A Polygenic Risk Score Based on a Cardioembolic Stroke Multitrait Analysis Improves a Clinical Prediction Model for This Stroke Subtype

Authors: Jara Cárcel-Márquez, Elena Muiño, Cristina Gallego-Fabrega, Natalia Cullell, Miquel Lledós, Laia Llucià-Carol, Tomás Sobrino, Francisco Campos, José Castillo, Marimar Freijo, Juan Francisco Arenillas, Victor Obach, José Álvarez-Sabín, Carlos A. Molina, Marc Ribó, Jordi Jiménez-Conde, Jaume Roquer, Lucia Muñoz-Narbona, Elena Lopez-Cancio, Mònica Millán, Rosa Diaz-Navarro, Cristòfol Vives-Bauza, Gemma Serrano-Heras, Tomás Segura, Laura Ibañez, Laura Heitsch, Pilar Delgado, Rajat Dhar, Jerzy Krupinski, Raquel Delgado-Mederos, Luis Prats-Sánchez, Pol Camps-Renom, Natalia Blay, Lauro Sumoy, Rafael de Cid, Joan Montaner, Carlos Cruchaga, Jin-Moo Lee, Joan Martí-Fàbregas, Israel Férnandez-Cadenas

Source: Frontiers in Cardiovascular Medicine, Vol 9 (2022)

Subject Terms: polygenic risk score, GWAS, multi-trait analysis, stroke, ESUs, Diseases of the circulatory (Cardiovascular) system, RC666-701

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcvm.2022.940696/full; https://doaj.org/toc/2297-055X

Access URL: https://doaj.org/article/59cc2ac670ff4756af4144e6cde2a58a

Plasma Hepcidin as a potential informative biomarker of Alzheimer disease and vascular dementia

Authors: Constance Delaby, Daniel Alcolea, Germain Busto, Audrey Gabelle, Xavier Ayrignac, Karim Bennys, Elena Muiño, Paula Villatoro, Israel Fernández-Cadenas, Nicolas Pradeilles, Shaima El Bounasri, Soraya Torres, Christophe Hirtz, Henrik Zetterberg, Alberto Lleó, Juan Fortea, Sylvain Lehmann

Source: Alzheimer’s Research & Therapy, Vol 17, Iss 1, Pp 1-12 (2025)

Subject Terms: Alzheimer’s disease, Blood biomarkers, Hepcidin, NfL, Diagnosis, Vascular dementia, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/1758-9193

Access URL: https://doaj.org/article/e7dc8f0ae42d4278a098be8bccdba504

Host factor PLAC8 is required for pancreas infection by SARS-CoV-2

Authors: Lesly Ibargüen-González, Sandra Heller, Darío López-García, Hanna Dietenberger, Thomas FE Barth, Patricia Gallego, Israel Fernández-Cadenas, Sayoa Alzate-Piñol, Catalina Crespí, Julieth A. Mena-Guerrero, Eugenia Cisneros-Barroso, Alejandro P. Ugalde, Gabriel Bretones, Charlotte Steenblock, Alexander Kleger, Marta L. DeDiego, Carles Barceló

Source: Communications Medicine, Vol 5, Iss 1, Pp 1-12 (2025)

Subject Terms: Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/2730-664X

Access URL: https://doaj.org/article/79686ef2949241d9b9b6c077d81ee12b

DNA methylation and stroke prognosis: an epigenome-wide association study

Authors: Joan Jiménez-Balado, Isabel Fernández-Pérez, Cristina Gallego-Fábrega, Uxue Lazcano, Carolina Soriano-Tárraga, Marta Vallverdú-Prats, Marina Mola-Caminal, Lucía Rey-Álvarez, Adrià Macias-Gómez, Antoni Suárez-Pérez, Eva Giralt-Steinhauer, Ana Rodríguez-Campello, Elisa Cuadrado-Godia, Ángel Ois, Manel Esteller, Jaume Roquer, Israel Fernández-Cadenas, Jordi Jiménez-Conde

