Identifying long-term survivors and those at higher or lower risk of relapse among patients with cytogenetically normal acute myeloid leukemia using a high-dimensional mixture cure model

Authors: Kellie J. Archer, Han Fu, Krzysztof Mrózek, Deedra Nicolet, Alice S. Mims, Geoffrey L. Uy, Wendy Stock, John C. Byrd, Wolfgang Hiddemann, Jan Braess, Karsten Spiekermann, Klaus H. Metzeler, Tobias Herold, Ann-Kathrin Eisfeld

Source: Journal of Hematology & Oncology, Vol 17, Iss 1, Pp 1-5 (2024)

Subject Terms: Prognostic classification, Penalized survival model, Regularized survival model, Least absolute shrinkage and selection operator, LASSO, Cox proportional hazards, Diseases of the blood and blood-forming organs, RC633-647.5, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1756-8722

Access URL: https://doaj.org/article/8f315fed381640c280c37db73db5c758

How accurate is clinical prognostication by oncologists during routine practice in a general hospital and can it be improved by a specific prognosis training programme: a prospective interventional study

Authors: Jan Braess, Alexander Crispin, Irma Kupf, Gabriele Thanner, Michael Gerken

Source: BMJ Open, Vol 14, Iss 6 (2024)

Subject Terms: Medicine

File Description: electronic resource

Relation: https://bmjopen.bmj.com/content/14/6/e081661.full; https://doaj.org/toc/2044-6055

Access URL: https://doaj.org/article/515ba3e389ac4c84ade76e7bb914bbea

Unsupervised meta-clustering identifies risk clusters in acute myeloid leukemia based on clinical and genetic profiles

Authors: Jan-Niklas Eckardt, Christoph Röllig, Klaus Metzeler, Peter Heisig, Sebastian Stasik, Julia-Annabell Georgi, Frank Kroschinsky, Friedrich Stölzel, Uwe Platzbecker, Karsten Spiekermann, Utz Krug, Jan Braess, Dennis Görlich, Cristina Sauerland, Bernhard Woermann, Tobias Herold, Wolfgang Hiddemann, Carsten Müller-Tidow, Hubert Serve, Claudia D. Baldus, Kerstin Schäfer-Eckart, Martin Kaufmann, Stefan W. Krause, Mathias Hänel, Wolfgang E. Berdel, Christoph Schliemann, Jiri Mayer, Maher Hanoun, Johannes Schetelig, Karsten Wendt, Martin Bornhäuser, Christian Thiede, Jan Moritz Middeke

Source: Communications Medicine, Vol 3, Iss 1, Pp 1-13 (2023)

Subject Terms: Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/2730-664X

Access URL: https://doaj.org/article/c4960d518e3d43029bd21cdce38e327f

P457: COMPLEX CARYOTYPE IS AN INDEPENDENT RISK FACTOR IN TP53-MUTATED AML

Authors: Christian Rausch, Maja Rothenberg-Thurley, Annika Dufour, Stephanie Schneider, Hanna Gittinger, Cristina Sauerland, Dennis Görlich, Utz Krug, Wolfgang E. Berdel, Bernhard E. Woermann, Wolfgang Hiddemann, Jan Braess, Michael von Bergwelt-Baildon, Karsten Spiekermann, Tobias Herold, Klaus H. Metzeler

Source: HemaSphere, Vol 7, p e0144445 (2023)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: http://journals.lww.com/10.1097/01.HS9.0000968736.01444.45; https://doaj.org/toc/2572-9241

Access URL: https://doaj.org/article/e4dbd3e4e52a47faa8af78cf7055a5e7

P446: COMPREHENSIVE CHARACTERIZATION OF DIFFERENTIAL GENE EXPRESSION AND ISOFORM USAGE IN SPLICING FACTOR-MUTATED ACUTE MYELOID LEUKEMIA USING LONG-READ SEQUENCING

Authors: Susanne Thieme, Alexander Graf, Stefan Krebs, Helmut Blum, Maria Solovey, Frank Ziemann, Jonathan Christ, Maja Rothenberg-Thurley, Annika Dufour, Stephanie Schneider, Maria Cristina Sauerland, Dennis Görlich, Utz Krug, Wolfgang E. Berdel, Bernhard Wörmann, Wolfgang Hiddemann, Jan Braess, Karsten Spiekermann, Klaus Metzeler, Ulrich Mannsmann, Tobias Herold

Source: HemaSphere, Vol 7, p e03586b2 (2023)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: http://journals.lww.com/10.1097/01.HS9.0000968692.03586.b2; https://doaj.org/toc/2572-9241

Access URL: https://doaj.org/article/72e658958a7b40f982f779afcdea8308

P434: MYELODYSPLASIA-RELATED MUTATIONS IN THE NEW ELN CLASSIFICATION: DOES CLONAL SIZE PLAY A ROLE?

