Proteins lead the way: JAK inhibitors as a new treatment option in toxic epidermal necrolysis

Authors: Benjamin Klein, J. Michelle Kahlenberg, Johann E. Gudjonsson

Source: Signal Transduction and Targeted Therapy, Vol 10, Iss 1, Pp 1-3 (2025)

Subject Terms: Medicine, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/2059-3635

Access URL: https://doaj.org/article/59d1404f63aa4211a5954d1a2f0a9640

Characterizing the immune infiltrate in secondary syphilis: implications for transmission and pathology

Authors: Irène Gallais Sérézal, Joseph Kirma, Mrinal K. Sarkar, Christopher Cole, Xianying Xing, Rachael Bogle, Jennifer Fox, Anthony Coon, Kelsey R. vanStraalen, Craig Dobry, Linda H. Xu, J. Michelle Kahlenberg, Paul W. Harms, Allison C. Billi, Lam C. Tsoi, Lorenzo Giacani, Johann E. Gudjonsson

Source: Frontiers in Immunology, Vol 16 (2025)

Subject Terms: syphilis, immune evasion, keratinocytes, transcriptome (RNA-seq), host-pathogen adaptation, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2025.1549206/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/9adcfc6bfd8948fa93e22caa0fd97886

Type I interferon governs immunometabolic checkpoints that coordinate inflammation during Staphylococcal infection

Authors: Mack B. Reynolds, Benjamin Klein, Michael J. McFadden, Norah K. Judge, Hannah E. Navarrete, Britton C Michmerhuizen, Dominik Awad, Tracey L. Schultz, Paul W. Harms, Li Zhang, Teresa R. O’Meara, Jonathan Z. Sexton, Costas A. Lyssiotis, J. Michelle Kahlenberg, Mary X. O’Riordan

Source: Cell Reports, Vol 43, Iss 8, Pp 114607- (2024)

Subject Terms: CP: Immunology, CP: Metabolism, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124724009574; https://doaj.org/toc/2211-1247

Access URL: https://doaj.org/article/b80ebd8315f645efa79adec43f6f9598

Systems-based identification of the Hippo pathway for promoting fibrotic mesenchymal differentiation in systemic sclerosis

Authors: Feiyang Ma, Pei-Suen Tsou, Mehrnaz Gharaee-Kermani, Olesya Plazyo, Xianying Xing, Joseph Kirma, Rachael Wasikowski, Grace A. Hile, Paul W. Harms, Yanyun Jiang, Enze Xing, Mio Nakamura, Danielle Ochocki, William D. Brodie, Shiv Pillai, Emanual Maverakis, Matteo Pellegrini, Robert L. Modlin, John Varga, Lam C. Tsoi, Robert Lafyatis, J. Michelle Kahlenberg, Allison C. Billi, Dinesh Khanna, Johann E. Gudjonsson

Source: Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/3b5a5e9a32fc4187b638ed4405b8d22c

Urinary complement biomarkers in immune-mediated kidney diseases

Authors: Vartika Kesarwani, Muhammad Hamza Bukhari, J. Michelle Kahlenberg, Shudan Wang

Source: Frontiers in Immunology, Vol 15 (2024)

Subject Terms: complement, kidney disease, urine biomarker, lupus nephritis (LN), complement drug, primary membranous nephropathy, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2024.1357869/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/a75ca5f6553645c997ec14dfd7ac79f6

Interferon alpha promotes caspase-8 dependent ultraviolet light-mediated keratinocyte apoptosis via interferon regulatory factor 1

Authors: Shannon N. Loftus, Mehrnaz Gharaee-Kermani, Bin Xu, Tyson M. Moore, Andrew Hannoudi, Mischa J. Mallbris, Benjamin Klein, Johann E. Gudjonsson, J. Michelle Kahlenberg

Source: Frontiers in Immunology, Vol 15 (2024)

Subject Terms: interferon, apoptosis, ultraviolet light, keratinocyte, lupus, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2024.1384606/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/2688932f602c4078829249e84a14bb01

Significance of stress keratin expression in normal and diseased epithelia

Authors: Erez Cohen, Craig N. Johnson, Rachael Wasikowski, Allison C. Billi, Lam C. Tsoi, J. Michelle Kahlenberg, Johann E. Gudjonsson, Pierre A. Coulombe

Source: iScience, Vol 27, Iss 2, Pp 108805- (2024)

Subject Terms: Dermatology, Biological sciences, Immunology, Transcriptomics, Science

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2589004224000269; https://doaj.org/toc/2589-0042

Access URL: https://doaj.org/article/b80278a23f364084a5342052f0952287

HERC6 regulates STING activity in a sex-biased manner through modulation of LATS2/VGLL3 Hippo signaling

