The DNA-based Lassa vaccine INO-4500 confers durable protective efficacy in cynomolgus macaques against lethal Lassa fever

Authors: Viviane M. Andrade, Kathleen Cashman, Kyle Rosenke, Eric Wilkinson, Nicole Josleyn, Ginger Lynn, Jesse Steffens, Sean Vantongeren, Jay Wells, Connie Schmaljohn, Paul Facemire, Jingjing Jiang, Jean Boyer, Aditya Patel, Friederike Feldmann, Patrick Hanley, Jamie Lovaglio, Kimberly White, Heinz Feldmann, Stephanie Ramos, Kate E. Broderick, Laurent M. Humeau, Trevor R. F. Smith

Source: Communications Medicine, Vol 4, Iss 1, Pp 1-14 (2024)

Subject Terms: Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/2730-664X

Access URL: https://doaj.org/article/db3fb6d49d26402a8130cf02b1e9ffb8

Jamaican fruit bat (Artibeus jamaicensis) insusceptibility to mucosal inoculation with SARS-CoV-2 Delta variant is not caused by receptor compatibility

Authors: Julia R. Port, Jade C. Riopelle, Sarah van Tol, Arthur Wickenhagen, Eric Bohrnsen, Daniel E. Sturdevant, Rebecca Rosenke, Jamie Lovaglio, Justin Lack, Sarah L. Anzick, Kathleen Cordova, Kwe Claude Yinda, Patrick W. Hanley, Tony Schountz, Lon V. Kendall, Carl I. Shaia, Greg Saturday, Craig Martens, Benjamin Schwarz, Vincent J. Munster

Source: npj Viruses, Vol 2, Iss 1, Pp 1-15 (2024)

Subject Terms: Infectious and parasitic diseases, RC109-216, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/2948-1767

Access URL: https://doaj.org/article/04082be39d684a2987f4130c09c16462

In vivo delivery of engineered synthetic DNA-encoded SARS-CoV-2 monoclonal antibodies for pre-exposure prophylaxis in non-human primates

Authors: Ami Patel, Kyle Rosenke, Elizabeth M. Parzych, Friederike Feldmann, Suman Bharti, Amanda J. Griffin, Blake Schouest, Matt Lewis, Jihae Choi, Neethu Chokkalingam, Viviane Machado, Brian J. Smith, Drew Frase, Ali R. Ali, Jamie Lovaglio, Brian Nguyen, Patrick W. Hanley, Susanne N. Walker, Ebony N. Gary, Abhijeet Kulkarni, Allison Generotti, Joseph R. Francica, Kim Rosenthal, Daniel W. Kulp, Mark T. Esser, Trevor R. F. Smith, Carl Shaia, David B. Weiner, Heinz Feldmann

Source: Emerging Microbes and Infections, Vol 13, Iss 1 (2024)

Subject Terms: SARS-CoV-2, monoclonal antibody, DNA, DNA-encoded monoclonal antibody, prevention, gene-encoded antibody, Infectious and parasitic diseases, RC109-216, Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/2222-1751

Access URL: https://doaj.org/article/b981edf4969f4fdb9843528b197ac517

A replicating RNA vaccine confers protection in a rhesus macaque model of Crimean-Congo hemorrhagic fever

Authors: David W. Hawman, Shanna S. Leventhal, Kimberly Meade-White, Amit Khandhar, Justin Murray, Jamie Lovaglio, Carl Shaia, Greg Saturday, Troy Hinkley, Jesse Erasmus, Heinz Feldmann

Source: npj Vaccines, Vol 9, Iss 1, Pp 1-9 (2024)

Subject Terms: Immunologic diseases. Allergy, RC581-607, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2059-0105

Access URL: https://doaj.org/article/ab14f955c4a64e3d9272d9bbe34d7b75

Sex differences and individual variability in the captive Jamaican fruit bat (Artibeus jamaicensis) intestinal microbiome and metabolome

Authors: Jade C. Riopelle, Amirhossein Shamsaddini, Myndi G. Holbrook, Eric Bohrnsen, Yue Zhang, Jamie Lovaglio, Kathleen Cordova, Patrick Hanley, Lon V. Kendall, Catharine M. Bosio, Tony Schountz, Benjamin Schwarz, Vincent J. Munster, Julia R. Port

Source: Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/3f00406f27a048499778d34600fe701a

ChAdOx1 NiV vaccination protects against lethal Nipah Bangladesh virus infection in African green monkeys

