Antarmycins: Discovery, Biosynthesis, Anti-pathogenic Bacterial Activity, and Mechanism of Action from Deep-Sea-Derived Pseudonocardia antarctica

Authors: Zhenbin Zhou, Jiafan Yang, Junying Ma, Zhuo Shang, Runping Fang, Xinpeng Tian, Qinglian Li, Jianhua Ju

Source: JACS Au, Vol 5, Iss 1, Pp 237-249 (2024)

Subject Terms: Chemistry, QD1-999

File Description: electronic resource

Relation: https://doaj.org/toc/2691-3704

Access URL: https://doaj.org/article/9905cbe7e8464187a784cc8585ecf116

EmbB and EmbC regulate the sensitivity of Mycobacterium abscessus to echinomycin

Authors: Jing He, Yamin Gao, Jingyun Wang, H. M. Adnan Hameed, Shuai Wang, Cuiting Fang, Xirong Tian, Jingran Zhang, Xingli Han, Yanan Ju, Yaoju Tan, Junying Ma, Jianhua Ju, Jinxing Hu, Jianxiong Liu, Tianyu Zhang

Source: mLife, Vol 3, Iss 3, Pp 459-470 (2024)

Subject Terms: echinomycin, EmbB, EmbC, functional compensation, Mycobacterium abscessus, Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/2770-100X

Access URL: https://doaj.org/article/923780d5ac9241eb8a63a45d3cc8cfd2

Intracellularly driven chemical modifications of antimicrobial secondary metabolites: Potent mechanisms of self-resistance

Authors: Xiaohua Li, Jianhua Ju

Source: Pharmaceutical Science Advances, Vol 2, Iss , Pp 100032- (2024)

Subject Terms: Natural products, Self-resistance, Chemical modifications, Antibiotic resistance, Self-defense, Chemical inactivation, Pharmacy and materia medica, RS1-441, Therapeutics. Pharmacology, RM1-950

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Relation: http://www.sciencedirect.com/science/article/pii/S2773216923000302; https://doaj.org/toc/2773-2169

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Metabolic Blockade-Based Genome Mining of Malbranchea circinata SDU050: Discovery of Diverse Secondary Metabolites

Authors: Hu Yang, Xiaowei Luo, Zhuo Shang, Kunlong Li, Jian Cai, Yingying Chen, Longchao Xin, Jianhua Ju

Source: Marine Drugs, Vol 23, Iss 1, p 50 (2025)

Subject Terms: secondary metabolites, fungi, deep-sea sediment, metabolic blockade, cytochalasin, Biology (General), QH301-705.5

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Relation: https://www.mdpi.com/1660-3397/23/1/50; https://doaj.org/toc/1660-3397

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Characterization of the depsidone gene cluster reveals etherification, decarboxylation and multiple halogenations as tailoring steps in depsidone assembly

Authors: Jiafan Yang, Zhenbin Zhou, Yingying Chen, Yongxiang Song, Jianhua Ju

Source: Acta Pharmaceutica Sinica B, Vol 13, Iss 9, Pp 3919-3929 (2023)

Subject Terms: Depside and depsidone, Polyketide synthase, Tailoring enzymes, Multiple-halogenated, Antibacterial activity, Therapeutics. Pharmacology, RM1-950

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Relation: http://www.sciencedirect.com/science/article/pii/S2211383523001995; https://doaj.org/toc/2211-3835

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Metabolic Blockade-Based Genome Mining of Sea Anemone-Associated Streptomyces sp. S1502 Identifies Atypical Angucyclines WS-5995 A–E: Isolation, Identification, Biosynthetic Investigation, and Bioactivities

Authors: Yuyang Wang, Le Zhou, Xiaoting Pan, Zhangjun Liao, Nanshan Qi, Mingfei Sun, Hua Zhang, Jianhua Ju, Junying Ma

Source: Marine Drugs, Vol 22, Iss 5, p 195 (2024)

Subject Terms: metabolic blockade-based genome mining, Streptomyces sp. S1502, WS-5995, biosynthesis, anticoccidial activity, Biology (General), QH301-705.5

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Relation: https://www.mdpi.com/1660-3397/22/5/195; https://doaj.org/toc/1660-3397

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Combinatorial strategies for production improvement of anti-tuberculosis antibiotics ilamycins E1/E2 from deep sea-derived Streptomyces atratus SCSIO ZH16 ΔilaR

Authors: Yunfei Zhu, Gaofan Zheng, Xiujuan Xin, Junying Ma, Jianhua Ju, Faliang An

Source: Bioresources and Bioprocessing, Vol 9, Iss 1, Pp 1-13 (2022)

Subject Terms: Ilamycins, Streptomyces atratus, Fermentation optimization, Exogenous adding strategy, Technology, Chemical technology, TP1-1185, Biotechnology, TP248.13-248.65

