Targeting hypoxia-inducible factor-1 alpha suppresses Helicobacter pylori-induced gastric injury via attenuation of both cag-mediated microbial virulence and proinflammatory host responses

Authors: Jennifer M. Noto, M. Blanca Piazuelo, Judith Romero-Gallo, Alberto G. Delgado, Giovanni Suarez, Konstantina Akritidou, Miguel Girod Hoffman, Juan Carlos Roa, Cormac T. Taylor, Richard M. Peek

Source: Gut Microbes, Vol 15, Iss 2 (2023)

Subject Terms: Helicobacter pylori, gastric inflammation, gastric cancer, hypoxia-inducible factor-1 alpha (HIF-1α), dimethyloxalylglycine (DMOG), prolyl hydroxylase (PHD), Diseases of the digestive system. Gastroenterology, RC799-869

File Description: electronic resource

Relation: https://doaj.org/toc/1949-0976; https://doaj.org/toc/1949-0984

Access URL: https://doaj.org/article/5ca1554c76e54c8382886b3806ff21b3

Helicobacter pylori actively suppresses innate immune nucleic acid receptors

Authors: Samuel D.R. Dooyema, Jennifer M. Noto, Lydia E. Wroblewski, M. Blanca Piazuelo, Uma Krishna, Giovanni Suarez, Judith Romero-Gallo, Alberto G. Delgado, Richard M. Peek

Source: Gut Microbes, Vol 14, Iss 1 (2022)

Subject Terms: Helicobacter pylori, gastric cancer, TLR9, STING, RIG-I, TRIM30, Diseases of the digestive system. Gastroenterology, RC799-869

File Description: electronic resource

Relation: https://doaj.org/toc/1949-0976; https://doaj.org/toc/1949-0984

Access URL: https://doaj.org/article/f93259ca2dbb4a9897baa17e0061a47a

Iron deficiency linked to altered bile acid metabolism promotes Helicobacter pylori–induced inflammation–driven gastric carcinogenesis

Authors: Jennifer M. Noto, M. Blanca Piazuelo, Shailja C. Shah, Judith Romero-Gallo, Jessica L. Hart, Chao Di, James D. Carmichael, Alberto G. Delgado, Alese E. Halvorson, Robert A. Greevy, Lydia E. Wroblewski, Ayushi Sharma, Annabelle B. Newton, Margaret M. Allaman, Keith T. Wilson, M. Kay Washington, M. Wade Calcutt, Kevin L. Schey, Bethany P. Cummings, Charles R. Flynn, Joseph P. Zackular, Richard M. Peek Jr.

Source: The Journal of Clinical Investigation, Vol 132, Iss 10 (2022)

Subject Terms: Gastroenterology, Infectious disease, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/1558-8238

Access URL: https://doaj.org/article/7d198f5f9fa7400583ab84388b9c0680

RNF43: A Biomarker With Potential Ramifications for Therapeutic Intervention in Gastric Cancer

Authors: Jennifer M. Noto, PhD, Richard M. Peek, Jr, MD

Source: Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 4, Pp 1202-1203 (2021)

Subject Terms: Diseases of the digestive system. Gastroenterology, RC799-869

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352345X20301983; https://doaj.org/toc/2352-345X

Access URL: https://doaj.org/article/d971009f9b8d4d0bae0a2b211414f462

Modification of the Gastric Mucosal Microbiota by a Strain-Specific Helicobacter pylori Oncoprotein and Carcinogenic Histologic Phenotype

Authors: Jennifer M. Noto, Joseph P. Zackular, Matthew G. Varga, Alberto Delgado, Judith Romero-Gallo, Matthew B. Scholz, M. Blanca Piazuelo, Eric P. Skaar, Richard M. Peek

Source: mBio, Vol 10, Iss 3 (2019)

Subject Terms: CagA, Helicobacter pylori, gastric cancer, gastric microbiota, iron deficiency, Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/2150-7511

Access URL: https://doaj.org/article/4e1d7e064e0343d7a2ef53ea353bd1c7

Helicobacter pylori genetic diversification in the Mongolian gerbil model

Authors: Amber C. Beckett, John T. Loh, Abha Chopra, Shay Leary, Aung Soe Lin, Wyatt J. McDonnell, Beverly R.E.A. Dixon, Jennifer M. Noto, Dawn A. Israel, Richard M. Peek Jr, Simon Mallal, Holly M. Scott Algood, Timothy L. Cover

