Author Correction: Disrupting TSLP–TSLP receptor interactions via putative small molecule inhibitors yields a novel and efficient treatment option for atopic diseases

Authors: Partho Protim Adhikary, Temilolu Idowu, Zheng Tan, Christopher Hoang, Selina Shanta, Malti Dumbani, Leah Mappalakayil, Bhuwan Awasthi, Marcel Bermudez, January Weiner, Dieter Beule, Gerhard Wolber, Brent D G Page, Sarah Hedtrich

Source: EMBO Molecular Medicine, Vol 16, Iss 12, Pp 3247-3250 (2024)

Subject Terms: Medicine (General), R5-920, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1757-4684

Access URL: https://doaj.org/article/e1e1a4c5983a4ecc98e0581004861b82

Disrupting TSLP–TSLP receptor interactions via putative small molecule inhibitors yields a novel and efficient treatment option for atopic diseases

Authors: Partho Protim Adhikary, Temilolu Idowu, Zheng Tan, Christopher Hoang, Selina Shanta, Malti Dumbani, Leah Mappalakayil, Bhuwan Awasthi, Marcel Bermudez, January Weiner, Dieter Beule, Gerhard Wolber, Brent DG Page, Sarah Hedtrich

Source: EMBO Molecular Medicine, Vol 16, Iss 7, Pp 1630-1656 (2024)

Subject Terms: TSLP, Atopic Diseases, Atopic Dermatitis, Organ-on-chip, Small Molecule Inhibitor, Medicine (General), R5-920, Genetics, QH426-470

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Relation: https://doaj.org/toc/1757-4684

Access URL: https://doaj.org/article/6e1c32879ae240dfae3a2ec89df67bbc

Soluble ACE2 correlates with severe COVID-19 and can impair antibody responses

Authors: Mikhail Lebedin, Christoph Ratswohl, Amar Garg, Marta Schips, Clara Vázquez García, Lisa Spatt, Charlotte Thibeault, Benedikt Obermayer, January Weiner, 3rd, Ilais Moreno Velásquez, Cathrin Gerhard, Paula Stubbemann, Leif-Gunnar Hanitsch, Tobias Pischon, Martin Witzenrath, Leif Erik Sander, Florian Kurth, Michael Meyer-Hermann, Kathrin de la Rosa

Source: iScience, Vol 27, Iss 3, Pp 109330- (2024)

Subject Terms: Human specimen, Properties of biomolecules, Immune response, In silico biology, Science

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2589004224005510; https://doaj.org/toc/2589-0042

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Generation of iPSC lines with SLC16A2:G401R or SLC16A2 knock out

Authors: Katarzyna Anna Ludwik, Robert Opitz, Sabine Jyrch, Matthias Megges, January Weiner, Dieter Beule, Peter Kühnen, Harald Stachelscheid

Source: Stem Cell Research, Vol 73, Iss , Pp 103256- (2023)

Subject Terms: Allan-Herndon-Dudley syndrome, SLC16A2, MCT8, Biology (General), QH301-705.5

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Relation: http://www.sciencedirect.com/science/article/pii/S1873506123002428; https://doaj.org/toc/1873-5061

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Pharmacological inhibition of bromodomain and extra-terminal proteins induces an NRF-2-mediated antiviral state that is subverted by SARS-CoV-2 infection.

Authors: Baxolele Mhlekude, Dylan Postmus, Saskia Stenzel, January Weiner, Jenny Jansen, Francisco J Zapatero-Belinchón, Ruth Olmer, Anja Richter, Julian Heinze, Nicolas Heinemann, Barbara Mühlemann, Simon Schroeder, Terry C Jones, Marcel A Müller, Christian Drosten, Andreas Pich, Volker Thiel, Ulrich Martin, Daniela Niemeyer, Gisa Gerold, Dieter Beule, Christine Goffinet

Source: PLoS Pathogens, Vol 19, Iss 9, p e1011657 (2023)

Subject Terms: Immunologic diseases. Allergy, RC581-607, Biology (General), QH301-705.5

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Relation: https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1011657&type=printable; https://doaj.org/toc/1553-7366; https://doaj.org/toc/1553-7374

