A multimodal deep learning tool for detection of junctional ectopic tachycardia in children with congenital heart disease

Authors: Ju, Yilong, Waugh, Jamie L.S., Singh, Satpreet, Rusin, Craig G., Patel, Ankit B., Jain, Parag N.

Source: In Heart Rhythm O2 July 2024 5(7):452-459

Machine learning-driven identification of the gene-expression signature associated with a persistent multiple organ dysfunction trajectory in critical illness

Authors: Cvijanovich, Natalie Z., Fitzgerald, Julie C., Weiss, Scott L., Bigham, Michael T., Jain, Parag N., Schwarz, Adam J., Lutfi, Riad, Nowak, Jeffrey, Allen, Geoffrey L., Thomas, Neal J., Grunwell, Jocelyn R., Baines, Torrey, Quasney, Michael, Haileselassie, Bereketeab, Lindsell, Chris J., Atreya, Mihir R. ^{a, b, ∗, k}, Banerjee, Shayantan ^{c, k}, Lautz, Andrew J. ^{a, b}, Alder, Matthew N. ^{a, b}, Varisco, Brian M. ^{a, b}, Wong, Hector R. ^{a, b, j}, Muszynski, Jennifer A. ^{d, e}, Hall, Mark W. ^{d, e}, Sanchez-Pinto, L. Nelson ^{f, g}, Kamaleswaran, Rishikesan ^{h, i}

Source: In eBioMedicine January 2024 99

A novel automated junctional ectopic tachycardia detection tool for children with congenital heart disease

Authors: Waugh, Jamie L.S., Patel, Raajen, Ju, Yilong, Patel, Ankit B., Rusin, Craig G., Jain, Parag N.

Source: In Heart Rhythm O2 June 2022 3(3):302-310

Risk Factors for Perioperative Morbidity in Adults Undergoing Cardiac Surgery at Children’s Hospitals

Authors: Jain, Parag N., Salciccioli, Katherine B., Guffey, Danielle, Byun, Jinyoung, Cotts, Timothy B., Ermis, Peter, Gaies, Michael, Ghanayem, Nancy, Kim, Francis, Lasa, Javier J., Smith, Andrew, Fuller, Stephanie

Source: In The Annals of Thoracic Surgery June 2022 113(6):2062-2070

Recalibration of the Renal Angina Index for Pediatric Septic Shock

Authors: Stanski, Natalja L., Wong, Hector R., Basu, Rajit K., Cvijanovich, Natalie Z., Fitzgerald, Julie C., Weiss, Scott L., Bigham, Michael T., Jain, Parag N., Schwarz, Adam, Lutfi, Riad, Nowak, Jeffrey, Allen, Geoffrey L., Thomas, Neal J., Grunwell, Jocelyn R., Quasney, Michael, Haileselassie, Bereketeab, Chawla, Lakhmir S., Goldstein, Stuart L.

Source: In Kidney International Reports July 2021 6(7):1858-1867

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Diagnostic Validation of the Updated Pediatric Sepsis Biomarker Risk II for Acute Kidney Injury Prediction Model in Pediatric Septic Shock.

Authors: Stanski, Natalja L., Bin Zhang, Cvijanovich, Natalie Z., Fitzgerald, Julie C., Bigham, Michael T., Jain, Parag N., Schwarz, Adam J., Lutfi, Riad, Allen, Geoffrey L., Thomas, Neal J., Baines, Torrey, Haileselassie, Bereketeab, Weiss, Scott L., Atreya, Mihir R., Lautz, Andrew J., Zingarelli, Basilia, Standage, Stephen W., Kaplan, Jennifer, Goldstein, Stuart L.

Source: Pediatric Critical Care Medicine; Nov2024, Vol. 25 Issue 11, p1005-1016, 12p

Identification and transcriptomic assessment of latent profile pediatric septic shock phenotypes.

Authors: Atreya, Mihir R., Huang, Min, Moore, Andrew R., Zheng, Hong, Hasin-Brumshtein, Yehudit, Fitzgerald, Julie C., Weiss, Scott L., Cvijanovich, Natalie Z., Bigham, Michael T., Jain, Parag N., Schwarz, Adam J., Lutfi, Riad, Nowak, Jeffrey, Thomas, Neal J., Quasney, Michael, Dahmer, Mary K., Baines, Torrey, Haileselassie, Bereketeab, Lautz, Andrew J., Stanski, Natalja L.

Source: Critical Care; 7/17/2024, Vol. 28 Issue 1, p1-13, 13p

Altered metabolic and inflammatory transcriptomics after cardiac surgery in neonates with congenital heart disease.

