Deep mutational scanning of H5 hemagglutinin to inform influenza virus surveillance.

Authors: Bernadeta Dadonaite, Jenny J Ahn, Jordan T Ort, Jin Yu, Colleen Furey, Annie Dosey, William W Hannon, Amy L Vincent Baker, Richard J Webby, Neil P King, Yan Liu, Scott E Hensley, Thomas P Peacock, Louise H Moncla, Jesse D Bloom

Source: PLoS Biology, Vol 22, Iss 11, p e3002916 (2024)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/1544-9173; https://doaj.org/toc/1545-7885

Access URL: https://doaj.org/article/b551513de7f34cac99356402507891c8

Influenza virus transcription and progeny production are poorly correlated in single cells

Authors: David J Bacsik, Bernadeta Dadonaite, Andrew Butler, Allison J Greaney, Nicholas S Heaton, Jesse D Bloom

Source: eLife, Vol 12 (2023)

Subject Terms: influenza virus, single-cell transcriptomics, NS, Medicine, Science, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://elifesciences.org/articles/86852; https://doaj.org/toc/2050-084X

Access URL: https://doaj.org/article/9127c1486737475b8b8868e7d39955cd

The E2 glycoprotein holds key residues for Mayaro virus adaptation to the urban Aedes aegypti mosquito.

Authors: Chelsea Cereghino, Ferdinand Roesch, Lucía Carrau, Alexandra Hardy, Helder V Ribeiro-Filho, Annabelle Henrion-Lacritick, Cassandra Koh, Jeffrey M Marano, Tyler A Bates, Pallavi Rai, Christina Chuong, Shamima Akter, Thomas Vallet, Hervé Blanc, Truitt J Elliott, Anne M Brown, Pawel Michalak, Tanya LeRoith, Jesse D Bloom, Rafael Elias Marques, Maria-Carla Saleh, Marco Vignuzzi, James Weger-Lucarelli

Source: PLoS Pathogens, Vol 19, Iss 4, p e1010491 (2023)

Subject Terms: Immunologic diseases. Allergy, RC581-607, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/1553-7366; https://doaj.org/toc/1553-7374

Access URL: https://doaj.org/article/1ea6de0034af46169fea46627e3b5c7a

The landscape of antibody binding affinity in SARS-CoV-2 Omicron BA.1 evolution

Authors: Alief Moulana, Thomas Dupic, Angela M Phillips, Jeffrey Chang, Anne A Roffler, Allison J Greaney, Tyler N Starr, Jesse D Bloom, Michael M Desai

Source: eLife, Vol 12 (2023)

Subject Terms: SARS-CoV-2, omicron variant, antibody escape, immune evasion, fitness landscape, Medicine, Science, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://elifesciences.org/articles/83442; https://doaj.org/toc/2050-084X

Access URL: https://doaj.org/article/af2ba229e801450dbdffb38ffb9301ac

Deep mutational scans for ACE2 binding, RBD expression, and antibody escape in the SARS-CoV-2 Omicron BA.1 and BA.2 receptor-binding domains.

Authors: Tyler N Starr, Allison J Greaney, Cameron M Stewart, Alexandra C Walls, William W Hannon, David Veesler, Jesse D Bloom

Source: PLoS Pathogens, Vol 18, Iss 11, p e1010951 (2022)

Subject Terms: Immunologic diseases. Allergy, RC581-607, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/1553-7366; https://doaj.org/toc/1553-7374

Access URL: https://doaj.org/article/935a02fbd2d6495d8f961be0fd3e02fe

The SARS-CoV-2 Delta variant induces an antibody response largely focused on class 1 and 2 antibody epitopes.

Authors: Allison J Greaney, Rachel T Eguia, Tyler N Starr, Khadija Khan, Nicholas Franko, Jennifer K Logue, Sandra M Lord, Cate Speake, Helen Y Chu, Alex Sigal, Jesse D Bloom

Source: PLoS Pathogens, Vol 18, Iss 6, p e1010592 (2022)

Subject Terms: Immunologic diseases. Allergy, RC581-607, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/1553-7366; https://doaj.org/toc/1553-7374

Access URL: https://doaj.org/article/673cd94aaa38462099996f44aeda4423

A SARS-CoV-2 variant elicits an antibody response with a shifted immunodominance hierarchy.

