Clinical spectrum and evolution of immune-checkpoint inhibitors toxicities over a decade—a worldwide perspectiveResearch in context

Authors: Paul Gougis, Floriane Jochum, Baptiste Abbar, Elise Dumas, Kevin Bihan, Bénédicte Lebrun-Vignes, Javid Moslehi, Jean-Philippe Spano, Enora Laas, Judicael Hotton, Fabien Reyal, Anne-Sophie Hamy, Joe-Elie Salem

Source: EClinicalMedicine, Vol 70, Iss , Pp 102536- (2024)

Subject Terms: Immune checkpoint inhibitors, Immune-related adverse events, Cancer, Pharmacology, Pharmacovigilance, Myotoxicity, Medicine (General), R5-920

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2589537024001159; https://doaj.org/toc/2589-5370

Access URL: https://doaj.org/article/ae6e36526ea542228ff87171701f0137

P579: SAFETY, TOLERABILITY, PHARMACOKINETICS, AND PRELIMINARY ANTITUMOR ACTIVITY OF AZD5991 IN RELAPSED/ REFRACTORY HEMATOLOGIC MALIGNANCIES: A PHASE 1 FIRST-IN-HUMAN STUDY

Authors: Pinkal Desai, Sagar Lonial, Amanda Cashen, Manali Kamdar, James S. Blachly, Ian W. Flinn, Susan O’brien, Jacqueline Garcia, Neha Korde, Javid Moslehi, Margaret Wey, Patricia Cheung, Shringi Sharma, Damilola Olabode, Hong Chen, Firasath Ali Syed, Mary Liu, Jamal Saeh, Raoul Tibes, Marcio Andrade, Tapan Kadia

Source: HemaSphere, Vol 7, p e98838e7 (2023)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: http://journals.lww.com/10.1097/01.HS9.0000969220.98838.e7; https://doaj.org/toc/2572-9241

Access URL: https://doaj.org/article/d5c07de1c1104e7abf60a32c2df2ca80

Society for Immunotherapy of Cancer (SITC) consensus definitions for immune checkpoint inhibitor-associated immune-related adverse events (irAEs) terminology

Authors: Laura C Cappelli, Maria E Suarez-Almazor, Michelle Turner, Stephane Champiat, Caroline Robert, Julie R Brahmer, Jarushka Naidoo, Jeffrey Weber, Joanne Riemer, Elad Sharon, Michael B Atkins, M Catherine Pietanza, Karthik Suresh, Catherine Murphy, Javid Moslehi, David Feltquate, Lee M Krug

Source: Journal for ImmunoTherapy of Cancer, Vol 11, Iss 3 (2023)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://jitc.bmj.com/content/11/3/e006398.full; https://doaj.org/toc/2051-1426

Access URL: https://doaj.org/article/ce3651e8e8104a2ca8905bdbc8dd0dd4

Breast cancer chemotherapy induces vascular dysfunction and hypertension through a NOX4-dependent mechanism

Authors: Piotr Szczepaniak, Mateusz Siedlinski, Diana Hodorowicz-Zaniewska, Ryszard Nosalski, Tomasz P. Mikolajczyk, Aneta M. Dobosz, Anna Dikalova, Sergey Dikalov, Joanna Streb, Katarzyna Gara, Pawel Basta, Jaroslaw Krolczyk, Joanna Sulicka-Grodzicka, Ewelina Jozefczuk, Anna Dziewulska, Blessy Saju, Iwona Laksa, Wei Chen, John Dormer, Maciej Tomaszewski, Pasquale Maffia, Marta Czesnikiewicz-Guzik, Filippo Crea, Agnieszka Dobrzyn, Javid Moslehi, Tomasz Grodzicki, David G. Harrison, Tomasz J. Guzik

Source: The Journal of Clinical Investigation, Vol 132, Iss 13 (2022)

Subject Terms: Vascular biology, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/1558-8238