Authors: Jain, Parag N.¹ pnjain@texaschildrens.org, Robertson, Matthew², Lasa, Javier J.¹, Shekerdemian, Lara¹, Guffey, Danielle², Zhang, Yuhao², Lingappan, Krithika¹, Checchia, Paul¹, Coarfa, Cristian² coarfa@bcm.edu

Source: Scientific Reports. 3/2/2021, Vol. 11 Issue 1, p1-11. 11p.

Subject Terms: *TRANSCRIPTOMES, *MESSENGER RNA, *PALLIATIVE treatment, *GENE expression, *INFLAMMATION

Revisiting Post-ICU Admission Fluid Balance Across Pediatric Sepsis Mortality Risk Strata: A Secondary Analysis of a Prospective Observational Cohort Study.

Authors: Atreya, Mihir R., Cvijanovich, Natalie Z., Fitzgerald, Julie C., Weiss, Scott L., Bigham, Michael T., Jain, Parag N., Abulebda, Kamal, Lutfi, Riad, Nowak, Jeffrey, Thomas, Neal J., Baines, Torrey, Quasney, Michael, Haileselassie, Bereketeab, Sahay, Rashmi, Bin Zhang, Alder, Matthew N., Stanski, Natalja L., Goldstein, Stuart L.

Source: Critical Care Explorations; Jan2024, Vol. 6 Issue 1, p1-11, 11p

SERUM HUMANIN IN PEDIATRIC SEPTIC SHOCK-ASSOCIATED MULTIPLE-ORGAN DYSFUNCTION SYNDROME.

Authors: Atreya, Mihir R., Piraino, Giovanna, Cvijanovich, Natalie Z., Fitzgerald, Julie C., Weiss, Scott L., Bigham, Michael T., Jain, Parag N., Schwarz, Adam J., Lutfi, Riad, Nowak, Jeffrey, Thomas, Neal J., Baines, Torrey, Haileselassie, Bereketeab, Zingarelli, Basilia

Source: Shock; Jan2024, Vol. 61 Issue 1, p83-88, 6p

External validation of the modified sepsis renal angina index for prediction of severe acute kidney injury in children with septic shock.

Authors: Stanski, Natalja L., Basu, Rajit K., Cvijanovich, Natalie Z., Fitzgerald, Julie C., Bigham, Michael T., Jain, Parag N., Schwarz, Adam J., Lutfi, Riad, Thomas, Neal J., Baines, Torrey, Haileselassie, Bereketeab, Weiss, Scott L., Atreya, Mihir R., Lautz, Andrew J., Zingarelli, Basilia, Standage, Stephen W., Kaplan, Jennifer, Chawla, Lakhmir S., Goldstein, Stuart L.

Source: Critical Care; 11/28/2023, Vol. 27 Issue 1, p1-9, 9p

SERUM SOLUBLE ENDOGLIN IN PEDIATRIC SEPTIC SHOCK--ASSOCIATED MULTIPLE ORGAN DYSFUNCTION SYNDROME.

Authors: Atreya, Mihir R., Cvijanovich, Natalie Z., Fitzgerald, Julie C., Weiss, Scott L., Bigham, Michael T., Jain, Parag N., Schwarz, Adam J., Lutfi, Riad, Nowak, Jeffrey, Thomas, Neal J., Quasney, Michael, Haileselassie, Bereketeab, Baines, Torrey D., Zingarelli, Basilia

Source: Shock; Sep2023, Vol. 60 Issue 3, p379-384, 6p

Serum renin and prorenin concentrations predict severe persistent acute kidney injury and mortality in pediatric septic shock.

Authors: Stanski, Natalja L., Pode Shakked, Naomi, Zhang, Bin, Cvijanovich, Natalie Z., Fitzgerald, Julie C., Jain, Parag N., Schwarz, Adam J., Nowak, Jeffrey, Weiss, Scott L., Allen, Geoffrey L., Thomas, Neal J., Haileselassie, Bereketeab, Goldstein, Stuart L.

Source: Pediatric Nephrology; Sep2023, Vol. 38 Issue 9, p3099-3108, 10p, 5 Charts

Subject Terms: RENIN, RESEARCH, INTENSIVE care units, SCIENTIFIC observation, CONFIDENCE intervals, CHRONIC diseases, MULTIPLE regression analysis, PEDIATRICS, INFECTION, RESEARCH funding, ODDS ratio, ACUTE kidney failure, SEPTIC shock, SECONDARY analysis, CHILDREN

Prognostic and predictive value of endothelial dysfunction biomarkers in sepsis-associated acute kidney injury: risk-stratified analysis from a prospective observational cohort of pediatric septic shock.

