De novo pyrimidine synthesis is a targetable vulnerability in IDH mutant glioma

Authors: Shi, Diana D., Savani, Milan R., Levitt, Michael M., Wang, Adam C., Endress, Jennifer E., Bird, Cylaina E., Buehler, Joseph, Stopka, Sylwia A., Regan, Michael S., Lin, Yu-Fen, Puliyappadamba, Vinesh T., Gao, Wenhua, Khanal, Januka, Evans, Laura, Lee, Joyce H., Guo, Lei, Xiao, Yi, Xu, Min, Huang, Bofu, Jennings, Rebecca B., Bonal, Dennis M., Martin-Sandoval, Misty S., Dang, Tammie, Gattie, Lauren C., Cameron, Amy B., Lee, Sungwoo, Asara, John M., Kornblum, Harley I., Mak, Tak W., Looper, Ryan E., Nguyen, Quang-De, Signoretti, Sabina, Gradl, Stefan, Sutter, Andreas, Jeffers, Michael, Janzer, Andreas, Lehrman, Mark A., Zacharias, Lauren G., Mathews, Thomas P., Losman, Julie-Aurore, Richardson, Timothy E., Cahill, Daniel P., DeBerardinis, Ralph J., Ligon, Keith L., Xu, Lin, Ly, Peter, Agar, Nathalie Y.R., Abdullah, Kalil G., Harris, Isaac S., Kaelin, William G., Jr., McBrayer, Samuel K.

Source: In Cancer Cell 12 September 2022 40(9):939-956

The novel dihydroorotate dehydrogenase (DHODH) inhibitor BAY 2402234 triggers differentiation and is effective in the treatment of myeloid malignancies

Authors: Christian, Sven, Merz, Claudia, Evans, Laura, Gradl, Stefan, Seidel, Henrik, Friberg, Anders, Eheim, Ashley, Lejeune, Pascale, Brzezinka, Krzysztof, Zimmermann, Katja, Ferrara, Steven, Meyer, Hanna, Lesche, Ralf, Stoeckigt, Detlef, Bauser, Marcus, Haegebarth, Andrea, Sykes, David, Scadden, David, Losman, Julie-Aurore, Janzer, Andreas

Source: Leukemia. 33(10):2403-2415

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100190817929.0x000001&indx=1&recIds=ETOCvdc_100190817929.0x000001

Genome-scale identification of transcription factors that mediate an inflammatory network during breast cellular transformation

Authors: Ji, Zhe, He, Lizhi, Rotem, Asaf, Janzer, Andreas, Cheng, Christine, Regev, Aviv, Struhl, Kevin

Source: Nature communications. 9(1):1-13

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100153417787.0x000001&indx=1&recIds=ETOCvdc_100153417787.0x000001

Overexpression of histone demethylase Fbxl10 leads to enhanced migration in mouse embryonic fibroblasts

Authors: Rohde, Magdalena, Sievers, Elisabeth, Janzer, Andreas, Willmann, Dominica, Egert, Angela, Schorle, Hubert, Schüle, Roland, Kirfel, Jutta

Source: In Experimental Cell Research 1 November 2016 348(2):123-131

Alternative to the soft-agar assay that permits high-throughput drug and genetic screens for cellular transformation

Authors: Rotem, Asaf, Janzer, Andreas, Izar, Benjamin, Ji, Zhe, Doench, John G., Garraway, Levi A., Struhl, Kevin

Source: Proceedings of the National Academy of Sciences of the United States of America, 2015 May 01. 112(18), 5708-5713.

Access URL: https://www.jstor.org/stable/26462650

Metformin and phenformin deplete tricarboxylic acid cycle and glycolytic intermediates during cell transformation and NTPs in cancer stem cells

Authors: Janzer, Andreas, German, Natalie J., Gonzalez-Herrera, Karina N., Asara, John M., Haigis, Marcia C., Struhl, Kevin

Source: Proceedings of the National Academy of Sciences of the United States of America, 2014 Jul . 111(29), 10574-10579.

Access URL: https://www.jstor.org/stable/23803678

Pan-PI3K inhibition with copanlisib overcomes Treg- and M2-TAM-mediated immune suppression and promotes anti-tumor immune responses.

Authors: Heller, Simon, Glaeske, Sarah, Gluske, Katja, Paul, Juliane, Böhme, Annika, Janzer, Andreas, Roider, Helge Gottfried, Montebaur, Anna, Nicke, Barbara, Lesche, Ralf, von Ahsen, Oliver, Politz, Oliver, Liu, Ningshu, Gorjánácz, Mátyás

Source: Clinical & Experimental Medicine; Dec2023, Vol. 23 Issue 8, p5445-5461, 17p

Subject Terms: IMMUNOSUPPRESSION, IMMUNE response, REGULATORY T cells, IMMUNE checkpoint inhibitors, T cells

The H3K4me3 Histone Demethylase Fbxl10 Is a Regulator of Chemokine Expression, Cellular Morphology, and the Metabolome of Fibroblasts

Authors: Janzer, Andreas, Stamm, Katrin, Becker, Astrid, Zimmer, Andreas, Buettner, Reinhard, Kirfel, Jutta

Source: In Journal of Biological Chemistry 7 September 2012 287(37):30984-30992

Inhibition of Dihydroorotate Dehydrogenase Overcomes Differentiation Blockade in Acute Myeloid Leukemia

Authors: Sykes, David B., Kfoury, Youmna S., Mercier, François E., Wawer, Mathias J., Law, Jason M., Haynes, Mark K., Lewis, Timothy A., Schajnovitz, Amir, Jain, Esha, Lee, Dongjun, Meyer, Hanna, Pierce, Kerry A., Tolliday, Nicola J., Waller, Anna, Ferrara, Steven J., Eheim, Ashley L., Stoeckigt, Detlef, Maxcy, Katrina L., Cobert, Julien M., Bachand, Jacqueline, Szekely, Brian A., Mukherjee, Siddhartha, Sklar, Larry A., Kotz, Joanne D., Clish, Clary B., Sadreyev, Ruslan I., Clemons, Paul A., Janzer, Andreas, Schreiber, Stuart L., Scadden, David T.

Source: Cell. 167(1):171-186.e15

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100061588203.0x000001&indx=1&recIds=ETOCvdc_100061588203.0x000001

Genome-scale identification of transcription factors that mediate an inflammatory network during breast cellular transformation.

Authors: Lizhi He, Struhl, Kevin, Zhe Ji, Rotem, Asaf, Janzer, Andreas, Cheng, Christine S., Regev, Aviv

Source: Nature Communications; 5/25/2018, Vol. 9 Issue 1, p1-13, 13p

Subject Terms: EPITHELIAL cells, DNA-binding proteins, GENE expression, GENETIC transcription, NUCLEOTIDE sequencing

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Lysine-specific demethylase 1 (LSD1) and histone deacetylase 1 (HDAC1) synergistically repress proinflammatory cytokines and classical complement pathway components

Authors: Janzer, Andreas, Lim, Soyoung, Fronhoffs, Florian, Niazy, Naima, Buettner, Reinhard, Kirfel, Jutta

Source: In Biochemical and Biophysical Research Communications 18 May 2012 421(4):665-670

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