P2Y2 receptor mediates dying cell removal via inflammatory activated microglia

Authors: Izumi Hide, Hiroko Shiraki, Akihiro Masuda, Takuya Maeda, Mayuka Kumagai, Nao Kunishige, Yuhki Yanase, Kana Harada, Shigeru Tanaka, Norio Sakai

Source: Journal of Pharmacological Sciences, Vol 153, Iss 1, Pp 55-67 (2023)

Subject Terms: Microglia, Inflammation, Dying cell removal, Lipopolysaccharide, P2Y2 receptor, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1347861323000385; https://doaj.org/toc/1347-8613

Access URL: https://doaj.org/article/2d9172ff569342c5b292d2925a9652a7

Features and mechanisms of propofol-induced protein kinase C (PKC) translocation and activation in living cells

Authors: Soma Noguchi, Taketoshi Kajimoto, Takuya Kumamoto, Masashi Shingai, Soshi Narasaki, Tomoaki Urabe, Serika Imamura, Kana Harada, Izumi Hide, Sigeru Tanaka, Yuhki Yanase, Shun-Ichi Nakamura, Yasuo M. Tsutsumi, Norio Sakai

Source: Frontiers in Pharmacology, Vol 14 (2023)

Subject Terms: protein kinase C (PKC), propofol, nuclear translocation of proteins, propofol derivatives, intracellular organelle, anesthetic, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2023.1284586/full; https://doaj.org/toc/1663-9812

Access URL: https://doaj.org/article/6905b40dd76244c5a441fae6f3e08a09

Potential role of inducible GPR3 expression under stimulated T cell conditions

Authors: Hiroko Shiraki, Shigeru Tanaka, Yun Guo, Kana Harada, Izumi Hide, Tomoharu Yasuda, Norio Sakai

Source: Journal of Pharmacological Sciences, Vol 148, Iss 3, Pp 307-314 (2022)

Subject Terms: GPR3, T cell, NR4A2, cAMP, Gαs protein, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1347861322000056; https://doaj.org/toc/1347-8613

Access URL: https://doaj.org/article/404c9a5e05b5429a86af4e272363a08c

Effects of flurbiprofen on the functional regulation of serotonin transporter and its misfolded mutant

Authors: Haruki Hirakawa, Kei Taguchi, Seiya Murakawa, Masaya Asano, Soma Noguchi, Satoshi Kikkawa, Kana Harada, Naoko Adachi, Takehiko Ueyama, Izumi Hide, Shigeru Tanaka, Norio Sakai

Source: Journal of Pharmacological Sciences, Vol 148, Iss 1, Pp 187-195 (2022)

Subject Terms: Serotonin transporter, Chemical chaperone, Membrane trafficking, ER stress, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1347861321001134; https://doaj.org/toc/1347-8613

Access URL: https://doaj.org/article/9330ce51e2554433b6a7217e7813e997

GPR3 expression in retinal ganglion cells contributes to neuron survival and accelerates axonal regeneration after optic nerve crush in mice

Authors: Shun Masuda, Shigeru Tanaka, Hiroko Shiraki, Yusuke Sotomaru, Kana Harada, Izumi Hide, Yoshiaki Kiuchi, Norio Sakai

Source: Neurobiology of Disease, Vol 172, Iss , Pp 105811- (2022)

Subject Terms: GPR3, cAMP, Axonal regeneration, Retinal granular cells, Neuronal survival, Optic nerve injury, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0969996122002030; https://doaj.org/toc/1095-953X

Access URL: https://doaj.org/article/cbcc8843261b4ff890e0fed40f1d323c

Syntaxin 3 interacts with serotonin transporter and regulates its function

Authors: Serika Motoike, Kei Taguchi, Kana Harada, Masaya Asano, Izumi Hide, Shigeru Tanaka, Masahiro Irifune, Norio Sakai

Source: Journal of Pharmacological Sciences, Vol 145, Iss 4, Pp 297-307 (2021)

Subject Terms: Serotonin transporter, Syntaxin 3, Membrane trafficking, Caco-2 cells, Glycosylation, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1347861321000086; https://doaj.org/toc/1347-8613

Access URL: https://doaj.org/article/a7c2315476ef45a8af9f1ada51c7284f

SKF-10047, a prototype Sigma-1 receptor agonist, augmented the membrane trafficking and uptake activity of the serotonin transporter and its C-terminus-deleted mutant via a Sigma-1 receptor-independent mechanism