Access URL: https://doaj.org/article/4b3b8954d7104657a53492a95dc463f4

Reversal of immune-checkpoint inhibitor fulminant myocarditis using personalized-dose-adjusted abatacept and ruxolitinib: proof of concept

Authors: Michelle Rosenzwajg, Joe-Elie Salem, Yves Allenbach, Stephane Ederhy, Noël Zahr, Jean-Paul Mira, Lee S Nguyen, Javid Moslehi, Marie Bretagne, Jennifer Arrondeau, Baptiste Abbar, Bruno Pinna

Source: Journal for ImmunoTherapy of Cancer, Vol 10, Iss 4 (2022)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://jitc.bmj.com/content/10/4/e004699.full; https://doaj.org/toc/2051-1426

Access URL: https://doaj.org/article/b52d42ec7efd48709f7ba5fce570309a

805 Clonal, activated CD8+ T cells recognizing cardiac alpha-myosin drive immune checkpoint inhibitor associated myocarditis in mice

Authors: James Allison, Spencer Wei, Douglas Johnson, Elizabeth Wescott, Justin Balko, Margaret Axelrod, Wouter Meijers, Elie Tannous, Xiaopeng Sun, Juan Qin, Ayaka Sugiura, Elles Screever, Susan Opalenik, Yueli Zhang, Javid Moslehi

Source: Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2051-1426

Access URL: https://doaj.org/article/e0622f78fa764167a6db867967ab1ab0

Editorial: Recent Advances in Cardiotoxicity Testing

Authors: Tamer M. A. Mohamed, Javid Moslehi, Jonathan Satin

Source: Frontiers in Pharmacology, Vol 12 (2021)

Subject Terms: cancer, cardiooncology, heart, toxicicity, hiPS cardiomycytes, heart slices, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2021.798189/full; https://doaj.org/toc/1663-9812

Access URL: https://doaj.org/article/2a8484dd1a7a46bebd72634103f52bce

Comparative Transcriptomics of Ex Vivo, Patient-Derived Endothelial Cells Reveals Novel Pathways Associated With Type 2 Diabetes Mellitus

Authors: Joshua A. Beckman, MD, Sean P. Doherty, BA, Zachary B. Feldman, BA, Emily S. Banks, BS, Javid Moslehi, MD, Iris Z. Jaffe, MD, PhD, Naomi M. Hamburg, MD, Quanhu Sheng, PhD, Jonathan D. Brown, MD

Source: JACC: Basic to Translational Science, Vol 4, Iss 5, Pp 567-574 (2019)

Subject Terms: Diseases of the circulatory (Cardiovascular) system, RC666-701

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2452302X19301810; https://doaj.org/toc/2452-302X

Access URL: https://doaj.org/article/b728fbf090354e778a680e203eefa2d7

Efficacy of Neurohormonal Therapies in Preventing Cardiotoxicity in Patients With Cancer Undergoing Chemotherapy

Authors: Muthiah Vaduganathan, MD, MPH, Sameer A. Hirji, MD, MPH, Arman Qamar, MD, Navkaranbir Bajaj, MD, MPH, Ankur Gupta, MD, PhD, Vlad G. Zaha, MD, Alvin Chandra, MD, Mark Haykowsky, PhD, Bonnie Ky, MD, MSCE, Javid Moslehi, MD, Anju Nohria, MD, Javed Butler, MD, MPH, MBA, Ambarish Pandey, MD, MSCS

Source: JACC. CardioOncology, Vol 1, Iss 1, Pp 54-65 (2019)

Subject Terms: anthracyclines, cardioprotection, cardiotoxicity, ejection fraction, heart failure, meta-analysis, Diseases of the circulatory (Cardiovascular) system, RC666-701, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2666087319300250; https://doaj.org/toc/2666-0873

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Cardiovascular adverse events in patients with chronic lymphocytic leukemia receiving acalabrutinib monotherapy: pooled analysis of 762 patients

