JAK/STAT signaling as a key regulator of ferroptosis: mechanisms and therapeutic potentials in cancer and diseases

Authors: Yimeng Dai, Chunguo Cui, Dan Jiao, Xuewei Zhu

Source: Cancer Cell International, Vol 25, Iss 1, Pp 1-40 (2025)

Subject Terms: Ferroptosis, JAK/STAT signaling, JAK2, STAT3, STAT1, STAT6, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, Cytology, QH573-671

File Description: electronic resource

Relation: https://doaj.org/toc/1475-2867

Access URL: https://doaj.org/article/a7ede0a72ee041568ceeded583d4aefe

Selective JAK2 pathway inhibition enhances anti-leukemic functionality in CD19 CAR-T cells

Authors: Kohei Mitsuno, Masaya Suematsu, Yuki Naito, Azusa Mayumi, Hideki Yoshida, Shinya Osone, Toshihiko Imamura, Yozo Nakazawa, Shigeki Yagyu, Tomoko Iehara

Source: Cancer Immunology, Immunotherapy, Vol 74, Iss 3, Pp 1-14 (2025)

Subject Terms: CAR-T cell therapy, JAK2 inhibitor, Memory T cell fraction, Ph-like ALL, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1432-0851

Access URL: https://doaj.org/article/233b96f248054e73aeede449c9a5c841

Fedratinib combined with ropeginterferon alfa-2b in patients with myelofibrosis (FEDORA): study protocol for a multicentre, open-label, Bayesian phase II trial

Authors: Graham McIlroy, Charlotte Gaskell, Aimee Jackson, Emily Yafai, Rachel Tasker, Catherine Thomas, Sonia Fox, Rebecca Boucher, Fitsum Ghebretinsea, Claire Harrison, Adam J. Mead, Mary Frances McMullin

Source: BMC Cancer, Vol 25, Iss 1, Pp 1-11 (2025)

Subject Terms: Myelofibrosis, Phase II, Clinical trial, Fedratinib, Ropeginterferon alfa-2b, JAK2 inhibition, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1471-2407

Access URL: https://doaj.org/article/602bbf7f2cd5496e88df64c1884057e4

Relation of JAK2 V617F allele burden and coronary calcium score in patients with essential thrombocythemia

Authors: Drofenik Ajda, Blinc Ales, Bozic Mijovski Mojca, Pajic Tadej, Vrtovec Matjaz, Sever Matjaz

Source: Radiology and Oncology, Vol 58, Iss 4, Pp 565-572 (2024)

Subject Terms: essential thrombocythemia, jak2 v617f mutation, jak2 v617f allele burden, coronary calcium score, Medical physics. Medical radiology. Nuclear medicine, R895-920

File Description: electronic resource

Relation: https://doaj.org/toc/1581-3207

Access URL: https://doaj.org/article/537a7cc588084dd9ad54dadc72bdeca8

Gender and age characteristics of JAK2 V617F mutation allelic burden and CALR and MPL driver mutations detection during primary examination of patients with suspected myeloproliferative neoplasms

Authors: I. A. Olkhovskiy, A. S. Gorbenko, M. A. Stolyar, V. I. Bakhtina, T. I. Olkhovik, E. V. Martynova, O. S. Simonova, I. V. Nazhivin, D. N. Belkin

Source: Онкогематология, Vol 19, Iss 4, Pp 164-172 (2024)

Subject Terms: myeloproliferative disease, allelic burden, jak2 v617f, Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://oncohematology.abvpress.ru/ongm/article/view/984; https://doaj.org/toc/1818-8346; https://doaj.org/toc/2413-4023

Access URL: https://doaj.org/article/670443a909394fe9bcf8c592dded1b29

Inhibition of JAK2 and MDM2 to treat secondary acute myeloid leukemia evolving from myelofibrosis

Authors: Fuping Wang, Longxin Chen, Limeng Zhang, Siyu Du, Yingying Feng

Source: Egyptian Journal of Medical Human Genetics, Vol 25, Iss 1, Pp 1-10 (2024)

Subject Terms: Secondary acute myeloid leukemia, Myelofibrosis, JAK2, P53, Targeted therapies, Medicine (General), R5-920, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/2090-2441

Access URL: https://doaj.org/article/6ff2c62ddad8422a8e364703b1ebf802

Daphnetin may protect from SARS-CoV-2 infection by reducing ACE2

Authors: Qian-wen Yang, Chang-ling Yue, Meng Chen, Yun-yun Ling, Qi Dong, Ying-xin Zhou, Yin Cao, Yan-xia Ding, Xu Zhao, Hai Huang, Zhao-huan Zhang, Lei Hu, Xiao-hui Xu

Source: Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)

Subject Terms: Severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2), Angiotensin-converting enzyme 2 (ACE2), Daphnetin (DAP), Prevention, HIF-1α, JAK2, Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/c7187b2a0b654c8693e1a67f865032d9