Source: Clinical Epigenetics, Vol 16, Iss 1, Pp 1-13 (2024)

Subject Terms: Epigenetics, Stroke outcome, Thrombospondin-2, DNA methylation, Medicine, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1868-7083

Access URL: https://doaj.org/article/3f0b1b34c1ca432b9a498408bb37c80e

Role of PATJ in stroke prognosis by modulating endothelial to mesenchymal transition through the Hippo/Notch/PI3K axis

Authors: Aina Medina-Dols, Guillem Cañellas, Toni Capó, Montse Solé, Marina Mola-Caminal, Natalia Cullell, Marina Jaume, Laura Nadal-Salas, Jaume Llinàs, Lluis Gómez, Silvia Tur, Carmen Jiménez, Rosa M. Díaz, Caty Carrera, Elena Muiño, Cristina Gallego-Fabrega, Carolina Soriano-Tárraga, Laura Ruiz-Guerra, Josep Pol-Fuster, Víctor Asensio, Josep Muncunill, Aarne Fleischer, Amanda Iglesias, Eva Giralt-Steinhauer, Uxue Lazcano, Isabel Fernández-Pérez, Joan Jiménez-Balado, Marina Gabriel-Salazar, Miguel Garcia-Gabilondo, Ting Lei, Nuria-Paz Torres-Aguila, Jara Cárcel-Márquez, Jerònia Lladó, Gabriel Olmos, Anna Rosell, Joan Montaner, Anna M. Planas, Raquel Rabionet, Mar Hernández-Guillamon, Jordi Jiménez-Conde, Israel Fernández-Cadenas, Cristòfol Vives-Bauzá

Source: Cell Death Discovery, Vol 10, Iss 1, Pp 1-13 (2024)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, Cytology, QH573-671

File Description: electronic resource

Relation: https://doaj.org/toc/2058-7716

Access URL: https://doaj.org/article/a3a6afd055e1410284b6f07d9b5f4bf3

A genome-wide association study for survival from a multi-centre European study identified variants associated with COVID-19 risk of death

Authors: Francesca Minnai, Filippo Biscarini, Martina Esposito, Tommaso A. Dragani, Luis Bujanda, Souad Rahmouni, Marta E. Alarcón-Riquelme, David Bernardo, Elena Carnero-Montoro, Maria Buti, Hugo Zeberg, Rosanna Asselta, Manuel Romero-Gómez, GEN-COVID Multicenter Study, Israel Fernandez-Cadenas, Chiara Fallerini, Kristina Zguro, Susanna Croci, Margherita Baldassarri, Mirella Bruttini, Simone Furini, Alessandra Renieri, Francesca Colombo

Source: Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/720db8359dd141d598d5bfa82cb29689

Genome-wide transcriptome study in skin biopsies reveals an association of E2F4 with cadasil and cognitive impairment

Authors: Elena Muiño, Olga Maisterra, Joan Jiménez-Balado, Natalia Cullell, Caty Carrera, Nuria P. Torres-Aguila, Jara Cárcel-Márquez, Cristina Gallego-Fabrega, Miquel Lledós, Jonathan González-Sánchez, Ferran Olmos-Alpiste, Eva Espejo, Álvaro March, Ramón Pujol, Ana Rodríguez-Campello, Gemma Romeral, Jurek Krupinski, Joan Martí-Fàbregas, Joan Montaner, Jaume Roquer, Israel Fernández-Cadenas

Source: Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/4a49c263a9844e49ac363edfee1aa85e

Identification of 20 novel loci associated with ischaemic stroke. Epigenome-wide association study

Authors: Carolina Soriano-Tárraga, Uxue Lazcano, Eva Giralt-Steinhauer, Carla Avellaneda-Gómez, Ángel Ois, Ana Rodríguez-Campello, Elisa Cuadrado-Godia, Alejandra Gómez-González, Alba Fernández-Sanlés, Roberto Elosua, Israel Fernández-Cadenas, Natalia Cullell, Joan Montaner, Sebastian Moran, Manel Esteller, Jordi Jiménez-Conde, Jaume Roquer

