Activation of Nrf2 pathway by 4-Octyl itaconate enhances donor lung function in cold preservation settings

Authors: Xinliang Gao, Mingbo Tang, Jialin Li, Jianzun Ma, Zhengrui Liu, Wei Liu

Source: Respiratory Research, Vol 26, Iss 1, Pp 1-17 (2025)

Subject Terms: Lung transplantation, Ischemia-reperfusion injury, Primary graft dysfunction, Static cold storage, 4-octyl itaconate, E2-related factor 2, Diseases of the respiratory system, RC705-779

File Description: electronic resource

Relation: https://doaj.org/toc/1465-993X

Access URL: https://doaj.org/article/7da24c7d6b434b34ba1602011198a7ca

IRG1/itaconate enhances efferocytosis by activating Nrf2-TIM4 signaling pathway to alleviate con A induced autoimmune liver injury

Authors: Liwu Zeng, Yaxin Wang, Yongzhou Huang, Wenchang Yang, Pei Zhou, Yaqi Wan, Kaixiong Tao, Ruidong Li

Source: Cell Communication and Signaling, Vol 23, Iss 1, Pp 1-21 (2025)

Subject Terms: Itaconate, Efferocytosis, TIM4, Autoimmune hepatitis, Medicine, Cytology, QH573-671

File Description: electronic resource

Relation: https://doaj.org/toc/1478-811X

Access URL: https://doaj.org/article/0cff2214499b4ea4962c1a7d8c8a8e77

4-Octyl itaconate inhibits synovitis in the mouse model of post-traumatic osteoarthritis and alleviates pain

Authors: Yu-Zhen Tang, Wan Chen, Bao-Yun Xu, Gang He, Xiu-Cheng Fan, Kang-Lai Tang

Source: Chinese Journal of Traumatology, Vol 28, Iss 1, Pp 50-61 (2025)

Subject Terms: 4-Octyl itaconate, Synovitis, Post-traumatic osteoarthritis, Pain, Medicine (General), R5-920

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1008127524001548; https://doaj.org/toc/1008-1275

Access URL: https://doaj.org/article/6eff1f91ea9b42928e180b3cb766c559

The role and therapeutic potential of itaconate in lung disease

Authors: Ruyuan He, Yifan Zuo, Ke Yi, Bohao Liu, Congkuan Song, Ning Li, Qing Geng

Source: Cellular & Molecular Biology Letters, Vol 29, Iss 1, Pp 1-23 (2024)

Subject Terms: Itaconate, Metabolite, Inflammation, Immunometabolism, Macrophage, Lung diseases, Cytology, QH573-671

File Description: electronic resource

Relation: https://doaj.org/toc/1689-1392

Access URL: https://doaj.org/article/2f56b0c6873b41948fd441a1b266fa9a

The cell autonomous and non-autonomous roles of itaconate in immune response

Authors: Chao Chen, Xinjian Li

Source: Cell Insight, Vol 4, Iss 1, Pp 100224- (2025)

Subject Terms: Itaconate, IRG1, Immunometabolism, Immunotransmitter, Innate immunity, Inflammation, Biology (General), QH301-705.5, Medicine (General), R5-920

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2772892724000798; https://doaj.org/toc/2772-8927

Access URL: https://doaj.org/article/964a6e27945847fbb5245f0d18332e58

Itaconate alleviates anesthesia/surgery-induced cognitive impairment by activating a Nrf2-dependent anti-neuroinflammation and neurogenesis via gut-brain axis

Authors: Xiangyi Kong, Wenyuan Lyu, Xiaojie Lin, Chunlong Lin, Hao Feng, Lin Xu, Kaiyue Shan, Penghui Wei, Jianjun Li

Source: Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-18 (2024)

Subject Terms: Itaconate, 4-octyl itaconate, Postoperative cognitive dysfunction, Neuroinflammation, Neurogenesis, Gut microbiota, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/1742-2094

Access URL: https://doaj.org/article/9f25b43506b242c09d68dd70f7d40a32

Immune-response gene 1 deficiency aggravates inflammation-triggered cardiac dysfunction by inducing M1 macrophage polarization and aggravating Ly6Chigh monocyte recruitment

