Novel translational mouse models of metabolic dysfunction-associated steatotic liver disease comparable to human MASLD with severe obesity

Authors: Katharina L. Hupa-Breier, Heiko Schenk, Alejandro Campos-Murguia, Freya Wellhöner, Benjamin Heidrich, Janine Dywicki, Björn Hartleben, Clara Böker, Julian Mall, Christoph Terkamp, Ludwig Wilkens, Friedrich Becker, Karl Lenhard Rudolph, Michael Peter Manns, Young-Seon Mederacke, Silke Marhenke, Hanna Redeker, Maren Lieber, Konstantinos Iordanidis, Richard Taubert, Heiner Wedemeyer, Fatih Noyan, Matthias Hardtke-Wolenski, Elmar Jaeckel

Source: Molecular Metabolism, Vol 93, Iss , Pp 102104- (2025)

Subject Terms: Metabolic dysfunction-associated steatotic liver disease, Metabolic syndrome, Mouse model, Kidney injury, Non-alcoholic fatty liver disease, Internal medicine, RC31-1245

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2212877825000110; https://doaj.org/toc/2212-8778

Access URL: https://doaj.org/article/a1a31a4aae184c21ba4d6c5dc40e7cf0

The GIBACHT fellowship: a multilateral initiative for strengthening capacity in biosafety and biosecurity towards pandemic preparedness

Authors: Eva Mertens, Marlow Zimmermann, Janine Dywicki, Min-Hi Lee, Joachim Pelikan, Barbara M. Bürkin, Elizeus Rutebemberwa, Axel Hoffmann

Source: Frontiers in Public Health, Vol 12 (2024)

Subject Terms: biosafety, biosecurity, non-proliferation, capacity strengthening, training-of-trainers (ToT), Public aspects of medicine, RA1-1270

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fpubh.2024.1385579/full; https://doaj.org/toc/2296-2565

Access URL: https://doaj.org/article/dac967234a304fa291e1e98e6a1675eb

Splenectomy induces biochemical remission and regeneration in experimental murine autoimmune hepatitis

Authors: Janine Dywicki, Laura Elisa Buitrago-Molina, Fatih Noyan, Jerome Schlue, Konstantinos Iordanidis, Michael P. Manns, Heiner Wedemeyer, Elmar Jaeckel, Matthias Hardtke-Wolenski

Source: European Journal of Medical Research, Vol 27, Iss 1, Pp 1-8 (2022)

Subject Terms: Autoimmune hepatitis, Transaminases, Splenectomy, Regeneration, Biochemical remission, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/2047-783X

Access URL: https://doaj.org/article/b06c23f9432545069705c91450ad0e1a

The Detrimental Role of Regulatory T Cells in Nonalcoholic Steatohepatitis

Authors: Janine Dywicki, Laura Elisa Buitrago‐Molina, Fatih Noyan, Ana C. Davalos‐Misslitz, Katharina L. Hupa‐Breier, Maren Lieber, Martin Hapke, Jerome Schlue, Christine S. Falk, Solaiman Raha, Immo Prinz, Christian Koenecke, Michael P. Manns, Heiner Wedemeyer, Matthias Hardtke‐Wolenski, Elmar Jaeckel

Source: Hepatology Communications, Vol 6, Iss 2, Pp 320-333 (2022)

Subject Terms: Diseases of the digestive system. Gastroenterology, RC799-869

File Description: electronic resource

Relation: https://doaj.org/toc/2471-254X

Access URL: https://doaj.org/article/c74f2c70e32d41ff853767285a092092

Anti-CD20 Therapy Alters the Protein Signature in Experimental Murine AIH, but Not Exclusively towards Regeneration

Authors: Laura Elisa Buitrago-Molina, Janine Dywicki, Fatih Noyan, Lena Schepergerdes, Julia Pietrek, Maren Lieber, Jerome Schlue, Michael P. Manns, Heiner Wedemeyer, Elmar Jaeckel, Matthias Hardtke-Wolenski

Source: Cells, Vol 10, Iss 6, p 1471 (2021)

Subject Terms: autoimmune hepatitis, anti-CD20 therapy, immune tolerance, regeneration, hepatic inflammation, Cytology, QH573-671

File Description: electronic resource

Relation: https://www.mdpi.com/2073-4409/10/6/1471; https://doaj.org/toc/2073-4409

Access URL: https://doaj.org/article/88cb606e6dfb4eec8cf7121b1307fd55

Dulaglutide Alone and in Combination with Empagliflozin Attenuate Inflammatory Pathways and Microbiome Dysbiosis in a Non-Diabetic Mouse Model of NASH

Authors: Katharina Luise Hupa-Breier, Janine Dywicki, Björn Hartleben, Freya Wellhöner, Benjamin Heidrich, Richard Taubert, Young-Seon Elisabeth Mederacke, Maren Lieber, Konstantinos Iordanidis, Michael P. Manns, Heiner Wedemeyer, Matthias Hardtke-Wolenski, Elmar Jaeckel

Source: Biomedicines, Vol 9, Iss 4, p 353 (2021)

Subject Terms: liver disease, non-alcoholic steatohepatitis, GLP-1 agonist, SGLT-2 inhibitor, type 2 diabetes, innate immune system, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.mdpi.com/2227-9059/9/4/353; https://doaj.org/toc/2227-9059

Access URL: https://doaj.org/article/10ab30e20bf14c3cad4a1213c8ed0316