Parbendazole as a promising drug for inducing differentiation of acute myeloid leukemia cells with various subtypes

Authors: Hidemasa Matsuo, Aina Inagami, Yuri Ito, Nana Ito, Shinju Iyoda, Yutarou Harata, Moe Higashitani, Kota Shoji, Miu Tanaka, Mina Noura, Takashi Mikami, Itaru Kato, Junko Takita, Tatsutoshi Nakahata, Souichi Adachi

Source: Communications Biology, Vol 7, Iss 1, Pp 1-9 (2024)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/2399-3642

Access URL: https://doaj.org/article/0b155634222645bfa3ab9af22a9b758f

Clinical utility of cerebrospinal fluid-placental alkaline phosphatase for the diagnosis of intracranial germinoma

Authors: Satoshi Obu, Katsutsugu Umeda, Kougoro Iwanaga, Satoshi Saida, Itaru Kato, Hidefumi Hiramatsu, Yohei Mineharu, Yoshiki Arakawa, Megumi Uto, Takashi Mizowaki, Souichi Adachi, Tomoo Daifu, Masahiko Kawai, Junko Takita

Source: Pediatric Hematology Oncology Journal, Vol 7, Iss 4, Pp 173-176 (2022)

Subject Terms: Germinoma, Intracranial germ cell tumor, Placental alkaline phosphatase, Diagnosis, Tumor marker, Pediatrics, RJ1-570

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2468124522005125; https://doaj.org/toc/2468-1245

Access URL: https://doaj.org/article/052a99c80f2f4df1b1755d9063abbae4

Multi-omics analysis defines highly refractory RAS burdened immature subgroup of infant acute lymphoblastic leukemia

Authors: Tomoya Isobe, Masatoshi Takagi, Aiko Sato-Otsubo, Akira Nishimura, Genta Nagae, Chika Yamagishi, Moe Tamura, Yosuke Tanaka, Shuhei Asada, Reina Takeda, Akiho Tsuchiya, Xiaonan Wang, Kenichi Yoshida, Yasuhito Nannya, Hiroo Ueno, Ryo Akazawa, Itaru Kato, Takashi Mikami, Kentaro Watanabe, Masahiro Sekiguchi, Masafumi Seki, Shunsuke Kimura, Mitsuteru Hiwatari, Motohiro Kato, Shiro Fukuda, Kenji Tatsuno, Shuichi Tsutsumi, Akinori Kanai, Toshiya Inaba, Yusuke Shiozawa, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Rishi S. Kotecha, Mark N. Cruickshank, Fumihiko Ishikawa, Tomohiro Morio, Mariko Eguchi, Takao Deguchi, Nobutaka Kiyokawa, Yuki Arakawa, Katsuyoshi Koh, Yuki Aoki, Takashi Ishihara, Daisuke Tomizawa, Takako Miyamura, Eiichi Ishii, Shuki Mizutani, Nicola K. Wilson, Berthold Göttgens, Satoru Miyano, Toshio Kitamura, Susumu Goyama, Akihiko Yokoyama, Hiroyuki Aburatani, Seishi Ogawa, Junko Takita

Source: Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/7fee3de7cd6b4b10b237a1df0b62b1d6

Safety and efficacy of post-haematopoietic cell transplantation maintenance therapy with blinatumomab for relapsed/refractory CD19-positive B-cell acute lymphoblastic leukaemia: protocol for a phase I–II, multicentre, non-blinded, non-controlled trial (JPLSG SCT-ALL-BLIN21)

Authors: Yoshiyuki Takahashi, Hisashi Noma, Akiko Saito, Keizo Horibe, Hirotoshi Sakaguchi, Katsustugu Umeda, Itaru Kato, Kimiyoshi Sakaguchi, Hidefumi Hiramatsu, Hiroyuki Ishida, Hiromasa Yabe, Hiroaki Goto, Yuta Kawahara, Yuka Iijima Yamashita, Masashi Sanada, Takao Deguchi, Takashi Taga, Souichi Adachi

Source: BMJ Open, Vol 13, Iss 4 (2023)

Subject Terms: Medicine

File Description: electronic resource

Relation: https://bmjopen.bmj.com/content/13/4/e070051.full; https://doaj.org/toc/2044-6055

Access URL: https://doaj.org/article/4e2a3190c22c4e4381335bdb12f4486c

Oncogenic cooperation between TCF7-SPI1 and NRAS(G12D) requires β-catenin activity to drive T-cell acute lymphoblastic leukemia

Authors: Quentin Van Thillo, Jolien De Bie, Janith A. Seneviratne, Sofie Demeyer, Sofia Omari, Anushree Balachandran, Vicki Zhai, Wai L. Tam, Bram Sweron, Ellen Geerdens, Olga Gielen, Sarah Provost, Heidi Segers, Nancy Boeckx, Glenn M. Marshall, Belamy B. Cheung, Kiyotaka Isobe, Itaru Kato, Junko Takita, Timothy G. Amos, Ira W. Deveson, Hannah McCalmont, Richard B. Lock, Ethan P. Oxley, Maximilian M. Garwood, Ross A. Dickins, Anne Uyttebroeck, Daniel R. Carter, Jan Cools, Charles E. de Bock