JAK2 inactivating mutations promotes endometrial cancer progression by targeting HIF-1α

Authors: Zheng Chen, Xuan Zheng, Weijian Zeng, Juan Wang, Qin Lin

Source: Discover Oncology, Vol 15, Iss 1, Pp 1-15 (2024)

Subject Terms: Endometrial cancer, JAK2, HIF-1α, Inactivating mutations, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2730-6011

Access URL: https://doaj.org/article/ee20460ccd0945649fcf15a6d9774d27

MiR-618 suppresses the proliferation, invasion, and migration of non-small lung cancer via the JAK2/STAT3 axis

Authors: Ziyuan Chen, Wei Chen, Zhiqi Hong, Xianqiao Wu, Tianzheng Fang, Yufei Sheng, Shuai Fang, Chengwei Zhou

Source: Journal of Cardiothoracic Surgery, Vol 19, Iss 1, Pp 1-9 (2024)

Subject Terms: Non-small cell lung cancer, miRNA, JAK2, miR-618, STAT3, Surgery, RD1-811, Anesthesiology, RD78.3-87.3

File Description: electronic resource

Relation: https://doaj.org/toc/1749-8090

Access URL: https://doaj.org/article/fe9ed84cf1c84b8d9fa4de93b7a07575

RUNX1::CBFA2T2 rearranged acute myeloid leukemia transformed from JAK2 V617F mutated primary myelofibrosis

Authors: Lina Han, Prasad Koduru, Miguel Cantu, Franklin Fuda, Weina Chen

Source: eJHaem, Vol 5, Iss 6, Pp 1330-1334 (2024)

Subject Terms: acute myeloid leukemia, JAK2, primary myelofibrosis, RUNX1::CBFA2T2, RUNX1::RUNX1T1, Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://doaj.org/toc/2688-6146

Access URL: https://doaj.org/article/4eb825cbe95b4d23b7126e96c2df8314

JAK2 Mutation Assessment in Thrombotic Events at Unusual Anatomical Sites: Insights from a High-Altitude Cohort

Authors: Alkhaldy HY, Yahya AO, Algarni AM, Bakheet OSE, Assiri M, Saboor M

Source: International Journal of General Medicine, Vol Volume 17, Pp 4551-4558 (2024)

Subject Terms: thrombosis, jak2, myeloproliferative neoplasm, deep vein thrombosis, Medicine (General), R5-920

File Description: electronic resource

Relation: https://www.dovepress.com/jak2-mutation-assessment-in-thrombotic-events-at-unusual-anatomical-si-peer-reviewed-fulltext-article-IJGM; https://doaj.org/toc/1178-7074

Access URL: https://doaj.org/article/3ce312bd2adf42bcba2ff7a9ac3edf22

Cerebral venous sinus thrombosis associated with JAK2 V617F mutation-related pre-primary myelofibrosis: a case report and literature review

Authors: Jiahao Song, Chanzi Huang, Lina Jia, Mengqi Wang, Chuanjie Wu, Xunming Ji, Haiqing Song, Ran Meng, Da Zhou

Source: BMC Neurology, Vol 24, Iss 1, Pp 1-9 (2024)

Subject Terms: Cerebral venous sinus thrombosis, Pre-primary myelofibrosis, JAK2 mutation, Case report, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/1471-2377

Access URL: https://doaj.org/article/ba2741115cdf415c971f68d9a0da4563

LncRNA BRE-AS1 regulates the JAK2/STAT3-mediated inflammatory activation via the miR-30b-5p/SOC3 axis in THP-1 cells

Authors: Jae-Joon Shin, Kyoungho Suk, Won-Ha Lee

Source: Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)

Subject Terms: LncRNA, miRNA, SOCS3, JAK2, STAT3, Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/d27e9530e9a442eb8163b04319c3f90c

The role and impact of the IL-6 mediated JAK2-STAT1/3 signaling pathway in the pathogenesis of gout

Authors: Zeng Zhang, Peng Wang, Tianyi Lei, Jianwei Guo, Yi Jiang, Yanhui Li, Jianxiong Zheng, Shunbing Wang, Haimuzi Xu, Guilin Jian, Quanbo Zhang, Yufeng Qing

Source: Frontiers in Pharmacology, Vol 16 (2025)

Subject Terms: gout, IL-6, JAK2, STAT1, stat3, inflammation, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2025.1480844/full; https://doaj.org/toc/1663-9812

Access URL: https://doaj.org/article/5f71c1ff5c634bd79a85c6b9fb8aa4af

Harnessing Tumor Cell‐Derived Exosomes for Immune Rejection Management in Corneal Transplantation

Authors: Jieru Yang, Huanmin Kang, Yingyi Liu, Shan Lu, Huihui Wu, Bikui Zhang, Yan He, Wenhu Zhou