Authors: Jennifer R. Brown, John C. Byrd, Paolo Ghia, Jeff P. Sharman, Peter Hillmen, Deborah M. Stephens, Clare Sun, Wojciech Jurczak, John M. Pagel, Alessandra Ferrajoli, Priti Patel, Lin Tao, Nataliya Kuptsova-Clarkson, Javid Moslehi, Richard R. Furman

Source: Haematologica, Vol 107, Iss 6 (2021)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://haematologica.org/article/view/10414; https://doaj.org/toc/0390-6078; https://doaj.org/toc/1592-8721

Access URL: https://doaj.org/article/539d278310f84aa3955bb4b7eb5f3b1d

Reverse Cardio‐Oncology: Cancer Development in Patients With Cardiovascular Disease

Authors: Joseph Pierre Aboumsallem, Javid Moslehi, Rudolf A. de Boer

Source: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 9, Iss 2 (2020)

Subject Terms: biomarker, cancer, cardiovascular disease, cardio‐oncology, cardiokines, inflammation, Diseases of the circulatory (Cardiovascular) system, RC666-701

File Description: electronic resource

Relation: https://doaj.org/toc/2047-9980

Access URL: https://doaj.org/article/6d4a48266b464181b68f4995134e7d12

21st Century Cardio-Oncology

Authors: Calvin Chen Sheng, MD, Laleh Amiri-Kordestani, MD, Todd Palmby, PhD, Thomas Force, MD, Charles C. Hong, MD, PhD, Joseph C. Wu, MD, PhD, Kevin Croce, MD, PhD, Geoffrey Kim, MD, Javid Moslehi, MD

Source: JACC: Basic to Translational Science, Vol 1, Iss 5, Pp 386-398 (2016)

Subject Terms: cardio-oncology, cardiotoxicity, nonclinical model, pre-clinical model, Diseases of the circulatory (Cardiovascular) system, RC666-701

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2452302X16300559; https://doaj.org/toc/2452-302X

Access URL: https://doaj.org/article/6158e6de3f1f4ac5ad684e83913463ba

Cardiotoxicity Associated with Gemcitabine: Literature Review and a Pharmacovigilance Study

Authors: Marc Hilmi, Stéphane Ederhy, Xavier Waintraub, Christian Funck-Brentano, Ariel Cohen, Aurore Vozy, Bénédicte Lebrun-Vignes, Javid Moslehi, Lee S. Nguyen, Joe-Elie Salem

Source: Pharmaceuticals, Vol 13, Iss 10, p 325 (2020)

Subject Terms: gemcitabine, pericarditis, myocardial ischemia, heart failure, arrhythmias, cardio-oncology, Medicine, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://www.mdpi.com/1424-8247/13/10/325; https://doaj.org/toc/1424-8247

Access URL: https://doaj.org/article/76b7f0dd77b44712ab43a212061e38ee

Apixaban for Primary Prevention of Venous Thromboembolism in Patients With Multiple Myeloma Receiving Immunomodulatory Therapy

Authors: Robert Frank Cornell, Samuel Z. Goldhaber, Brian G. Engelhardt, Javid Moslehi, Madan Jagasia, Daryl Patton, Shelton Harrell, Robert Hall, Houston Wyatt, Greg Piazza

Source: Frontiers in Oncology, Vol 9 (2019)

Subject Terms: Apixaban (Eliquis®), myeloma, anticoagulation (AC), immunomodualtors, venous thomboembolism, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fonc.2019.00045/full; https://doaj.org/toc/2234-943X

Access URL: https://doaj.org/article/3e99427cfcfe44a3b85f22487ff529be

Bid maintains mitochondrial cristae structure and function and protects against cardiac disease in an integrative genomics study