Source: Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/097bfb27edca4477bb37a09172ff1f71

Author Correction: Pluripotent stem cell model of Shwachman–Diamond syndrome reveals apoptotic predisposition of hemoangiogenic progenitors

Authors: Takayuki Hamabata, Katsutsugu Umeda, Kagehiro Kouzuki, Takayuki Tanaka, Tomoo Daifu, Seishiro Nodomi, Satoshi Saida, Itaru Kato, Shiro Baba, Hidefumi Hiramatsu, Mitsujiro Osawa, Akira Niwa, Megumu K. Saito, Yasuhiko Kamikubo, Souichi Adachi, Yoshiko Hashii, Akira Shimada, Hiroyoshi Watanabe, Kenji Osafune, Keisuke Okita, Tatsutoshi Nakahata, Kenichiro Watanabe, Junko Takita, Toshio Heike

Source: Scientific Reports, Vol 11, Iss 1, Pp 1-4 (2021)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/b950f5eee1ed4eed9297ec002e679c2f

Direct Delivery of piggyBac CD19 CAR T Cells Has Potent Anti-tumor Activity against ALL Cells in CNS in a Xenograft Mouse Model

Authors: Kuniaki Tanaka, Itaru Kato, Miyuki Tanaka, Daisuke Morita, Kazuyuki Matsuda, Yoshiyuki Takahashi, Tatsutoshi Nakahata, Katsutsugu Umeda, Hidefumi Hiramatsu, Souichi Adachi, Junko Takita, Yozo Nakazawa

Source: Molecular Therapy: Oncolytics, Vol 18, Iss , Pp 37-46 (2020)

Subject Terms: CNS-ALL, xenograft mouse model, piggyBac transposon, CD19 CAR T cells, intra thecal delivery, intra-cerebroventricular, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2372770520300760; https://doaj.org/toc/2372-7705

Access URL: https://doaj.org/article/fc0639d98e2d409a8e4a7f1de57b7b1f

BRAF V600E-positive cells as molecular markers of bone marrow disease in pediatric Langerhans cell histiocytosis

Authors: Ko Kudo, Tsutomu Toki, Rika Kanezaki, Tatsuhiko Tanaka, Takuya Kamio, Tomohiko Sato, Shinya Sasaki, Masaru Imamura, Chihaya Imai, Kumiko Ando, Harumi Kakuda, Takehiko Doi, Hiroshi Kawaguchi, Masahiro Irie, Yoji Sasahara, Akihiro Tamura, Daiichiro Hasegawa, Yosuke Itakura, Kenichiro Watanabe, Kenichi Sakamoto, Yoko Shioda, Motohiro Kato, Kazuko Kudo, Reiji Fukano, Atsushi Sato, Hiroshi Yagasaki, Hirokazu Kanegane, Itaru Kato, Katsutsugu Umeda, Souichi Adachi, Tatsuki Kataoka, Akira Kurose, Atsuko Nakazawa, Kiminori Terui, Etsuro Ito

Source: Haematologica, Vol 107, Iss 7 (2022)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://haematologica.org/article/view/10573; https://doaj.org/toc/0390-6078; https://doaj.org/toc/1592-8721

Access URL: https://doaj.org/article/0c155267656c45e884c7240dec147ef7

Case Report: A Case of Epstein-Barr Virus-Associated Acute Liver Failure Requiring Hematopoietic Cell Transplantation After Emergent Liver Transplantation

Authors: Koji Nakajima, Eitaro Hiejima, Hiroshi Nihira, Kentaro Kato, Yoshitaka Honda, Kazushi Izawa, Naoko Kawabata, Itaru Kato, Eri Ogawa, Mari Sonoda, Tatsuya Okamoto, Hideaki Okajima, Takahiro Yasumi, Junko Takita

Source: Frontiers in Immunology, Vol 13 (2022)

Subject Terms: hemophagocytic lymphohistiocytosis (HLH), Epstein-Barr virus (EBV), acute liver failure (ALF), hematopoietic cell transplantation (HCT), case report, CAEBV infection, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2022.825806/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/c6d833a3b68648ffa7d1d6a96bacc5a5

Genetic correction of HAX1 in induced pluripotent stem cells from a patient with severe congenital neutropenia improves defective granulopoiesis

Authors: Tatsuya Morishima, Ken-ichiro Watanabe, Akira Niwa, Hideyo Hirai, Satoshi Saida, Takayuki Tanaka, Itaru Kato, Katsutsugu Umeda, Hidefumi Hiramatsu, Megumu K. Saito, Kousaku Matsubara, Souichi Adachi, Masao Kobayashi, Tatsutoshi Nakahata, Toshio Heike

Source: Haematologica, Vol 99, Iss 1 (2014)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://haematologica.org/article/view/6897; https://doaj.org/toc/0390-6078; https://doaj.org/toc/1592-8721

Access URL: https://doaj.org/article/3e732a8ef27a49e492a55924f9999c11

A novel serum-free monolayer culture for orderly hematopoietic differentiation of human pluripotent cells via mesodermal progenitors.