Authors: Neeltje van Doremalen, Victoria A. Avanzato, Kerry Goldin, Friederike Feldmann, Jonathan E. Schulz, Elaine Haddock, Atsushi Okumura, Jamie Lovaglio, Patrick W. Hanley, Kathleen Cordova, Greg Saturday, Emmie de Wit, Teresa Lambe, Sarah C. Gilbert, Vincent J. Munster

Source: npj Vaccines, Vol 7, Iss 1, Pp 1-8 (2022)

Subject Terms: Immunologic diseases. Allergy, RC581-607, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2059-0105

Access URL: https://doaj.org/article/83a42009c7d8459eafa1e723eb0e5001

Immunological correlates of protection afforded by PHV02 live, attenuated recombinant vesicular stomatitis virus vector vaccine against Nipah virus disease

Authors: Thomas P. Monath, Richard Nichols, Friederike Feldmann, Amanda Griffin, Elaine Haddock, Julie Callison, Kimberly Meade-White, Atsushi Okumura, Jamie Lovaglio, Patrick W. Hanley, Chad S. Clancy, Carl Shaia, Wasima Rida, Joan Fusco

Source: Frontiers in Immunology, Vol 14 (2023)

Subject Terms: Nipah virus, vaccine, recombinant VSV, immune correlate, neutralizing antibody, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2023.1216225/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/040301b818554706ad4fda037c526189

A replicon RNA vaccine can induce durable protective immunity from SARS-CoV-2 in nonhuman primates after neutralizing antibodies have waned.

Authors: Megan A O'Connor, David W Hawman, Kimberly Meade-White, Shanna Leventhal, Wenjun Song, Samantha Randall, Jacob Archer, Thomas B Lewis, Brieann Brown, Megan N Fredericks, Kaitlin R Sprouse, Hillary C Tunggal, Mara Maughan, Naoto Iwayama, Chul Ahrens, William Garrison, Solomon Wangari, Kathryn A Guerriero, Patrick Hanley, Jamie Lovaglio, Greg Saturday, David Veesler, Paul T Edlefsen, Amit P Khandhar, Heinz Feldmann, Deborah Heydenburg Fuller, Jesse H Erasmus

Source: PLoS Pathogens, Vol 19, Iss 4, p e1011298 (2023)

Subject Terms: Immunologic diseases. Allergy, RC581-607, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/1553-7366; https://doaj.org/toc/1553-7374

Access URL: https://doaj.org/article/d4af23eb43be40bcaa467db922cd5121

Combined molnupiravir-nirmatrelvir treatment improves the inhibitory effect on SARS-CoV-2 in macaques

Authors: Kyle Rosenke, Matt C. Lewis, Friederike Feldmann, Eric Bohrnsen, Benjamin Schwarz, Atsushi Okumura, W. Forrest Bohler, Julie Callison, Carl Shaia, Catharine M. Bosio, Jamie Lovaglio, Greg Saturday, Michael A. Jarvis, Heinz Feldmann

Source: JCI Insight, Vol 8, Iss 4 (2023)

Subject Terms: COVID-19, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/2379-3708

Access URL: https://doaj.org/article/8c4c6d11714643ca966ef175993be046

Distinct VSV-based Nipah virus vaccines expressing either glycoprotein G or fusion protein F provide homologous and heterologous protection in a nonhuman primate modelResearch in context

Authors: Emmie de Wit, Friederike Feldmann, Jacqueline Cronin, Kerry Goldin, Reinaldo Mercado-Hernandez, Brandi N. Williamson, Kimberly Meade-White, Atsushi Okumura, Julie Callison, Sarah Weatherman, Rebecca Rosenke, Victoria A. Avanzato, Jamie Lovaglio, Dana P. Scott, Andrea Marzi, Heinz Feldmann

Source: EBioMedicine, Vol 87, Iss , Pp 104405- (2023)

Subject Terms: Nipah virus, VSV-based vaccines, African green monkey, Vaccine efficacy, Heterologous protection, Medicine, Medicine (General), R5-920

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352396422005874; https://doaj.org/toc/2352-3964

Access URL: https://doaj.org/article/dfff7aaf39d542d6855906a23c3664cd

Severe acute respiratory disease in American mink experimentally infected with SARS-CoV-2

