Analyzing PKC Gamma (+ 19,506 A/G) polymorphism as a promising genetic marker for HCV-induced hepatocellular carcinoma

Authors: Fizzah Abid, Talha Iqbal, Khushbukhat Khan, Yasmin Badshah, Janeen H Trembley, Naeem Mahmood Ashraf, Maria Shabbir, Tayyaba Afsar, Ali Almajwal, Suhail Razak

Source: Biomarker Research, Vol 10, Iss 1, Pp 1-11 (2022)

Subject Terms: PRKCG, K359R, Alanine aminotransferase, Biomarker, Serine-threonine kinases, Missense SNPs, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://doaj.org/toc/2050-7771

Access URL: https://doaj.org/article/c418dbd2e877404c8689f13b24aa6ca2

Unravelling the role of PRKCI and key-cancer related genes in breast cancer development and metastasis

Authors: Hania Shah, Khushbukhat Khan, Yasmin Badshah, Janeen H. Trembley, Naeem Mahmood Ashraf, Maria Shabbir, Tayyaba Afsar, Dara Aldisi, Dilawer Khan, Suhail Razak

Source: Discover Oncology, Vol 16, Iss 1, Pp 1-16 (2025)

Subject Terms: PKC, Cancer, SNP, Mutation, Expression analysis, ARM’s PCR, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2730-6011

Access URL: https://doaj.org/article/22982ba06bdd4b61929945d895f20fc0

Investigating the role of non-synonymous variant D67N of ADGRE2 in chronic myeloid leukemia

Authors: Ayesha Afzal, Harooma Jamshaid, Yasmin Badshah, Maria Shabbir, Janeen H. Trembley, Sameen Zafar, Ghulam Murtaza Kamal, Tayyaba Afsar, Fohad Mabood Husain, Suhail Razak

Source: BMC Cancer, Vol 24, Iss 1, Pp 1-13 (2024)

Subject Terms: Non-synonymous, CML, Bioinformatics tools, ARMS PCR, In silico analysis, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1471-2407

Access URL: https://doaj.org/article/88f3ec3131af4cbc841ca8ca1519d148

Impact of protein kinase CK2 downregulation and inhibition on oncomir clusters 17 ~ 92 and 106b ~ 25 in prostate, breast, and head and neck cancers

Authors: Betsy T. Kren, Christine M. Henzler, Khalil Ahmed, Janeen H. Trembley

Source: Molecular Medicine, Vol 30, Iss 1, Pp 1-16 (2024)

Subject Terms: CK2, Casein kinase 2, Oncomir, MicroRNA, Cancer, Transcription, Therapeutics. Pharmacology, RM1-950, Biochemistry, QD415-436

File Description: electronic resource

Relation: https://doaj.org/toc/1528-3658

Access URL: https://doaj.org/article/b1b36ae62d1a4ec9b4b7caab9dd949fe

Current understanding of the impact of United States military airborne hazards and burn pit exposures on respiratory health

Authors: Janeen H. Trembley, Paul Barach, Julie M. Tomáška, Jedidah T. Poole, Pamela K. Ginex, Robert F. Miller, Jacob B. Lindheimer, Anthony M. Szema, Kimberly Gandy, Trishul Siddharthan, Jason P. Kirkness, Joshua P. Nixon, Rosie Lopez Torres, Mark A. Klein, Timothy R. Nurkiewicz, Tammy A. Butterick

Source: Particle and Fibre Toxicology, Vol 21, Iss 1, Pp 1-12 (2024)

Subject Terms: PACT Act, Veterans, Military, Burn pit, Airborne hazards, Inhalation, Toxicology. Poisons, RA1190-1270, Industrial hygiene. Industrial welfare, HD7260-7780.8

File Description: electronic resource

Relation: https://doaj.org/toc/1743-8977

Access URL: https://doaj.org/article/f6a54d160d4d450db019d44fb0c34f7c

Pathogenic nsSNPs of protein kinase C-eta with hepatocellular carcinoma susceptibility

Authors: Tayyaba Hussain, Yasmin Badshah, Maria Shabbir, Fizzah Abid, Ghulam Murtaza Kamal, Amna Fayyaz, Janeen H. Trembley, Tayyaba Afsar, Fohad Mabood Husain, Suhail Razak

Source: Cancer Cell International, Vol 24, Iss 1, Pp 1-8 (2024)

Subject Terms: nsSNPs, PRKCH, Hepatocellular Carcinoma, ARMS-PCR, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, Cytology, QH573-671

File Description: electronic resource

Relation: https://doaj.org/toc/1475-2867

Access URL: https://doaj.org/article/5e3038e4338b4b46ac0340cab2e1ca94

Genetic polymorphism in untranslated regions of PRKCZ influences mRNA structure, stability and binding sites

Authors: Aneela Mustafa, Maria Shabbir, Yasmin Badshah, Khushbukhat Khan, Fizzah Abid, Janeen H. Trembley, Tayyaba Afsar, Ali Almajwal, Suhail Razak