Authors: Ranjitha Uppala, Mrinal K. Sarkar, Kelly Z. Young, Feiyang Ma, Pritika Vemulapalli, Rachael Wasikowski, Olesya Plazyo, William R. Swindell, Emanual Maverakis, Mehrnaz Gharaee-Kermani, Allison C. Billi, Lam C. Tsoi, J. Michelle Kahlenberg, Johann E. Gudjonsson

Source: iScience, Vol 27, Iss 2, Pp 108986- (2024)

Subject Terms: Molecular biology, Cell biology, Bioinformatics, Omics, Science

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2589004224002074; https://doaj.org/toc/2589-0042

Access URL: https://doaj.org/article/87cba07b11fb49b59bbc593a99230d5e

Large-scale epidemiological analysis of common skin diseases to identify shared and unique comorbidities and demographic factors

Authors: Qinmengge Li, Matthew T. Patrick, Sutharzan Sreeskandarajan, Jian Kang, J. Michelle Kahlenberg, Johann E. Gudjonsson, Zhi He, Lam C. Tsoi

Source: Frontiers in Immunology, Vol 14 (2024)

Subject Terms: epidemiology, claims, skin disease, comorbidity, Optum, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2023.1309549/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/0fbcd6f6234f491598f3c09a1839c789

Single cell and spatial sequencing define processes by which keratinocytes and fibroblasts amplify inflammatory responses in psoriasis

Authors: Feiyang Ma, Olesya Plazyo, Allison C. Billi, Lam C. Tsoi, Xianying Xing, Rachael Wasikowski, Mehrnaz Gharaee-Kermani, Grace Hile, Yanyun Jiang, Paul W. Harms, Enze Xing, Joseph Kirma, Jingyue Xi, Jer-En Hsu, Mrinal K. Sarkar, Yutein Chung, Jeremy Di Domizio, Michel Gilliet, Nicole L. Ward, Emanual Maverakis, Eynav Klechevsky, John J. Voorhees, James T. Elder, Jun Hee Lee, J. Michelle Kahlenberg, Matteo Pellegrini, Robert L. Modlin, Johann E. Gudjonsson

Source: Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/7d7e27df0a374d5eb3a7f42f1d8c5e5f

Cystic fibrosis autoantibody signatures associate with Staphylococcus aureus lung infection or cystic fibrosis-related diabetes

Authors: Ruchi Yadav, Quan-Zhen Li, Hanwen Huang, S. Louis Bridges, J. Michelle Kahlenberg, Arlene A. Stecenko, Balázs Rada

Source: Frontiers in Immunology, Vol 14 (2023)

Subject Terms: CFRD, CF-related diabetes, cystic fibrosis, autoimmunity, autoantibody signature, Staphylococcus aureus, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2023.1151422/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/0786abdff9e54abbba1b6e68cd82499e

Pansclerotic morphea is characterized by IFN-γ responses priming dendritic cell fibroblast crosstalk to promote fibrosis

Authors: Enze Xing, Feiyang Ma, Rachael Wasikowski, Allison C. Billi, Mehrnaz Gharaee-Kermani, Jennifer Fox, Craig Dobry, Amanda Victory, Mrinal K. Sarkar, Xianying Xing, Olesya Plazyo, Henry W. Chen, Grant Barber, Heidi Jacobe, Pei-Suen Tsou, Robert L. Modlin, John Varga, J. Michelle Kahlenberg, Lam C. Tsoi, Johann E. Gudjonsson, Dinesh Khanna

Source: JCI Insight, Vol 8, Iss 16 (2023)

Subject Terms: Dermatology, Inflammation, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/2379-3708

Access URL: https://doaj.org/article/40503665b3474f938f778ca913681263

Key patient demographics shape innate immune topography in noncritical hypoxic COVID-19 pneumonia

Authors: Allison C. Billi, Rachael Wasikowski, Feiyang Ma, Srilakshmi Yalavarthi, Claire K. Hoy, Yu Zuo, Matthew T. Patrick, Neha Shah, Christine Parker, Chad Aaronson, Alyssa Harbaugh, Matthew F. Lucido, Kerby Shedden, Krishna Rao, Heidi B. IglayReger, Charles F. Burant, J. Michelle Kahlenberg, Lam C. Tsoi, Johann E. Gudjonsson, Jason S. Knight, Yogendra Kanthi

Source: JCI Insight, Vol 8, Iss 16 (2023)

Subject Terms: COVID-19, Immunology, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/2379-3708

Access URL: https://doaj.org/article/db7b5f12e7994ea49aa1f66cc4afaa01

The lupus susceptibility allele DRB1*03:01 encodes a disease-driving epitope

Authors: Bruna Miglioranza Scavuzzi, Vincent van Drongelen, Bhavneet Kaur, Jennifer Callahan Fox, Jianhua Liu, Raquel A. Mesquita-Ferrari, J. Michelle Kahlenberg, Evan A. Farkash, Fernando Benavides, Frederick W. Miller, Amr H. Sawalha, Joseph Holoshitz

