Global Biobank analyses provide lessons for developing polygenic risk scores across diverse cohorts

Authors: Ying Wang, Shinichi Namba, Esteban Lopera, Sini Kerminen, Kristin Tsuo, Kristi Läll, Masahiro Kanai, Wei Zhou, Kuan-Han Wu, Marie-Julie Favé, Laxmi Bhatta, Philip Awadalla, Ben Brumpton, Patrick Deelen, Kristian Hveem, Valeria Lo Faro, Reedik Mägi, Yoshinori Murakami, Serena Sanna, Jordan W. Smoller, Jasmina Uzunovic, Brooke N. Wolford, Cristen Willer, Eric R. Gamazon, Nancy J. Cox, Ida Surakka, Yukinori Okada, Alicia R. Martin, Jibril Hirbo, Kuan-Han H. Wu, Humaira Rasheed, Jibril B. Hirbo, Arjun Bhattacharya, Huiling Zhao, Esteban A. Lopera-Maya, Sinéad B. Chapman, Juha Karjalainen, Mitja Kurki, Maasha Mutaamba, Juulia J. Partanen, Ben M. Brumpton, Sameer Chavan, Tzu-Ting Chen, Michelle Daya, Yi Ding, Yen-Chen A. Feng, Christopher R. Gignoux, Sarah E. Graham, Whitney E. Hornsby, Nathan Ingold, Ruth Johnson, Triin Laisk, Kuang Lin, Jun Lv, Iona Y. Millwood, Priit Palta, Anita Pandit, Michael H. Preuss, Unnur Thorsteinsdottir, Matthew Zawistowski, Xue Zhong, Archie Campbell, Kristy Crooks, Geertruida H. de Bock, Nicholas J. Douville, Sarah Finer, Lars G. Fritsche, Christopher J. Griffiths, Yu Guo, Karen A. Hunt, Takahiro Konuma, Riccardo E. Marioni, Jansonius Nomdo, Snehal Patil, Nicholas Rafaels, Anne Richmond, Jonathan A. Shortt, Peter Straub, Ran Tao, Brett Vanderwerff, Kathleen C. Barnes, Marike Boezen, Zhengming Chen, Chia-Yen Chen, Judy Cho, George Davey Smith, Hilary K. Finucane, Lude Franke, Andrea Ganna, Tom R. Gaunt, Tian Ge, Hailiang Huang, Jennifer Huffman, Jukka T. Koskela, Clara Lajonchere, Matthew H. Law, Liming Li, Cecilia M. Lindgren, Ruth J.F. Loos, Stuart MacGregor, Koichi Matsuda, Catherine M. Olsen, David J. Porteous, Jordan A. Shavit, Harold Snieder, Richard C. Trembath, Judith M. Vonk, David Whiteman, Stephen J. Wicks, Cisca Wijmenga, John Wright, Jie Zheng, Xiang Zhou, Michael Boehnke, Daniel H. Geschwind, Caroline Hayward, Eimear E. Kenny, Yen-Feng Lin, Hilary C. Martin, Sarah E. Medland, Aarno V. Palotie, Bogdan Pasaniuc, Kari Stefansson, David A. van Heel, Robin G. Walters, Sebastian Zöllner, Cristen J. Willer, Mark J. Daly, Benjamin M. Neale

Source: Cell Genomics, Vol 3, Iss 1, Pp 100241- (2023)

Subject Terms: Global-Biobank Meta-analysis Initiative, polygenic risk scores, multi-ancestry genetic prediction, accuracy heterogeneity, Genetics, QH426-470, Internal medicine, RC31-1245

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2666979X2200204X; https://doaj.org/toc/2666-979X

Access URL: https://doaj.org/article/ab70f310dfdd4e7dbc3dc7fc2ba9b939

Transancestry Genome-wide Association Study of Varicose Veins in More Than 1 Million Individuals Reveals Circulating Effectors of Venous Disease

Authors: Michael G. Levin, Jennifer Huffman, Anurag Verma, Alexis Rodriguez, Alexander Bick, Ravi Madduri, Scott Damrauer

Source: JVS - Vascular Science, Vol 2, Iss , Pp 276- (2021)

Subject Terms: Diseases of the circulatory (Cardiovascular) system, RC666-701

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2666350321000274; https://doaj.org/toc/2666-3503

Access URL: https://doaj.org/article/bec3c6ccb4c246d0901938437acf42ef

Correction: Pedigree- and SNP-Associated Genetics and Recent Environment are the Major Contributors to Anthropometric and Cardiometabolic Trait Variation.

