Tryptophan fuels MYC-dependent liver tumorigenesis through indole 3-pyruvate synthesis

Authors: Niranjan Venkateswaran, Roy Garcia, M. Carmen Lafita-Navarro, Yi-Heng Hao, Lizbeth Perez-Castro, Pedro A. S. Nogueira, Ashley Solmonson, Ilgen Mender, Jessica A. Kilgore, Shun Fang, Isabella N. Brown, Li Li, Emily Parks, Igor Lopes dos Santos, Mahima Bhaskar, Jiwoong Kim, Yuemeng Jia, Andrew Lemoff, Nick V. Grishin, Lisa Kinch, Lin Xu, Noelle S. Williams, Jerry W. Shay, Ralph J. DeBerardinis, Hao Zhu, Maralice Conacci-Sorrell

Source: Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

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A Phosphatidyl Conjugated Telomerase-Dependent Telomere-Targeting Nucleoside Demonstrates Colorectal Cancer Direct Killing and Immune Signaling

Authors: Merve Yilmaz, Sibel Goksen, Ilgen Mender, Gunes Esendagli, Sefik Evren Erdener, Alessandra Ahmed, Ates Kutay Tenekeci, Larisa L. Birichevskaya, Sergei M. Gryaznov, Jerry W. Shay, Z. Gunnur Dikmen

Source: Biomolecules, Vol 14, Iss 12, p 1616 (2024)

Subject Terms: cancer, telomerase, telomere-targeted therapy, 6-thio-dG, phosphatidyl lipid conjugated 6-thio-dG, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.mdpi.com/2218-273X/14/12/1616; https://doaj.org/toc/2218-273X

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A telomere-targeting drug depletes cancer initiating cells and promotes anti-tumor immunity in small cell lung cancer

Authors: Buse Eglenen-Polat, Ryan R. Kowash, Hai-Cheng Huang, Silvia Siteni, Mingrui Zhu, Kenian Chen, Matthew E. Bender, Ilgen Mender, Victor Stastny, Benjamin J. Drapkin, Prithvi Raj, John D. Minna, Lin Xu, Jerry W. Shay, Esra A. Akbay

Source: Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/d143811484044c1b88f499b5d0432d04

Alternative lengthening of telomeres (ALT) cells viability is dependent on C-rich telomeric RNAs

Authors: Ilaria Rosso, Corey Jones-Weinert, Francesca Rossiello, Matteo Cabrini, Silvia Brambillasca, Leonel Munoz-Sagredo, Zeno Lavagnino, Emanuele Martini, Enzo Tedone, Massimiliano Garre’, Julio Aguado, Dario Parazzoli, Marina Mione, Jerry W. Shay, Ciro Mercurio, Fabrizio d’Adda di Fagagna

Source: Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/96aecb24e77f4ab3b16b729a382e090c

Influenza virus mRNAs encode determinants for nuclear export via the cellular TREX-2 complex

Authors: Prasanna Bhat, Vasilisa Aksenova, Matthew Gazzara, Emily A. Rex, Sadaf Aslam, Christina Haddad, Shengyan Gao, Matthew Esparza, Tolga Cagatay, Kimberly Batten, Sara S. El Zahed, Alexei Arnaoutov, Hualin Zhong, Jerry W. Shay, Blanton S. Tolbert, Mary Dasso, Kristen W. Lynch, Adolfo García-Sastre, Beatriz M. A. Fontoura

Source: Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/ef526c85c77e4e78867cbdc75323343a

Structural basis for high-order complex of SARNP and DDX39B to facilitate mRNP assembly

Authors: Yihu Xie, Shengyan Gao, Ke Zhang, Prasanna Bhat, Bradley P. Clarke, Kimberly Batten, Menghan Mei, Matthew Gazzara, Jerry W. Shay, Kristen W. Lynch, Alexia E. Angelos, Pate S. Hill, Austin L. Ivey, Beatriz M.A. Fontoura, Yi Ren

Source: Cell Reports, Vol 42, Iss 8, Pp 112988- (2023)

Subject Terms: CP: Molecular biology, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124723009993; https://doaj.org/toc/2211-1247

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The cholesterol uptake regulator PCSK9 promotes and is a therapeutic target in APC/KRAS-mutant colorectal cancer

