Individual bioenergetic capacity as a potential source of resilience to Alzheimer’s disease

Authors: Matthias Arnold, Mustafa Buyukozkan, P. Murali Doraiswamy, Kwangsik Nho, Tong Wu, Vilmundur Gudnason, Lenore J. Launer, Rui Wang-Sattler, Jerzy Adamski, The Alzheimer’s Disease Neuroimaging Initiative, Alzheimer’s Disease Metabolomics Consortium, Philip L. De Jager, Nilüfer Ertekin-Taner, David A. Bennett, Andrew J. Saykin, Annette Peters, Karsten Suhre, Rima Kaddurah-Daouk, Gabi Kastenmüller, Jan Krumsiek

Source: Nature Communications, Vol 16, Iss 1, Pp 1-15 (2025)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/193737912505468d849ea8fa121a4645

Consuming a modified Mediterranean ketogenic diet reverses the peripheral lipid signature of Alzheimer’s disease in humans

Authors: Bryan J. Neth, Kevin Huynh, Corey Giles, Tingting Wang, Natalie A. Mellett, Thy Duong, Colette Blach, Leyla Schimmel, Thomas C. Register, Kaj Blennow, Henrik Zetterberg, Richa Batra, Annalise Schweickart, Amanda Hazel Dilmore, Cameron Martino, Matthias Arnold, Jan Krumsiek, Xianlin Han, Pieter C. Dorrestein, Rob Knight, Peter J. Meikle, Suzanne Craft, Rima Kaddurah-Daouk

Source: Communications Medicine, Vol 5, Iss 1, Pp 1-15 (2025)

Subject Terms: Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/2730-664X

Access URL: https://doaj.org/article/1d683ff91c3b4ab8869f7b492b29745e

AutoFocus: a hierarchical framework to explore multi-omic disease associations spanning multiple scales of biomolecular interaction

Authors: Annalise Schweickart, Kelsey Chetnik, Richa Batra, Rima Kaddurah-Daouk, Karsten Suhre, Anna Halama, Jan Krumsiek

Source: Communications Biology, Vol 7, Iss 1, Pp 1-14 (2024)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/2399-3642

Access URL: https://doaj.org/article/cec5ef3672b344ce946b9619b1219d95

A roadmap to the molecular human linking multiomics with population traits and diabetes subtypes

Authors: Anna Halama, Shaza Zaghlool, Gaurav Thareja, Sara Kader, Wadha Al Muftah, Marjonneke Mook-Kanamori, Hina Sarwath, Yasmin Ali Mohamoud, Nisha Stephan, Sabine Ameling, Maja Pucic Baković, Jan Krumsiek, Cornelia Prehn, Jerzy Adamski, Jochen M. Schwenk, Nele Friedrich, Uwe Völker, Manfred Wuhrer, Gordan Lauc, S. Hani Najafi-Shoushtari, Joel A. Malek, Johannes Graumann, Dennis Mook-Kanamori, Frank Schmidt, Karsten Suhre

Source: Nature Communications, Vol 15, Iss 1, Pp 1-23 (2024)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/711d016111244d3c97a32572e4aba254

Bidirectional modulation of TCA cycle metabolites and anaplerosis by metformin and its combination with SGLT2i

Authors: Makoto Harada, Jonathan Adam, Marcela Covic, Jianhong Ge, Stefan Brandmaier, Caroline Muschet, Jialing Huang, Siyu Han, Martina Rommel, Markus Rotter, Margit Heier, Robert P. Mohney, Jan Krumsiek, Gabi Kastenmüller, Wolfgang Rathmann, Zhongmei Zou, Sven Zukunft, Markus F. Scheerer, Susanne Neschen, Jerzy Adamski, Christian Gieger, Annette Peters, Donna P. Ankerst, Thomas Meitinger, Tanya L. Alderete, Martin Hrabe de Angelis, Karsten Suhre, Rui Wang-Sattler

