Amyloidogenic propensity of self-assembling peptides and their adjuvant potential for use as DNA vaccines

Authors: Shrimali, Paresh C., Chen, Sheng, Das, Anirban, Dreher, Rachel, Howard, Matthew K., Ryan, Jeremy J., Buck, Jeremy, Kim, Darren, Sprunger, Macy L., Rudra, Jai S., Jackrel, Meredith E.

Source: In Acta Biomaterialia 1 October 2023 169:464-476

Tuning Hsp104 specificity to selectively detoxify α-synuclein

Authors: Mack, Korrie L., Kim, Hanna, Barbieri, Edward M., Lin, JiaBei, Braganza, Sylvanne, Jackrel, Meredith E., DeNizio, Jamie E., Yan, Xiaohui, Chuang, Edward, Tariq, Amber, Cupo, Ryan R., Castellano, Laura M., Caldwell, Kim A., Caldwell, Guy A., Shorter, James

Source: In Molecular Cell 21 September 2023 83(18):3314-3332

Molecular determinants and modifiers of Matrin-3 toxicity, condensate dynamics, and droplet morphology

Authors: Sprunger, Macy L., Lee, Ken, Sohn, Brian S., Jackrel, Meredith E.

Source: In iScience 18 March 2022 25(3)

Drivers of Hsp104 potentiation revealed by scanning mutagenesis of the middle domain

Authors: Ryan, Jeremy J., Bao, Aaron, Bell, Braxton, Ling, Cendi, Jackrel, Meredith E.

Source: Protein science. 30(8):1667-1685

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100123673165.0x000001&indx=1&recIds=ETOCvdc_100123673165.0x000001

Seeding-competent TDP-43 persists in human patient and mouse muscle.

Authors: Lynch, Eileen M., Pittman, Sara, Daw, Jil, Ikenaga, Chiseko, Chen, Sheng, Dhavale, Dhruva D., Jackrel, Meredith E., Ayala, Yuna M., Kotzbauer, Paul, Ly, Cindy V., Pestronk, Alan, Lloyd, Thomas E., Weihl, Conrad C.

Source: Science Translational Medicine; 11/27/2024, Vol. 16 Issue 775, p1-16, 16p

Subject Terms: FLUORESCENCE resonance energy transfer, INCLUSION body myositis, DNA-binding proteins, RNA-binding proteins, AMYOTROPHIC lateral sclerosis, FRONTOTEMPORAL lobar degeneration

Mining Disaggregase Sequence Space to Safely Counter TDP-43, FUS, and α-Synuclein Proteotoxicity

Authors: Tariq, Amber, Lin, JiaBei, Jackrel, Meredith E., Hesketh, Christina D., Carman, Peter J., Mack, Korrie L., Weitzman, Rachel, Gambogi, Craig, Hernandez Murillo, Oscar A., Sweeny, Elizabeth A., Gurpinar, Esin, Yokom, Adam L., Gates, Stephanie N., Yee, Keolamau, Sudesh, Saurabh, Stillman, Jacob, Rizo, Alexandra N., Southworth, Daniel R., Shorter, James

Source: In Cell Reports 20 August 2019 28(8):2080-2095

Engineered protein disaggregases mitigate toxicity of aberrant prion-like fusion proteins underlying sarcoma

Alternate Title: Enhanced protein disaggregases to counter sarcoma (English)

Authors: Ryan, Jeremy J., Sprunger, Macy L., Holthaus, Kayla, Shorter, James, Jackrel, Meredith E.

Source: In Journal of Biological Chemistry 19 July 2019 294(29):11286-11296

Hsp104 and Potentiated Variants Can Operate as Distinct Nonprocessive Translocases

Authors: Durie, Clarissa L., Lin, JiaBei, Scull, Nathaniel W., Mack, Korrie L., Jackrel, Meredith E., Sweeny, Elizabeth A., Castellano, Laura M., Shorter, James, Lucius, Aaron L.

Source: In Biophysical Journal 21 May 2019 116(10):1856-1872

Structure of Calcarisporiella thermophila Hsp104 Disaggregase that Antagonizes Diverse Proteotoxic Misfolding Events

Authors: Michalska, Karolina, Zhang, Kaiming, March, Zachary M., Hatzos-Skintges, Catherine, Pintilie, Grigore, Bigelow, Lance, Castellano, Laura M., Miles, Leann J., Jackrel, Meredith E., Chuang, Edward, Jedrzejczak, Robert, Shorter, James, Chiu, Wah, Joachimiak, Andrzej

Source: In Structure 5 March 2019 27(3):449-463

Nuclear-Import Receptors Reverse Aberrant Phase Transitions of RNA-Binding Proteins with Prion-like Domains