Authors: Song Shen, Jianhui Li, Zhonghai Wei, Yihai Liu, Lina Kang, Rong Gu, Xuan Sun, Biao Xu, QiaoLing Li

Source: Biology Direct, Vol 19, Iss 1, Pp 1-12 (2024)

Subject Terms: Septic myocardial injury, Itaconate, Monocyte mobilization, Macrophage polarization, NRF2, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/1745-6150

Access URL: https://doaj.org/article/0a256f7a83e34fcd90fda2e7361ab7b5

Multifunctional hydrogel loaded with 4-octyl itaconate and exosomes to induce bone regeneration for diabetic infected bone defect via Keap1-Nrf2 pathway

Authors: Yizhou Wan, Qing Gao, Bing Ye, Wenzhe Sun, Kaifang Chen, Xiaodong Guo

Source: Materials Today Bio, Vol 31, Iss , Pp 101588- (2025)

Subject Terms: 4-Octyl itaconate, Exosomes, Diabetic infected bone defect, Innervation, Vascularization, Medicine (General), R5-920, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2590006425001462; https://doaj.org/toc/2590-0064

Access URL: https://doaj.org/article/77ce22cfc49d41f3bb451cbd3adb5deb

Immune-responsive gene 1/itaconate pathway inhibits microglia activation to alleviate traumatic optic neuropathy in mice

Authors: Deng, Jiaxing ^{a, b, 1}, Feng, Zhou ^{a, b, c, 1}, Luodan, A ^{a, b, 1}, Ma, Chao ^c, He, Juncai ^{a, b}, Gong, Yu ^{a, b}, Huang, Xiaona ^{a, b}, Xiao, Weizuo ^{a, b}, Fan, Xiaotang ^{d, ⁎}, Xu, Haiwei ^{a, b, ⁎⁎}

Source: In International Immunopharmacology 6 March 2025 149

Itaconate facilitates methane-induced Nrf2 pathway activation for mitigating liver ischemia and reperfusion injury

Authors: Zhang, Tianyi ^{a, 1}, Fan, Danfeng ^{b, 1}, Qin, Kewei ^{c, 1}, Lu, Hongtao ^d, Zhao, Linwei ^e, Liu, Kexin ^e, Zhang, Pei ^f, Sun, Qiang ^{b, ⁎}, Ye, Zhouheng ^{g, ⁎}

Source: In iLIVER March 2025 4(1)

The absence of IRG1 exacerbates bone loss in a mouse model of ovariectomy‐induced osteoporosis by increasing osteoclastogenesis through the potentiation of NLRP3 inflammasome activation

Authors: Wang, Fang ^{a, 1}, Liu, Yanqiao ^{b, 1}, Zhao, Yanqin ^{b, 1}, Zheng, Hongyin ^c, Zhang, Lei ^{b, ⁎}

Source: In International Immunopharmacology 20 February 2025 148

Itaconate transporter SLC13A3 confers immunotherapy resistance via alkylation-mediated stabilization of PD-L1

Authors: Fan, Yizeng ^{1, 2, 3, 7}, Dan, Weichao ^{1, 2, 3, 7}, Wang, Yuzhao ^{1, 2, 3, 7}, Ma, Zhiqiang ⁴, Jian, Yanlin ^{1, 2, 3}, Liu, Tianjie ^{1, 2, 3}, Li, Mengxing ^{1, 2, 3}, Wang, Zixi ^{1, 2, 3}, Wei, Yi ^{1, 2, 3}, Liu, Bo ^{1, 2, 3}, Ding, Peng ⁵, Lei, Yuzeshi ^{1, 2, 3}, Guo, Chendong ^{1, 2, 3}, Zeng, Jin ^{1, 2, 3}, Yan, Xiaolong ⁵, Wei, Wenyi ^{6, ∗}, Li, Lei ^{1, 2, 3, 8, ∗∗}

Source: In Cell Metabolism 4 February 2025 37(2):514-526

New anti-inflammatory mechanism of glucocorticoids uncovered

Authors: Cummins, Carolyn L. ^{1, 3, 4, @, ⁎}, Goldstein, Ido ^{2, 4}

Source: In Trends in Endocrinology & Metabolism February 2025 36(2):99-101

Tissue-engineered balloonfish stomach vascular patches coated with 4-octyl itaconate inhibit neointimal hyperplasia

