Dependency on host vitamin B12 has shaped Mycobacterium tuberculosis Complex evolution

Authors: Elena Campos-Pardos, Santiago Uranga, Ana Picó, Ana Belén Gómez, Jesús Gonzalo-Asensio

Source: Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/4c7f286e3a644e99bce19ffacfec4b65

Transcriptomic profile of the most successful Mycobacterium tuberculosis strain in Aragon, the MtZ strain, during exponential and stationary growth phases

Authors: Jessica Comín, Elena Campos, Jesús Gonzalo-Asensio, Sofía Samper

Source: Microbiology Spectrum, Vol 11, Iss 6 (2023)

Subject Terms: transcriptome, mycobacteria, iron metabolism, Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/2165-0497

Access URL: https://doaj.org/article/a95cfc7543a04c24849f5b113575d564

A microfluidic-based analysis of 3D macrophage migration after stimulation by Mycobacterium, Salmonella and Escherichia

Authors: Sandra Pérez-Rodríguez, Carlos Borau, José Manuel García-Aznar, Jesús Gonzalo-Asensio

Source: BMC Microbiology, Vol 22, Iss 1, Pp 1-14 (2022)

Subject Terms: Microfluidics, Intracellular pathogens, Phagocytes, Chemotaxis, Mycobacterium, Salmonella, Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/1471-2180

Access URL: https://doaj.org/article/70ecc78508334f30be2443a05fffc59f

Targeted Chromosomal Barcoding Establishes Direct Genotype-Phenotype Associations for Antibiotic Resistance in Mycobacterium abscessus

Authors: Juan Calvet-Seral, Estefanía Crespo-Yuste, Vanessa Mathys, Hector Rodriguez-Villalobos, Pieter-Jan Ceyssens, Anandi Martin, Jesús Gonzalo-Asensio

Source: Microbiology Spectrum, Vol 11, Iss 3 (2023)

Subject Terms: bedaquiline, Bq, Bdq, drug resistance, nontuberculous mycobacteria, cystic fibrosis, Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/2165-0497

Access URL: https://doaj.org/article/6e7ca9fac41e431e8570e5a28c44a941

The Mycobacterium tuberculosis PhoPR virulence system regulates expression of the universal second messenger c-di-AMP and impacts vaccine safety and efficacy

Authors: Irene Pérez, Elena Campos-Pardos, Caridad Díaz, Santiago Uranga, Fadel Sayes, Francisca Vicente, Nacho Aguiló, Roland Brosch, Carlos Martín, Jesús Gonzalo-Asensio

Source: Molecular Therapy: Nucleic Acids, Vol 27, Iss , Pp 1235-1248 (2022)

Subject Terms: MT:therapies and applications, tuberculosis, live vaccines, cyclic dinucleotides, BCG, MTBVAC, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2162253122000397; https://doaj.org/toc/2162-2531

Access URL: https://doaj.org/article/816e8da91577439ba1f2ef6ffc3163c6

Microfluidic devices for studying bacterial taxis, drug testing and biofilm formation

Authors: Sandra Pérez‐Rodríguez, José Manuel García‐Aznar, Jesús Gonzalo‐Asensio

Source: Microbial Biotechnology, Vol 15, Iss 2, Pp 395-414 (2022)

Subject Terms: Biotechnology, TP248.13-248.65

File Description: electronic resource

Relation: https://doaj.org/toc/1751-7915

Access URL: https://doaj.org/article/abad6b1e79de48fbac9ac0d0dfd226cf

Engineering a new vaccine platform for heterologous antigen delivery in live-attenuated Mycobacterium tuberculosis

Authors: Esther Broset, Juan Calvet Seral, Carmen Arnal, Santiago Uranga, Alex I. Kanno, Luciana C.C. Leite, Carlos Martín, Jesús Gonzalo-Asensio

Source: Computational and Structural Biotechnology Journal, Vol 19, Iss , Pp 4273-4283 (2021)

Subject Terms: Synthetic biology, Fastidious bacteria, Tuberculosis vaccine, DTP antigens, Twin arginine translocation (TAT), BCG, Biotechnology, TP248.13-248.65

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2001037021003251; https://doaj.org/toc/2001-0370