Authors: Chi Chun Wong, Jian-Lin Wu, Fenfen Ji, Wei Kang, Xiqing Bian, Huarong Chen, Lam-Shing Chan, Simson Tsz Yat Luk, Samuel Tong, Jiaying Xu, Qiming Zhou, Dabin Liu, Hao Su, Hongyan Gou, Alvin Ho-Kwan Cheung, Ka Fai To, Zongwei Cai, Jerry W. Shay, Jun Yu

Source: Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/b983ec1445e54ade901f9b1e5f30d6ee

Genetic and clinical determinants of telomere length

Authors: Patrick Allaire, Jing He, John Mayer, Luke Moat, Peter Gerstenberger, Reynor Wilhorn, Sierra Strutz, David S.L. Kim, Chenjie Zeng, Nancy Cox, Jerry W. Shay, Joshua Denny, Lisa Bastarache, Scott Hebbring

Source: HGG Advances, Vol 4, Iss 3, Pp 100201- (2023)

Subject Terms: telomere, GWAS, PheWAS, aging, Genetics, QH426-470

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2666247723000337; https://doaj.org/toc/2666-2477

Access URL: https://doaj.org/article/6d78ffb73da14b06ada708fe5fdd4135

Telomeres and replicative cellular aging of the human placenta and chorioamniotic membranes

Authors: Tsung-Po Lai, Mark Simpson, Krunal Patel, Simon Verhulst, Jungsik Noh, Natalie Roche, Debra Heller, George Guirguis, Jerry W. Shay, Utz Herbig, Abraham Aviv

Source: Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/13552a04d1b744908ff53b255f946d51

NOVA1 regulates hTERT splicing and cell growth in non-small cell lung cancer

Authors: Andrew T. Ludlow, Mandy Sze Wong, Jerome D. Robin, Kimberly Batten, Laura Yuan, Tsung-Po Lai, Nicole Dahlson, Lu Zhang, Ilgen Mender, Enzo Tedone, Mohammed E. Sayed, Woodring E. Wright, Jerry W. Shay

Source: Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/2cd190c0898f4b9ebf7b01ae510309b7

Telomerase-Mediated Strategy for Overcoming Non–Small Cell Lung Cancer Targeted Therapy and Chemotherapy Resistance

Authors: Ilgen Mender, Ryan LaRanger, Krishna Luitel, Michael Peyton, Luc Girard, Tsung-Po Lai, Kimberly Batten, Crystal Cornelius, Maithili P. Dalvi, Michael Ramirez, Wenting Du, Lani F. Wu, Steven J. Altschuler, Rolf Brekken, Elisabeth D. Martinez, John D. Minna, Woodring E. Wright, Jerry W. Shay

Source: Neoplasia: An International Journal for Oncology Research, Vol 20, Iss 8, Pp 826-837 (2018)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1476558618302525; https://doaj.org/toc/1476-5586

Access URL: https://doaj.org/article/4cb2a9b75e64451da5d6b5d27e43a411

A method for measuring the distribution of the shortest telomeres in cells and tissues

Authors: Tsung-Po Lai, Ning Zhang, Jungsik Noh, Ilgen Mender, Enzo Tedone, Ejun Huang, Woodring E. Wright, Gaudenz Danuser, Jerry W. Shay

Source: Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/5c7e184272eb490ebbc0a34207c6f69d

The Maintenance of Telomere Length in CD28+ T Cells During T Lymphocyte Stimulation

Authors: Ejun (Elijah) Huang, Enzo Tedone, Ryan O’Hara, Crystal Cornelius, Tsung-Po Lai, Andrew Ludlow, Woodring E. Wright, Jerry W. Shay

Source: Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/c2dc49f6b23047739c01bec8a08dc03e

Resveratrol reverses the Warburg effect by targeting the pyruvate dehydrogenase complex in colon cancer cells

Authors: Elise Saunier, Samantha Antonio, Anne Regazzetti, Nicolas Auzeil, Olivier Laprévote, Jerry W. Shay, Xavier Coumoul, Robert Barouki, Chantal Benelli, Laurence Huc, Sylvie Bortoli

Source: Scientific Reports, Vol 7, Iss 1, Pp 1-16 (2017)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/3a75a7d127634bdc9062881bbbb61ac9

TRA-1-60-positive/CD45low cells found in the peripheral blood of prostate cancer patients with metastatic disease – A proof-of-concept study

