2015)

Subject Terms: axon guidance, Drosophila, fragile X syndrome, nuclear export, nucleolus, Medicine (General), R5-920, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1757-4676; https://doaj.org/toc/1757-4684

Access URL: https://doaj.org/article/97ced3301746408890cf35b88d3c70ea

Evolutionary changes in transcription factor coding sequence quantitatively alter sensory organ development and function

Authors: Simon Weinberger, Matthew P Topping, Jiekun Yan, Annelies Claeys, Natalie De Geest, Duru Ozbay, Talah Hassan, Xiaoli He, Joerg T Albert, Bassem A Hassan, Ariane Ramaekers

Source: eLife, Vol 6 (2017)

Subject Terms: EvoDevo, neurogenesis, atonal homologues, Medicine, Science, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://elifesciences.org/articles/26402; https://doaj.org/toc/2050-084X

Access URL: https://doaj.org/article/199375c1820145b58b15d9f19d50a00a

Mutual inhibition among postmitotic neurons regulates robustness of brain wiring in Drosophila

Authors: Marion Langen, Marta Koch, Jiekun Yan, Natalie De Geest, Maria-Luise Erfurth, Barret D Pfeiffer, Dietmar Schmucker, Yves Moreau, Bassem A Hassan

Source: eLife, Vol 2 (2013)

Subject Terms: Neurobiology, Neural Circuit, Robustness, Variability, Notch Signaling, Axonal targeting, Medicine, Science, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://elifesciences.org/articles/00337; https://doaj.org/toc/2050-084X

Access URL: https://doaj.org/article/258d5181d118405eb0d694e1b6c5a305

The Drosophila homologue of the amyloid precursor protein is a conserved modulator of Wnt PCP signaling.

Authors: Alessia Soldano, Zeynep Okray, Pavlina Janovska, Kateřina Tmejová, Elodie Reynaud, Annelies Claeys, Jiekun Yan, Zeynep Kalender Atak, Bart De Strooper, Jean-Maurice Dura, Vítězslav Bryja, Bassem A Hassan

Source: PLoS Biology, Vol 11, Iss 5, p e1001562 (2013)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.1001562&type=printable; https://doaj.org/toc/1544-9173; https://doaj.org/toc/1545-7885

Access URL: https://doaj.org/article/3db69bb975404b6395981c87d0f49d1e

Robust target gene discovery through transcriptome perturbations and genome-wide enhancer predictions in Drosophila uncovers a regulatory basis for sensory specification.

Authors: Stein Aerts, Xiao-Jiang Quan, Annelies Claeys, Marina Naval Sanchez, Phillip Tate, Jiekun Yan, Bassem A Hassan

Source: PLoS Biology, Vol 8, Iss 7, p e1000435 (2010)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC2910651?pdf=render; https://doaj.org/toc/1544-9173; https://doaj.org/toc/1545-7885

Access URL: https://doaj.org/article/cd19c781272241a2850d6f85798250d6

Integrating computational biology and forward genetics in Drosophila.

Authors: Stein Aerts, Sven Vilain, Shu Hu, Leon-Charles Tranchevent, Roland Barriot, Jiekun Yan, Yves Moreau, Bassem A Hassan, Xiao-Jiang Quan

Source: PLoS Genetics, Vol 5, Iss 1, p e1000351 (2009)

Subject Terms: Genetics, QH426-470

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC2628282?pdf=render; https://doaj.org/toc/1553-7390; https://doaj.org/toc/1553-7404

Access URL: https://doaj.org/article/48b8e25fcd7f4b29aabd731c461451d8

Depletion of lamins B1 and B2 promotes chromatin mobility and induces differential gene expression by a mesoscale-motion-dependent mechanism

