Intravitreal injection of the Galectin-3 inhibitor TD139 provides neuroprotection in a rat model of ocular hypertensive glaucoma

Authors: Anne Rombaut, Rune Brautaset, Pete A. Williams, James R. Tribble

Source: Molecular Brain, Vol 17, Iss 1, Pp 1-4 (2024)

Subject Terms: Galectin-3, TD139, Neurodegeneration, Neuroinflammation, Neuroprotection, Retina, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/1756-6606

Access URL: https://doaj.org/article/4e5b23d2a1a04099a223a787e8b2bf3a

Oral nicotinamide provides robust, dose-dependent structural and metabolic neuroprotection of retinal ganglion cells in experimental glaucoma

Authors: Gloria Cimaglia, James R. Tribble, Marcela Votruba, Pete A. Williams, James E. Morgan

Source: Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-17 (2024)

Subject Terms: Dendrite, DiOlistics, Glaucoma, NAD, Metabolomics, Nicotinamide, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/2051-5960

Access URL: https://doaj.org/article/c62d4651bc754691a932e223690ee151

NMNAT2 is a druggable target to drive neuronal NAD production

Authors: James R. Tribble, Melissa Jöe, Carmine Varricchio, Amin Otmani, Alessio Canovai, Baninia Habchi, Evangelia Daskalakis, Romanas Chaleckis, Andrea Loreto, Jonathan Gilley, Craig E. Wheelock, Gauti Jóhannesson, Raymond C. B. Wong, Michael P. Coleman, Andrea Brancale, Pete A. Williams

Source: Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/752e0ceae3fe4a6387d7e708ced0fe15

Intravitreal MPTP drives retinal ganglion cell loss with oral nicotinamide treatment providing robust neuroprotection

Authors: Anne Rombaut, Danica Jovancevic, Raymond Ching-Bong Wong, Alan Nicol, Rune Brautaset, David I. Finkelstein, Christine T. O. Nguyen, James R. Tribble, Pete A. Williams

Source: Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-16 (2024)

Subject Terms: Retina, Retinal ganglion cell, Astrocyte, Microglia, Müller glia, MPTP, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/2051-5960

Access URL: https://doaj.org/article/ce457f07715247b08e1d0a372c5df54f

Prophylactic nicotinamide treatment protects from rotenone-induced neurodegeneration by increasing mitochondrial content and volume

Authors: Amin Otmani, Gauti Jóhannesson, Rune Brautaset, James R. Tribble, Pete A. Williams

Source: Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-12 (2024)

Subject Terms: Nicotinamide, Retina, Retina ganglion cells, Mitochondria, Neurodegeneration, Optic nerve, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/2051-5960

Access URL: https://doaj.org/article/c38a73fa7f8049deb758ef1af5f2a4a5

Author Correction: NMNAT2 is a druggable target to drive neuronal NAD production

Authors: James R. Tribble, Melissa Jöe, Carmine Varricchio, Amin Otmani, Alessio Canovai, Baninia Habchi, Evangelia Daskalakis, Romanas Chaleckis, Andrea Loreto, Jonathan Gilley, Craig E. Wheelock, Gauti Jóhannesson, Raymond C. B. Wong, Michael P. Coleman, Andrea Brancale, Pete A. Williams

Source: Nature Communications, Vol 15, Iss 1, Pp 1-2 (2024)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/26dff57e67d64561bc637003537e66aa

Pyrroloquinoline quinone drives ATP synthesis in vitro and in vivo and provides retinal ganglion cell neuroprotection

Authors: Alessio Canovai, James R. Tribble, Melissa Jöe, Daniela Y. Westerlund, Rosario Amato, Ian A. Trounce, Massimo Dal Monte, Pete A. Williams

Source: Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-23 (2023)

Subject Terms: Pyrroloquinoline quinone (PQQ), Mitochondria, Metabolism, Metabolomics, ATP, Retinal ganglion cell, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/2051-5960

Access URL: https://doaj.org/article/9b0fb1fc29404f1ebda176ae9e7a591f

NAD salvage pathway machinery expression in normal and glaucomatous retina and optic nerve

Authors: James R. Tribble, Anna Hagström, Kenza Jusseaume, Emma Lardner, Raymond Ching-Bong Wong, Gustav Stålhammar, Pete A. Williams

Source: Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-11 (2023)

Subject Terms: Glaucoma, Retinal ganglion cell, Optic nerve, Neurodegeneration, Axon degeneration, NAD, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/2051-5960

Access URL: https://doaj.org/article/71825edfd2cc4d87962e407799ffb3ff

Glial metabolic alterations during glaucoma pathogenesis

Authors: Anne Rombaut, Rune Brautaset, Pete A. Williams, James R. Tribble

Source: Frontiers in Ophthalmology, Vol 3 (2023)

Subject Terms: glaucoma, metabolism, glia, microglia, astrocytes, Müller cells, Medicine

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fopht.2023.1290465/full; https://doaj.org/toc/2674-0826

Access URL: https://doaj.org/article/5e0a6e3bbd9142cb9aa51537fa8e23ce

Widespread retina and optic nerve neuroinflammation in enucleated eyes from glaucoma patients

