MCPIP1 is a novel link between diabetogenic conditions and impaired insulin secretory capacity

Authors: Tyka, Karolina, Jörns, Anne, Dunst, Alessia, Tang, Yadi, Bryde, Tenna Holgersen, Mehmeti, Ilir, Walentinsson, Anna, Marselli, Lorella, Cnop, Miriam, Tyrberg, Björn, Marzec, Michal T., Gurgul-Convey, Ewa

Source: In BBA - Molecular Basis of Disease 1 October 2021 1867(10)

The importance of aquaporin-8 for cytokine-mediated toxicity in rat insulin-producing cells

Authors: Krüger, Christina, Jörns, Anne, Kaynert, Jonas, Waldeck-Weiermair, Markus, Michel, Thomas, Elsner, Matthias, Lenzen, Sigurd

Source: In Free Radical Biology and Medicine October 2021 174:135-143

The central role of glutathione peroxidase 4 in the regulation of ferroptosis and its implications for pro-inflammatory cytokine-mediated beta-cell death

Authors: Krümmel, Bastian, Plötz, Thomas, Jörns, Anne, Lenzen, Sigurd, Mehmeti, Ilir

Source: In BBA - Molecular Basis of Disease 1 June 2021 1867(6)

Therapy concepts in type 1 diabetes mellitus treatment: disease modifying versus curative approaches.

Authors: Lenzen, Sigurd^1,2 (AUTHOR) lenzen.sigurd@mh-hannover.de, Jörns, Anne² (AUTHOR)

Source: Journal of Molecular Medicine. Dec2024, Vol. 102 Issue 12, p1451-1455. 5p.

Subject Terms: *TYPE 1 diabetes, *AUTOIMMUNE diseases, *PANCREATIC beta cells, *ISLANDS of Langerhans, *THERAPEUTICS

PNLIPRP1 Hypermethylation in Exocrine Pancreas Links Type 2 Diabetes and Cholesterol Metabolism.

Authors: Maurin, Lucas, Marselli, Lorella, Boissel, Mathilde, Ning, Lijiao, Boutry, Raphael, Fernandes, Justine, Suleiman, Mara, De Luca, Carmela, Leloire, Audrey, Pascat, Vincent, Toussaint, Bénédicte, Amanzougarene, Souhila, Derhourhi, Mehdi, Jörns, Anne, Lenzen, Sigurd, Pattou, François, Kerr-Conte, Julie, Canouil, Mickaël, Marchetti, Piero, Bonnefond, Amélie

Source: Diabetes; Nov2024, Vol. 73 Issue 11, p1908-1918, 11p

Subject Terms: PANCREATIC diseases, TYPE 2 diabetes, CHOLESTEROL metabolism, LDL cholesterol, GENE expression, GENE enhancers

Tafazzin-dependent cardiolipin composition in C6 glioma cells correlates with changes in mitochondrial and cellular functions, and cellular proliferation

Authors: Gürtler, Sarah, Wolke, Carmen, Otto, Oliver, Heise, Nico, Scholz, Fritz, Laporte, Anna, Elsner, Matthias, Jörns, Anne, Weinert, Sönke, Döring, Mona, Jansing, Steffen, Gardemann, Andreas, Lendeckel, Uwe, Schild, Lorenz

Source: In BBA - Molecular and Cell Biology of Lipids April 2019 1864(4):452-465

Rat Models of Human Type 1 Diabetes

Authors: Lenzen, Sigurd, Arndt, Tanja, Elsner, Matthias, Wedekind, Dirk, Jörns, Anne

Source: Methods in molecular biology. 2128:69-86

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN624303529&indx=1&recIds=ETOCRN624303529

Translation of curative therapy concepts with T cell and cytokine antibody combinations for type 1 diabetes reversal in the IDDM rat

Authors: Jörns, Anne [and others]

Source: Journal of molecular medicine. 98(8):1125-1137

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100190627459.0x000001&indx=1&recIds=ETOCvdc_100190627459.0x000001

Exploring dose–response variability and relative severity assessment in STZ-induced diabetes male NSG mice.

Authors: Talbot, Steven R., Heider, Miriam, Wirth, Martin, Jörns, Anne, Naujok, Ortwin

Source: Scientific Reports; 7/17/2024, Vol. 14 Issue 1, p1-11, 11p

Subject Terms: MICE, DIABETES, EFFECT of stress on animals, ISLANDS of Langerhans, PANCREATIC beta cells, STREPTOZOTOCIN

Enhanced activation of interleukin-10, heme oxygenase-1, and AKT in C5aR2-deficient mice is associated with protection from ischemia reperfusion injury–induced inflammation and fibrosis

Authors: Thorenz, Anja, Derlin, Katja, Schröder, Christoph, Dressler, Lisa, Vijayan, Vijith, Pradhan, Pooja, Immenschuh, Stephan, Jörns, Anne, Echtermeyer, Frank, Herzog, Christine, Chen, Rongjun, Rong, Song, Bräsen, Jan Hinrich, van Kooten, Cees, Kirsch, Torsten, Klemann, Christian, Meier, Martin, Klos, Andreas, Haller, Hermann, Hensen, Bennet, Gueler, Faikah

Source: In Kidney International October 2018 94(4):741-755

Asymmetric dimethylation and citrullination in the LEW.1AR1-iddm rat, an animal model of human type 1 diabetes, and effects of anti-TCR/anti-TNF-α antibody-based therapy

Authors: Bollenbach, Alexander, Tsikas, Dimitrios, Lenzen, Sigurd, Jörns, Anne

Source: Amino acids. 52(1):103-110

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100118376807.0x000001&indx=1&recIds=ETOCvdc_100118376807.0x000001