Source: Epigenetics, Vol 15, Iss 9, Pp 988-997 (2020)

Subject Terms: ischaemic stroke, dna methylation, ewas, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1559-2294; https://doaj.org/toc/1559-2308

Access URL: https://doaj.org/article/cd7b5cf0052944f88b5bb2e56eef03c4

Leveraging Genetic Data to Elucidate the Relationship Between COVID‐19 and Ischemic Stroke

Authors: Verena Zuber, Alan Cameron, Evangelos P. Myserlis, Leonardo Bottolo, Israel Fernandez‐Cadenas, Stephen Burgess, Christopher D. Anderson, Jesse Dawson, Dipender Gill

Source: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 10, Iss 22 (2021)

Subject Terms: COVID‐19, cross‐trait linkage disequilibrium score regression, ischemic stroke, Mendelian randomization, Diseases of the circulatory (Cardiovascular) system, RC666-701

File Description: electronic resource

Relation: https://doaj.org/toc/2047-9980

Access URL: https://doaj.org/article/efd6862a711f49dab73f5f4d00680cd5

Clinical Variables and Genetic Risk Factors Associated with the Acute Outcome of Ischemic Stroke: A Systematic Review

Authors: Nuria P Torres-Aguila, Caty Carrera, Elena Muiño, Natalia Cullell, Jara Cárcel-Márquez, Cristina Gallego-Fabrega, Jonathan González-Sánchez, Alejandro Bustamante, Pilar Delgado, Laura Ibañez, Laura Heitsch, Jerzy Krupinski, Joan Montaner, Joan Martí-Fàbregas, Carlos Cruchaga, Jin-Moo Lee, Israel Fernandez-Cadenas

Source: Journal of Stroke, Vol 21, Iss 3, Pp 276-289 (2019)

Subject Terms: stroke, outcome, clinical variables, genetics, Diseases of the circulatory (Cardiovascular) system, RC666-701

File Description: electronic resource

Relation: http://www.j-stroke.org/upload/pdf/jos-2019-01522.pdf; https://doaj.org/toc/2287-6391; https://doaj.org/toc/2287-6405

Access URL: https://doaj.org/article/abcde46cee5342b881dc0c3ba4264269

Epigenome-wide association study of COVID-19 severity with respiratory failure

Authors: Manuel Castro de Moura, Veronica Davalos, Laura Planas-Serra, Damiana Alvarez-Errico, Carles Arribas, Montserrat Ruiz, Sergio Aguilera-Albesa, Jesús Troya, Juan Valencia-Ramos, Valentina Vélez-Santamaria, Agustí Rodríguez-Palmero, Judit Villar-Garcia, Juan P. Horcajada, Sergiu Albu, Carlos Casasnovas, Anna Rull, Laia Reverte, Beatriz Dietl, David Dalmau, Maria J. Arranz, Laia Llucià-Carol, Anna M. Planas, Jordi Pérez-Tur, Israel Fernandez-Cadenas, Paula Villares, Jair Tenorio, Roger Colobran, Andrea Martin-Nalda, Pere Soler-Palacin, Francesc Vidal, Aurora Pujol, Manel Esteller

Source: EBioMedicine, Vol 66, Iss , Pp 103339- (2021)

Subject Terms: Coronavirus, SARS-CoV-2, COVID-19, Epigenetics, DNA methylation, Medicine, Medicine (General), R5-920

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352396421001328; https://doaj.org/toc/2352-3964

Access URL: https://doaj.org/article/b46e8f4e01864856b49fc6a4d33afe0f

DNA methylation analyses identify an intronic ZDHHC6 locus associated with time to recurrent stroke in the Vitamin Intervention for Stroke Prevention (VISP) clinical trial.