Authors: Claudia Schäfer, Yawen Ju, Youngbin Tak, Cesar Vazquez, Sangyoon J. Han, Edwin Tan, Jerry W. Shay, Mats Holmqvist, Gaudenz Danuser, William M. Schopperle, Glenn Bubley

Source: Heliyon, Vol 6, Iss 1, Pp e03263- (2020)

Subject Terms: Oncology, Cancer research, Cancer, Diagnostics, TRA-1-60, Metastasis, Science (General), Q1-390, Social sciences (General), H1-99

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2405844020301080; https://doaj.org/toc/2405-8440

Access URL: https://doaj.org/article/520573ffb5aa479f9218d8f1e9d2ed89

Impaired telomere maintenance in Alazami syndrome patients with LARP7 deficiency

Authors: Brody Holohan, Wanil Kim, Tsung-Po Lai, Hirotoshi Hoshiyama, Ning Zhang, Anas M. Alazami, Woodring E. Wright, M. Stephen Meyn, Fowzan S. Alkuraya, Jerry W. Shay

Source: BMC Genomics, Vol 17, Iss S9, Pp 79-87 (2016)

Subject Terms: Biotechnology, TP248.13-248.65, Genetics, QH426-470

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s12864-016-3093-4; https://doaj.org/toc/1471-2164

Access URL: https://doaj.org/article/bf3705eae1334bc4bfd78824e385c77d

The Third International Genomic Medicine Conference (3rd IGMC, 2015): overall activities and outcome highlights

Authors: Muhammad Abu-Elmagd, Mourad Assidi, Ashraf Dallol, Abdelbaset Buhmeida, Peter Natesan Pushparaj, Gauthaman Kalamegam, Emad Al-Hamzi, Jerry W. Shay, Stephen W. Scherer, Ashok Agarwal, Bruce Budowle, Mamdooh Gari, Adeel Chaudhary, Adel Abuzenadah, Mohammed Al-Qahtani

Source: BMC Genomics, Vol 17, Iss S9, Pp 1-9 (2016)

Subject Terms: Biotechnology, TP248.13-248.65, Genetics, QH426-470

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s12864-016-3085-4; https://doaj.org/toc/1471-2164

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Fatty Acid Oxidation Mediated by Acyl-CoA Synthetase Long Chain 3 Is Required for Mutant KRAS Lung Tumorigenesis

Authors: Mahesh S. Padanad, Georgia Konstantinidou, Niranjan Venkateswaran, Margherita Melegari, Smita Rindhe, Matthew Mitsche, Chendong Yang, Kimberly Batten, Kenneth E. Huffman, Jingwen Liu, Ximing Tang, Jaime Rodriguez-Canales, Neda Kalhor, Jerry W. Shay, John D. Minna, Jeffrey McDonald, Ignacio I. Wistuba, Ralph J. DeBerardinis, Pier Paolo Scaglioni

Source: Cell Reports, Vol 16, Iss 6, Pp 1614-1628 (2016)

Subject Terms: ACSL3, mutant KRAS, lung cancer, cancer metabolism, fatty acid oxidation, lipid metabolism, mouse cancer models, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124716308956; https://doaj.org/toc/2211-1247

Access URL: https://doaj.org/article/accd4720f8274f44bb862c81497526a0

Generation of digoxigenin-incorporated probes to enhance DNA detection sensitivity

Authors: Tsung-Po Lai, Woodring E. Wright, Jerry W. Shay

Source: BioTechniques, Vol 60, Iss 6, Pp 306-309 (2016)

Subject Terms: oligonucleotide, telomere, bridged nucleic acid (BNA), terminal restriction fragments (TRF), Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/0736-6205; https://doaj.org/toc/1940-9818

Access URL: https://doaj.org/article/b62980e959f84437828f2beb53eb67e6

Regulation of Telomerase Alternative Splicing: A Target for Chemotherapy

Authors: Mandy S. Wong, Ling Chen, Christopher Foster, Radhika Kainthla, Jerry W. Shay, Woodring E. Wright

Source: Cell Reports, Vol 3, Iss 4, Pp 1028-1035 (2013)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124713001186; https://doaj.org/toc/2211-1247

Access URL: https://doaj.org/article/a9669b4c41d2439994ef4b4c27ec90ef