Source: BMC Cancer, Vol 24, Iss 1, Pp 1-12 (2024)

Subject Terms: UTR, PRKCZ, Non-coding SNPs, In-silico tools, miRNA, Oncological disorders, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1471-2407

Access URL: https://doaj.org/article/26f43689afa74e5cbf7f1e4a28e45a0a

Assessment of Bryophyllum pinnatum mediated Ag and ZnO nanoparticles as efficient antimicrobial and cytotoxic agent

Authors: Huma Noor, Asma Ayub, Erum Dilshad, Tayyaba afsar, Suhail Razak, Fohad Mabood Husain, Janeen H. Trembley

Source: Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)

Subject Terms: Antimicrobial, Antioxidant, Bryophyllum pinnatum, Cytotoxic, Silver nanoparticles, ZnO nanoparticles, Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/72906a9e121e46788ef607471567bc83

Photoactive metabolite mediated photodynamic therapy of Rhabdomyosarcoma cell lines using medicinal plants and Doxorubicin co-treatments

Authors: Sumbal Javaid, Irfan Zia Qureshi, Ahmat Khurshid, Tayyaba Afsar, Fohad Mabood Husain, Muhammad Khurshid, Janeen H. Trembley, Suhail Razak

Source: BMC Complementary Medicine and Therapies, Vol 24, Iss 1, Pp 1-13 (2024)

Subject Terms: Photosensitizer, Rhabdomyosarcoma cancer, Photodynamic therapy, Absorption spectroscopy, Combination index, Medicinal plants, Other systems of medicine, RZ201-999

File Description: electronic resource

Relation: https://doaj.org/toc/2662-7671

Access URL: https://doaj.org/article/d1e296fc6b864a9e868c179ea2ce22b0

Tenfibgen ligand nanoencapsulation delivers bi-functional anti-CK2 RNAi oligomer to key sites for prostate cancer targeting using human xenograft tumors in mice.

Authors: Janeen H Trembley, Gretchen M Unger, Vicci L Korman, Md Joynal Abedin, Lucas P Nacusi, Rachel I Vogel, Joel W Slaton, Betsy T Kren, Khalil Ahmed

Source: PLoS ONE, Vol 9, Iss 10, p e109970 (2014)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC4198192?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/8ba3a800ed764abfb326c8718b911d34

Possible prognostic impact of PKCι genetic variants in prostate cancer

Authors: Amna Hafeez, Maria Shabbir, Khushbukhat Khan, Janeen H. Trembley, Yasmin Badshah, Sameen Zafar, Kanza Shahid, Hania Shah, Naeem Mahmood Ashraf, Arslan Hamid, Tayyaba Afsar, Ali Almajwal, Afifa Marium, Suhail Razak

Source: Cancer Cell International, Vol 24, Iss 1, Pp 1-12 (2024)

Subject Terms: PKCι, Prostate cancer, Pathways, Molecular dynamic simulations, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, Cytology, QH573-671

File Description: electronic resource

Relation: https://doaj.org/toc/1475-2867

Access URL: https://doaj.org/article/7bdd5663135e429f9ba26e50ca32aa0e

Cross talk of tumor protein D52 (TPD52) with KLF9, PKCε, and MicroRNA 223 in ovarian cancer

Authors: Khushbukhat Khan, Sameen Zafar, Yasmin Badshah, Naeem Mahmood Ashraf, Mehak Rafiq, Lubna Danish, Maria Shabbir, Janeen H. Trembley, Tayyaba Afsar, Ali Almajwal, Suhail Razak

Source: Journal of Ovarian Research, Vol 16, Iss 1, Pp 1-13 (2023)

Subject Terms: Ovarian cancer, TPD52, Protein kinase C epsilon, microRNA, Gynecology and obstetrics, RG1-991

File Description: electronic resource

Relation: https://doaj.org/toc/1757-2215

Access URL: https://doaj.org/article/fa654053675642f1a0b52271742e231e

The prevalence of post-traumatic stress disorder among emergency medical services personnel in Saudi Red Crescent Authority, Riyadh, Saudi Arabia

Authors: Sattam Zaid Alanazi, Ali Abusharha, Tayyaba Afsar, Janeen H. Trembley, Suhail Razak

Source: Frontiers in Psychiatry, Vol 15 (2024)

Subject Terms: post-traumatic stress disorder (PTSD), prevalence, Saudi Arabia, gender difference, emergency medical services (EMS), occupation, Psychiatry, RC435-571

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fpsyt.2024.1391586/full; https://doaj.org/toc/1664-0640

Access URL: https://doaj.org/article/a05e4d8b57db43659047a2713f866e70

Exploring the prognostic significance of PKCε variants in cervical cancer

Authors: Sameen Zafar, Khushbukhat Khan, Yasmin Badshah, Kanza Shahid, Janeen H. Trembley, Amna Hafeez, Naeem Mahmood Ashraf, Hamid Arslan, Maria Shabbir, Tayyaba Afsar, Ali Almajwal, Suhail Razak