Authors: Emily M. Pujadas Liwag, Xiaolong Wei, Nicolas Acosta, Lucas M. Carter, Jiekun Yang, Luay M. Almassalha, Surbhi Jain, Ali Daneshkhah, Suhas S. P. Rao, Fidan Seker-Polat, Kyle L. MacQuarrie, Joe Ibarra, Vasundhara Agrawal, Erez Lieberman Aiden, Masato T. Kanemaki, Vadim Backman, Mazhar Adli

Source: Genome Biology, Vol 25, Iss 1, Pp 1-42 (2024)

Subject Terms: Nuclear lamina, Auxin-inducible degron system, 3D chromatin organization, Lamin-associated domains, Topologically associated domains, Partial Wave Spectroscopic Microscopy, Biology (General), QH301-705.5, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1474-760X

Access URL: https://doaj.org/article/4305f5fcf633415aacff6d99aeabee41

Exercise training remodels inguinal white adipose tissue through adaptations in innervation, vascularization, and the extracellular matrix

Authors: Pasquale Nigro, Maria Vamvini, Jiekun Yang, Tiziana Caputo, Li-Lun Ho, Nicholas P. Carbone, Danae Papadopoulos, Royce Conlin, Jie He, Michael F. Hirshman, Joseph D. White, Jacques Robidoux, Robert C. Hickner, Søren Nielsen, Bente K. Pedersen, Manolis Kellis, Roeland J.W. Middelbeek, Laurie J. Goodyear

Source: Cell Reports, Vol 42, Iss 4, Pp 112392- (2023)

Subject Terms: CP: Metabolism, CP: Molecular biology, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124723004035; https://doaj.org/toc/2211-1247

Access URL: https://doaj.org/article/577f9f4134734bcd932687cedaaa5648

Investigation of the genetic effect of 56 tobacco-smoking susceptibility genes on DNA methylation and RNA expression in human brain

Authors: Zhongli Yang, Jiekun Yang, Ying Mao, Ming D. Li

Source: Frontiers in Psychiatry, Vol 13 (2022)

Subject Terms: brain, eQTL, functional SNPs, gene expression, methylation, smoking, Psychiatry, RC435-571

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fpsyt.2022.924062/full; https://doaj.org/toc/1664-0640

Access URL: https://doaj.org/article/3efb5f41b84546acb9809a321e68d9f7

Evolutionary changes in transcription factor coding sequence quantitatively alter sensory organ development and function.

Authors: Weinberger, Simon, Topping, Matthew P., Jiekun Yan, Claeys, Annelies, De Geest, Natalie, Ozbay, Duru, Hassan, Talah, Xiaoli He, Albert, Joerg T., Hassan, Bassem A., Ramaekers, Ariane

Source: eLife; Apr2017, p1-23, 23p

The Drosophila neurogenin Tap functionally interacts with the Wnt-PCP pathway to regulate neuronal extension and guidance.

Authors: Liqun Yuan, Shu Hu, Okray, Zeynep, Xi Ren, De Geest, Natalie, Claeys, Annelies, Jiekun Yan, Bellefroid, Eric, Hassan, Bassem A., Xiao-Jiang Quan

Source: Development (09501991); Aug2016, Vol. 143 Issue 15, p2760-2766, 7p

Subject Terms: DEVELOPMENTAL neurobiology, NEUROGENINS, NEURONS, GENE expression, DEVELOPMENTAL stability (Genetics)

Recurrent mutations at estrogen receptor binding sites alter chromatin topology and distal gene expression in breast cancer

Authors: Jiekun Yang, Xiaolong Wei, Turan Tufan, Cem Kuscu, Hayrunnisa Unlu, Saadia Farooq, Elif Demirtas, Bryce M. Paschal, Mazhar Adli

Source: Genome Biology, Vol 19, Iss 1, Pp 1-15 (2018)

Subject Terms: Biology (General), QH301-705.5, Genetics, QH426-470

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s13059-018-1572-4; https://doaj.org/toc/1474-760X