Authors: Masaya Asano, Serika Motoike, Chika Yokota, Naoto Usuki, Hikaru Yamamoto, Tomoaki Urabe, Kazusa Katarao, Izumi Hide, Shigeru Tanaka, Masashi Kawamoto, Masahiro Irifune, Norio Sakai

Source: Journal of Pharmacological Sciences, Vol 139, Iss 1, Pp 29-36 (2019)

Subject Terms: Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1347861318302068; https://doaj.org/toc/1347-8613

Access URL: https://doaj.org/article/d73623f3346246769ae8dadbf2c820a5

Propofol induced diverse and subtype-specific translocation of PKC families

Authors: Takeshi Miyahara, Naoko Adachi, Takahiro Seki, Izumi Hide, Shigeru Tanaka, Naoaki Saito, Masahiro Irifune, Norio Sakai

Source: Journal of Pharmacological Sciences, Vol 137, Iss 1, Pp 20-29 (2018)

Subject Terms: Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1347861318300677; https://doaj.org/toc/1347-8613

Access URL: https://doaj.org/article/ec404e1d2af64916b6335269c03bae0d

Component of nicotine-induced intracellular calcium elevation mediated through α3- and α5-containing nicotinic acetylcholine receptors are regulated by cyclic AMP in SH-SY 5Y cells.

Authors: Tamayo Takahashi, Takayuki Yoshida, Kana Harada, Tatsuhiko Miyagi, Kouichi Hashimoto, Izumi Hide, Shigeru Tanaka, Masahiro Irifune, Norio Sakai

Source: PLoS ONE, Vol 15, Iss 11, p e0242349 (2020)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/0494c2af5e2c4eec969d98a15d14dab9

Evaluation of the Effectiveness of Post-Stroke Metformin Treatment Using Permanent Middle Cerebral Artery Occlusion in Rats

Authors: Gintare Zemgulyte, Shigeru Tanaka, Izumi Hide, Norio Sakai, Katryna Pampuscenko, Vilmante Borutaite, Daiva Rastenyte

Source: Pharmaceuticals, Vol 14, Iss 4, p 312 (2021)

Subject Terms: metformin, post-stroke treatment, permanent middle cerebral artery occlusion, ischemia, microglia, Medicine, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://www.mdpi.com/1424-8247/14/4/312; https://doaj.org/toc/1424-8247

Access URL: https://doaj.org/article/24b066560a21425293be75f3b7ddcec6

Developmental expression of GPR3 in rodent cerebellar granule neurons is associated with cell survival and protects neurons from various apoptotic stimuli

Authors: Shigeru Tanaka, Tatsuhiro Miyagi, Eisuke Dohi, Takahiro Seki, Izumi Hide, Yusuke Sotomaru, Yoshinaga Saeki, E. Antonio Chiocca, Masayasu Matsumoto, Norio Sakai

Source: Neurobiology of Disease, Vol 68, Iss , Pp 215-227 (2014)

Subject Terms: GPR3, Brain ischemia, Cerebellar granular neurons, Neuronal protection, cAMP, Apoptosis, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0969996114000965; https://doaj.org/toc/1095-953X

Access URL: https://doaj.org/article/493abb24d81d437fa9bfdd4eb7ac2168

Long-Term Exposure of RN46A Cells Expressing Serotonin Transporter (SERT) to a cAMP Analog Up-regulates SERT Activity and Is Accompanied by Neural Differentiation of the Cells

Authors: Hikaru Yammamoto, Shigeru Tanaka, Anna Tanaka, Izumi Hide, Takahiro Seki, Norio Sakai

Source: Journal of Pharmacological Sciences, Vol 121, Iss 1, Pp 25-38 (2013)

Subject Terms: Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1347861319304013; https://doaj.org/toc/1347-8613

Access URL: https://doaj.org/article/bc643fd25c0840598d432c74645a8b7f

Effects of the Chemical Chaperone 4-Phenylbutylate on the Function of the Serotonin Transporter (SERT) Expressed in COS-7 Cells

Authors: Masayuki Fujiwara, Hikaru Yamamoto, Tatsuhiro Miyagi, Takahiro Seki, Shigeru Tanaka, Izumi Hide, Norio Sakai