Authors: Akira Niwa, Toshio Heike, Katsutsugu Umeda, Koichi Oshima, Itaru Kato, Hiromi Sakai, Hirofumi Suemori, Tatsutoshi Nakahata, Megumu K Saito

Source: PLoS ONE, Vol 6, Iss 7, p e22261 (2011)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3144871?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/6446579136894666bc2a45e78bcdcd53

Identification of hepatic niche harboring human acute lymphoblastic leukemic cells via the SDF-1/CXCR4 axis.

Authors: Itaru Kato, Akira Niwa, Toshio Heike, Hisanori Fujino, Megumu K Saito, Katsutsugu Umeda, Hidefumi Hiramatsu, Mamoru Ito, Makiko Morita, Yoko Nishinaka, Souichi Adachi, Fumihiko Ishikawa, Tatsutoshi Nakahata

Source: PLoS ONE, Vol 6, Iss 11, p e27042 (2011)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3206061?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/06f0489001b444babb951a583c10f3c8

CD146 is a potential immunotarget for neuroblastoma.

Authors: Satoshi Obu, Katsutsugu Umeda, Hiroo Ueno, Mari Sonoda, Keiji Tasaka, Hideto Ogata, Kagehiro Kouzuki, Seishiro Nodomi, Satoshi Saida, Itaru Kato, Hidefumi Hiramatsu, Tatsuya Okamoto, Eri Ogawa, Hideaki Okajima, Ken Morita, Yasuhiko Kamikubo, Koji Kawaguchi, Kenichiro Watanabe, Hideto Iwafuchi, Shigeki Yagyu

Source: Cancer Science; Nov2021, Vol. 112 Issue 11, p4617-4626, 10p

Intensive Multimodal Therapy Combined With Long-term Temozolomide and Etoposide Treatment for Recurrent Osteosarcoma to the Liver and Stomach.

Authors: Katsutsugu Umeda, Kojiro Taura, Itaru Kato, Satoshi Saida, Hidefumi Hiramatsu, Hironori Shimizu, Yuji Nakamoto, Megumi Uto, Takashi Mizowaki, Akio Sakamoto, Souichi Adachi, Takeshi Okamoto, Junko Takita

Source: Journal of Pediatric Hematology/Oncology; May2022, Vol. 44 Issue 4, p175-177, 3p

Hypoxic adaptation of leukemic cells infiltrating the CNS affords a therapeutic strategy targeting VEGFA.

Authors: Itaru Kato^1,2,3, Yoko Nishinaka², Masahiro Nakamura⁴, Ayse U. Akarca⁵, Akira Niwa², Hiroki Ozawa¹, Kenichi Yoshida⁶, Makiko Mori⁷, Dapeng Wang^1,8, Makiko Morita⁹, Hiroo Ueno^3,6, Yusuke Shiozawa¹⁰, Yuichi Shiraishi¹¹, Satoru Miyano^11,12, Rajeev Gupta¹, Katsutsugu Umeda³, Kenichiro Watanabe^3,13, Katsuyoshi Koh⁷, Souichi Adachi⁹, Toshio Heike³

Source: Blood. 6/8/2017, Vol. 129 Issue 23, p3126-3129. 4p.

Subject Terms: *LEUKEMIA, *CENTRAL nervous system, *VASCULAR endothelial cells, *LYMPHOBLASTIC leukemia, *BEVACIZUMAB

Central nervous system recurrence of desmoplastic small round cell tumor following aggressive multimodal therapy: A case report.

Authors: KATSUTSUGU UMEDA, SATOSHI SAIDA, HIDEKI YAMAGUCHI, SHINYA OKAMOTO, TAKESHI OKAMOTO, ITARU KATO, HIDEFUMI HIRAMATSU, TSUYOSHI IMAI, TAKESHI KODAIRA, TOSHIO HEIKE, SOUICHI ADACHI, KEN-ICHIRO WATANABE

Source: Oncology Letters; Jan2016, Vol. 11 Issue 1, p856-860, 5p

Subject Terms: CENTRAL nervous system, COMBINED modality therapy, DESMOPLASTIC small round cell tumor, EWING'S sarcoma, CANCER chemotherapy

Good Response to Chemotherapy Spares Irradiation for Extrarenal Rhabdoid Tumor Conferring Better Activities of Daily Living.

Authors: Nariaki Asada, Itaru Kato, Tomoo Daifu, Katsutsugu Umeda, Hidefumi Hiramatsu, Takeshi Okamoto, Junya Toguchida, Satoko Yamawaki, Katsuhiro Yoshikawa, Souichi Adachi, Toshio Heike, Kenichiro Watanabe

Source: Journal of Pediatric Hematology/Oncology; Jan2015, Vol. 37 Issue 1, pe57-e59, 3p