Authors: Allison J Greaney, Tyler N Starr, Rachel T Eguia, Andrea N Loes, Khadija Khan, Farina Karim, Sandile Cele, John E Bowen, Jennifer K Logue, Davide Corti, David Veesler, Helen Y Chu, Alex Sigal, Jesse D Bloom

Source: PLoS Pathogens, Vol 18, Iss 2, p e1010248 (2022)

Subject Terms: Immunologic diseases. Allergy, RC581-607, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/1553-7366; https://doaj.org/toc/1553-7374

Access URL: https://doaj.org/article/47294b3432084a629a2f2e376fdff936

Humoral immunogenicity of the seasonal influenza vaccine before and after CAR-T-cell therapy: a prospective observational study

Authors: Helen Y Chu, Caitlin R Wolf, Rebecca A Gardner, Cameron J Turtle, Joshua A Hill, Carla S Walti, Andrea N Loes, Kiel Shuey, Elizabeth M Krantz, Jim Boonyaratanakornkit, Jacob Keane-Candib, Tillie Loeffelholz, Justin J Taylor, Damian J Green, Andrew J Cowan, David G Maloney, Steven A Pergam, Jesse D Bloom

Source: Journal for ImmunoTherapy of Cancer, Vol 9, Iss 10 (2021)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://jitc.bmj.com/content/9/10/e003428.full; https://doaj.org/toc/2051-1426

Access URL: https://doaj.org/article/287ae1b301ef47aab23e2cd038c0f88b

Functional development of a V3/glycan-specific broadly neutralizing antibody isolated from a case of HIV superinfection

Authors: Mackenzie M Shipley, Vidya Mangala Prasad, Laura E Doepker, Adam Dingens, Duncan K Ralph, Elias Harkins, Amrit Dhar, Dana Arenz, Vrasha Chohan, Haidyn Weight, Kishor Mandaliya, Jesse D Bloom, Frederick A Matsen IV, Kelly K Lee, Julie M Overbaugh

Source: eLife, Vol 10 (2021)

Subject Terms: HIV, broadly neutralizing antibody, V3, superinfection, cryo-EM, lineage development, Medicine, Science, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://elifesciences.org/articles/68110; https://doaj.org/toc/2050-084X

Access URL: https://doaj.org/article/7b8bfe9ce0bb4d1981024e1033369263

A human coronavirus evolves antigenically to escape antibody immunity.

Authors: Rachel T Eguia, Katharine H D Crawford, Terry Stevens-Ayers, Laurel Kelnhofer-Millevolte, Alexander L Greninger, Janet A Englund, Michael J Boeckh, Jesse D Bloom

Source: PLoS Pathogens, Vol 17, Iss 4, p e1009453 (2021)

Subject Terms: Immunologic diseases. Allergy, RC581-607, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1009453&type=printable; https://doaj.org/toc/1553-7366; https://doaj.org/toc/1553-7374

Access URL: https://doaj.org/article/b0411573015b4743ab53aa2f4aedcd83

High-resolution mapping of the neutralizing and binding specificities of polyclonal sera post-HIV Env trimer vaccination

Authors: Adam S Dingens, Payal Pratap, Keara Malone, Sarah K Hilton, Thomas Ketas, Christopher A Cottrell, Julie Overbaugh, John P Moore, PJ Klasse, Andrew B Ward, Jesse D Bloom

Source: eLife, Vol 10 (2021)

Subject Terms: HIV, polyclonal sera, Env trimer immunization, mutational antigenic profiling, electron microscopy polyclonal epitope mapping, Medicine, Science, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://elifesciences.org/articles/64281; https://doaj.org/toc/2050-084X

Access URL: https://doaj.org/article/fa6f1f9b6b094cd8a36eefa873071ef2

When two are better than one: Modeling the mechanisms of antibody mixtures.

Authors: Tal Einav, Jesse D Bloom

Source: PLoS Computational Biology, Vol 16, Iss 5, p e1007830 (2020)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/1553-734X; https://doaj.org/toc/1553-7358

Access URL: https://doaj.org/article/992e534f31ec40588d56c8a25ceb5d1a

A framework for exhaustively mapping functional missense variants

Authors: Jochen Weile, Song Sun, Atina G Cote, Jennifer Knapp, Marta Verby, Joseph C Mellor, Yingzhou Wu, Carles Pons, Cassandra Wong, Natascha van Lieshout, Fan Yang, Murat Tasan, Guihong Tan, Shan Yang, Douglas M Fowler, Robert Nussbaum, Jesse D Bloom, Marc Vidal, David E Hill, Patrick Aloy, Frederick P Roth

Source: Molecular Systems Biology, Vol 13, Iss 12, Pp 1-17 (2017)

Subject Terms: complementation, deep mutational scanning, genotype–phenotype, variants of uncertain significance, Biology (General), QH301-705.5, Medicine (General), R5-920

