Variegated clonality and rapid emergence of new molecular lesions in xenografts of acute lymphoblastic leukemia are associated with drug resistance

Authors: Nowak, Daniel ^∗, Liem, Natalia L.M., Mossner, Maximilian, Klaumünzer, Marion, Papa, Rachael A., Nowak, Verena, Jann, Johann C., Akagi, Tadayuki, Kawamata, Norihiko, Okamoto, Ryoko, Thoennissen, Nils H., Kato, Motohiro, Sanada, Masashi, Hofmann, Wolf-Karsten, Ogawa, Seishi, Marshall, Glenn M., Lock, Richard B., Koeffler, H. Phillip

Source: In Experimental Hematology January 2015 43(1):32-43

Splicing modulators impair DNA damage response and induce killing of cohesin-mutant MDS and AML.

Authors: Wheeler, Emily C., Martin, Benjamin J. E., Doyle, William C., Neaher, Sofia, Conway, Caroline A., Pitton, Caroline N., Gorelov, Rebecca A., Donahue, Melanie, Jann, Johann C., Abdel-Wahab, Omar, Taylor, Justin, Seiler, Michael, Buonamici, Silvia, Pikman, Yana, Garcia, Jacqueline S., Belizaire, Roger, Adelman, Karen, Tothova, Zuzana

Source: Science Translational Medicine; 1/3/2024, Vol. 16 Issue 728, p1-13, 13p

Subject Terms: DNA repair, ACUTE myeloid leukemia, MYELODYSPLASTIC syndromes, GENE expression, DNA damage