Authors: Danielle R. Adney, Jamie Lovaglio, Jonathan E. Schulz, Claude Kwe Yinda, Victoria A. Avanzato, Elaine Haddock, Julia R. Port, Myndi G. Holbrook, Patrick W. Hanley, Greg Saturday, Dana Scott, Carl Shaia, Andrew M. Nelson, Jessica R. Spengler, Cassandra Tansey, Caitlin M. Cossaboom, Natalie M. Wendling, Craig Martens, John Easley, Seng Wai Yap, Stephanie N. Seifert, Vincent J. Munster

Source: JCI Insight, Vol 7, Iss 22 (2022)

Subject Terms: COVID-19, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/2379-3708

Access URL: https://doaj.org/article/031af6abe49245eab4d9857ca6bed35e

UK B.1.1.7 (Alpha) variant exhibits increased respiratory replication and shedding in nonhuman primates

Authors: Kyle Rosenke, Friederike Feldmann, Atsushi Okumura, Frederick Hansen, Tsing-Lee Tang-Huau, Kimberly Meade-White, Benjamin Kaza, Julie Callison, Matthew C. Lewis, Brian J. Smith, Patrick W. Hanley, Jamie Lovaglio, Michael A. Jarvis, Carl Shaia, Heinz Feldmann

Source: Emerging Microbes and Infections, Vol 10, Iss 1, Pp 2173-2182 (2021)

Subject Terms: SARS-CoV-2, variants of concern (VOC), African green monkey, transmission, virulence, Infectious and parasitic diseases, RC109-216, Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/2222-1751

Access URL: https://doaj.org/article/8c4cfecdfb7f4ce6b472dcefa93fa95e

Toward Optimization of a Rabbit Model of Staphylococcus aureus (USA300) Skin and Soft Tissue Infection

Authors: Natalia Malachowa, Will McGuinness, Scott D. Kobayashi, Adeline R. Porter, Carl Shaia, Jamie Lovaglio, Brian Smith, Viktoria Rungelrath, Greg Saturday, Dana P. Scott, Fabiana Falugi, Dominique Missiakas, Olaf Schneewind, Frank R. DeLeo

Source: Microbiology Spectrum, Vol 10, Iss 2 (2022)

Subject Terms: rabbit, MRSA, USA300, abscess, recurrent infection, animal model, Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/2165-0497

Access URL: https://doaj.org/article/3bd61d6df61c4ce5a25836c22438198e

Rapid Protection from COVID-19 in Nonhuman Primates Vaccinated Intramuscularly but Not Intranasally with a Single Dose of a Vesicular Stomatitis Virus-Based Vaccine

Authors: Wakako Furuyama, Kyle Shifflett, Amanda N. Pinski, Amanda J. Griffin, Friederike Feldmann, Atsushi Okumura, Tylisha Gourdine, Allen Jankeel, Jamie Lovaglio, Patrick W. Hanley, Tina Thomas, Chad S. Clancy, Ilhem Messaoudi, Kyle L. O’Donnell, Andrea Marzi

Source: mBio, Vol 13, Iss 1 (2022)

Subject Terms: VSV, vesicular stomatitis virus, SARS-CoV-2, i.m., i.n., rhesus macaques, Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/2150-7511

Access URL: https://doaj.org/article/b1453d6466b74f36931bb1ccc3680e0a

A pigtailed macaque model of Kyasanur Forest disease virus and Alkhurma hemorrhagic disease virus pathogenesis.

Authors: Rebecca M Broeckel, Friederike Feldmann, Kristin L McNally, Abhilash I Chiramel, Gail L Sturdevant, Jacqueline M Leung, Patrick W Hanley, Jamie Lovaglio, Rebecca Rosenke, Dana P Scott, Greg Saturday, Fadila Bouamr, Angela L Rasmussen, Shelly J Robertson, Sonja M Best

Source: PLoS Pathogens, Vol 17, Iss 12, p e1009678 (2021)

Subject Terms: Immunologic diseases. Allergy, RC581-607, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/1553-7366; https://doaj.org/toc/1553-7374

Access URL: https://doaj.org/article/e75b0f0e8a774ab2b7bf41f32357fe43

Recovery from Acute SARS-CoV-2 Infection and Development of Anamnestic Immune Responses in T Cell-Depleted Rhesus Macaques