Source: Journal of Pharmacological Sciences, Vol 122, Iss 2, Pp 71-83 (2013)

Subject Terms: Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S134786131930324X; https://doaj.org/toc/1347-8613

Access URL: https://doaj.org/article/f91c093133a245e5b6a4f5984d922fa8

New Mastoparan Peptides in the Venom of the Solitary Eumenine Wasp Eumenes micado

Authors: Katsuhiro Konno, Kohei Kazuma, Marisa Rangel, Joacir Stolarz-de-Oliveira, Renato Fontana, Marii Kawano, Hiroyuki Fuchino, Izumi Hide, Tadashi Yasuhara, Yoshihiro Nakata

Source: Toxins, Vol 11, Iss 3, p 155 (2019)

Subject Terms: solitary wasp, venom, mastoparan peptide, linear cationic α-helical peptide, amphipathic α-helix structure., Medicine

File Description: electronic resource

Relation: http://www.mdpi.com/2072-6651/11/3/155; https://doaj.org/toc/2072-6651

Access URL: https://doaj.org/article/f516da0a86164a8b80f1d6d6fc4b2423

Congo Red, an Amyloid-Inhibiting Compound, Alleviates Various Types of Cellular Dysfunction Triggered by Mutant Protein Kinase Cγ That Causes Spinocerebellar Ataxia Type 14 (SCA14) by Inhibiting Oligomerization and Aggregation

Authors: Takahiro Seki, Hideyuki Takahashi, Kazuhiro Yamamoto, Kota Ogawa, Tomoya Onji, Naoko Adachi, Shigeru Tanaka, Izumi Hide, Naoaki Saito, Norio Sakai

Source: Journal of Pharmacological Sciences, Vol 114, Iss 2, Pp 206-216 (2010)

Subject Terms: Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1347861319308618; https://doaj.org/toc/1347-8613

Access URL: https://doaj.org/article/a12bc3ee848840fa9e0987a9db91f00b

The Subcellular Dynamics of the Gs-Linked Receptor GPR3 Contribute to the Local Activation of PKA in Cerebellar Granular Neurons.

Authors: Tatsuhiro Miyagi, Shigeru Tanaka, Izumi Hide, Toshihiko Shirafuji, Norio Sakai

Source: PLoS ONE, Vol 11, Iss 1, p e0147466 (2016)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC4723318?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/a4792f16da7e4622a47d3563ec8d4b88

Anti-allergic Substances Contained in the Pollen of Cryptomeria japonica Possess Diverse Effects on the Degranulation of RBL-2H3 Cells

Authors: Yukiko Morimoto, Tadashi Yasuhara, Akiko Sugimoto, Atsuko Inoue, Izumi Hide, Mitoshi Akiyama, Yoshihiro Nakata

Source: Journal of Pharmacological Sciences, Vol 92, Iss 3, Pp 291-295 (2003)

Subject Terms: Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1347861319326611; https://doaj.org/toc/1347-8613

Access URL: https://doaj.org/article/8b686f8f1c074b5781c9e11f586ec805

Establishment of a novel fluorescence-based method to evaluate chaperone-mediated autophagy in a single neuron.

Authors: Takahiro Seki, Ken-ich Yoshino, Shigeru Tanaka, Eisuke Dohi, Tomoya Onji, Kazuhiro Yamamoto, Izumi Hide, Henry L Paulson, Naoaki Saito, Norio Sakai

Source: PLoS ONE, Vol 7, Iss 2, p e31232 (2012)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3280339?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/998a4e3d7def49dcbb78b9980c8eceb4

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The role of cysteine string protein alpha (CSPα) phosphorylation at Serine 10, and 34, by protein kinase Cγ for presynaptic maintenance.

Authors: Toshihiko Shirafuji, Takehiko Ueyama, Naoko Adachi, Ken-Ichi Yoshino, Yusuke Sotomaru, Junsuke Uwada, Azumi Kaneoka, Taro Ueda, Shigeru Tanaka, Izumi Hide, Naoaki Saito, Norio Sakai

Source: Journal of Neuroscience; 1/10/2018, Vol. 38 Issue 2, p278-290, 13p

Subject Terms: PARKINSON'S disease, CYSTEINE string proteins, PHOSPHORYLATION, PROTEIN kinase C, MOLECULAR chaperones