Source: Cardiovascular Diabetology, Vol 23, Iss 1, Pp 1-14 (2024)

Subject Terms: Pharmacometabolomics, Metformin, SGLT2 inhibitors, TCA cycle, Anaplerosis, Anti-inflammatory effects, Diseases of the circulatory (Cardiovascular) system, RC666-701

File Description: electronic resource

Relation: https://doaj.org/toc/1475-2840

Access URL: https://doaj.org/article/5843fb532be04b438b4aad8078618b3c

Secretome profiling reveals acute changes in oxidative stress, brain homeostasis, and coagulation following short-duration spaceflight

Authors: Nadia Houerbi, JangKeun Kim, Eliah G. Overbey, Richa Batra, Annalise Schweickart, Laura Patras, Serena Lucotti, Krista A. Ryon, Deena Najjar, Cem Meydan, Namita Damle, Christopher Chin, S. Anand Narayanan, Joseph W. Guarnieri, Gabrielle Widjaja, Afshin Beheshti, Gabriel Tobias, Fanny Vatter, Jeremy Wain Hirschberg, Ashley Kleinman, Evan E. Afshin, Matthew MacKay, Qiuying Chen, Dawson Miller, Aaron S. Gajadhar, Lucy Williamson, Purvi Tandel, Qiu Yang, Jessica Chu, Ryan Benz, Asim Siddiqui, Daniel Hornburg, Steven Gross, Bader Shirah, Jan Krumsiek, Jaime Mateus, Xiao Mao, Irina Matei, Christopher E. Mason

Source: Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/247c896f001a435c9ecc55bb10c04051

A Comprehensive Metabolomic and Microbial Analysis Following Dietary Amino Acid Reduction in Mice

Authors: Raghad Khalid Al-Ishaq, Carmen R. Ferrara, Nisha Stephan, Jan Krumsiek, Karsten Suhre, David C. Montrose

Source: Metabolites, Vol 14, Iss 12, p 706 (2024)

Subject Terms: metabolomics, diet, protein, bacteria, 16S, nutrition, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.mdpi.com/2218-1989/14/12/706; https://doaj.org/toc/2218-1989

Access URL: https://doaj.org/article/d6b23054b48444d3b06156c28f5108a6

Plasma metabolomics profiling of 580 patients from an Early Detection Research Network prostate cancer cohort

Authors: Elisa Benedetti, Kelsey Chetnik, Thomas Flynn, Christopher E. Barbieri, Douglas S. Scherr, Massimo Loda, Jan Krumsiek

Source: Scientific Data, Vol 10, Iss 1, Pp 1-8 (2023)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2052-4463

Access URL: https://doaj.org/article/d0a20e13995d4a0ca46dac4e068bf0ec

Urine-based multi-omic comparative analysis of COVID-19 and bacterial sepsis-induced ARDS

Authors: Richa Batra, Rie Uni, Oleh M. Akchurin, Sergio Alvarez-Mulett, Luis G. Gómez-Escobar, Edwin Patino, Katherine L. Hoffman, Will Simmons, William Whalen, Kelsey Chetnik, Mustafa Buyukozkan, Elisa Benedetti, Karsten Suhre, Edward Schenck, Soo Jung Cho, Augustine M. K. Choi, Frank Schmidt, Mary E. Choi, Jan Krumsiek

Source: Molecular Medicine, Vol 29, Iss 1, Pp 1-10 (2023)

Subject Terms: COVID-19, Acute respiratory distress syndrome (ARDS), Multi-omic, Mortality signature, Network-based, Computational analysis, Therapeutics. Pharmacology, RM1-950, Biochemistry, QD415-436

File Description: electronic resource

Relation: https://doaj.org/toc/1528-3658

Access URL: https://doaj.org/article/73b7e4f3cafd424db0c9cb48062b9e13

Variational autoencoders learn transferrable representations of metabolomics data