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A Colonic Organoid Model Challenged with the Large Toxins of Clostridioides difficile TcdA and TcdB Exhibit Deregulated Tight Junction Proteins

Authors: Martina Schneemann, Lucas Heils, Verena Moos, Franziska Weiß, Susanne M. Krug, January Weiner, Dieter Beule, Ralf Gerhard, Jörg-Dieter Schulzke, Roland Bücker

Source: Toxins, Vol 15, Iss 11, p 643 (2023)

Subject Terms: intestinal epithelial human colonic organoid monolayer, claudin, leak flux diarrhea, leaky gut, super-resolution STED microscopy, tricellulin, Medicine

File Description: electronic resource

Relation: https://www.mdpi.com/2072-6651/15/11/643; https://doaj.org/toc/2072-6651

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Highly multiplexed immune repertoire sequencing links multiple lymphocyte classes with severity of response to COVID-19

Authors: Richard Dannebaum, Phillip Suwalski, Hosseinali Asgharian, Gracie Du Zhipei, Hai Lin, January Weiner, 3rd, Manuel Holtgrewe, Charlotte Thibeault, Melina Müller, Xiaomin Wang, Zehra Karadeniz, Jacopo Saccomanno, Jan-Moritz Doehn, Ralf-Harto Hübner, Bernd Hinzmann, Anja Blüher, Sandra Siemann, Dilduz Telman, Norbert Suttorp, Martin Witzenrath, Stefan Hippenstiel, Carsten Skurk, Wolfgang Poller, Leif E Sander, Dieter Beule, Florian Kurth, Toumy Guettouche, Ulf Landmesser, Jan Berka, Khai Luong, Florian Rubelt, Bettina Heidecker

Source: EClinicalMedicine, Vol 48, Iss , Pp 101438- (2022)

Subject Terms: COVID-19, Immune repertoires, Immune receptor, Clinical course, Medicine (General), R5-920

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Relation: http://www.sciencedirect.com/science/article/pii/S2589537022001687; https://doaj.org/toc/2589-5370

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Venn Diagrams May Indicate Erroneous Statistical Reasoning in Transcriptomics

Authors: January Weiner, Benedikt Obermayer, Dieter Beule

Source: Frontiers in Genetics, Vol 13 (2022)

Subject Terms: gene set analysis, functional genomics, gene set enrichment, transcriptomics, venn diagram, Genetics, QH426-470

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Relation: https://www.frontiersin.org/articles/10.3389/fgene.2022.818683/full; https://doaj.org/toc/1664-8021

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Gene Set Enrichment Analysis Reveals Individual Variability in Host Responses in Tuberculosis Patients

Authors: Teresa Domaszewska, Joanna Zyla, Raik Otto, Stefan H. E. Kaufmann, January Weiner

Source: Frontiers in Immunology, Vol 12 (2021)

Subject Terms: tuberculosis, endotypes, individual variability in host response, interferon, immune response, gene set enrichment analysis, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2021.694680/full; https://doaj.org/toc/1664-3224

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Systematic Evaluation of Kinetics and Distribution of Muscle and Lymph Node Activation Measured by 18F-FDG- and 11C-PBR28-PET/CT Imaging, and Whole Blood and Muscle Transcriptomics After Immunization of Healthy Humans With Adjuvanted and Unadjuvanted Vaccines

Authors: Zarni Win, January Weiner 3rd, Allan Listanco, Neva Patel, Rohini Sharma, Aldona Greenwood, Jeroen Maertzdorf, Hans-Joachim Mollenkopf, Kat Pizzoferro, Thomas Cole, Caroline L. Bodinham, Stefan H. E. Kaufmann, Philippe Denoel, Giuseppe Del Giudice, David J. M. Lewis

Source: Frontiers in Immunology, Vol 11 (2021)

Subject Terms: PET/CT (positron emission tomography/computed tomography), transcriptomics, systems vaccinology, reactogenicity, muscle, fluorodeoxyglucose (F-FDG) 18, Immunologic diseases. Allergy, RC581-607

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Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2020.613496/full; https://doaj.org/toc/1664-3224

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Metabolite changes in blood predict the onset of tuberculosis