File Description: electronic resource

Relation: https://doaj.org/toc/1744-4292

Access URL: https://doaj.org/article/bdf5a797af864ab19cb037d766ead388

Mapping person-to-person variation in viral mutations that escape polyclonal serum targeting influenza hemagglutinin

Authors: Juhye M Lee, Rachel Eguia, Seth J Zost, Saket Choudhary, Patrick C Wilson, Trevor Bedford, Terry Stevens-Ayers, Michael Boeckh, Aeron C Hurt, Seema S Lakdawala, Scott E Hensley, Jesse D Bloom

Source: eLife, Vol 8 (2019)

Subject Terms: influenza virus, deep mutational scanning, hemagglutinin, antigenic drift, mutational antigenic profiling, Medicine, Science, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://elifesciences.org/articles/49324; https://doaj.org/toc/2050-084X

Access URL: https://doaj.org/article/2119b3de6f684d84a4356f027f1983d8

Comprehensive mapping of adaptation of the avian influenza polymerase protein PB2 to humans

Authors: YQ Shirleen Soh, Louise H Moncla, Rachel Eguia, Trevor Bedford, Jesse D Bloom

Source: eLife, Vol 8 (2019)

Subject Terms: influenza, deep mutational scanning, host jump, PB2, cross-species transmission, pandemic, Medicine, Science, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://elifesciences.org/articles/45079; https://doaj.org/toc/2050-084X

Access URL: https://doaj.org/article/eeefa0aa9b104993becc20dc2cb8d6e5

Comprehensive profiling of translation initiation in influenza virus infected cells.

Authors: Heather M Machkovech, Jesse D Bloom, Arvind R Subramaniam

Source: PLoS Pathogens, Vol 15, Iss 1, p e1007518 (2019)

Subject Terms: Immunologic diseases. Allergy, RC581-607, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/1553-7366; https://doaj.org/toc/1553-7374

Access URL: https://doaj.org/article/bab93e2720b2400b93c3ab61b548756f

Destabilized adaptive influenza variants critical for innate immune system escape are potentiated by host chaperones.

Authors: Angela M Phillips, Anna I Ponomarenko, Kenny Chen, Orr Ashenberg, Jiayuan Miao, Sean M McHugh, Vincent L Butty, Charles A Whittaker, Christopher L Moore, Jesse D Bloom, Yu-Shan Lin, Matthew D Shoulders

Source: PLoS Biology, Vol 16, Iss 9, p e3000008 (2018)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/1544-9173; https://doaj.org/toc/1545-7885

Access URL: https://doaj.org/article/03c96514412046398bcb4ae5688e4934

Enhanced ER proteostasis and temperature differentially impact the mutational tolerance of influenza hemagglutinin

Authors: Angela M Phillips, Michael B Doud, Luna O Gonzalez, Vincent L Butty, Yu-Shan Lin, Jesse D Bloom, Matthew D Shoulders

Source: eLife, Vol 7 (2018)

Subject Terms: influenza, evolution, proteostasis, protein folding, unfolded protein response, membrane protein, Medicine, Science, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://elifesciences.org/articles/38795; https://doaj.org/toc/2050-084X

Access URL: https://doaj.org/article/bde65080ca6046dca52b4266f86786eb

Complete functional mapping of infection- and vaccine-elicited antibodies against the fusion peptide of HIV.

Authors: Adam S Dingens, Priyamvada Acharya, Hugh K Haddox, Reda Rawi, Kai Xu, Gwo-Yu Chuang, Hui Wei, Baoshan Zhang, John R Mascola, Bridget Carragher, Clinton S Potter, Julie Overbaugh, Peter D Kwong, Jesse D Bloom

Source: PLoS Pathogens, Vol 14, Iss 7, p e1007159 (2018)

Subject Terms: Immunologic diseases. Allergy, RC581-607, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1007159&type=printable; https://doaj.org/toc/1553-7366; https://doaj.org/toc/1553-7374

Access URL: https://doaj.org/article/7396244872b54dd7b3e97ee5bf534f38

Mapping mutational effects along the evolutionary landscape of HIV envelope

Authors: Hugh K Haddox, Adam S Dingens, Sarah K Hilton, Julie Overbaugh, Jesse D Bloom

Source: eLife, Vol 7 (2018)

Subject Terms: deep mutational scanning, BG505, epistasis, transmitted-founder virus, ExpCM, positive selection, Medicine, Science, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://elifesciences.org/articles/34420; https://doaj.org/toc/2050-084X

Access URL: https://doaj.org/article/2c00bb7d06de4f0f97a123e6ce718f88