Dual roles of p62/SQSTM1 in the injury and recovery phases of acetaminophen-induced liver injury in mice

Authors: Hui Qian, Qingyun Bai, Xiao Yang, Jephte Y. Akakpo, Lili Ji, Li Yang, Thomas Rülicke, Kurt Zatloukal, Hartmut Jaeschke, Hong-Min Ni, Wen-Xing Ding

Source: Acta Pharmaceutica Sinica B, Vol 11, Iss 12, Pp 3791-3805 (2021)

Subject Terms: Autophagy, Coagulation, DILI, Liver regeneration, Macrophage, Hepatotoxicity, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211383521004421; https://doaj.org/toc/2211-3835

Access URL: https://doaj.org/article/11c1a25a9fed4671869e8d06a1fde45d

Recommendations for the use of the acetaminophen hepatotoxicity model for mechanistic studies and how to avoid common pitfalls

Authors: Hartmut Jaeschke, Olamide B. Adelusi, Jephte Y. Akakpo, Nga T. Nguyen, Giselle Sanchez-Guerrero, David S. Umbaugh, Wen-Xing Ding, Anup Ramachandran

Source: Acta Pharmaceutica Sinica B, Vol 11, Iss 12, Pp 3740-3755 (2021)

Subject Terms: Acetaminophen hepatotoxicity, Drug metabolism, Mitochondria, Apoptosis, Ferroptosis, Autophagy, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211383521003828; https://doaj.org/toc/2211-3835

Access URL: https://doaj.org/article/bd69267488f147738d37afb49958d353

Fructose Protects Against Acetaminophen‐Induced Hepatotoxicity Mainly by Activating the Carbohydrate‐Response Element‐Binding Protein α–Fibroblast Growth Factor 21 Axis in Mice

Authors: Deqiang Zhang, Sujuan Wang, Erin Ospina, Omar Shabandri, Daniel Lank, Jephte Y. Akakpo, Zifeng Zhao, Meichan Yang, Jun Wu, Hartmut Jaeschke, Pradip Saha, Xin Tong, Lei Yin

Source: Hepatology Communications, Vol 5, Iss 6, Pp 992-1008 (2021)

Subject Terms: Diseases of the digestive system. Gastroenterology, RC799-869

File Description: electronic resource

Relation: https://doaj.org/toc/2471-254X

Access URL: https://doaj.org/article/d973ec40c44041ec95c9274d31c85615

Liver-specific deletion of mechanistic target of rapamycin does not protect against acetaminophen-induced liver injury in mice

Authors: Hua Sun, Hong-Min Ni, Jennifer M. McCracken, Jephte Y Akakpo, Sam Fulte, Tara McKeen, Hartmut Jaeschke, Hua Wang, Wen-Xing Ding

Source: Liver Research, Vol 5, Iss 2, Pp 79-87 (2021)

Subject Terms: Acetaminophen (APAP), Autophagy, Hepatotoxicity, Liver injury, Liver regeneration, Mechanistic target of rapamycin (mTOR), Diseases of the digestive system. Gastroenterology, RC799-869

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2542568421000180; https://doaj.org/toc/2542-5684

Access URL: https://doaj.org/article/d508065859c34b95a7f32d4f600b16df