Authors: January Weiner, Jeroen Maertzdorf, Jayne S. Sutherland, Fergal J. Duffy, Ethan Thompson, Sara Suliman, Gayle McEwen, Bonnie Thiel, Shreemanta K. Parida, Joanna Zyla, Willem A. Hanekom, Robert P. Mohney, W. Henry Boom, Harriet Mayanja-Kizza, Rawleigh Howe, Hazel M. Dockrell, Tom H. M. Ottenhoff, Thomas J. Scriba, Daniel E. Zak, Gerhard Walzl, Stefan H. E. Kaufmann, The GC6-74 consortium

Source: Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/05ed44b4c9294316afa2b3d18f1beb1a

Postnaturalizm w narracjach dwóch kultur, czyli dlaczego kryzys cywilizacji jest nieuchronny

Authors: January Weiner

Source: Zagadnienia Filozoficzne w Nauce, Vol 65, Pp 197-212 (2018)

Subject Terms: anthropocene, Philosophy (General), B1-5802

File Description: electronic resource

Relation: http://zfn.edu.pl/index.php/zfn/article/view/446; https://doaj.org/toc/0867-8286; https://doaj.org/toc/2451-0602

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Accelerating tuberculosis vaccine trials with diagnostic and prognostic biomarkers

Authors: Stefan H.E. Kaufmann, January Weiner, Jeroen Maertzdorf

Source: Expert Review of Vaccines, Vol 16, Iss 8, Pp 845-853 (2017)

Subject Terms: biomarkers, clinical tb, diagnostic markers, prognostic markers, subclinical tb, tuberculosis, vaccine design, Internal medicine, RC31-1245

File Description: electronic resource

Relation: https://doaj.org/toc/1476-0584; https://doaj.org/toc/1744-8395

Access URL: https://doaj.org/article/d2f3470329424f499a0d6811ec55baff

Ranking metrics in gene set enrichment analysis: do they matter?

Authors: Joanna Zyla, Michal Marczyk, January Weiner, Joanna Polanska

Source: BMC Bioinformatics, Vol 18, Iss 1, Pp 1-12 (2017)

Subject Terms: GSEA, Ranking metrics, Pathway analysis, Functional genomics, Computer applications to medicine. Medical informatics, R858-859.7, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s12859-017-1674-0; https://doaj.org/toc/1471-2105

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FX11 limits Mycobacterium tuberculosis growth and potentiates bactericidal activity of isoniazid through host-directed activity

Authors: Gopinath Krishnamoorthy, Peggy Kaiser, Ulrike Abu Abed, January Weiner, Pedro Moura-Alves, Volker Brinkmann, Stefan H. E. Kaufmann

Source: Disease Models & Mechanisms, Vol 13, Iss 3 (2020)

Subject Terms: glycolysis, lactate dehydrogenase a, fx11, mycobacterium tuberculosis, granuloma, hypoxia, immunometabolism, host-directed therapy, Medicine, Pathology, RB1-214

File Description: electronic resource

Relation: http://dmm.biologists.org/content/13/3/dmm041954; https://doaj.org/toc/1754-8403; https://doaj.org/toc/1754-8411

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Identification of potential biomarkers of vaccine inflammation in mice

Authors: Paul F McKay, Deniz Cizmeci, Yoann Aldon, Jeroen Maertzdorf, January Weiner, Stefan HE Kaufmann, David JM Lewis, Robert A van den Berg, Giuseppe Del Giudice, Robin J Shattock

Source: eLife, Vol 8 (2019)

Subject Terms: transcriptomics, vaccine, TLR agonist, biomarkers, Medicine, Science, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://elifesciences.org/articles/46149; https://doaj.org/toc/2050-084X

Access URL: https://doaj.org/article/0606bcca2516407c88d1b305a3b30e83

High-throughput and computational approaches for diagnostic and prognostic host tuberculosis biomarkers

Authors: January Weiner, Stefan H.E. Kaufmann

Source: International Journal of Infectious Diseases, Vol 56, Iss C, Pp 258-262 (2017)

Subject Terms: Tuberculosis, Biomarker, High-throughput, Gene set enrichment analysis, Infectious and parasitic diseases, RC109-216

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1201971216312012; https://doaj.org/toc/1201-9712; https://doaj.org/toc/1878-3511

