Challenges in the discovery of tumor-specific alternative splicing-derived cell-surface antigens in glioma

Authors: Takahide Nejo, Lin Wang, Kevin K. Leung, Albert Wang, Senthilnath Lakshmanachetty, Marco Gallus, Darwin W. Kwok, Chibo Hong, Lee H. Chen, Diego A. Carrera, Michael Y. Zhang, Nicholas O. Stevers, Gabriella C. Maldonado, Akane Yamamichi, Payal B. Watchmaker, Akul Naik, Anny Shai, Joanna J. Phillips, Susan M. Chang, Arun P. Wiita, James A. Wells, Joseph F. Costello, Aaron A. Diaz, Hideho Okada

Source: Scientific Reports, Vol 14, Iss 1, Pp 1-17 (2024)

Subject Terms: Glioma, Alternative splicing, Antigen, Neojunction, Bulk RNA-sequencing, Long-read sequencing, Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/4c9ca26f096d46feb278b4dfc8e66f04

Photoproximity Labeling from Single Catalyst Sites Allows Calibration and Increased Resolution for Carbene Labeling of Protein Partners In Vitro and on Cells

Authors: Thomas G. Bartholow, Paul W.W. Burroughs, Susanna K. Elledge, James R. Byrnes, Lisa L. Kirkemo, Virginia Garda, Kevin K. Leung, James A. Wells

Source: ACS Central Science, Vol 10, Iss 1, Pp 199-208 (2023)

Subject Terms: Chemistry, QD1-999

File Description: electronic resource

Relation: https://doaj.org/toc/2374-7951

Access URL: https://doaj.org/article/467e7849bb1545af957ab89503b40167

The surfaceome of multiple myeloma cells suggests potential immunotherapeutic strategies and protein markers of drug resistance

Authors: Ian D. Ferguson, Bonell Patiño-Escobar, Sami T. Tuomivaara, Yu-Hsiu T. Lin, Matthew A. Nix, Kevin K. Leung, Corynn Kasap, Emilio Ramos, Wilson Nieves Vasquez, Alexis Talbot, Martina Hale, Akul Naik, Audrey Kishishita, Priya Choudhry, Antonia Lopez-Girona, Weili Miao, Sandy W. Wong, Jeffrey L. Wolf, Thomas G. Martin, Nina Shah, Scott Vandenberg, Sonam Prakash, Lenka Besse, Christoph Driessen, Avery D. Posey, R. Dyche Mullins, Justin Eyquem, James A. Wells, Arun P. Wiita

Source: Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/c60c92825695486592fb827ec64cf75c

Targeting a proteolytic neoepitope on CUB domain containing protein 1 (CDCP1) for RAS-driven cancers

Authors: Shion A. Lim, Jie Zhou, Alexander J. Martinko, Yung-Hua Wang, Ekaterina V. Filippova, Veronica Steri, Donghui Wang, Soumya G. Remesh, Jia Liu, Byron Hann, Anthony A. Kossiakoff, Michael J. Evans, Kevin K. Leung, James A. Wells

Source: The Journal of Clinical Investigation, Vol 132, Iss 4 (2022)

Subject Terms: Therapeutics, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/1558-8238

Access URL: https://doaj.org/article/185e24f5d7a047799beb370607485344

Precision Engineering of an Anti-HLA-A2 Chimeric Antigen Receptor in Regulatory T Cells for Transplant Immune Tolerance

Authors: Yannick D. Muller, Leonardo M. R. Ferreira, Emilie Ronin, Patrick Ho, Vinh Nguyen, Gaetano Faleo, Yu Zhou, Karim Lee, Kevin K. Leung, Nikolaos Skartsis, Anupurna M. Kaul, Arend Mulder, Frans H. J. Claas, James A. Wells, Jeffrey A. Bluestone, Qizhi Tang

Source: Frontiers in Immunology, Vol 12 (2021)

Subject Terms: chimeric antigen receptor, regulatory T cells, genome editing, transplantation, humanized mouse model, immune tolerance, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2021.686439/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/0e55594766a242cca34a7e2ce34bf567

The CD28-Transmembrane Domain Mediates Chimeric Antigen Receptor Heterodimerization With CD28

Authors: Yannick D. Muller, Duy P. Nguyen, Leonardo M. R. Ferreira, Patrick Ho, Caroline Raffin, Roxxana Valeria Beltran Valencia, Zion Congrave-Wilson, Theodore L. Roth, Justin Eyquem, Frederic Van Gool, Alexander Marson, Laurent Perez, James A. Wells, Jeffrey A. Bluestone, Qizhi Tang

Source: Frontiers in Immunology, Vol 12 (2021)

Subject Terms: chimeric antigen receptor, CAR T cell, CD28, transmembrane domain, hinge domain, heterodimerization, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2021.639818/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/34363d2fe7bb42ecbbfa473401a411ce

Bispecific VH/Fab antibodies targeting neutralizing and non-neutralizing Spike epitopes demonstrate enhanced potency against SARS-CoV-2

Authors: Shion A. Lim, Josef A. Gramespacher, Katarina Pance, Nicholas J. Rettko, Paige Solomon, Jing Jin, Irene Lui, Susanna K. Elledge, Jia Liu, Colton J. Bracken, Graham Simmons, Xin X. Zhou, Kevin K. Leung, James A. Wells

Source: mAbs, Vol 13, Iss 1 (2021)

Subject Terms: Bispecific, neutralizing antibody, knob-in-hole, COVID-19, SARS-CoV-2, Therapeutics. Pharmacology, RM1-950, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://doaj.org/toc/1942-0862; https://doaj.org/toc/1942-0870