Source: PeerJ, Vol 6, p e4803 (2018)

Subject Terms: Helicobacter pylori, Quasispecies, Mutation, Genetic diversity, Evolution, Animal models, Medicine, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://peerj.com/articles/4803.pdf; https://peerj.com/articles/4803/; https://doaj.org/toc/2167-8359

Access URL: https://doaj.org/article/7e2557821c3244d6b83bd4644d72624f

Research Scientists

Authors: Jennifer M. Noto, PhD

Source: Cellular and Molecular Gastroenterology and Hepatology, Vol 2, Iss 4, Pp 409-411 (2016)

Subject Terms: Diseases of the digestive system. Gastroenterology, RC799-869

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352345X16300340; https://doaj.org/toc/2352-345X

Access URL: https://doaj.org/article/402c2edd76a24b5c92bd26c1b453bd29

The role of microRNAs in Helicobacter pylori pathogenesis and gastric carcinogenesis

Authors: Jennifer M. Noto, Richard M. Peek

Source: Frontiers in Cellular and Infection Microbiology, Vol 1 (2012)

Subject Terms: Apoptosis, Cell Cycle, Helicobacter pylori, microRNA, proliferation, gastric cancer, Microbiology, QR1-502

File Description: electronic resource

Relation: http://journal.frontiersin.org/Journal/10.3389/fcimb.2011.00021/full; https://doaj.org/toc/2235-2988

Access URL: https://doaj.org/article/8c5a0880ad1841e09257016e35a88a99

Sound the Alarmin: Interleukin-33 Commandeers the Gastric Immune Response

Authors: Jennifer M. Noto, PhD, Richard M. Peek, Jr., MD

Source: Cellular and Molecular Gastroenterology and Hepatology, Vol 1, Iss 2, Pp 127-128 (2015)

Subject Terms: Diseases of the digestive system. Gastroenterology, RC799-869

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352345X15000429; https://doaj.org/toc/2352-345X

Access URL: https://doaj.org/article/7b17a733e29f41cb8d98865728b02907

The gastric microbiome, its interaction with Helicobacter pylori, and its potential role in the progression to stomach cancer.

Authors: Jennifer M Noto, Richard M Peek

Source: PLoS Pathogens, Vol 13, Iss 10, p e1006573 (2017)

Subject Terms: Immunologic diseases. Allergy, RC581-607, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC5629027?pdf=render; https://doaj.org/toc/1553-7366; https://doaj.org/toc/1553-7374

Access URL: https://doaj.org/article/67e56336961d48a09023488affcc1841

Microbial Regulation of p53 Tumor Suppressor.

Authors: Alexander I Zaika, Jinxiong Wei, Jennifer M Noto, Richard M Peek

Source: PLoS Pathogens, Vol 11, Iss 9, p e1005099 (2015)

Subject Terms: Immunologic diseases. Allergy, RC581-607, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC4574736?pdf=render; https://doaj.org/toc/1553-7366; https://doaj.org/toc/1553-7374

Access URL: https://doaj.org/article/1a6a71f61f99485e8aa6e5f0d93fc838

Helicobacter pylori promotes the expression of Krüppel-like factor 5, a mediator of carcinogenesis, in vitro and in vivo.

Authors: Jennifer M Noto, Tinatin Khizanishvili, Rupesh Chaturvedi, M Blanca Piazuelo, Judith Romero-Gallo, Alberto G Delgado, Shradha S Khurana, Johanna C Sierra, Uma S Krishna, Giovanni Suarez, Anne E Powell, James R Goldenring, Robert J Coffey, Vincent W Yang, Pelayo Correa, Jason C Mills, Keith T Wilson, Richard M Peek

Source: PLoS ONE, Vol 8, Iss 1, p e54344 (2013)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3553174?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/1cc0b00deeb940f8b0d725b0b82385e7

Helicobacter pylori perturbs iron trafficking in the epithelium to grow on the cell surface.

Authors: Shumin Tan, Jennifer M Noto, Judith Romero-Gallo, Richard M Peek, Manuel R Amieva

Source: PLoS Pathogens, Vol 7, Iss 5, p e1002050 (2011)

Subject Terms: Immunologic diseases. Allergy, RC581-607, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3093365?pdf=render; https://doaj.org/toc/1553-7366; https://doaj.org/toc/1553-7374

Access URL: https://doaj.org/article/9740d0bf8abe4fc5934f9dcf268add59