Authors: Shi, Pengfei ^{a, b, ⁎}, Lou, Chunyang ^{a, b}, Fang, Jianbang ^a, Zhang, Liwei ^{a, b}, Wang, Wang ^{b, c}, Li, Jing’an ^{d, ⁎⁎}

Source: In Materials Today Communications February 2025 43

IRG1/Itaconate inhibits hepatic stellate cells ferroptosis and attenuates TAA-induced liver fibrosis by regulating SLC39A14 expression

Authors: Zhou, Pei ^{a, 1}, Yang, Lei ^{b, 1}, Li, Hang ^{a, 1}, Zeng, Liwu ^a, Zhang, Yizhuo ^c, Zhong, Ziyou ^c, Li, Ruidong ^a, Yin, Yuping ^a, Tao, Kaixiong ^{a, ⁎}, Zhang, Peng ^{a, ⁎}

Source: In International Immunopharmacology 27 January 2025 146

Ah receptor, vitamin B12 and itaconate: how localized decrease of vitamin B12 prevents survival of macrophage-ingested bacteria

Authors: Karl Walter Bock

Source: Frontiers in Toxicology, Vol 6 (2024)

Subject Terms: Ah receptor, vitamin B12, itaconate, macrophages, bacteria, Toxicology. Poisons, RA1190-1270

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/ftox.2024.1491184/full; https://doaj.org/toc/2673-3080

Access URL: https://doaj.org/article/19848cd23e6d4ab6bffb4be5d530376a

Engineering thioesterase as a driving force for novel itaconate production via its degradation scheme

Authors: Ryan S. Wang, Siang-Wun Siao, Jessica C. Wang, Patrick Y. Lin, Claire R. Shen

Source: Metabolic Engineering Communications, Vol 19, Iss , Pp e00246- (2024)

Subject Terms: Itaconate, Driving force, Thioesterase, CoA hydrolysis, Metabolic engineering, Biotechnology, TP248.13-248.65, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2214030124000154; https://doaj.org/toc/2214-0301

Access URL: https://doaj.org/article/84a39d7ca46b41df917fb29864741a06

4-Octyl itaconate attenuates renal tubular injury in db/db mice by activating Nrf2 and promoting PGC-1α-mediated mitochondrial biogenesis

Authors: Muqing Shao, Jiayao Chen, Fuwei Zhang, Qian Su, Xiaoqian Lin, Weiwei Wang, Caiyu Chen, Hongmei Ren, Shuo Zheng, Suocheng Hui, Si Qin, Yinxing Ni, Jian Zhong, Jian Yang

Source: Renal Failure, Vol 46, Iss 2 (2024)

Subject Terms: Diabetic kidney disease, immune responsive gene 1, mitochondrial biogenesis, Nrf2, 4-octyl itaconate, renal tubular injury, Diseases of the genitourinary system. Urology, RC870-923

File Description: electronic resource

Relation: https://doaj.org/toc/0886-022X; https://doaj.org/toc/1525-6049

Access URL: https://doaj.org/article/fe6833a8df3342d4b3c1d5149ffaa784

Future applications of host direct therapies for infectious disease treatment

Authors: Ruth E. Thom, R V. D’Elia

Source: Frontiers in Immunology, Vol 15 (2024)

Subject Terms: host-directed, therapeutic, STING, pyroptosis, itaconate, infection, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2024.1436557/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/7a9b5707e5a9465096e217273763504b

Immunometabolites Direct the Pathogenesis of Bacterial Infection

Authors: Alice Prince

Source: Journal of Innate Immunity, Vol 16, Iss 1, Pp 367-369 (2024)

Subject Terms: immunometabolism, bacterial pathogenesis, itaconate, fumarate, Medicine, Internal medicine, RC31-1245

File Description: electronic resource

Relation: https://beta.karger.com/Article/FullText/540093; https://doaj.org/toc/1662-8128

Access URL: https://doaj.org/article/95ad22cfe5eb4ae28b627daed163855e