Access URL: https://doaj.org/article/58387a18a15c49f9b2ec691ffba6d02b

ReScan, a Multiplex Diagnostic Pipeline, Pans Human Sera for SARS-CoV-2 Antigens

Authors: Colin R. Zamecnik, Jayant V. Rajan, Kevin A. Yamauchi, Sabrina A. Mann, Rita P. Loudermilk, Gavin M. Sowa, Kelsey C. Zorn, Bonny D. Alvarenga, Christian Gaebler, Marina Caskey, Mars Stone, Philip J. Norris, Wei Gu, Charles Y. Chiu, Dianna Ng, James R. Byrnes, Xin X. Zhou, James A. Wells, Davide F. Robbiani, Michel C. Nussenzweig, Joseph L. DeRisi, Michael R. Wilson

Source: Cell Reports Medicine, Vol 1, Iss 7, Pp 100123- (2020)

Subject Terms: SARS-CoV-2, serology, phage display, COVID-19, diagnostics, assay development, Medicine (General), R5-920

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2666379120301658; https://doaj.org/toc/2666-3791

Access URL: https://doaj.org/article/fb798e3575304cdbbba3b382901cca64

Competitive SARS-CoV-2 Serology Reveals Most Antibodies Targeting the Spike Receptor-Binding Domain Compete for ACE2 Binding

Authors: James R. Byrnes, Xin X. Zhou, Irene Lui, Susanna K. Elledge, Jeff E. Glasgow, Shion A. Lim, Rita P. Loudermilk, Charles Y. Chiu, Taia T. Wang, Michael R. Wilson, Kevin K. Leung, James A. Wells

Source: mSphere, Vol 5, Iss 5 (2020)

Subject Terms: COVID-19, SARS-CoV-2, angiotensin-converting enzyme 2, immunoserology, neutralizing antibodies, receptor-binding domain, Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/2379-5042

Access URL: https://doaj.org/article/37d9f89d63ed4f75ab01f6157803f4a4

Ligand-binding domains of nuclear receptors facilitate tight control of split CRISPR activity

Authors: Duy P. Nguyen, Yuichiro Miyaoka, Luke A. Gilbert, Steven J. Mayerl, Brian H. Lee, Jonathan S. Weissman, Bruce R. Conklin, James A. Wells

Source: Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/e153d09732764e8691f331233833775d

Light railways in Egypt.

Authors: PEACOCK, James Albert Wells

Source: Cassiers Magazine; March 1902, Vol. 21, p373-384, 12p

Enabling electroweak baryogenesis through dark matter

Authors: Marek Lewicki (Institute of Theoretical Physics, Faculty of Physics, University of Warsaw), Tanja Rindler-Daller (Department of Astrophysics, Faculty of Earth Sciences, Geography and Astronomy, University of Vienna), James D. Wells (Department of Physics and Michigan Center for Theoretical Physics, University of Michigan)

Availability: http://data.europeana.eu/aggregation/europeana/1300/https___phaidra_univie_ac_at_o_925410

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Identification of molecular markers that are expressed in discrete anterior–posterior domains of the endoderm from the gastrula stage to mid‐gestation.

Authors: Billie A. Moore‐Scott, Robert Opoka, Suh‐Chin J. Lin, Jennifer J. Kordich, James M. Wells

Source: Developmental Dynamics; Jul2007, Vol. 236 Issue 7, p1997-2003, 7p

Subject Terms: EMBRYOLOGY, GASTRULATION, BILIARY tract, ABDOMEN

Genes expressed in the developing endocrine pancreas and their importance for stem cell and diabetes research.

Authors: James M. Wells

Source: Diabetes/Metabolism Research & Reviews; May/Jun2003, Vol. 19 Issue 3, p191-201, 11p

A synthetic cyclic peptide for promoting antigen presentation and immune activation

Authors: Jiahui Zhang, Harrison Y. R. Madge, Asmaa Mahmoud, Lantian Lu, Wanyi Wang, Wenbin Huang, Prashamsa Koirala, Jazmina L. Gonzalez Cruz, Wei Yang Kong, Sahra Bashiri, Ahmed O. Shalash, Waleed M. Hussein, Zeinab G. Khalil, James W. Wells, Istvan Toth, Rachel J. Stephenson

Source: npj Vaccines, Vol 10, Iss 1, Pp 1-13 (2025)

Subject Terms: Immunologic diseases. Allergy, RC581-607, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2059-0105

Access URL: https://doaj.org/article/80c59d6d3f66411886425a81320832d1

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Longitudinal assessment of the prevalence of Fusobacterium necrophorum, Fusobacterium varium, and Salmonella enterica in the nasal cavity, ruminal fluid, and feces of finishing beef steers with and without liver abscesses

Authors: Colten W. Dornbach, Paul R. Broadway, James E. Wells, Kallie D. Childress, Aubrey C. Thompson-Smith, Landon G. Canterbury, Nicole C. Burdick Sanchez, Jacque Mathieu, Cory Schwarz, Jenny Laverde Gomez, Marina Tikhonova, T. G. Nagaraja, Michael L. Galyean, Kristin E. Hales

Source: Frontiers in Microbiology, Vol 16 (2025)

Subject Terms: feedlot beef cattle, Fusobacterium necrophorum, Fusobacterium varium, Salmonella, liver abscess, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fmicb.2025.1565303/full; https://doaj.org/toc/1664-302X

Access URL: https://doaj.org/article/666c6af050af48df80117f38b04c0958

A sensitivity target for an impactful Higgs boson self coupling measurement

Authors: Prudhvi N. Bhattiprolu, James D. Wells

Source: Physics Letters B, Vol 861, Iss , Pp 139263- (2025)

Subject Terms: Physics, QC1-999

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0370269325000231; https://doaj.org/toc/0370-2693

Access URL: https://doaj.org/article/198ff1cc7903435db466d6e0872e21db