STK19 drives transcription-coupled repair by stimulating repair complex stability, RNA Pol II ubiquitylation, and TFIIH recruitment

Authors: Ramadhin, Anisha R. ^{1, 6}, Lee, Shun-Hsiao ^{2, 6}, Zhou, Di ¹, Salmazo, Anita ⁴, Gonzalo-Hansen, Camila ¹, van Sluis, Marjolein ¹, Blom, Cindy M.A. ¹, Janssens, Roel C. ¹, Raams, Anja ¹, Dekkers, Dick ³, Bezstarosti, Karel ³, Slade, Dea ⁵, Vermeulen, Wim ¹, Pines, Alex ¹, Demmers, Jeroen A.A. ³, Bernecky, Carrie ⁴, Sixma, Titia K. ^{2, ∗}, Marteijn, Jurgen A. ^{1, 7, ∗∗}

Source: In Molecular Cell 19 December 2024 84(24):4740-4757

Live-cell imaging of endogenous CSB-mScarletI as a sensitive marker for DNA-damage-induced transcription stress

Authors: Zhou, Di, Yu, Qing, Janssens, Roel C., Marteijn, Jurgen A.

Source: In Cell Reports Methods 22 January 2024 4(1)

Differential processing of RNA polymerase II at DNA damage correlates with transcription-coupled repair syndrome severity.

Authors: Gonzalo-Hansen, Camila, Steurer, Barbara, Janssens, Roel C, Zhou, Di, van Sluis, Marjolein, Lans, Hannes, Marteijn, Jurgen A

Source: Nucleic Acids Research; 9/9/2024, Vol. 52 Issue 16, p9596-9612, 17p

Live-cell analysis of endogenous GFP-RPB1 uncovers rapid turnover of initiating and promoter-paused RNA Polymerase II

Authors: Steurer, Barbara, Janssens, Roel C., Geverts, Bart, Geijer, Marit E., Wienholz, Franziska, Theil, Arjan F., Chang, Jiang, Dealy, Shannon, Pothof, Joris, van Cappellen, Wiggert A., Houtsmuller, Adriaan B., Marteijn, Jurgen A.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2018 May 01. 115(19), E4368-E4376.

Access URL: https://www.jstor.org/stable/26509606

Phase locking and multiple oscillating attractors for the coupled mammalian clock and cell cycle

Authors: Feillet, Céline, Krusche, Peter, Tamanini, Filippo, Janssens, Roel C., Downey, Mike J., Martin, Patrick, Teboul, Michèle, Saito, Shoko, Lévi, Francis A., Bretschneider, Till, van der Horst, Gijsbertus T. J., Delaunay, Franck, Rand, David A.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2014 Jul 01. 111(27), 9828-9833.

Access URL: https://www.jstor.org/stable/23802672

ATXN3 controls DNA replication and transcription by regulating chromatin structure.

Authors: Hernández‐Carralero, Esperanza, Cabrera, Elisa, Rodríguez-Torres, Gara, Hernández-Reyes, Yeray, Singh, Abhay N, Santa-María, Cristina, Fernández-Justel, José Miguel, Janssens, Roel C, Marteijn, Jurgen A, Evert, Bernd O, Mailand, Niels, Gómez, María, Ramadan, Kristijan, Smits, Veronique A J, Freire, Raimundo

Source: Nucleic Acids Research; 6/23/2023, Vol. 51 Issue 11, p5396-5413, 18p

DNA damage-induced transcription stress triggers the genome-wide degradation of promoter-bound Pol II.

Authors: Steurer, Barbara, Janssens, Roel C., Geijer, Marit E., Aprile-Garcia, Fernando, Geverts, Bart, Theil, Arjan F., Hummel, Barbara, van Royen, Martin E., Evers, Bastiaan, Bernards, René, Houtsmuller, Adriaan B., Sawarkar, Ritwick, Marteijn, Jurgen

Source: Nature Communications; 6/25/2022, Vol. 13 Issue 1, p1-18, 18p

Subject Terms: DNA polymerases, RNA polymerases, RNA polymerase II, DNA repair, RNA regulation, DNA, DNA damage, TRANSGENIC organisms

Mammalian TIMELESS Is Involved in Period Determination and DNA Damage-Dependent Phase Advancing of the Circadian Clock.

Authors: Engelen, Erik^1,2, Janssens, Roel C.¹, Yagita, Kazuhiro³, Smits, Veronique A. J.⁴, van der Horst, Gijsbertus T. J.¹ g.vanderhorst@erasmusmc.nl, Tamanini, Filippo¹ f.tamanini@erasmusmc.nl

Source: PLoS ONE. Feb2013, Vol. 8 Issue 2, p1-12. 12p.

Subject Terms: *DNA damage, *GENE expression, *PROTEIN engineering, *PROTEIN-protein interactions, *BIOLOGICAL evolution, *MOLECULAR biology, *SOMATIC cells, *RNA interference, *CELL division

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DNA damage and transcription stress cause ATP-mediated redesign of metabolism and potentiation of anti-oxidant buffering.

Authors: Milanese, Chiara, Bombardieri, Cíntia R., Sepe, Sara, Barnhoorn, Sander, Payán-Goméz, César, Caruso, Donatella, Audano, Matteo, Pedretti, Silvia, Vermeij, Wilbert P., Brandt, Renata M. C., Gyenis, Akos, Wamelink, Mirjam M., de Wit, Annelieke S., Janssens, Roel C., Leen, René, van Kuilenburg, André B. P., Mitro, Nico, Hoeijmakers, Jan H. J., Mastroberardino, Pier G.

Source: Nature Communications; 10/25/2019, Vol. 10 Issue 1, p1-16, 16p

Subject Terms: DNA damage, DNA repair, PENTOSE phosphate pathway, NUCLEOTIDES, COCKAYNE syndrome

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