Authors: Kim J. Hasenkrug, Friederike Feldmann, Lara Myers, Mario L. Santiago, Kejun Guo, Bradley S. Barrett, Kaylee L. Mickens, Aaron Carmody, Atsushi Okumura, Deepashri Rao, Madison M. Collins, Ronald J. Messer, Jamie Lovaglio, Carl Shaia, Rebecca Rosenke, Neeltje van Doremalen, Chad Clancy, Greg Saturday, Patrick Hanley, Brian J. Smith, Kimberly Meade-White, W. Lesley Shupert, David W. Hawman, Heinz Feldmann

Source: mBio, Vol 12, Iss 4 (2021)

Subject Terms: SARS-CoV-2, T cells, macaque, neutralizing antibodies, Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/2150-7511

Access URL: https://doaj.org/article/65f5955351984f9f865c72eabf9ac06e

Intradermal delivery of a synthetic DNA vaccine protects macaques from Middle East respiratory syndrome coronavirus

Authors: Ami Patel, Emma L. Reuschel, Ziyang Xu, Faraz I. Zaidi, Kevin Y. Kim, Dana P. Scott, Janess Mendoza, Stephanie Ramos, Regina Stoltz, Friederike Feldmann, Atsushi Okumura, Kimberly Meade-White, Elaine Haddock, Tina Thomas, Rebecca Rosenke, Jamie Lovaglio, Patrick W. Hanley, Greg Saturday, Kar Muthumani, Heinz Feldmann, Laurent M. Humeau, Kate E. Broderick, David B. Weiner

Source: JCI Insight, Vol 6, Iss 10 (2021)

Subject Terms: Infectious disease, Vaccines, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/2379-3708

Access URL: https://doaj.org/article/6a1a7018c4ed4003a8f49aaa184d7f1a

A single intranasal dose of chimpanzee adenovirus-vectored vaccine protects against SARS-CoV-2 infection in rhesus macaques

Authors: Ahmed O. Hassan, Friederike Feldmann, Haiyan Zhao, David T. Curiel, Atsushi Okumura, Tsing-Lee Tang-Huau, James Brett Case, Kimberly Meade-White, Julie Callison, Rita E. Chen, Jamie Lovaglio, Patrick W. Hanley, Dana P. Scott, Daved H. Fremont, Heinz Feldmann, Michael S. Diamond

Source: Cell Reports Medicine, Vol 2, Iss 4, Pp 100230- (2021)

Subject Terms: vaccine, SARS-CoV-2, immunity, non-human primates, immunogenicity, mucosal, Medicine (General), R5-920

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S266637912100046X; https://doaj.org/toc/2666-3791

Access URL: https://doaj.org/article/80b40b01f714480999494aa418767c57

Hydroxychloroquine prophylaxis and treatment is ineffective in macaque and hamster SARS-CoV-2 disease models

Authors: Kyle Rosenke, Michael A. Jarvis, Friederike Feldmann, Benjamin Schwarz, Atsushi Okumura, Jamie Lovaglio, Greg Saturday, Patrick W. Hanley, Kimberly Meade-White, Brandi N. Williamson, Frederick Hansen, Lizette Perez-Perez, Shanna Leventhal, Tsing-Lee Tang-Huau, Julie Callison, Elaine Haddock, Kaitlin A. Stromberg, Dana Scott, Graham Sewell, Catharine M. Bosio, David Hawman, Emmie de Wit, Heinz Feldmann

Source: JCI Insight, Vol 5, Iss 23 (2020)

Subject Terms: COVID-19, Therapeutics, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/2379-3708

Access URL: https://doaj.org/article/28b738a56bae42afa6e041613cef0ac9

Use of Favipiravir to Treat Lassa Virus Infection in Macaques

Authors: Kyle Rosenke, Heinz Feldmann, Jonna B. Westover, Patrick William Hanley, Cynthia Martellaro, Friederike Feldmann, Greg Saturday, Jamie Lovaglio, Dana P. Scott, Yousuke Furuta, Takashi Komeno, Brian B. Gowen, David Safronetz

Source: Emerging Infectious Diseases, Vol 24, Iss 9, Pp 1696-1699 (2018)

Subject Terms: Lassa virus, antiviral, favipiravir, treatment, viruses, macaques, Medicine, Infectious and parasitic diseases, RC109-216

File Description: electronic resource

Relation: https://wwwnc.cdc.gov/eid/article/24/9/18-0233_article; https://doaj.org/toc/1080-6040; https://doaj.org/toc/1080-6059

Access URL: https://doaj.org/article/3aecf98e94ba4838974e7b84ddf68363