Access URL: https://doaj.org/article/a0aa4c6c152b42498f9386a4963c14ed

The MtZ Strain: Molecular Characteristics and Outbreak Investigation of the Most Successful Mycobacterium tuberculosis Strain in Aragon Using Whole-Genome Sequencing

Authors: Jessica Comín, Jan Madacki, Isabel Rabanaque, María Zúñiga-Antón, Daniel Ibarz, Alberto Cebollada, Jesús Viñuelas, Luis Torres, Juan Sahagún, Christophe Klopp, Jesús Gonzalo-Asensio, Roland Brosch, María-José Iglesias, Sofía Samper

Source: Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)

Subject Terms: tuberculosis outbreak, molecular epidemiology, tuberculosis, WGS, tuberculosis virulence, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcimb.2022.887134/full; https://doaj.org/toc/2235-2988

Access URL: https://doaj.org/article/35918df456cf4a1292565844155c5e2e

MTBVAC-Based TB-HIV Vaccine Is Safe, Elicits HIV-T Cell Responses, and Protects against Mycobacterium tuberculosis in Mice

Authors: Esther Broset, Narcís Saubi, Núria Guitart, Nacho Aguilo, Santiago Uranga, Athina Kilpeläinen, Yoshiki Eto, Tomáš Hanke, Jesús Gonzalo-Asensio, Carlos Martín, Joan Joseph-Munné

Source: Molecular Therapy: Methods & Clinical Development, Vol 13, Iss , Pp 253-264 (2019)

Subject Terms: Genetics, QH426-470, Cytology, QH573-671

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2329050119300178; https://doaj.org/toc/2329-0501

Access URL: https://doaj.org/article/4a25bf7bef1a4aa7909cc3e9194b2412

Independent genomic polymorphisms in the PknH serine threonine kinase locus during evolution of the Mycobacterium tuberculosis Complex affect virulence and host preference.

Authors: Elena Mata, Damien Farrell, Ruoyao Ma, Santiago Uranga, Ana Belen Gomez, Marta Monzon, Juan Badiola, Alberto Anel, Jesús Gonzalo-Asensio, Carlos Martin, Stephen V Gordon, Nacho Aguilo

Source: PLoS Pathogens, Vol 16, Iss 12, p e1009061 (2020)

Subject Terms: Immunologic diseases. Allergy, RC581-607, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/1553-7366; https://doaj.org/toc/1553-7374

Access URL: https://doaj.org/article/534f6085cb604acda0e806cc85f98f78

Live attenuated TB vaccines representing the three modern Mycobacterium tuberculosis lineages reveal that the Euro–American genetic background confers optimal vaccine potential

Authors: Irene Pérez, Santiago Uranga, Fadel Sayes, Wafa Frigui, Sofía Samper, Ainhoa Arbués, Nacho Aguiló, Roland Brosch, Carlos Martín, Jesús Gonzalo-Asensio

Source: EBioMedicine, Vol 55, Iss , Pp - (2020)

Subject Terms: Tuberculosis, Virulence, Live vaccines, Epidemiology, Pathogen evolution, PDIM, Medicine, Medicine (General), R5-920

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352396420301365; https://doaj.org/toc/2352-3964

Access URL: https://doaj.org/article/ad2a78e067c8439d9387b50429cbef1c

Editorial: Update on the Immune Mechanisms Against Respiratory Pathogens

Authors: Junkal Garmendia, Jesús Gonzalo-Asensio

Source: Frontiers in Immunology, Vol 10 (2019)

Subject Terms: bacterial respiratory pathogens, viral airway pathogens, respiratory fungi, vaccines, antimicrobials, host immunity, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fimmu.2019.01730/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/94fa7418f58844f5b618f5e4d9febd08

New insights into the transposition mechanisms of IS6110 and its dynamic distribution between Mycobacterium tuberculosis Complex lineages.