Source: Advanced Science, Vol 12, Iss 2, Pp n/a-n/a (2025)

Subject Terms: angiogenesis, B16‐F10 melanoma, corneal transplantation, exosomes, JAK2, myeloid‐derived suppressor cells, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2198-3844

Access URL: https://doaj.org/article/a570c95d964d4d7ba51bed29a65deb33

Association of JAK2 Haplotype GGCC_46/1 with the Response to Onco-Drug in MPNs Patients Positive for JAK2V617F Mutation

Authors: Michela Perrone, Sara Sergio, Amalia Tarantino, Giuseppina Loglisci, Rosella Matera, Davide Seripa, Michele Maffia, Nicola Di Renzo

Source: Onco, Vol 4, Iss 3, Pp 241-256 (2024)

Subject Terms: JAK V617F mutation, JAK2 haplotype GGCC_46/1, myeloproliferative neoplasm, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.mdpi.com/2673-7523/4/3/18; https://doaj.org/toc/2673-7523

Access URL: https://doaj.org/article/b6644800e3fa4ac3a94a455d1b360179

JAK 2-Positive Diseases and Spontaneous Coronary Artery Dissection: Case Series

Authors: Ahmed K.A. Yasin, Shehab Fareed Mohamed, Elmustafa Abdalla, Girish Rao, Abdulaziz M. Alkhulaifi, Mohamed A. Yassin, Deena Mudawi, Abdulrahman Fadhl Al-Mashdali, Samah Kohla, Feryal A. Ibrahim, Dina Soliman, Cornelia S. Carr

Source: Case Reports in Oncology, Vol 17, Iss 1, Pp 1008-1013 (2024)

Subject Terms: jak2, polycythemia vera, coronary artery dissection, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://beta.karger.com/Article/FullText/541036; https://doaj.org/toc/1662-6575

Access URL: https://doaj.org/article/535a6baf179e4d20a42555ee797e7e21

Clinical and hematological factors predicting the effectiveness of ruxolitinib in primary and secondary myelofibrosis. Results of a prospective single-center study

Authors: O. Yu. Vinogradova, M. M. Pankraskina, A. L. Neverova, D. I. Shikhbabaeva, M. A. Murzabekova, M. V. Chernikov, A. V. Popova, V. P. Kosenkova, L. B. Egoryan, V. V. Ptushkin

Source: Онкогематология, Vol 19, Iss 3, Pp 16-33 (2024)

Subject Terms: myeloproliferative neoplasm, myeloproliferative disease, myelofibrosis, primary myelofibrosis, postthrombocythemic myelofibrosis, post-polycythemic myelofibrosis, jak2 v617f, targeted therapy, ruxolitinib, Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://oncohematology.abvpress.ru/ongm/article/view/934; https://doaj.org/toc/1818-8346; https://doaj.org/toc/2413-4023

Access URL: https://doaj.org/article/32b92dd0c58149d28216d7e1ea000c8a

Transformation into acute myeloid leukemia with t(8;21)(q22;q22.1); RUNX1::RUNX1T1 from JAK2-mutated essential thrombocythemia: a case report

Authors: Chie Asou, Tomoyuki Sakamoto, Kodai Suzuki, Itoko Okuda, Atsushi Osaki, Ryohei Abe, Yoshihiro Ito, Emi Kakegawa, Yoshitaka Miyakawa, Yasuhito Terui, Yuichi Nakamura

Source: Journal of Medical Case Reports, Vol 18, Iss 1, Pp 1-5 (2024)

Subject Terms: Myeloproliferative neoplasms, Essential thrombocythemia, Secondary acute myeloid leukemia, JAK2 V617F, t(8, 21)(q22, q22.1), RUNX1::RUNX1T1, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/1752-1947

Access URL: https://doaj.org/article/20ad831a1d844d00a58a9546ec999cd6

Biologics in Focus: A Comprehensive Review of Current Biological and Small Molecules Therapies for Crohn’s Disease in the United Arab Emirates (UAE)

Authors: Laith Alrubaiy, Louise Christine Pitsillides, Thomas O’Connor, Matilda Woodhill, Harry Higgins, Thaer Khaleel Swaid, Doa’a Alkhader, Zaher Koutoubi

Source: Gastrointestinal Disorders, Vol 6, Iss 3, Pp 644-660 (2024)

Subject Terms: Crohn’s disease, inflammatory bowel disease, biologics, Anti-TNF, JAK2 inhibitor, Middle East, Medicine, Diseases of the digestive system. Gastroenterology, RC799-869

File Description: electronic resource

Relation: https://www.mdpi.com/2624-5647/6/3/43; https://doaj.org/toc/2624-5647

Access URL: https://doaj.org/article/accd77bec9924bc094bdbe18d1cf9aa6