Source: BMC Cancer, Vol 23, Iss 1, Pp 1-15 (2023)

Subject Terms: PKCε, Cervical cancer, Genotyping, Protein-protein interactions, Molecular docking, Molecular dynamics simulations, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1471-2407

Access URL: https://doaj.org/article/209bc828e2ab4024aa791f64fbdfcef4

Correction: Exploring the prognostic significance of PKCε variants in cervical cancer

Authors: Sameen Zafar, Khushbukhat Khan, Yasmin Badshah, Kanza Shahid, Janeen H. Trembley, Amna Hafeez, Naeem Mahmood Ashraf, Hamid Arslan, Maria Shabbir, Tayyaba Afsar, Ali Almajwal, Suhail Razak

Source: BMC Cancer, Vol 23, Iss 1, Pp 1-1 (2023)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1471-2407

Access URL: https://doaj.org/article/3681cd701b4a414b8e1b55b0d4a75148

Identification of high protein kinase CK2α in HPV(+) oropharyngeal squamous cell carcinoma and correlation with clinical outcomes

Authors: Janeen H. Trembley, Bin Li, Betsy T. Kren, Justin Peltola, Juan Manivel, Devi Meyyappan, Amy Gravely, Mark Klein, Khalil Ahmed, Emiro Caicedo-Granados

Source: PeerJ, Vol 9, p e12519 (2021)

Subject Terms: Oropharyngeal squamous cell carcinoma, Head and neck neoplasms, Human papillomavirus, CK2, Casein kinase II, Ki-67, Medicine, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://peerj.com/articles/12519.pdf; https://peerj.com/articles/12519/; https://doaj.org/toc/2167-8359

Access URL: https://doaj.org/article/6fc21c8604004e1bb39420863b1ecaef

Prevention of Testicular Damage by Indole Derivative MMINA via Upregulated StAR and CatSper Channels with Coincident Suppression of Oxidative Stress and Inflammation: In Silico and In Vivo Validation

Authors: Tayyaba Afsar, Suhail Razak, Janeen H. Trembley, Khushbukhat Khan, Maria Shabbir, Ali Almajwal, Nawaf W. Alruwaili, Muhammad Umar Ijaz

Source: Antioxidants, Vol 11, Iss 10, p 2063 (2022)

Subject Terms: cisplatin, indole, testicular tissues, molecular interactome, molecular docking, antineoplastic agent, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.mdpi.com/2076-3921/11/10/2063; https://doaj.org/toc/2076-3921

Access URL: https://doaj.org/article/16429fd85cc942a9a5374b785e1e5a9a

CX-4945 and siRNA-Mediated Knockdown of CK2 Improves Cisplatin Response in HPV(+) and HPV(−) HNSCC Cell Lines

Authors: Janeen H. Trembley, Bin Li, Betsy T. Kren, Amy A. Gravely, Emiro Caicedo-Granados, Mark A. Klein, Khalil Ahmed

Source: Biomedicines, Vol 9, Iss 5, p 571 (2021)

Subject Terms: head and neck cancer, HNSCC, human papillomavirus, HPV, CK2, NFκB, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.mdpi.com/2227-9059/9/5/571; https://doaj.org/toc/2227-9059

Access URL: https://doaj.org/article/e916da35ab43400cbc1b96e5ef289ab9

CK2 Pro-Survival Role in Prostate Cancer Is Mediated via Maintenance and Promotion of Androgen Receptor and NFκB p65 Expression

Authors: Janeen H. Trembley, Betsy T. Kren, Md. J. Abedin, Daniel P. Shaughnessy, Yingming Li, Scott M. Dehm, Khalil Ahmed

Source: Pharmaceuticals, Vol 12, Iss 2, p 89 (2019)

Subject Terms: prostate, CK2, AR, Tenfibgen, mitochondria, survival, cell death, xenograft, CRPC, in vivo delivery, nanoparticle, nanocapsule, Medicine, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://www.mdpi.com/1424-8247/12/2/89; https://doaj.org/toc/1424-8247

Access URL: https://doaj.org/article/de9d2f5343754bf59e5941d139a1fc27

CDK11 Loss Induces Cell Cycle Dysfunction and Death of BRAF and NRAS Melanoma Cells

Authors: Rehana L. Ahmed, Daniel P. Shaughnessy, Todd P. Knutson, Rachel I. Vogel, Khalil Ahmed, Betsy T. Kren, Janeen H. Trembley

Source: Pharmaceuticals, Vol 12, Iss 2, p 50 (2019)

Subject Terms: CDK11, Cyclin L1, Cyclin L2, cell cycle, cancer, melanoma, Medicine, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://www.mdpi.com/1424-8247/12/2/50; https://doaj.org/toc/1424-8247

Access URL: https://doaj.org/article/c36cf854d71c4daca8db8a3ed125a87d