Authors: Christian Rausch, Maja Rothenberg-Thurley, Annika Dufour, Stephanie Schneider, Hanna Gittinger, Cristina Sauerland, Dennis Görlich, Utz Krug, Wolfgang E. Berdel, Bernhard J. Woermann, Wolfgang Hiddemann, Jan Braess, Michael von Bergwelt-Baildon, Karsten Spiekermann, Tobias Herold, Klaus H. Metzeler

Source: HemaSphere, Vol 7, p e6798588 (2023)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: http://journals.lww.com/10.1097/01.HS9.0000968644.67985.88; https://doaj.org/toc/2572-9241

Access URL: https://doaj.org/article/aeabb7fd70fe4eb989ddd720b4227443

P1122: A PROSPECTIVE, NON-INTERVENTIONAL STUDY OF REAL-WORLD TREATMENT AND OUTCOME IN SECONDARY CNS LYMPHOMA

Authors: Stefan Habringer, Uta Demel, Anne-Katrin Fietz, Felicitas Lammer, Roland Schroers, Silvia Hofer, Osnat Bairey, Jan Braess, Anna Sofia Meier-Stiegen, Reingard Stuhlmann, Martin Schmidt-Hieber, Johannes Hoffmann, Bettina Zinngrebe, Ulrich Kaiser, Peter Reimer, Robert Möhle, Peter Fix, Heinz-Gert Höffkes, Ulrich Langenkamp, Christian Meyer Zum Büschenfelde, Olaf Hopfer, Andrea Stoltefuß, Paul La Rosée, Henning Blasberg, Karin Jordan, Stephan Kaun, Meike Unteroberdörster, Ann-Christin von Brünneck, David Capper, Frank L. Heppner, Björn Chapuy, Martin Janz, Stefan Schwartz, Frank Konietschke, Peter Vajkoczy, Agnieszka Korfel, Ulrich Keller

Source: HemaSphere, Vol 7, p e23520df (2023)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: http://journals.lww.com/10.1097/01.HS9.0000971384.23520.df; https://doaj.org/toc/2572-9241

Access URL: https://doaj.org/article/d67d23a0e17241f095d53631b5f4bf8c

Impact of IDH1 and IDH2 mutational subgroups in AML patients after allogeneic stem cell transplantation

Authors: Desiree Kunadt, Sebastian Stasik, Klaus H. Metzeler, Christoph Röllig, Christoph Schliemann, Philipp A. Greif, Karsten Spiekermann, Maja Rothenberg-Thurley, Utz Krug, Jan Braess, Alwin Krämer, Andreas Hochhaus, Sebastian Scholl, Inken Hilgendorf, Tim H. Brümmendorf, Edgar Jost, Björn Steffen, Gesine Bug, Hermann Einsele, Dennis Görlich, Cristina Sauerland, Kerstin Schäfer-Eckart, Stefan W. Krause, Mathias Hänel, Maher Hanoun, Martin Kaufmann, Bernhard Wörmann, Michael Kramer, Katja Sockel, Katharina Egger-Heidrich, Tobias Herold, Gerhard Ehninger, Andreas Burchert, Uwe Platzbecker, Wolfgang E. Berdel, Carsten Müller-Tidow, Wolfgang Hiddemann, Hubert Serve, Matthias Stelljes, Claudia D. Baldus, Andreas Neubauer, Johannes Schetelig, Christian Thiede, Martin Bornhäuser, Jan M. Middeke, Friedrich Stölzel, the A. M. L. Cooperative Group (AMLCG), Study Alliance Leukemia (SAL)

Source: Journal of Hematology & Oncology, Vol 15, Iss 1, Pp 1-15 (2022)

Subject Terms: Acute myeloid leukemia, IDH mutations, Allogeneic hematopoietic cell transplantation, Diseases of the blood and blood-forming organs, RC633-647.5, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1756-8722

Access URL: https://doaj.org/article/1665eacc6b1a46028a7f2723eae46d4a

Indurated erythema of abdominal skin: An unusual presentation of metastatic endometrial carcinoma—Case report with literature review

