Pharmacokinetic and pharmacodynamic assessments of atogepant in healthy male adults: Results from phase 1 studies

Authors: Ramesh Boinpally, Marleen Depré, Griet Van Lancker, Marissa F Dockendorf, Phung Bondiskey, Jean-Francois Denef, Tom Reynders, Catherine Zhou Matthews, K Chris Min, Jialin Xu, Joel M Trugman, Jan de Hoon

Source: Cephalalgia Reports, Vol 6 (2023)

Subject Terms: Therapeutics. Pharmacology, RM1-950, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: https://doaj.org/toc/2515-8163

Access URL: https://doaj.org/article/5322ddc1d94045a5bbfac12682cc3682

First‐in‐human development of a pharmacodynamic biomarker for PAC1 receptor antagonists using intradermal injections of maxadilan

Authors: Heleen Marynissen, Linde Buntinx, Dorien Bamps, Marleen Depre, Els Ampe, Anne Van Hecken, Kristin Gabriel, Steve Sands, Gabriel Vargas, Jan de Hoon

Source: Clinical and Translational Science, Vol 15, Iss 8, Pp 1968-1977 (2022)

Subject Terms: Therapeutics. Pharmacology, RM1-950, Public aspects of medicine, RA1-1270

File Description: electronic resource

Relation: https://doaj.org/toc/1752-8054; https://doaj.org/toc/1752-8062

Access URL: https://doaj.org/article/5f31137aa46647bc88467882c8d81c9b

SDI-118, a novel procognitive SV2A modulator: First-in-human randomized controlled trial including PET/fMRI assessment of target engagement

Authors: Wouter Botermans, Michel Koole, Koen Van Laere, Jonathan R. Savidge, John A. Kemp, Stefan Sunaert, Maeve M. Duffy, Steven Ramael, Andrea M. Cesura, Kevin D’Ostilio, Denis Gossen, Torsten M. Madsen, Thomas Lodeweyckx, Jan de Hoon

Source: Frontiers in Pharmacology, Vol 13 (2023)

Subject Terms: randomized controlled trial, SDI-118, synaptic vesicle glycoprotein, SV2A, positron emission tomography, resting state functional MRI (rsfMRI), Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2022.1066447/full; https://doaj.org/toc/1663-9812

Access URL: https://doaj.org/article/df0ee95e51f84642be55f2415ae1522e

Minimally invasive quantification of cerebral P2X7R occupancy using dynamic [18F]JNJ-64413739 PET and MRA-driven image derived input function

Authors: Nathalie Mertens, Mark E. Schmidt, Anja Hijzen, Donatienne Van Weehaeghe, Paulien Ravenstijn, Marleen Depre, Jan de Hoon, Koen Van Laere, Michel Koole

Source: Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/956ae6697f2b4d23a1f6acaf3aaf905f

Human biodistribution and dosimetry of [11C]-UCB-J, a PET radiotracer for imaging synaptic density

Authors: Christopher Cawthorne, Paul Maguire, Joel Mercier, David Sciberras, Kim Serdons, Guy Bormans, Jan de Hoon, Koen Van Laere, Michel Koole

Source: EJNMMI Physics, Vol 8, Iss 1, Pp 1-11 (2021)

Subject Terms: [11C]-UCB-J, Synaptic density, Radiation dosimetry, Human biodistribution, OLINDA, Medical physics. Medical radiology. Nuclear medicine, R895-920

File Description: electronic resource

Relation: https://doaj.org/toc/2197-7364

Access URL: https://doaj.org/article/dcd084ea376c46a987d154271c5ed03c

Antenatal sildenafil administration to prevent pulmonary hypertension in congenital diaphragmatic hernia (SToP-PH): study protocol for a phase I/IIb placenta transfer and safety study

Authors: Francesca Maria Russo, Alexandra Benachi, Tim Van Mieghem, Jan De Hoon, Kristel Van Calsteren, Pieter Annaert, Jean-Marc Tréluyer, Karel Allegaert, Jan Deprest

Source: Trials, Vol 19, Iss 1, Pp 1-8 (2018)

Subject Terms: Sildenafil citrate, Congenital diaphragmatic hernia, Transplacental therapy, Placenta transfer study, Medicine (General), R5-920

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s13063-018-2897-8; https://doaj.org/toc/1745-6215