Source: Communications Biology, Vol 5, Iss 1, Pp 1-15 (2022)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/2399-3642

Access URL: https://doaj.org/article/225d5438d9e94ec6a68096613924641c

Loss of interleukin-1 beta is not protective in the lupus-prone NZM2328 mouse model

Authors: Shannon N. Loftus, Jianhua Liu, Celine C. Berthier, Johann E. Gudjonsson, Mehrnaz Gharaee-Kermani, Lam C. Tsoi, J. Michelle Kahlenberg

Source: Frontiers in Immunology, Vol 14 (2023)

Subject Terms: lupus, nephritis, interleukin-1beta (IL-1ß), inflammasome, proteinuria, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2023.1162799/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/aa064b19d56a431ba58940d74183f8e1

Keratinocytes sense and eliminate CRISPR DNA through STING/IFN-κ activation and APOBEC3G induction

Authors: Mrinal K. Sarkar, Ranjitha Uppala, Chang Zeng, Allison C. Billi, Lam C. Tsoi, Austin Kidder, Xianying Xing, Bethany E. Perez White, Shuai Shao, Olesya Plazyo, Sirisha Sirobhushanam, Enze Xing, Yanyun Jiang, Katherine A. Gallagher, John J. Voorhees, J. Michelle Kahlenberg, Johann E. Gudjonsson

Source: The Journal of Clinical Investigation, Vol 133, Iss 9 (2023)

Subject Terms: Cell biology, Dermatology, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/1558-8238

Access URL: https://doaj.org/article/2e6f622a55a149e8bca5194f792c60eb

Tofacitinib blocks IFN-regulated biomarker genes in skin fibroblasts and keratinocytes in a systemic sclerosis trial

Authors: Dinesh Khanna, Cristina Padilla, Lam C. Tsoi, Vivek Nagaraja, Puja P. Khanna, Tracy Tabib, J. Michelle Kahlenberg, Amber Young, Suiyuan Huang, Johann E. Gudjonsson, David A. Fox, Robert Lafyatis

Source: JCI Insight, Vol 7, Iss 17 (2022)

Subject Terms: Clinical trials, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/2379-3708

Access URL: https://doaj.org/article/c75c7f302c8941289e403e34846ce699

Biogeographic and disease-specific alterations in epidermal lipid composition and single-cell analysis of acral keratinocytes

Authors: Alexander A. Merleev, Stephanie T. Le, Claire Alexanian, Atrin Toussi, Yixuan Xie, Alina I. Marusina, Steven M. Watkins, Forum Patel, Allison C. Billi, Julie Wiedemann, Yoshihiro Izumiya, Ashish Kumar, Ranjitha Uppala, J. Michelle Kahlenberg, Fu-Tong Liu, Iannis E. Adamopoulos, Elizabeth A. Wang, Chelsea Ma, Michelle Y. Cheng, Halani Xiong, Amanda Kirane, Guillaume Luxardi, Bogi Andersen, Lam C. Tsoi, Carlito B. Lebrilla, Johann E. Gudjonsson, Emanual Maverakis

Source: JCI Insight, Vol 7, Iss 16 (2022)

Subject Terms: Dermatology, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/2379-3708

Access URL: https://doaj.org/article/29f7b5c3c7314462ae63385c896e06c5

IFN-κ is critical for normal wound repair and is decreased in diabetic wounds

Authors: Sonya J. Wolf, Christopher O. Audu, Amrita Joshi, Aaron denDekker, William J. Melvin, Frank M. Davis, Xianying Xing, Rachael Wasikowski, Lam C. Tsoi, Steven L. Kunkel, Johann E. Gudjonsson, Mary X. O’Riordan, J. Michelle Kahlenberg, Katherine A. Gallagher

Source: JCI Insight, Vol 7, Iss 9 (2022)

Subject Terms: Inflammation, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/2379-3708

Access URL: https://doaj.org/article/eca6cf178c67407eb93d2292893b3a0c

Single-cell transcriptomics reveals distinct effector profiles of infiltrating T cells in lupus skin and kidney

Authors: Garrett S. Dunlap, Allison C. Billi, Xianying Xing, Feiyang Ma, Mitra P. Maz, Lam C. Tsoi, Rachael Wasikowski, Jeffrey B. Hodgin, Johann E. Gudjonsson, J. Michelle Kahlenberg, Deepak A. Rao

Source: JCI Insight, Vol 7, Iss 8 (2022)

Subject Terms: Autoimmunity, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/2379-3708

Access URL: https://doaj.org/article/aa9befc0293c47f9a47cc27bbdbf3050