MCPIP1 regulates the sensitivity of pancreatic beta-cells to cytokine toxicity

Authors: Tyka, Karolina, Jörns, Anne, Turatsinze, Jean-Valery, Eizirik, Decio, Lenzen, Sigurd, Gurgul-Convey, Ewa

Source: Cell death and disease. 10(1):1-17

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100103849543.0x000001&indx=1&recIds=ETOCvdc_100103849543.0x000001

ER-resident antioxidative GPx7 and GPx8 enzyme isoforms protect insulin-secreting INS-1E β-cells against lipotoxicity by improving the ER antioxidative capacity

Authors: Mehmeti, Ilir, Lortz, Stephan, Avezov, Edward, Jörns, Anne, Lenzen, Sigurd

Source: In Free Radical Biology and Medicine November 2017 112:121-130

Motor properties of Myosin 5c are modulated by tropomyosin isoforms and inhibited by pentabromopseudilin.

Authors: Kengyel, András, Palarz, Philip M., Krohn, Jacqueline, Marquardt, Anja, Greve, Johannes N., Heiringhoff, Robin, Jörns, Anne, Manstein, Dietmar J.

Source: Frontiers in Physiology; 2024, p1-13, 13p

Results, meta-analysis and a first evaluation of UNOxR, the urinary nitrate-to-nitrite molar ratio, as a measure of nitrite reabsorption in experimental and clinical settings

Authors: Tsikas, Dimitrios, Hanff, Erik, Bollenbach, Alexander, Kruger, Ruan, Pham, Vu Vi, Chobanyan-Jürgens, Kristine, Wedekind, Dirk, Arndt, Tanja, Jörns, Anne, Berbée, Jimmy F. P., Princen, Hans M. G., Lücke, Thomas, Mariotti, François, Huneau, Jean-François, Ückert, Stefan, Frölich, Jürgen C., Lenzen, Sigurd

Source: Amino acids. 50(7):799-821

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100119727444.0x000001&indx=1&recIds=ETOCvdc_100119727444.0x000001

Restoration of mucosal integrity and epithelial transport function by concomitant anti-TNFα treatment in chronic DSS-induced colitis

Authors: Lenzen, Henrike, Qian, Jiajie, Manns, Michael P, Seidler, Ursula, Jörns, Anne

Source: Journal of molecular medicine. 96(8):831-843

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100118090725.0x000001&indx=1&recIds=ETOCvdc_100118090725.0x000001

Changes in immune cell frequencies in primary and secondary lymphatic organs of LEW.1AR1-iddm rats, a model of human type 1 diabetes compared to other MHC congenic LEW inbred strains

Authors: Arndt, Tanja, Jörns, Anne, Wedekind, Dirk

Source: Immunologic research. 66(4):462-470

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100128527428.0x000001&indx=1&recIds=ETOCvdc_100128527428.0x000001

Interleukin 17, Produced by γδ T Cells, Contributes to Hepatic Inflammation in a Mouse Model of Biliary Atresia and Is Increased in Livers of Patients

Authors: Klemann, Christian, Schröder, Arne, Dreier, Anika, Möhn, Nora, Dippel, Stephanie, Winterberg, Thomas, Wilde, Anne, Yu, Yi, Thorenz, Anja, Gueler, Faikah, Jörns, Anne, Tolosa, Eva, Leonhardt, Johannes, Haas, Jan D., Prinz, Immo, Vieten, Gertrud, Petersen, Claus, Kuebler, Joachim F.

Source: In Gastroenterology January 2016 150(1):229-241

Systems biology of the IMIDIA biobank from organ donors and pancreatectomised patients defines a novel transcriptomic signature of islets from individuals with type 2 diabetes

Authors: Solimena, Michele, Schulte, Anke M., Marselli, Lorella, Ehehalt, Florian, Richter, Daniela, Kleeberg, Manuela, Mziaut, Hassan, Knoch, Klaus-Peter, Parnis, Julia, Bugliani, Marco, Siddiq, Afshan, Jörns, Anne, Burdet, Frédéric, Liechti, Robin, Suleiman, Mara, Margerie, Daniel, Syed, Farooq, Distler, Marius, Grützmann, Robert, Petretto, Enrico, Moreno-Moral, Aida, Wegbrod, Carolin, Sönmez, Anke, Pfriem, Katja, Friedrich, Anne, Meinel, Jörn, Wollheim, Claes B., Baretton, Gustavo B., Scharfmann, Raphael, Nogoceke, Everson, Bonifacio, Ezio, Sturm, Dorothée, Meyer-Puttlitz, Birgit, Boggi, Ugo, Saeger, Hans-Detlev, Filipponi, Franco, Lesche, Mathias, Meda, Paolo, Dahl, Andreas, Wigger, Leonore, Xenarios, Ioannis, Falchi, Mario, Thorens, Bernard, Weitz, Jürgen, Bokvist, Krister, Lenzen, Sigurd, Rutter, Guy A., Froguel, Philippe, von Bülow, Manon, Ibberson, Mark, Marchetti, Piero

Source: Diabetologia. 61(3):641-657

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100125286536.0x000001&indx=1&recIds=ETOCvdc_100125286536.0x000001

Effect of fluoroquinolones on mitochondrial function in pancreatic beta cells

Authors: Ghaly, Hany, Jörns, Anne, Rustenbeck, Ingo

Source: In European Journal of Pharmaceutical Sciences 14 February 2014 52:206-214