Authors: Charley Xia, Carmen Amador, Jennifer Huffman, Holly Trochet, Archie Campbell, David Porteous, Generation Scotland, Nicholas D Hastie, Caroline Hayward, Veronique Vitart, Pau Navarro, Chris S Haley

Source: PLoS Genetics, Vol 13, Iss 2, p e1006608 (2017)

Subject Terms: Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1553-7390; https://doaj.org/toc/1553-7404

Access URL: https://doaj.org/article/7e8361b5f7c944aba05299cc458c6014

Pedigree- and SNP-Associated Genetics and Recent Environment are the Major Contributors to Anthropometric and Cardiometabolic Trait Variation.

Authors: Charley Xia, Carmen Amador, Jennifer Huffman, Holly Trochet, Archie Campbell, David Porteous, Generation Scotland, Nicholas D Hastie, Caroline Hayward, Veronique Vitart, Pau Navarro, Chris S Haley

Source: PLoS Genetics, Vol 12, Iss 2, p e1005804 (2016)

Subject Terms: Genetics, QH426-470

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC4737500?pdf=render; https://doaj.org/toc/1553-7390; https://doaj.org/toc/1553-7404

Access URL: https://doaj.org/article/fcf6c56e90904ad59f7dd47c50ccb1d9

Genome wide association identifies common variants at the SERPINA6/SERPINA1 locus influencing plasma cortisol and corticosteroid binding globulin.

Authors: Jennifer L Bolton, Caroline Hayward, Nese Direk, John G Lewis, Geoffrey L Hammond, Lesley A Hill, Anna Anderson, Jennifer Huffman, James F Wilson, Harry Campbell, Igor Rudan, Alan Wright, Nicholas Hastie, Sarah H Wild, Fleur P Velders, Albert Hofman, Andre G Uitterlinden, Jari Lahti, Katri Räikkönen, Eero Kajantie, Elisabeth Widen, Aarno Palotie, Johan G Eriksson, Marika Kaakinen, Marjo-Riitta Järvelin, Nicholas J Timpson, George Davey Smith, Susan M Ring, David M Evans, Beate St Pourcain, Toshiko Tanaka, Yuri Milaneschi, Stefania Bandinelli, Luigi Ferrucci, Pim van der Harst, Judith G M Rosmalen, Stephen J L Bakker, Niek Verweij, Robin P F Dullaart, Anubha Mahajan, Cecilia M Lindgren, Andrew Morris, Lars Lind, Erik Ingelsson, Laura N Anderson, Craig E Pennell, Stephen J Lye, Stephen G Matthews, Joel Eriksson, Dan Mellstrom, Claes Ohlsson, Jackie F Price, Mark W J Strachan, Rebecca M Reynolds, Henning Tiemeier, Brian R Walker, CORtisol NETwork (CORNET) Consortium

Source: PLoS Genetics, Vol 10, Iss 7, p e1004474 (2014)

Subject Terms: Genetics, QH426-470

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC4091794?pdf=render; https://doaj.org/toc/1553-7390; https://doaj.org/toc/1553-7404

Access URL: https://doaj.org/article/2b72a476ad934a7490ba2d6ab00344d3

Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations.

Authors: Ayşe Demirkan, Cornelia M van Duijn, Peter Ugocsai, Aaron Isaacs, Peter P Pramstaller, Gerhard Liebisch, James F Wilson, Åsa Johansson, Igor Rudan, Yurii S Aulchenko, Anatoly V Kirichenko, A Cecile J W Janssens, Ritsert C Jansen, Carsten Gnewuch, Francisco S Domingues, Cristian Pattaro, Sarah H Wild, Inger Jonasson, Ozren Polasek, Irina V Zorkoltseva, Albert Hofman, Lennart C Karssen, Maksim Struchalin, James Floyd, Wilmar Igl, Zrinka Biloglav, Linda Broer, Arne Pfeufer, Irene Pichler, Susan Campbell, Ghazal Zaboli, Ivana Kolcic, Fernando Rivadeneira, Jennifer Huffman, Nicholas D Hastie, Andre Uitterlinden, Lude Franke, Christopher S Franklin, Veronique Vitart, DIAGRAM Consortium, Christopher P Nelson, Michael Preuss, CARDIoGRAM Consortium, Joshua C Bis, Christopher J O'Donnell, Nora Franceschini, CHARGE Consortium, Jacqueline C M Witteman, Tatiana Axenovich, Ben A Oostra, Thomas Meitinger, Andrew A Hicks, Caroline Hayward, Alan F Wright, Ulf Gyllensten, Harry Campbell, Gerd Schmitz, EUROSPAN consortium