Access URL: https://doaj.org/article/38f9c182c9fd4c8e82b0afe9fe805d7e

Simultaneous Semi-Mechanistic Population Pharmacokinetic Modeling Analysis of Enalapril and Enalaprilat Serum and Urine Concentrations From Child Appropriate Orodispersible Minitablets

Authors: Muhammad Faisal, Willi Cawello, Bjoern B. Burckhardt, Jan de Hoon, Stephanie Laer, LENA Consortium

Source: Frontiers in Pediatrics, Vol 7 (2019)

Subject Terms: enalapril, enalaprilat, heart failure, population pharmacokinetics modeling analysis, NONMEM, orodispersible mini-tablets, Pediatrics, RJ1-570

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fped.2019.00281/full; https://doaj.org/toc/2296-2360

Access URL: https://doaj.org/article/8a63134b5d524c8e93bb47088beac1b1

The New First-in-Human EMA Guideline: Disruptive or Constructive? Outcomes From the First EUFEMED Discussion Forum

Authors: Kerstin Breithaupt-Grögler, Tim Hardman, Jan de Hoon, Yves Donazzolo, Sylvie Rottey, Hildegard Sourgens, Steffan Stringer

Source: Frontiers in Pharmacology, Vol 10 (2019)

Subject Terms: early phase clinical drug development, revised first-in-human guideline, conference report, EMA (European Medicines Agency), guidelines, EUFEMED, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fphar.2019.00398/full; https://doaj.org/toc/1663-9812

Access URL: https://doaj.org/article/b23e4873d6a34cf49989b280af3ddd46

EUFEMED London Conference 2017: Exploratory Medicines Development: Innovation and Risk Management

Authors: Luc Van Bortel, Hildegard Sourgens, Kerstin Breithaupt-Grögler, Henri Caplain, Yves Donazzolo, Ingrid Klingmann, Michael Hammond, Timothy C. Hardman, Steffan Stringer, Jan de Hoon

Source: Frontiers in Pharmacology, Vol 8 (2018)

Subject Terms: early phase clinical drug development, innovation in drug development, risk mitigation, conference report, the EUropean Federation for Exploratory MEdicines Development (EUFEMED), Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: http://journal.frontiersin.org/article/10.3389/fphar.2017.00901/full; https://doaj.org/toc/1663-9812

Access URL: https://doaj.org/article/e8d56503f6a649c0a713009e2c78b9b5

Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of the CGRP Binding Monoclonal Antibody LY2951742 (Galcanezumab) in Healthy Volunteers

Authors: David Monteith, Emily C. Collins, Corinne Vandermeulen, Anne Van Hecken, Eyas Raddad, Joel C. Scherer, David Grayzel, Thomas J. Schuetz, Jan de Hoon

Source: Frontiers in Pharmacology, Vol 8 (2017)

Subject Terms: CGRP, dermal blood flow, humanized monoclonal antibody, headache, migraine disorders, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: http://journal.frontiersin.org/article/10.3389/fphar.2017.00740/full; https://doaj.org/toc/1663-9812

Access URL: https://doaj.org/article/575cfbd32890489aa7734d36b48339e5

Renal Side Effects of Non-Steroidal Anti-Inflammatory Drugs in Neonates

Authors: Marc Gewillig, Anne Debeer, Jan de Hoon, Karel Allegaert

Source: Pharmaceuticals, Vol 3, Iss 2, Pp 393-405 (2010)

Subject Terms: non-steroidal anti-inflammatory drugs, renal side effects, quantification, Medicine, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: http://www.mdpi.com/1424-8247/3/2/393/; https://doaj.org/toc/1424-8247

Access URL: https://doaj.org/article/a5ff093682794effb71514ecd17fec8c

Effective analgesia after cesarean delivery needs pharmacokinetic input

Authors: Aida Kulo, Jan de Hoon, Nedzad Mulabegovic, Karel Allegaert

Source: Journal of Anaesthesiology Clinical Pharmacology, Vol 28, Iss 3, Pp 409-410 (2012)

Subject Terms: Anesthesiology, RD78.3-87.3, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: http://www.joacp.org/article.asp?issn=0970-9185;year=2012;volume=28;issue=3;spage=409;epage=410;aulast=Kulo; https://doaj.org/toc/0970-9185

Access URL: https://doaj.org/article/ea233b5f0a6f494496526e6243b17b3b

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