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Relation: https://doaj.org/toc/2197-4365

Access URL: https://doaj.org/article/1765f36970a84641af92388c5c8102d9

Deciphering the Glycosylation Steps in the Biosynthesis of P-1894B and Grincamycin Isolated from Marine-Derived Streptomyces lusitanus SCSIO LR32

Authors: Hongbo Huang, Yun Zhang, Yongxiang Song, Chunyao Ling, Siyan Peng, Bo Ding, Yiwen Tao, Jianhua Ju

Source: Marine Drugs, Vol 22, Iss 1, p 32 (2024)

Subject Terms: angucycline, glycosylation, biosynthesis, P-1894B, grincamycin, marine Streptomyces, Biology (General), QH301-705.5

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Relation: https://www.mdpi.com/1660-3397/22/1/32; https://doaj.org/toc/1660-3397

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OSMAC-Based Discovery and Biosynthetic Gene Clusters Analysis of Secondary Metabolites from Marine-Derived Streptomyces globisporus SCSIO LCY30

Authors: Yanqing Li, Naying Gong, Le Zhou, Zhijie Yang, Hua Zhang, Yucheng Gu, Junying Ma, Jianhua Ju

Source: Marine Drugs, Vol 22, Iss 1, p 21 (2023)

Subject Terms: OSMAC, biosynthetic gene clusters (BGCs), angucyclines, streptophenazines, tumor cytotoxic activity, Biology (General), QH301-705.5

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Relation: https://www.mdpi.com/1660-3397/22/1/21; https://doaj.org/toc/1660-3397

Access URL: https://doaj.org/article/102576d2c947494fb7b5eb5bd6760f0a

Nonspecific Heme-Binding Cyclase, AbmU, Catalyzes [4 + 2] Cycloaddition during Neoabyssomicin Biosynthesis

Authors: Qinglian Li, Wenjuan Ding, Jiajia Tu, Changbiao Chi, Hongbo Huang, Xiaoqi Ji, Ziwei Yao, Ming Ma, Jianhua Ju

Source: ACS Omega, Vol 5, Iss 32, Pp 20548-20557 (2020)

Subject Terms: Chemistry, QD1-999

File Description: electronic resource

Relation: https://doaj.org/toc/2470-1343

Access URL: https://doaj.org/article/bc54b58c5c15427593303d9cbf6cf7ca

Genome Sequencing of Streptomyces griseus SCSIO PteL053, the Producer of 2,2′-Bipyridine and Actinomycin Analogs, and Associated Biosynthetic Gene Cluster Analysis

Authors: Ganesan Govindarajan, Ziwei Yao, Zhenbin Zhou, Xiaohong Zheng, Junying Ma, Pachaiyappan Saravana Kumar, Jianhua Ju, Changli Sun

Source: Journal of Marine Science and Engineering, Vol 11, Iss 2, p 396 (2023)

Subject Terms: genome sequencing, PKS/NRPS, 2,2′-bipyridine, actinomycin, Naval architecture. Shipbuilding. Marine engineering, VM1-989, Oceanography, GC1-1581

File Description: electronic resource

Relation: https://www.mdpi.com/2077-1312/11/2/396; https://doaj.org/toc/2077-1312

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Development of Marker Recycling Systems for Sequential Genetic Manipulation in Marine-Derived Fungi Spiromastix sp. SCSIO F190 and Aspergillus sp. SCSIO SX7S7

Authors: Yingying Chen, Jiafan Yang, Cunlei Cai, Junjie Shi, Yongxiang Song, Junying Ma, Jianhua Ju

Source: Journal of Fungi, Vol 9, Iss 3, p 302 (2023)

Subject Terms: pyrG marker, amdS marker, marine-derived fungi, genome editing, secondary metabolite, Biology (General), QH301-705.5

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Relation: https://www.mdpi.com/2309-608X/9/3/302; https://doaj.org/toc/2309-608X

Access URL: https://doaj.org/article/854ca5f9fb8140b892d1722c9884057b

Semi-Synthesis of Marine-Derived Ilamycin F Derivatives and Their Antitubercular Activities

Authors: Jun Li, Zhiyong Liu, Mingye Hong, Changli Sun, Tianyu Zhang, Hua Zhang, Jianhua Ju, Junying Ma

Source: Frontiers in Chemistry, Vol 9 (2021)

Subject Terms: streptomycetes, cyclopeptide, antitubercular activity, ilamycin, semi-synthesis, derivatization, Chemistry, QD1-999

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Relation: https://www.frontiersin.org/articles/10.3389/fchem.2021.774555/full; https://doaj.org/toc/2296-2646

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Ilamycin C induces apoptosis and inhibits migration and invasion in triple-negative breast cancer by suppressing IL-6/STAT3 pathway