Authors: Dennis Niebel, Paula Kranert, Mark Berneburg, Konstantin Drexler, Maria Isabel vonEichborn, Jan Braess, Michael Allgäuer, Sigrid Karrer

Source: Skin Health and Disease, Vol 3, Iss 2, Pp n/a-n/a (2023)

Subject Terms: Dermatology, RL1-803

File Description: electronic resource

Relation: https://doaj.org/toc/2690-442X

Access URL: https://doaj.org/article/1c1fcc0a611e4e78a24c207b48959a62

Prediction of complete remission and survival in acute myeloid leukemia using supervised machine learning

Authors: Jan-Niklas Eckardt, Christoph Röllig, Klaus Metzeler, Michael Kramer, Sebastian Stasik, Julia-Annabell Georgi, Peter Heisig, Karsten Spiekermann, Utz Krug, Jan Braess, Dennis Görlich, Cristina M. Sauerland, Bernhard Woermann, Tobias Herold, Wolfgang E. Berdel, Wolfgang Hiddemann, Frank Kroschinsky, Johannes Schetelig, Uwe Platzbecker, Carsten Müller-Tidow, Tim Sauer, Hubert Serve, Claudia Baldus, Kerstin Schäfer-Eckart, Martin Kaufmann, Stefan Krause, Mathias Hänel, Christoph Schliemann, Maher Hanoun, Christian Thiede, Martin Bornhäuser, Karsten Wendt, Jan Moritz Middeke

Source: Haematologica, Vol 108, Iss 3 (2022)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://haematologica.org/article/view/10678; https://doaj.org/toc/0390-6078; https://doaj.org/toc/1592-8721

Access URL: https://doaj.org/article/1a08167ea2bf4756b3b1d34012b7dc50

Clinical and molecular relevance of genetic variants in the non-coding transcriptome of patients with cytogenetically normal acute myeloid leukemia

Authors: Dimitrios Papaioannou, Hatice G. Ozer, Deedra Nicolet, Amog P. Urs, Tobias Herold, Krzysztof Mrózek, Aarif M.N. Batcha, Klaus H. Metzeler, Ayse S. Yilmaz, Stefano Volinia, Marius Bill, Jessica Kohlschmidt, Maciej Pietrzak, Christopher J. Walker, Andrew J. Carroll, Jan Braess, Bayard L. Powell, Ann-Kathrin Eisfeld, Geoffrey L. Uy, Eunice S. Wang, Jonathan E. Kolitz, Richard M. Stone, Wolfgang Hiddemann, John C. Byrd, Clara D. Bloomfield, Ramiro Garzon

Source: Haematologica, Vol 107, Iss 5 (2021)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://haematologica.org/article/view/10331; https://doaj.org/toc/0390-6078; https://doaj.org/toc/1592-8721

Access URL: https://doaj.org/article/7f9bf447eead48ccb2195be68f8f7b08

Community-driven development of a modified progression-free survival ratio for precision oncology

Authors: Sebastian Schölch, Benedikt Brors, Albrecht Stenzinger, Ursula Ehmer, Ulrich-Frank Pape, Christoph Springfeld, Dirk Jäger, Felix J Hüttner, Andreas Mock, Christoph E Heilig, Simon Kreutzfeldt, Daniel Huebschmann, Christoph Heining, Evelin Schröck, Richard Schlenk, Hanno Glimm, Stefan Fröhling, Peter Horak, Leonidas Apostolidis, Marinela Augustin, Daniela Aust, Irfan Ahmed Bhatti, Johannes Bloehdorn, Cornelia Brendel, Christian Britschgi, Jan Braess, Stefan Burdach, Elena Busch, Jozefina Casuscelli, Alexander Desuki, Thomas Deutsch, Mareike Dietrich, Thomas J Ettrich, Johanna Falkenhorst, Tanja Fehm, Anne Flörcken, Andrea Forschner, Stefan Fuxius, Maria Gonzales-Carmona, Frank Griesinger, Sabine Grill, Stefan Gröschel, Georg Martin Haag, Ulrich Haag, Niels Halama, Holger Hebart, Nina Heidger, Barbara Hermes, Georg Hess, Simone Hettmer, Manuela Hoechstetter, Martin Hoffmann, Anna L Illert, Maximilian Jenzer, Bernd Kasper, Stefan Kasper-Virchow, Thomas Kindler, Ewa Koscielniak, Jan Krönke, Michael Kühn, Volker Kunzmann, Alois Lang, Jonas Leichsenring, Elisabeth Livingstone, Lucia Liotta, Kim Luley, Elisabeth Mack, Uwe M Martens, Klaus Metzeler, Jan Moritz Middeke, Lino Möhrmann, Roopa Jayarama-Naidu, Lukas Perkhofer, Arne Pfeufer, Constantin Pixberg, Michael Quante, Bernhard Rendenbach, Damian Rieke, Christian Rothermundt, Andre Norbert Sagerer, Martin Salzmann, Dieter Saur, Bastian Schilling, Jan Schleicher, Anke Schlenska-Lange, Thomas Schmidt, Sophia Schmitz, Rajiv Shah, Khalid Shoumariyeh, Alexander Siebenhüner, Martin Singh, Jens Siveke, Helen Starke, Sophia Strobel, Veronica Teleanu, Niklas Thon, Sebastian Wagner, Thomas Walle, Benedikt Westphalen, Bettina Whitlock, Eva Winkler, Naita Maren Wirsik, Lena Woydack, Angelika Zabel-du Bois, Stefanie Zschäbitz