Authors: Daniel P. Gomari, Annalise Schweickart, Leandro Cerchietti, Elisabeth Paietta, Hugo Fernandez, Hassen Al-Amin, Karsten Suhre, Jan Krumsiek

Source: Communications Biology, Vol 5, Iss 1, Pp 1-9 (2022)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/2399-3642

Access URL: https://doaj.org/article/3961c9d5fe67404480bd95c5c6999ff4

Multi-omic comparative analysis of COVID-19 and bacterial sepsis-induced ARDS

Authors: Richa Batra, William Whalen, Sergio Alvarez-Mulett, Luis G. Gomez-Escobar, Katherine L. Hoffman, Will Simmons, John Harrington, Kelsey Chetnik, Mustafa Buyukozkan, Elisa Benedetti, Mary E. Choi, Karsten Suhre, Edward Schenck, Augustine M. K. Choi, Frank Schmidt, Soo Jung Cho, Jan Krumsiek

Source: PLoS Pathogens, Vol 18, Iss 9 (2022)

Subject Terms: Immunologic diseases. Allergy, RC581-607, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9484674/?tool=EBI; https://doaj.org/toc/1553-7366; https://doaj.org/toc/1553-7374

Access URL: https://doaj.org/article/045db0b9a19544b4881ea62a59729541

Integrative metabolomic and proteomic signatures define clinical outcomes in severe COVID-19

Authors: Mustafa Buyukozkan, Sergio Alvarez-Mulett, Alexandra C. Racanelli, Frank Schmidt, Richa Batra, Katherine L. Hoffman, Hina Sarwath, Rudolf Engelke, Luis Gomez-Escobar, Will Simmons, Elisa Benedetti, Kelsey Chetnik, Guoan Zhang, Edward Schenck, Karsten Suhre, Justin J. Choi, Zhen Zhao, Sabrina Racine-Brzostek, He S. Yang, Mary E. Choi, Augustine M.K. Choi, Soo Jung Cho, Jan Krumsiek

Source: iScience, Vol 25, Iss 7, Pp 104612- (2022)

Subject Terms: Biological sciences, Clinical finding, Human metabolism, Medicine, Physiology, Science

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2589004222008847; https://doaj.org/toc/2589-0042

Access URL: https://doaj.org/article/a62f77fb3df5497ebf2ec8150d80ce78

A strategy to incorporate prior knowledge into correlation network cutoff selection

Authors: Elisa Benedetti, Maja Pučić-Baković, Toma Keser, Nathalie Gerstner, Mustafa Büyüközkan, Tamara Štambuk, Maurice H. J. Selman, Igor Rudan, Ozren Polašek, Caroline Hayward, Hassen Al-Amin, Karsten Suhre, Gabi Kastenmüller, Gordan Lauc, Jan Krumsiek

Source: Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/010a6cf3af164aa7978eb3f55d61f7d7

Identification of Robust Protein Associations With COVID-19 Disease Based on Five Clinical Studies

Authors: Karsten Suhre, Hina Sarwath, Rudolf Engelke, Muhammad Umar Sohail, Soo Jung Cho, William Whalen, Sergio Alvarez-Mulett, Jan Krumsiek, Augustine M. K. Choi, Frank Schmidt

Source: Frontiers in Immunology, Vol 12 (2022)

Subject Terms: COVID-19, Olink proteomics, inflammation and cardiovascular markers, cytokine storm syndrome, CCL16, CXCL10, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2021.781100/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/4225c005d4cc4dfe8655d4d9aa57ed52

Metabolic and Immune Markers for Precise Monitoring of COVID-19 Severity and Treatment

Authors: André F. Rendeiro, Charles Kyriakos Vorkas, Jan Krumsiek, Harjot K. Singh, Shashi N. Kapadia, Luca Vincenzo Cappelli, Maria Teresa Cacciapuoti, Giorgio Inghirami, Olivier Elemento, Mirella Salvatore

Source: Frontiers in Immunology, Vol 12 (2022)

