Transposon mediated functional genomic screening for BRAF inhibitor resistance reveals convergent Hippo and MAPK pathway activation events

Authors: Li Chen, Iulian Pruteanu-Malinici, Anahita Dastur, Xunqin Yin, Dennie Frederick, Ruslan I. Sadreyev, Cyril H. Benes

Source: Scientific Reports, Vol 15, Iss 1, Pp 1-12 (2025)

Subject Terms: BRAF inhibitor resistance, Transposon mutagenesis screen, Hippo pathway, TAZ, NEDD4L, Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/7d1d6ee315774d589b0cd6f455ff8219

1378 Discovery and characterization of PM-4321, a selective inhibitor of the aryl hydrocarbon receptor (AHR) with anti-tumor immunomodulatory effects

Authors: Charles Sinclair, Luisa Salter-Cid, Benjamin Carter, Ming Bai, Christopher Wrocklage, Kritika Ramani, Anna Nicole Bosco, Iulian Pruteanu-Malinici, Lizeth Perales, Wojciech Dworakowski, Brenda K Eustace, Kun Don Yi, Seema Kumar, Matthew Abbinanti, Alessandra Bartolozzi, John Robert Proudfoot, Timothy Briggs, John Steven Taylor, Sheila Ranganath

Source: Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2051-1426

Access URL: https://doaj.org/article/e7ba96b5cb4a4d5ebfb7f9389ad00812

TGFβ-blockade uncovers stromal plasticity in tumors by revealing the existence of a subset of interferon-licensed fibroblasts

Authors: Angelo L. Grauel, Beverly Nguyen, David Ruddy, Tyler Laszewski, Stephanie Schwartz, Jonathan Chang, Julie Chen, Michelle Piquet, Marc Pelletier, Zheng Yan, Nathaniel D. Kirkpatrick, Jincheng Wu, Antoine deWeck, Markus Riester, Matt Hims, Felipe Correa Geyer, Joel Wagner, Kenzie MacIsaac, James Deeds, Rohan Diwanji, Pushpa Jayaraman, Yenyen Yu, Quincey Simmons, Shaobu Weng, Alina Raza, Brian Minie, Mirek Dostalek, Pavitra Chikkegowda, Vera Ruda, Oleg Iartchouk, Naiyan Chen, Raphael Thierry, Joseph Zhou, Iulian Pruteanu-Malinici, Claire Fabre, Jeffrey A. Engelman, Glenn Dranoff, Viviana Cremasco

Source: Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/55eb6b2ee746490ba919c1fb7bbcfb1d

Landscape of Targeted Anti-Cancer Drug Synergies in Melanoma Identifies a Novel BRAF-VEGFR/PDGFR Combination Treatment.

Authors: Adam A Friedman, Arnaud Amzallag, Iulian Pruteanu-Malinici, Subash Baniya, Zachary A Cooper, Adriano Piris, Leeza Hargreaves, Vivien Igras, Dennie T Frederick, Donald P Lawrence, Daniel A Haber, Keith T Flaherty, Jennifer A Wargo, Sridhar Ramaswamy, Cyril H Benes, David E Fisher

Source: PLoS ONE, Vol 10, Iss 10, p e0140310 (2015)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0140310&type=printable; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/2c65cc61a9ae4bf8a9a2e40f9c38d289

Automatic annotation of spatial expression patterns via sparse Bayesian factor models.

Authors: Iulian Pruteanu-Malinici, Daniel L Mace, Uwe Ohler

Source: PLoS Computational Biology, Vol 7, Iss 7, p e1002098 (2011)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002098&type=printable; https://doaj.org/toc/1553-734X; https://doaj.org/toc/1553-7358

Access URL: https://doaj.org/article/5a5a02022de5477b9d0926030077474a