Source: ESMO Open, Vol 4, Iss 6 (2019)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://esmoopen.bmj.com/content/4/6/e000583.full; https://doaj.org/toc/2059-7029

Access URL: https://doaj.org/article/0122f1ac148444cbaeb951db5af876a5

ZBTB7A mutations in acute myeloid leukaemia with t(8;21) translocation

Authors: Luise Hartmann, Sayantanee Dutta, Sabrina Opatz, Sebastian Vosberg, Katrin Reiter, Georg Leubolt, Klaus H. Metzeler, Tobias Herold, Stefanos A. Bamopoulos, Kathrin Bräundl, Evelyn Zellmeier, Bianka Ksienzyk, Nikola P. Konstandin, Stephanie Schneider, Karl-Peter Hopfner, Alexander Graf, Stefan Krebs, Helmut Blum, Jan Moritz Middeke, Friedrich Stölzel, Christian Thiede, Stephan Wolf, Stefan K. Bohlander, Caroline Preiss, Linping Chen-Wichmann, Christian Wichmann, Maria Cristina Sauerland, Thomas Büchner, Wolfgang E. Berdel, Bernhard J. Wörmann, Jan Braess, Wolfgang Hiddemann, Karsten Spiekermann, Philipp A. Greif

Source: Nature Communications, Vol 7, Iss 1, Pp 1-7 (2016)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/34dfb0d723444cba95f2984a6162b8c6

Genetics of acute myeloid leukemia in the elderly: mutation spectrum and clinical impact in intensively treated patients aged 75 years or older

Authors: Victoria V. Prassek, Maja Rothenberg-Thurley, Maria C. Sauerland, Tobias Herold, Hanna Janke, Bianka Ksienzyk, Nikola P. Konstandin, Dennis Goerlich, Utz Krug, Andreas Faldum, Wolfgang E. Berdel, Bernhard Wörmann, Jan Braess, Stephanie Schneider, Marion Subklewe, Stefan K. Bohlander, Wolfgang Hiddemann, Karsten Spiekermann, Klaus H. Metzeler

Source: Haematologica, Vol 103, Iss 11 (2018)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://haematologica.org/article/view/8663; https://doaj.org/toc/0390-6078; https://doaj.org/toc/1592-8721

Access URL: https://doaj.org/article/7feeda87d24b4382806c53940e31c3a4

A 29-gene and cytogenetic score for the prediction of resistance to induction treatment in acute myeloid leukemia

Authors: Tobias Herold, Vindi Jurinovic, Aarif M. N. Batcha, Stefanos A. Bamopoulos, Maja Rothenberg-Thurley, Bianka Ksienzyk, Luise Hartmann, Philipp A. Greif, Julia Phillippou-Massier, Stefan Krebs, Helmut Blum, Susanne Amler, Stephanie Schneider, Nikola Konstandin, Maria Cristina Sauerland, Dennis Görlich, Wolfgang E. Berdel, Bernhard J. Wörmann, Johanna Tischer, Marion Subklewe, Stefan K. Bohlander, Jan Braess, Wolfgang Hiddemann, Klaus H. Metzeler, Ulrich Mansmann, Karsten Spiekermann

Source: Haematologica, Vol 103, Iss 3 (2018)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://haematologica.org/article/view/8383; https://doaj.org/toc/0390-6078; https://doaj.org/toc/1592-8721

Access URL: https://doaj.org/article/956fa59394534fb582a2e57fcf9044da

Correction: Patients with Acute Myeloid Leukemia Admitted to Intensive Care Units: Outcome Analysis and Risk Prediction.