Authors: Qing Xie, Zhijie Yang, Xuanmei Huang, Zikang Zhang, Jiangbin Li, Jianhua Ju, Hua Zhang, Junying Ma

Source: Journal of Hematology & Oncology, Vol 12, Iss 1, Pp 1-14 (2019)

Subject Terms: Ilamycin C, Triple-negative breast cancer, Apoptosis, Invasion, Migration, IL-6, Diseases of the blood and blood-forming organs, RC633-647.5, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

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Relation: http://link.springer.com/article/10.1186/s13045-019-0744-3; https://doaj.org/toc/1756-8722

Access URL: https://doaj.org/article/60ae34078e5b41d2bcfe4a10bd468098

Halo- and Thiocarbazomycins from Coral- and Coral Reef Sands-Derived Actinomycetes

Authors: Qiaoling Wu, Hongjie Zhu, Changli Sun, Le Zhou, Huimin Wang, Songbiao Shi, Xinpeng Tian, Jianhua Ju

Source: Marine Drugs, Vol 20, Iss 8, p 537 (2022)

Subject Terms: carbazole, alkaloids, coral-associated actinomycetes, halogen compound, natural products, Biology (General), QH301-705.5

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Relation: https://www.mdpi.com/1660-3397/20/8/537; https://doaj.org/toc/1660-3397

Access URL: https://doaj.org/article/eb98ab30029c4f94968f7b31f5bd298e

Development of the CRISPR-Cas9 System for the Marine-Derived Fungi Spiromastix sp. SCSIO F190 and Aspergillus sp. SCSIO SX7S7

Authors: Yingying Chen, Cunlei Cai, Jiafan Yang, Junjie Shi, Yongxiang Song, Dan Hu, Junying Ma, Jianhua Ju

Source: Journal of Fungi, Vol 8, Iss 7, p 715 (2022)

Subject Terms: marine-derived fungi, CRISPR-Cas9, Spiromastix sp. SCSIO F190, Aspergillus sp. SCSIO SX7S7, secondary metabolites, histone deacetylase, Biology (General), QH301-705.5

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Relation: https://www.mdpi.com/2309-608X/8/7/715; https://doaj.org/toc/2309-608X

Access URL: https://doaj.org/article/2f1dc8492f064ca59d173d98b0d02ddd

Complete genome sequence of the deep South China Sea-derived Streptomyces niveus SCSIO 3406, the producer of cytotoxic and antibacterial marfuraquinocins.

Authors: Qinghua Zhu, Weige Cheng, Yongxiang Song, Qing He, Jianhua Ju, Qinglian Li

Source: PLoS ONE, Vol 16, Iss 3, p e0248404 (2021)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0248404&type=printable; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/39e7233389e44be1b77bb0769a9b2788

Secondary Metabolites and Biosynthetic Gene Clusters Analysis of Deep-Sea Hydrothermal Vent-Derived Streptomyces sp. SCSIO ZS0520

Authors: Huaran Zhang, Yingying Chen, Yanqing Li, Yongxiang Song, Junying Ma, Jianhua Ju

Source: Marine Drugs, Vol 20, Iss 6, p 393 (2022)

Subject Terms: polyketide, biosynthesis, Streptomyces, hydrothermal vent, deep sea, Biology (General), QH301-705.5

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Relation: https://www.mdpi.com/1660-3397/20/6/393; https://doaj.org/toc/1660-3397

Access URL: https://doaj.org/article/26246d01b2c346b99052e9330995b6cc

Overexpression of a type III PKS gene affording novel violapyrones with enhanced anti-influenza A virus activity

Authors: Lukuan Hou, Huiming Huang, Huayue Li, Shuyao Wang, Jianhua Ju, Wenli Li

Source: Microbial Cell Factories, Vol 17, Iss 1, Pp 1-11 (2018)

Subject Terms: Violapyrones (VLPs), Overexpression, Type III polyketide synthase (PKS), Anti-influenza A (H1N1) virus activity, Microbiology, QR1-502

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s12934-018-0908-9; https://doaj.org/toc/1475-2859

Access URL: https://doaj.org/article/285cd0b7184448109d657cf0e1a238fb

Characterization and heterologous expression of the neoabyssomicin/abyssomicin biosynthetic gene cluster from Streptomyces koyangensis SCSIO 5802

Authors: Jiajia Tu, Siting Li, Jiang Chen, Yongxiang Song, Shaobin Fu, Jianhua Ju, Qinglian Li

Source: Microbial Cell Factories, Vol 17, Iss 1, Pp 1-14 (2018)

Subject Terms: Abyssomicin, Tetronate, Biosynthesis, Transporter, Pathway-specific regulator, Microbiology, QR1-502

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s12934-018-0875-1; https://doaj.org/toc/1475-2859

Access URL: https://doaj.org/article/1a921d3caeea4a7fbc7fab8c898002f5