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Novel approaches to tuberculosis vaccine development

Authors: Stefan H.E. Kaufmann, January Weiner, C. Fordham von Reyn

Source: International Journal of Infectious Diseases, Vol 56, Iss C, Pp 263-267 (2017)

Subject Terms: Preventive vaccine, Therapeutic vaccine, Pre-exposure vaccine, Post-exposure vaccine, Subunit vaccine, Whole-cell vaccine, Infectious and parasitic diseases, RC109-216

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1201971216312024; https://doaj.org/toc/1201-9712; https://doaj.org/toc/1878-3511

Access URL: https://doaj.org/article/c451dcd1b39944de862062acf01e2428

Phylogenetic profiles of all membrane transport proteins of the malaria parasite highlight new drug targets

Authors: January Weiner 3rd, Taco W.A. Kooij

Source: Microbial Cell, Vol 3, Iss 10, Pp 511-521 (2016)

Subject Terms: drug target, experimental genetics, malaria parasite, membrane transport protein, orthology, phylogeny, Plasmodium, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://microbialcell.com/researcharticles/phylogenetic-profiles-of-all-membrane-transport-proteins-of-the-malaria-parasite-highlight-new-drug-targets/; https://doaj.org/toc/2311-2638

Access URL: https://doaj.org/article/a0ed6842f2854ab6b5545ec73b138f84

Immunometabolic Signatures Predict Risk of Progression to Active Tuberculosis and Disease Outcome

Authors: Fergal J. Duffy, January Weiner, Scott Hansen, David L. Tabb, Sara Suliman, Ethan Thompson, Jeroen Maertzdorf, Smitha Shankar, Gerard Tromp, Shreemanta Parida, Drew Dover, Michael K. Axthelm, Jayne S. Sutherland, Hazel M. Dockrell, Tom H. M. Ottenhoff, Thomas J. Scriba, Louis J. Picker, Gerhard Walzl, Stefan H. E. Kaufmann, Daniel E. Zak, The GC6-74 Consortium, S. H. E. Kaufmann, S. K. Parida, R. Golinski, J. Maertzdorf, J. Weiner, M. Jacobson, G. McEwen, G. Walzl, G. F. Black, G. van der Spuy, K. Stanley, M. Kriel, N. Du Plessis, N. Nene, A. G. Loxton, N. N. Chegou, S. Suliman, T. Scriba, M. Fisher, H. Mahomed, J. Hughes, K. Downing, A. Penn-Nicholson, H. Mulenga, B. Abel, M. Bowmaker, B. Kagina, W. Kwong, C. W. Hanekom, T. H. M. Ottenhoff, M. R. Klein, M. C. Haks, K. L. Franken, A. Geluk, K. E. van Meijgaarden, S. A. Joosten, D. van Baarle, F. Miedema, W. H. Boom, B. Thiel, J. Sadoff, D. Sizemore, S. Ramachandran, L. Barker, M. Brennan, F. Weichold, S. Muller, L. Geiter, G. Schoolnik, G. Dolganov, T. Van, H. Mayanja-Kizza, M. Joloba, S. Zalwango, M. Nsereko, B. Okwera, H. Kisingo, H. M. Dockrell, S. Smith, P. Gorak-Stolinska, Y.-G. Hur, M. Lalor, J.-S. Lee, A. C. Crampin, N. French, B. Ngwira, A. B. Smith, K. Watkins, L. Ambrose, F. Simukonda, H. Mvula, F. Chilongo, J. Saul, K. Branson, D. Kassa, A. Abebe, T. Mesele, B. Tegbaru, R. Howe, A. Mihret, A. Aseffa, Y. Bekele, R. Iwnetu, M. Tafesse, L. Yamuah, M. Ota, J. Sutherland, P. Hill, R. Adegbola, T. Corrah, M. Antonio, T. Togun, I. Adetifa, S. Donkor, P. Andersen, I. Rosenkrands, M. Doherty, K. Weldingh

Source: Frontiers in Immunology, Vol 10 (2019)

Subject Terms: rhesus macaque, household contact, biomarker, transcriptomics, metabolomics, tuberculosis, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fimmu.2019.00527/full; https://doaj.org/toc/1664-3224

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