Authors: Christi T Salisbury-Ruf, Clinton C Bertram, Aurelia Vergeade, Daniel S Lark, Qiong Shi, Marlene L Heberling, Niki L Fortune, G Donald Okoye, W Gray Jerome, Quinn S Wells, Josh Fessel, Javid Moslehi, Heidi Chen, L Jackson Roberts II, Olivier Boutaud, Eric R Gamazon, Sandra S Zinkel

Source: eLife, Vol 7 (2018)

Subject Terms: mitochondria, cristae, Bcl-2 family, human genetics & genomics, myocardial infarction, electronic health record, Medicine, Science, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://elifesciences.org/articles/40907; https://doaj.org/toc/2050-084X

Access URL: https://doaj.org/article/713e95df63974051b6c65861bd7d12a1

Characterization of atrial fibrillation adverse events reported in ibrutinib randomized controlled registration trials

Authors: Jennifer R. Brown, Javid Moslehi, Susan O’Brien, Paolo Ghia, Peter Hillmen, Florence Cymbalista, Tait D. Shanafelt, Graeme Fraser, Simon Rule, Thomas J. Kipps, Steven Coutre, Marie-Sarah Dilhuydy, Paula Cramer, Alessandra Tedeschi, Ulrich Jaeger, Martin Dreyling, John C. Byrd, Angela Howes, Michael Todd, Jessica Vermeulen, Danelle F. James, Fong Clow, Lori Styles, Rudy Valentino, Mark Wildgust, Michelle Mahler, Jan A. Burger

Source: Haematologica, Vol 102, Iss 10 (2017)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://haematologica.org/article/view/8228; https://doaj.org/toc/0390-6078; https://doaj.org/toc/1592-8721

Access URL: https://doaj.org/article/f2985c5022894b3aa2128bf6561c3340

Loss of the melanocortin-4 receptor in mice causes dilated cardiomyopathy

Authors: Michael J Litt, G Donald Okoye, Daniel Lark, Isin Cakir, Christy Moore, Mary C Barber, James Atkinson, Josh Fessel, Javid Moslehi, Roger D Cone

Source: eLife, Vol 6 (2017)

Subject Terms: heart, cardiovascular, cardiomyopathy, MC4R, melanocortin-4 receptor, obesity, Medicine, Science, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://elifesciences.org/articles/28118; https://doaj.org/toc/2050-084X

Access URL: https://doaj.org/article/be1fdf60b9af4a499d962141b59a7a77

Cardio-Oncology

Authors: Javid Moslehi, MD, Daniel J. Lenihan, MD

Source: JACC: Basic to Translational Science, Vol 2, Iss 1, Pp 54-55 (2017)

Subject Terms: Diseases of the circulatory (Cardiovascular) system, RC666-701

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2452302X17300025; https://doaj.org/toc/2452-302X

Access URL: https://doaj.org/article/5f32a6d714ad47e28447d6fe97221886

The challenge of cross-trial comparisons using limited data

Authors: Jacob P. Laubach, Edward A. Faber, Peter Voorhees, Javid Moslehi, Cindy Varga, Liviu Niculescu, Kenneth C. Anderson, Paul G. Richardson

Source: Haematologica, Vol 99, Iss 8 (2014)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://haematologica.org/article/view/7129; https://doaj.org/toc/0390-6078; https://doaj.org/toc/1592-8721

Access URL: https://doaj.org/article/ef380ef367114a7e83a468a2260bbcff

In Silico Pharmacoepidemiologic Evaluation of Drug-Induced Cardiovascular Complications Using Combined Classifiers.

Authors: Chuipu Cai¹, Jiansong Fang¹, fangjs@gzucm.edu.cn, Pengfei Guo¹, Qi Wang¹, Huixiao Hong², Javid Moslehi^3,4, Feixiong Cheng^5,6, fxcheng1985@gmail.com

Source: Journal of Chemical Information & Modeling; 5/29/2018, Vol. 58 Issue 5, p943-956, 14p