Authors: Michele Pohlen, Nils H Thoennissen, Jan Braess, Johannes Thudium, Christoph Schmid, Matthias Kochanek, Karl-Anton Kreuzer, Pia Lebiedz, Dennis Görlich, Hans U Gerth, Christian Rohde, Torsten Kessler, Carsten Müller-Tidow, Matthias Stelljes, Carsten Hullerman, Thomas Büchner, Günter Schlimok, Michael Hallek, Johannes Waltenberger, Wolfgang Hiddemann, Wolfgang E Berdel, Bernhard Heilmeier, Utz Krug

Source: PLoS ONE, Vol 13, Iss 1, p e0190802 (2018)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC5749855?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/9fcb6b44a1924af08f984f6692d3ab43

Patients with Acute Myeloid Leukemia Admitted to Intensive Care Units: Outcome Analysis and Risk Prediction.

Authors: Michele Pohlen, Nils H Thoennissen, Jan Braess, Johannes Thudium, Christoph Schmid, Matthias Kochanek, Karl-Anton Kreuzer, Pia Lebiedz, Dennis Görlich, Hans U Gerth, Christian Rohde, Torsten Kessler, Carsten Müller-Tidow, Matthias Stelljes, Carsten Hullermann, Thomas Büchner, Günter Schlimok, Michael Hallek, Johannes Waltenberger, Wolfgang Hiddemann, Wolfgang E Berdel, Bernhard Heilmeier, Utz Krug

Source: PLoS ONE, Vol 11, Iss 8, p e0160871 (2016)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC5004890?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/f8c82c56718a42398c00033cbc6529d6

Molecular response assessment by quantitative real-time polymerase chain reaction after induction therapy in NPM1-mutated patients identifies those at high risk of relapse

Authors: Max Hubmann, Thomas Köhnke, Eva Hoster, Stephanie Schneider, Annika Dufour, Evelyn Zellmeier, Michael Fiegl, Jan Braess, Stefan K. Bohlander, Marion Subklewe, Maria-Cristina Sauerland, Wolfgang E. Berdel, Thomas Büchner, Bernhard Wörmann, Wolfgang Hiddemann, Karsten Spiekermann

Source: Haematologica, Vol 99, Iss 8 (2014)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://haematologica.org/article/view/7111; https://doaj.org/toc/0390-6078; https://doaj.org/toc/1592-8721

Access URL: https://doaj.org/article/201c4346a69c45b491ad3984a46c0ffc

The NPM1 mutation type has no impact on survival in cytogenetically normal AML.

Authors: Friederike Pastore, Philipp A Greif, Stephanie Schneider, Bianka Ksienzyk, Gudrun Mellert, Evelyn Zellmeier, Jan Braess, Cristina M Sauerland, Achim Heinecke, Utz Krug, Wolfgang E Berdel, Thomas Buechner, Bernhard Woermann, Wolfgang Hiddemann, Karsten Spiekermann

Source: PLoS ONE, Vol 9, Iss 10, p e109759 (2014)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC4192029?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/72cac2ed796c4b849ad5045a6ac22024

Influence of molecular subgroups on outcome of acute myeloid leukemia with normal karyotype in 141 patients undergoing salvage allogeneic stem cell transplantation in primary induction failure or beyond first relapse

Authors: Tim Pfeiffer, Michael Schleuning, Jiri Mayer, Karl-Heinz Haude, Johanna Tischer, Stefanie Buchholz, Donald Bunjes, Gesine Bug, Ernst Holler, Ralf G. Meyer, Hildegard Greinix, Christof Scheid, Maximilian Christopeit, Susanne Schnittger, Jan Braess, Günter Schlimok, Karsten Spiekermann, Arnold Ganser, Hans-Jochem Kolb, Christoph Schmid

Source: Haematologica, Vol 98, Iss 4 (2013)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://haematologica.org/article/view/6617; https://doaj.org/toc/0390-6078; https://doaj.org/toc/1592-8721

Access URL: https://doaj.org/article/8b1f0386697848fcab9df7c98443f169