Subject Terms: COVID-19, metabolism, immunology, infection biology, precision medicine, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2021.809937/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/f84a3d4b49de41628b6a7ebc565b5ab1

rox: A Statistical Model for Regression with Missing Values

Authors: Mustafa Buyukozkan, Elisa Benedetti, Jan Krumsiek

Source: Metabolites, Vol 13, Iss 1, p 127 (2023)

Subject Terms: missing values, regression analysis, limit-of-detection, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.mdpi.com/2218-1989/13/1/127; https://doaj.org/toc/2218-1989

Access URL: https://doaj.org/article/01a23bdacd264387bb8f7ac2c1695bf7

Sex and APOE ε4 genotype modify the Alzheimer’s disease serum metabolome

Authors: Matthias Arnold, Kwangsik Nho, Alexandra Kueider-Paisley, Tyler Massaro, Kevin Huynh, Barbara Brauner, Siamak MahmoudianDehkordi, Gregory Louie, M. Arthur Moseley, J. Will Thompson, Lisa St John-Williams, Jessica D. Tenenbaum, Colette Blach, Rui Chang, Roberta D. Brinton, Rebecca Baillie, Xianlin Han, John Q. Trojanowski, Leslie M. Shaw, Ralph Martins, Michael W. Weiner, Eugenia Trushina, Jon B. Toledo, Peter J. Meikle, David A. Bennett, Jan Krumsiek, P. Murali Doraiswamy, Andrew J. Saykin, Rima Kaddurah-Daouk, Gabi Kastenmüller

Source: Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/4622f4afa16f4c509372906b7b40a13c

The gut microbiota promotes hepatic fatty acid desaturation and elongation in mice

Authors: Alida Kindt, Gerhard Liebisch, Thomas Clavel, Dirk Haller, Gabriele Hörmannsperger, Hongsup Yoon, Daniela Kolmeder, Alexander Sigruener, Sabrina Krautbauer, Claudine Seeliger, Alexandra Ganzha, Sabine Schweizer, Rosalie Morisset, Till Strowig, Hannelore Daniel, Dominic Helm, Bernhard Küster, Jan Krumsiek, Josef Ecker

Source: Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/5e32139272c34b6ea782afa0b254afc8

Metabolomic Profiling Reveals Cellular Reprogramming of B-Cell Lymphoma by a Lysine Deacetylase Inhibitor through the Choline Pathway

Authors: Benet Pera, Jan Krumsiek, Sarit E. Assouline, Rossella Marullo, Jayeshkumar Patel, Jude M. Phillip, Lidia Román, Koren K. Mann, Leandro Cerchietti

Source: EBioMedicine, Vol 28, Iss C, Pp 80-89 (2018)

Subject Terms: DLBCL, Metabolomics, Panobinostat, Choline pathway, PI3K, Medicine, Medicine (General), R5-920

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352396418300185; https://doaj.org/toc/2352-3964

Access URL: https://doaj.org/article/70c266c93da24d23921073b49e235d89

Network inference from glycoproteomics data reveals new reactions in the IgG glycosylation pathway

Authors: Elisa Benedetti, Maja Pučić-Baković, Toma Keser, Annika Wahl, Antti Hassinen, Jeong-Yeh Yang, Lin Liu, Irena Trbojević-Akmačić, Genadij Razdorov, Jerko Štambuk, Lucija Klarić, Ivo Ugrina, Maurice H. J. Selman, Manfred Wuhrer, Igor Rudan, Ozren Polasek, Caroline Hayward, Harald Grallert, Konstantin Strauch, Annette Peters, Thomas Meitinger, Christian Gieger, Marija Vilaj, Geert-Jan Boons, Kelley W. Moremen, Tatiana Ovchinnikova, Nicolai Bovin, Sakari Kellokumpu, Fabian J. Theis, Gordan Lauc, Jan Krumsiek

Source: Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/11aecacd968d49ca905c6b1672c3015d