Authors: Carola Rutigliani, James R. Tribble, Anna Hagström, Emma Lardner, Gauti Jóhannesson, Gustav Stålhammar, Pete A. Williams

Source: Acta Neuropathologica Communications, Vol 10, Iss 1, Pp 1-13 (2022)

Subject Terms: Neuroinflammation, Retina, Glaucoma, Histopathology, Optic nerve, Microglia, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/2051-5960

Access URL: https://doaj.org/article/9cedc7a28e9f4dbc89520469f8b93d6f

Protrudin functions from the endoplasmic reticulum to support axon regeneration in the adult CNS

Authors: Veselina Petrova, Craig S. Pearson, Jared Ching, James R. Tribble, Andrea G. Solano, Yunfei Yang, Fiona M. Love, Robert J. Watt, Andrew Osborne, Evan Reid, Pete A. Williams, Keith R. Martin, Herbert M. Geller, Richard Eva, James W. Fawcett

Source: Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/719ad1bd15824dbeb84c041f6d0b9924

Ocular hypertension suppresses homeostatic gene expression in optic nerve head microglia of DBA/2 J mice

Authors: James R. Tribble, Jeffrey M. Harder, Pete A. Williams, Simon W. M. John

Source: Molecular Brain, Vol 13, Iss 1, Pp 1-14 (2020)

Subject Terms: Glaucoma, Optic nerve head, Microglia, RNA-sequencing, DBA/2 J, Neuroinflammation, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s13041-020-00603-7; https://doaj.org/toc/1756-6606

Access URL: https://doaj.org/article/c394d9a5b8684faf95d68c47cc50bbfd

Valproic Acid Reduces Neuroinflammation to Provide Retinal Ganglion Cell Neuroprotection in the Retina Axotomy Model

Authors: James R. Tribble, Elizabeth Kastanaki, A. Berşan Uslular, Carola Rutigliani, Tim J. Enz, Pete A. Williams

Source: Frontiers in Cell and Developmental Biology, Vol 10 (2022)

Subject Terms: neuroinflammation, microglia, astrocyte, retina, glaucoma, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcell.2022.903436/full; https://doaj.org/toc/2296-634X

Access URL: https://doaj.org/article/73ac1c2c1cad4c30a6555b12750ce2f7

Nicotinamide provides neuroprotection in glaucoma by protecting against mitochondrial and metabolic dysfunction

Authors: James R. Tribble, Amin Otmani, Shanshan Sun, Sevannah A. Ellis, Gloria Cimaglia, Rupali Vohra, Melissa Jöe, Emma Lardner, Abinaya P. Venkataraman, Alberto Domínguez-Vicent, Eirini Kokkali, Seungsoo Rho, Gauti Jóhannesson, Robert W. Burgess, Peter G. Fuerst, Rune Brautaset, Miriam Kolko, James E. Morgan, Jonathan G. Crowston, Marcela Votruba, Pete A. Williams

Source: Redox Biology, Vol 43, Iss , Pp 101988- (2021)

Subject Terms: Glaucoma, Retina, Retinal ganglion cell, Nicotinamide, Metabolism, Metabolomics, Medicine (General), R5-920, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2213231721001361; https://doaj.org/toc/2213-2317

Access URL: https://doaj.org/article/11535b7d2b994327966f83eaacbf9faa

Digestion of the glycosaminoglycan extracellular matrix by chondroitinase ABC supports retinal ganglion cell dendritic preservation in a rodent model of experimental glaucoma

Authors: James R. Tribble, Pete A. Williams, Bruce Caterson, Frank Sengpiel, James E. Morgan

Source: Molecular Brain, Vol 11, Iss 1, Pp 1-4 (2018)

Subject Terms: Retinal ganglion cell, Dendrite, Glaucoma, Neuro-protection, Chondroitinase ABC, Glycosaminoglycan, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s13041-018-0412-5; https://doaj.org/toc/1756-6606

Access URL: https://doaj.org/article/2d116326b1a346f4abee11a6206c9aea

Targeting Diet and Exercise for Neuroprotection and Neurorecovery in Glaucoma

Authors: James R. Tribble, Flora Hui, Melissa Jöe, Katharina Bell, Vicki Chrysostomou, Jonathan G. Crowston, Pete A. Williams

Source: Cells, Vol 10, Iss 2, p 295 (2021)

Subject Terms: glaucoma, optic nerve, retinal ganglion cells, diet, exercise, NAD, Cytology, QH573-671

File Description: electronic resource

Relation: https://www.mdpi.com/2073-4409/10/2/295; https://doaj.org/toc/2073-4409

Access URL: https://doaj.org/article/1b68f454598f428cbf402e0c99468f00

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Identifying potential key metabolic pathways and biomarkers in glaucoma: a systematic review and meta-analysis

Authors: Maria Nilsson, Navid Golpour, Rune L Brautaset, Flora Hui, Jonas E Svensson, Pete A Williams, James R Tribble

Source: BMJ Open Ophthalmology, Vol 10, Iss 1 (2025)

Subject Terms: Ophthalmology, RE1-994

File Description: electronic resource

Relation: https://bmjophth.bmj.com/content/10/1/e002103.full; https://doaj.org/toc/2397-3269

Access URL: https://doaj.org/article/dc46571c51834b43964ca320e8126062