Authors: Jesús Gonzalo-Asensio, Irene Pérez, Nacho Aguiló, Santiago Uranga, Ana Picó, Carlos Lampreave, Alberto Cebollada, Isabel Otal, Sofía Samper, Carlos Martín

Source: PLoS Genetics, Vol 14, Iss 4, p e1007282 (2018)

Subject Terms: Genetics, QH426-470

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC5896891?pdf=render; https://doaj.org/toc/1553-7390; https://doaj.org/toc/1553-7404

Access URL: https://doaj.org/article/63a268e40f9d484f87ba48f6d074ff46

Evolutionary Landscape of the Mycobacterium tuberculosis Complex from the Viewpoint of PhoPR: Implications for Virulence Regulation and Application to Vaccine Development

Authors: Esther Broset, Carlos Martín, Jesús Gonzalo-Asensio

Source: mBio, Vol 6, Iss 5 (2015)

Subject Terms: Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/2150-7511

Access URL: https://doaj.org/article/dc68ad2f42ef426fa0c0e7ef283f2033

The PhoP-dependent ncRNA Mcr7 modulates the TAT secretion system in Mycobacterium tuberculosis.

Authors: Luis Solans, Jesús Gonzalo-Asensio, Claudia Sala, Andrej Benjak, Swapna Uplekar, Jacques Rougemont, Christophe Guilhot, Wladimir Malaga, Carlos Martín, Stewart T Cole

Source: PLoS Pathogens, Vol 10, Iss 5, p e1004183 (2014)

Subject Terms: Immunologic diseases. Allergy, RC581-607, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24874799/pdf/?tool=EBI; https://doaj.org/toc/1553-7366; https://doaj.org/toc/1553-7374

Access URL: https://doaj.org/article/ac0b6184c8934c1cb51230f9313de08e

A novel antisense RNA from the Salmonella virulence plasmid pSLT expressed by non-growing bacteria inside eukaryotic cells.

Authors: Jesús Gonzalo-Asensio, Alvaro D Ortega, Gadea Rico-Pérez, M Graciela Pucciarelli, Francisco García-Del Portillo

Source: PLoS ONE, Vol 8, Iss 10, p e77939 (2013)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3815029?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/63f58071d444437a9f87513beb1663c1

PhoP: a missing piece in the intricate puzzle of Mycobacterium tuberculosis virulence.

Authors: Jesús Gonzalo-Asensio, Serge Mostowy, Jose Harders-Westerveen, Kris Huygen, Rogelio Hernández-Pando, Jelle Thole, Marcel Behr, Brigitte Gicquel, Carlos Martín

Source: PLoS ONE, Vol 3, Iss 10, p e3496 (2008)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC2566814?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/acf078ffa7584179b0b1223916c2ab17

BCG vaccination improves DTaP immune responses in mice and is associated with lower pertussis incidence in ecological epidemiological studies

Authors: Esther Broset, Jacobo Pardo-Seco, Alex I. Kanno, Nacho Aguilo, Ana Isabel Dacosta, Irene Rivero-Calle, Jesus Gonzalo-Asensio, Camille Locht, Luciana C.C. Leite, Carlos Martin, Federico Martinón-Torres

Source: EBioMedicine, Vol 65, Iss , Pp 103254- (2021)

Subject Terms: Live-tuberculosis vaccines, Heterologous immunity, Non-specific effects, DTP, BCG, MTBVAC, Medicine, Medicine (General), R5-920

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352396421000475; https://doaj.org/toc/2352-3964

Access URL: https://doaj.org/article/cae65a52f6424aab9984632c9bf74420

Reactogenicity to major tuberculosis antigens absent in BCG is linked to improved protection against Mycobacterium tuberculosis

Authors: Nacho Aguilo, Jesus Gonzalo-Asensio, Samuel Alvarez-Arguedas, Dessislava Marinova, Ana Belen Gomez, Santiago Uranga, Ralf Spallek, Mahavir Singh, Regine Audran, François Spertini, Carlos Martin

Source: Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/35ef7cab9f89487f836fea009d468458

MTBVAC from discovery to clinical trials in tuberculosis-endemic countries

Authors: Dessislava Marinova, Jesus Gonzalo-Asensio, Nacho Aguilo, Carlos Martin

Source: Expert Review of Vaccines, Vol 16, Iss 6, Pp 565-576 (2017)

Subject Terms: animal models, bcg, live vaccine, clinical development, efficacy, Internal medicine, RC31-1245

File Description: electronic resource

Relation: https://doaj.org/toc/1476-0584; https://doaj.org/toc/1744-8395

Access URL: https://doaj.org/article/36484b78d2c44d88ba7e04db670e9ac1