Authors: Nicole M Davis Armstrong, Wei-Min Chen, Fang-Chi Hsu, Michael S Brewer, Natalia Cullell, Israel Fernández-Cadenas, Stephen R Williams, Michèle M Sale, Bradford B Worrall, Keith L Keene

Source: PLoS ONE, Vol 16, Iss 7, p e0254562 (2021)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0254562&type=printable; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/cce8071ac4734336850320c53dea1cbf

DNA Methylation in Stroke. Update of Latest Advances

Authors: Jerzy Krupinski, Caty Carrera, Elena Muiño, Nuria Torres, Raid Al-Baradie, Natalia Cullell, Israel Fernandez-Cadenas

Source: Computational and Structural Biotechnology Journal, Vol 16, Iss , Pp 1-5 (2018)

Subject Terms: Biotechnology, TP248.13-248.65

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2001037017300624; https://doaj.org/toc/2001-0370

Access URL: https://doaj.org/article/c29f46272d624efcb37d3dfbf2c575fa

Automated quantification of cerebral edema following hemispheric infarction: Application of a machine-learning algorithm to evaluate CSF shifts on serial head CTs

Authors: Yasheng Chen, Rajat Dhar, Laura Heitsch, Andria Ford, Israel Fernandez-Cadenas, Caty Carrera, Joan Montaner, Weili Lin, Dinggang Shen, Hongyu An, Jin-Moo Lee

Source: NeuroImage: Clinical, Vol 12, Iss C, Pp 673-680 (2016)

Subject Terms: Active contour, Cerebral edema, CSF segmentation, Ischemic stroke CT, Mass effect, Random forest, Computer applications to medicine. Medical informatics, R858-859.7, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2213158216301760; https://doaj.org/toc/2213-1582

Access URL: https://doaj.org/article/390c1caba3bc47bfa6ecdd2f1e27dc77

An Inflammatory Polymorphisms Risk Scoring System for the Differentiation of Ischemic Stroke Subtypes

Authors: Elena Muiño, Jurek Krupinski, Caty Carrera, Cristina Gallego-Fabrega, Joan Montaner, Israel Fernández-Cadenas

Source: Mediators of Inflammation, Vol 2015 (2015)

Subject Terms: Pathology, RB1-214

File Description: electronic resource

Relation: https://doaj.org/toc/0962-9351; https://doaj.org/toc/1466-1861

Access URL: https://doaj.org/article/335bfec54fa041869ccd23a6476595f4

Global DNA methylation of ischemic stroke subtypes.

Authors: Carolina Soriano-Tárraga, Jordi Jiménez-Conde, Eva Giralt-Steinhauer, Marina Mola, Angel Ois, Ana Rodríguez-Campello, Elisa Cuadrado-Godia, Israel Fernández-Cadenas, Caty Carrera, Joan Montaner, Roberto Elosua, Jaume Roquer, GeneStroke, “The Spanish Stroke Genetics Consortium”

Source: PLoS ONE, Vol 9, Iss 4, p e96543 (2014)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0096543&type=printable; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/00e9c660ea714c4eb765b9c52e27217f

DNA isolation method is a source of global DNA methylation variability measured with LUMA. Experimental analysis and a systematic review.

Authors: Carolina Soriano-Tárraga, Jordi Jiménez-Conde, Eva Giralt-Steinhauer, Angel Ois, Ana Rodríguez-Campello, Elisa Cuadrado-Godia, Israel Fernández-Cadenas, Joan Montaner, Gavin Lucas, Roberto Elosua, Jaume Roquer, GeneStroke “The Spanish Stroke Genetics Consortium”

Source: PLoS ONE, Vol 8, Iss 4, p e60750 (2013)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3621987?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/56108988da8643899761bdeb636d5a00

Brain perihematoma genomic profile following spontaneous human intracerebral hemorrhage.

Authors: Anna Rosell, Anna Vilalta, Teresa García-Berrocoso, Israel Fernández-Cadenas, Sophie Domingues-Montanari, Eloy Cuadrado, Pilar Delgado, Marc Ribó, Elena Martínez-Sáez, Arantxa Ortega-Aznar, Joan Montaner

Source: PLoS ONE, Vol 6, Iss 2, p e16750 (2011)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3032742?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/051faeadb4ee4292912ae3ba1dc46c58