Source: PLoS Genetics, Vol 8, Iss 2, p e1002490 (2012)

Subject Terms: Genetics, QH426-470

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3280968?pdf=render; https://doaj.org/toc/1553-7390; https://doaj.org/toc/1553-7404

Access URL: https://doaj.org/article/1056cf3c6b034729babb9ff6cf53a034

Genome-wide association study to identify common variants associated with brachial circumference: a meta-analysis of 14 cohorts.

Authors: Vesna Boraska, Aaron Day-Williams, Christopher S Franklin, Katherine S Elliott, Kalliope Panoutsopoulou, Ioanna Tachmazidou, Eva Albrecht, Stefania Bandinelli, Lawrence J Beilin, Murielle Bochud, Gemma Cadby, Florian Ernst, David M Evans, Caroline Hayward, Andrew A Hicks, Jennifer Huffman, Cornelia Huth, Alan L James, Norman Klopp, Ivana Kolcic, Zoltán Kutalik, Debbie A Lawlor, Arthur W Musk, Marina Pehlic, Craig E Pennell, John R B Perry, Annette Peters, Ozren Polasek, Beate St Pourcain, Susan M Ring, Erika Salvi, Sabine Schipf, Jan A Staessen, Alexander Teumer, Nicholas Timpson, Veronique Vitart, Nicole M Warrington, Hanieh Yaghootkar, Tatijana Zemunik, Lina Zgaga, Ping An, Verneri Anttila, Ingrid B Borecki, Jostein Holmen, Ioanna Ntalla, Aarno Palotie, Kirsi H Pietiläinen, Juho Wedenoja, Bendik S Winsvold, George V Dedoussis, Jaakko Kaprio, Michael A Province, John-Anker Zwart, Michel Burnier, Harry Campbell, Daniele Cusi, George Davey Smith, Timothy M Frayling, Christian Gieger, Lyle J Palmer, Peter P Pramstaller, Igor Rudan, Henry Völzke, H-Erich Wichmann, Alan F Wright, Eleftheria Zeggini

Source: PLoS ONE, Vol 7, Iss 3, p e31369 (2012)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3315559?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/796957df8bba401b9cf154fcb070e256

Characterisation of genome-wide association epistasis signals for serum uric acid in human population isolates.

Authors: Wenhua Wei, Gibran Hemani, Andrew A Hicks, Veronique Vitart, Claudia Cabrera-Cardenas, Pau Navarro, Jennifer Huffman, Caroline Hayward, Sara A Knott, Igor Rudan, Peter P Pramstaller, Sarah H Wild, James F Wilson, Harry Campbell, Malcolm G Dunlop, Nicholas Hastie, Alan F Wright, Chris S Haley

Source: PLoS ONE, Vol 6, Iss 8, p e23836 (2011)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21886828/?tool=EBI; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/4e6e1ec452014e6e9ec7fbcbfd1c12a9

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How to solve the affordable-housing crisis

Authors: Gabriela Rico, Emily Hamer, Mary Steurer, Siandhara Bonnet, David Erickson, Jennifer Huffman, Jeff Mullins

Source: Arizona Daily Star (Tucson, AZ). 09/18/2022.

Low-frequency variation in TP53 has large effects on head circumference and intracranial volume

Authors: Simon Haworth, Chin Yang Shapland, Caroline Hayward, Bram P. Prins, Janine F. Felix, Carolina Medina-Gomez, Fernando Rivadeneira, Carol Wang, Tarunveer S. Ahluwalia, Martine Vrijheid, Mònica Guxens, Jordi Sunyer, Ioanna Tachmazidou, Klaudia Walter, Valentina Iotchkova, Andrew Jackson, Louise Cleal, Jennifer Huffmann, Josine L. Min, Lærke Sass, Paul R. H. J. Timmers, UK10K consortium, George Davey Smith, Simon E. Fisher, James F. Wilson, Tim J. Cole, Dietmar Fernandez-Orth, Klaus Bønnelykke, Hans Bisgaard, Craig E. Pennell, Vincent W. V. Jaddoe, George Dedoussis, Nicholas Timpson, Eleftheria Zeggini, Veronique Vitart, Beate St Pourcain

Source: Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/f76d0c11b2064d1e81bbe40dde812983

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