The three-tails approach as a new strategy to improve selectivity of action of sulphonamide inhibitors against tumour-associated carbonic anhydrase IX and XII

Authors: Alessandro Bonardi, Silvia Bua, Jacob Combs, Carrie Lomelino, Jacob Andring, Sameh Mohamed Osman, Alessandra Toti, Lorenzo Di Cesare Mannelli, Paola Gratteri, Carla Ghelardini, Robert McKenna, Alessio Nocentini, Claudiu T. Supuran

Source: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 930-939 (2022)

Subject Terms: Tail approach, carbonic anhydrase, inhibitor, X-ray crystallography, hypoxic tumour, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://doaj.org/toc/1475-6366; https://doaj.org/toc/1475-6374

Access URL: https://doaj.org/article/412ee4b931a947cf9e44dab830b6bc29

Protein Degradation by Gammaherpesvirus RTAs: More Than Just Viral Transactivators

Authors: Lauren R. Combs, Jacob Combs, Robert McKenna, Zsolt Toth

Source: Viruses, Vol 15, Iss 3, p 730 (2023)

Subject Terms: KSHV, RTA, ubiquitination, protein degradation, gammaherpesviruses, E3 ubiquitin ligases, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.mdpi.com/1999-4915/15/3/730; https://doaj.org/toc/1999-4915

Access URL: https://doaj.org/article/8ad286f8afb0429fb02a7fc68dd198bb

New Insights into Conformationally Restricted Carbonic Anhydrase Inhibitors

Authors: Jacob Combs, Murat Bozdag, Lochlin D. Cravey, Anusha Kota, Robert McKenna, Andrea Angeli, Fabrizio Carta, Claudiu T. Supuran

Source: Molecules, Vol 28, Iss 2, p 890 (2023)

Subject Terms: X-ray crystallography, carbonic anhydrase IX, structure activity relationships, Organic chemistry, QD241-441

File Description: electronic resource

Relation: https://www.mdpi.com/1420-3049/28/2/890; https://doaj.org/toc/1420-3049

Access URL: https://doaj.org/article/d56a5514d26a4d64a108c5634632f7d5

Aspirin: A Suicide Inhibitor of Carbonic Anhydrase II

Authors: Jacob Andring, Jacob Combs, Robert McKenna

Source: Biomolecules, Vol 10, Iss 4, p 527 (2020)

Subject Terms: carbonic anhydrase, Aspirin, salicylic acid, esterase, X-ray crystallography, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.mdpi.com/2218-273X/10/4/527; https://doaj.org/toc/2218-273X

Access URL: https://doaj.org/article/1e5ac0d504d14d91b03af4405bceb485