Access URL: https://doaj.org/article/5400a3be0d2d456a8c2bb7c7e8aad587

CRISPR knockout screening identifies combinatorial drug targets in pancreatic cancer and models cellular drug response

Authors: Karol Szlachta, Cem Kuscu, Turan Tufan, Sara J. Adair, Stephen Shang, Alex D. Michaels, Matthew G. Mullen, Natasha Lopes Fischer, Jiekun Yang, Limin Liu, Prasad Trivedi, Edward B. Stelow, P. Todd Stukenberg, J. Thomas Parsons, Todd W. Bauer, Mazhar Adli

Source: Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/5878576fa2b34029942f52a332a9c423

Genetically encoded dendritic marker sheds light on neuronal connectivity in Drosophila.

Authors: Nicolaï, Laura J. J., Ramaekers, Ariane, Raemaekers, Tim, Drozdzecki, Andrzej, Maus, Alex S., Jiekun Yan, Landgraf, Matthias, Annaert, Wim, Hassan, Bassem A.

Source: Proceedings of the National Academy of Sciences of the United States of America; 11/23/2010, Vol. 107 Issue 47, p20553-20558, 6p, 4 Color Photographs

Subject Terms: DROSOPHILA melanogaster, NEURAL circuitry, CENTRAL nervous system, PROTEINS, DENDRITES

Robust Target Gene Discovery through Transcriptome Perturbations and Genome-Wide Enhancer Predictions in Drosophila Uncovers a Regulatory Basis for Sensory Specification.

Authors: Aerts, Stein, Xiao-Jiang Quan, Claeys, Annelies, Sanchez, Marina Naval, Tate, Phillip, Jiekun Yan, Hassan, Bassem A.

Source: PLoS Biology; Jul2010, Vol. 8 Issue 7, p1-18, 18p, 1 Color Photograph, 2 Diagrams, 4 Charts, 3 Graphs

Subject Terms: GENETICS, TRANSCRIPTION factors, TUMOR suppressor genes, PHOTORECEPTORS, DROSOPHILA ananassae, GENETIC regulation

Integrating Computational Biology and Forward Genetics in Drosophila.

Authors: Aerts, Stein, Vilain, Sven, Shu Hu, Tranchevent, Leon-Charles, Barriot, Roland, Jiekun Yan, Moreau4, Yves, Hassan, Bassem A., Xiao-Jiang Quan

Source: PLoS Genetics; Jan2009, Vol. 5 Issue 1, p1-14, 14p, 1 Diagram, 4 Charts, 6 Graphs

Subject Terms: GENETIC testing, GENOTYPE-environment interaction, GENETICS, GENOMES, DROSOPHILA

Axonal Injury and Regeneration in the Adult Brain of Drosophila.

Authors: Ayaz, Derya, Leyssen, Maarten, Koch, Marta, Jiekun Yan, Srahna, Mohammed, Sheeba, Vasu, Fogle, Keri J., Holmes, Todd C., Hassan, Bassem A.

Source: Journal of Neuroscience; 6/4/2008, Vol. 28 Issue 23, p6010-6021, 12p, 8 Diagrams

Subject Terms: DROSOPHILA melanogaster, BRAIN injuries, REGENERATION (Biology), AXONS, CENTRAL nervous system, PROTEIN kinases

Evolution of neural precursor selection: functional divergence of proneural proteins.

Authors: Xiao-Jiang Quan, Denayer, Tinneke, Jiekun Yan, Jafar-Nejad, Hamed, Philippi, Anne, Lichtarge, Olivier, Vleminckx, Kris, Hassan, Bassem A.

Source: Development (09501991); Apr2004, Vol. 131 Issue 8, p1679-1689, 11p, 4 Color Photographs, 3 Diagrams, 5 Graphs

Subject Terms: BIOLOGICAL evolution, PERIPHERAL nervous system, PROTEINS, TRANSCRIPTION factors, NEUROGENETICS, NEUROPHYSIOLOGY, MOLECULAR genetics