Authors: Atreya, Mihir R., Cvijanovich, Natalie Z., Fitzgerald, Julie C., Weiss, Scott L., Bigham, Michael T., Jain, Parag N., Schwarz, Adam J., Lutfi, Riad, Nowak, Jeffrey, Allen, Geoffrey L., Thomas, Neal J., Grunwell, Jocelyn R., Baines, Torrey, Quasney, Michael, Haileselassie, Bereketeab, Alder, Matthew N., Goldstein, Stuart L., Stanski, Natalja L.

Source: Critical Care; 7/3/2023, Vol. 27 Issue 1, p1-11, 11p

Detrimental effects of PCSK9 loss-of-function in the pediatric host response to sepsis are mediated through independent influence on Angiopoietin-1.

Authors: Atreya, Mihir R., Cvijanovich, Natalie Z., Fitzgerald, Julie C., Weiss, Scott L., Bigham, Michael T., Jain, Parag N., Schwarz, Adam J., Lutfi, Riad, Nowak, Jeffrey, Allen, Geoffrey L., Thomas, Neal J., Grunwell, Jocelyn R., Baines, Torrey, Quasney, Michael, Haileselassie, Bereketeab, Alder, Matthew N., Lahni, Patrick, Ripberger, Scarlett, Ekunwe, Adesuwa, Campbell, Kyle R.

Source: Critical Care; 6/26/2023, Vol. 27 Issue 1, p1-12, 12p

Postoperative physiological parameters associated with severe acute kidney injury after pediatric heart transplant.

Authors: Alali, Alexander, Acosta, Sebastian, Ahmed, Mubbasheer, Spinner, Joseph, Akcan‐Arikan, Ayse, Morris, Shaine A., Jain, Parag N.

Source: Pediatric Transplantation; Aug2022, Vol. 26 Issue 5, p1-9, 9p

Subject Terms: ACUTE kidney failure, HEART transplantation, KIDNEY transplantation, INTENSIVE care units, UNIVARIATE analysis

Integrated PERSEVERE and endothelial biomarker risk model predicts death and persistent MODS in pediatric septic shock: a secondary analysis of a prospective observational study.

Authors: Atreya, Mihir R., Cvijanovich, Natalie Z., Fitzgerald, Julie C., Weiss, Scott L., Bigham, Michael T., Jain, Parag N., Schwarz, Adam J., Lutfi, Riad, Nowak, Jeffrey, Allen, Geoffrey L., Thomas, Neal J., Grunwell, Jocelyn R., Baines, Torrey, Quasney, Michael, Haileselassie, Bereketeab, Lindsell, Christopher J., Alder, Matthew N., Wong, Hector R.

Source: Critical Care; 7/11/2022, Vol. 26 Issue 1, p1-9, 9p

PERSEVERE Biomarkers Predict Severe Acute Kidney Injury and Renal Recovery in Pediatric Septic Shock.

Authors: Stanski, Natalja L., Stenson, Erin K., Cvijanovich, Natalie Z., Weiss, Scott L., Fitzgerald, Julie C., Bigham, Michael T., Jain, Parag N., Schwarz, Adam, Lutfi, Riad, Nowak, Jeffrey, Allen, Geoffrey L., Thomas, Neal J., Grunwell, Jocelyn R., Baines, Torrey, Quasney, Michael, Haileselassie, Bereketeab, Wong, Hector R.

Source: American Journal of Respiratory & Critical Care Medicine; 4/1/2020, Vol. 201 Issue 7, p848-855, 10p

Subject Terms: BIOMARKERS, ACUTE kidney failure, SEPTIC shock, SEPSIS, INDIVIDUALIZED medicine, CONVALESCENCE, RISK assessment, SEVERITY of illness index, RESEARCH funding, STATISTICAL models, LONGITUDINAL method, DISEASE complications

Prospective clinical testing and experimental validation of the Pediatric Sepsis Biomarker Risk Model.

Authors: Wong, Hector R., Caldwell, J. Timothy, Cvijanovich, Natalie Z., Weiss, Scott L., Fitzgerald, Julie C., Bigham, Michael T., Jain, Parag N., Schwarz, Adam, Lutfi, Riad, Nowak, Jeffrey, Allen, Geoffrey L., Thomas, Neal J., Grunwell, Jocelyn R., Baines, Torrey, Quasney, Michael, Haileselassie, Bereketeab, Lindsell, Christopher J.

Source: Science Translational Medicine; 11/13/2019, Vol. 11 Issue 518, p1-10, 10p

Subject Terms: SEPSIS, CRITICALLY ill children, SEPTIC shock, EXPERIMENTAL medicine, INDIVIDUALIZED medicine