Authors: Guo, Lin, Kim, Hong Joo, Wang, Hejia, Monaghan, John, Freyermuth, Fernande, Sung, Julie C., O’Donovan, Kevin, Fare, Charlotte M., Diaz, Zamia, Singh, Nikita, Zhang, Zi Chao, Coughlin, Maura, Sweeny, Elizabeth A., DeSantis, Morgan E., Jackrel, Meredith E., Rodell, Christopher B., Burdick, Jason A., King, Oliver D., Gitler, Aaron D., Lagier-Tourenne, Clotilde, Pandey, Udai Bhan, Chook, Yuh Min, Taylor, J. Paul, Shorter, James

Source: In Cell 19 April 2018 173(3):677-692

Ratchet-like polypeptide translocation mechanism of the AAA+ disaggregase Hsp104

Authors: Gates, Stephanie N., Yokom, Adam L., Lin, JiaBei, Jackrel, Meredith E., Rizo, Alexandrea N., Kendsersky, Nathan M., Buell, Courtney E., Sweeny, Elizabeth A., Mack, Korrie L., Chuang, Edward, Torrente, Mariana P., Su, Min, Shorter, James, Southworth, Daniel R.

Source: Science, 2017 Jul . 357(6348), 273-279.

Access URL: https://www.jstor.org/stable/26399471

The role of Matrin-3 in physiology and its dysregulation in disease.

Authors: Sprunger, Macy L.¹, Jackrel, Meredith E.¹ mjackrel@wustl.edu

Source: Biochemical Society Transactions. Jun2024, Vol. 52 Issue 3, p961-972. 12p.

Subject Terms: *DNA repair, *AMYOTROPHIC lateral sclerosis, *PHYSIOLOGY, *RNA splicing, *RNA-binding proteins, *FRONTOTEMPORAL dementia

Mechanistic Insights into Hsp104 Potentiation

Authors: Torrente, Mariana P., Chuang, Edward, Noll, Megan M., Jackrel, Meredith E., Go, Michelle S., Shorter, James

Source: In Journal of Biological Chemistry 4 March 2016 291(10):5101-5115

HTRA1 disaggregates α-synuclein amyloid fibrils and converts them into non-toxic and seeding incompetent species.

Authors: Chen, Sheng, Puri, Anuradhika, Bell, Braxton, Fritsche, Joseph, Palacios, Hector H., Balch, Maurie, Sprunger, Macy L., Howard, Matthew K., Ryan, Jeremy J., Haines, Jessica N., Patti, Gary J., Davis, Albert A., Jackrel, Meredith E.

Source: Nature Communications; 3/18/2024, Vol. 15 Issue 1, p1-18, 18p

The Hsp104 N-Terminal Domain Enables Disaggregase Plasticity and Potentiation

Authors: Sweeny, Elizabeth A., Jackrel, Meredith E., Go, Michelle S., Sochor, Matthew A., Razzo, Beatrice M., DeSantis, Morgan E., Gupta, Kushol, Shorter, James

Source: In Molecular Cell 5 March 2015 57(5):836-849

Avidity for Polypeptide Binding by Nucleotide-Bound Hsp104 Structures

Authors: Weaver, Clarissa L., Duran, Elizabeth C., Mack, Korrie L., Lin, JiaBei, Jackrel, Meredith E., Sweeny, Elizabeth A., Shorter, James, Lucius, Aaron L.

Source: Biochemistry. 56(15):2071-2075

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN610961081&indx=1&recIds=ETOCRN610961081

FUS inclusions disrupt RNA localization by sequestering kinesin-1 and inhibiting microtubule detyrosination

Authors: Yasuda, Kyota, Clatterbuck-Soper, Sarah F., Jackrel, Meredith E., Shorter, James, Mili, Stavroula

Source: Journal of cell biology. 216(4):1015-1034

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN610790950&indx=1&recIds=ETOCRN610790950

Engineering enhanced protein disaggregases for neurodegenerative disease

Authors: Jackrel, Meredith E, Shorter, James

Source: Prion. 9(2):90-109

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCETOCvdc_100029009944.0x000001&indx=1&recIds=ETOCETOCvdc_100029009944.0x000001

Quality Control in the ER: Misfolded Prohormones Get a Checkup

Authors: Sprunger, Macy L., Jackrel, Meredith E.

Source: In Molecular Cell 8 August 2019 75(3):415-416

Potentiated Hsp104 Variants Antagonize Diverse Proteotoxic Misfolding Events

Authors: Jackrel, Meredith E., DeSantis, Morgan E., Martinez, Bryan A., Castellano, Laura M., Stewart, Rachel M., Caldwell, Kim A., Caldwell, Guy A., Shorter, James

Source: In Cell 16 January 2014 156(1-2):170-182