Antagonistic interactions between spinosad and macrocyclic lactones in combination against larvae of the sheep blowfly, Lucilia cuprina, in vitro

Authors: Kotze, Andrew C. ^{a, b, ⁎}, Knowles, Aleta G. ^c

Source: In Veterinary Parasitology February 2025 334

Advancing analytical and graphical methods for binary and ternary mixtures: The toxic interactions of divalent metal ions in human lung cells

Authors: James Y. Liu, Jonathan M. Beard, Saber Hussain, Christie M. Sayes

Source: Heliyon, Vol 10, Iss 22, Pp e40481- (2024)

Subject Terms: Toxicology, Mixtures, Interactions, Isobologram, Regression, Modeling, Science (General), Q1-390, Social sciences (General), H1-99

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2405844024165127; https://doaj.org/toc/2405-8440

Access URL: https://doaj.org/article/437d23f80b084b039ca910c2bee81cc8

Synergistic antidepressant-like effect of xylopic acid co-administered with selected antidepressants

Authors: Charles Kwaku Benneh, Wonder Kofi Mensah Abotsi, Robert Peter Biney, Priscilla Kolibea Mante, Mustapha Kobina Abeka, Augustine Tandoh, Eric Woode

Source: IBRO Neuroscience Reports, Vol 16, Iss , Pp 329-335 (2024)

Subject Terms: Xylopic acid, Antidepressant, Isobologram, Forced swim test, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2667242124000083; https://doaj.org/toc/2667-2421

Access URL: https://doaj.org/article/4797d0ff48d3474698cfd2a16423cdf5

In vitro drug interaction of ionophores with artemisinin and chloroquine against Plasmodium falciparum 3D7 blood-stage infection

Authors: Vinoth Rajendran, Keerthana Gurukkalot

Source: Frontiers in Drug Discovery, Vol 3 (2023)

Subject Terms: ionophores, drug-interaction, isobologram, P. falciparum, antimalarials, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fddsv.2023.1257698/full; https://doaj.org/toc/2674-0338

Access URL: https://doaj.org/article/13d02c9ad9ad446796ff8658d2130ebb

'Tranq-dope' overdose and mortality: lethality induced by fentanyl and xylazine

Authors: Mark A. Smith, Samantha L. Biancorosso, Jacob D. Camp, Salome H. Hailu, Alexandra N. Johansen, Mackenzie H. Morris, Hannah N. Carlson

Source: Frontiers in Pharmacology, Vol 14 (2023)

Subject Terms: addiction, isobologram, opioid use disorder, preclinical model, sex differences, substance use, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2023.1280289/full; https://doaj.org/toc/1663-9812

Access URL: https://doaj.org/article/9cad9c0601484c888466497ee4af864d

Efficacy of Combination Therapy with Pregabalin in Neuropathic Pain: A Preclinical Study in the Rat L5 Spinal Nerve Ligation Model

Authors: Nozawa K, Karasawa Y, Shidahara Y, Ushida T

Source: Journal of Pain Research, Vol Volume 15, Pp 3469-3478 (2022)

Subject Terms: analgesic, animal model, isobologram, synergistic effects, Medicine (General), R5-920

File Description: electronic resource

Relation: https://www.dovepress.com/efficacy-of-combination-therapy-with-pregabalin-in-neuropathic-pain-a--peer-reviewed-fulltext-article-JPR; https://doaj.org/toc/1178-7090

Access URL: https://doaj.org/article/60c1bb1f37dc44629c2d4dd3aa732681

Synergistic interaction of two antimalarial drugs, artemisinin and concanamycin A

Authors: Nurul Izzaty Najwa Zahari, Noor Fardziatun Ujal, Nurhidanatasha Abu-Bakar

Source: Life Sciences, Medicine and Biomedicine, Vol 7, Iss 1 (2023)

Subject Terms: artemisinin, concanamycin a, plasmodium falciparum, proton pump, isobologram analysis, Biotechnology, TP248.13-248.65, Medicine (General), R5-920, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://biomescientia.com/index.php/lsmb/article/view/107; https://doaj.org/toc/2600-7207

Access URL: https://doaj.org/article/47973199834b4b39899e104005032471

Identification of coniferyl ferulate as the bioactive compound behind the xanthine oxidase inhibitory activity of Chuanxiong Rhizome

Authors: Hui Wang, Hongwei Zhang, Xiaomei Zhang, Yichen Yin, Guiquan Ding, Xiaowen Tang, Pengyi Hou, Shiwei Sun, Wei Wang

Source: Journal of Functional Foods, Vol 100, Iss , Pp 105378- (2023)

Subject Terms: Coniferyl ferulate, Xanthine oxidase inhibitor, UPLC-ZenoTOF, Isobologram, Fluorescence quenching, Molecular docking, Nutrition. Foods and food supply, TX341-641

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1756464622004480; https://doaj.org/toc/1756-4646

Access URL: https://doaj.org/article/c7378ff42b5947eb91f8ebafeb14d2d2

Lumefantrine attenuates Plasmodium falciparum artemisinin resistance during the early ring stage

Authors: Krittikorn Kümpornsin, Duangkamon Loesbanluechai, Cristina de Cozar, Namfon Kotanan, Kesinee Chotivanich, Nicholas J. White, Prapon Wilairat, Maria G. Gomez-Lorenzo, Francisco Javier Gamo, Laura Maria Sanz, Marcus C.S. Lee, Thanat Chookajorn

Source: International Journal for Parasitology: Drugs and Drug Resistance, Vol 17, Iss , Pp 186-190 (2021)

Subject Terms: Artemisinin, Drug resistance, Isobologram, Lumefantrine, Malaria, Infectious and parasitic diseases, RC109-216

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211320721000488; https://doaj.org/toc/2211-3207

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The Additive Antinociceptive Effect of Resveratrol and Ketorolac in the Formalin Test in Mice

Authors: Fidencio Abner Rojas-Aguilar, Alfredo Briones-Aranda, Osmar Antonio Jaramillo-Morales, Rodrigo Romero-Nava, Héctor Armando Esquinca-Avilés, Josué Vidal Espinosa-Juárez

Source: Pharmaceuticals, Vol 16, Iss 8, p 1078 (2023)

Subject Terms: resveratrol, ketorolac, isobologram, pain, gastric damage, drug interactions, Medicine, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://www.mdpi.com/1424-8247/16/8/1078; https://doaj.org/toc/1424-8247

Access URL: https://doaj.org/article/41e7058a1f8b407e87c9dffb2ebbecda

Toxicological Effects of Mycotoxins on Target Cells

Contributors: Juan-García, Ana

Subject Terms: Destruxin A, Bombyx mori, binding protein, BmTudor-sn, Bm12 cell, Ochratoxin A (OTA), human Stem Cells, mycotoxins, cells, cytotoxicity, cell culture, T-2 toxin, HT-2 toxin, apoptosis, autophagy, endophyte, fungi, neurotoxin, lolitrems, ochratoxin A, beauvericin, mixtures, HepG2 cells, genotoxicity, cell cycle, Fusarium, Aspergillus, Penicillium, Alternaria, emerging mycotoxin, in vitro, IPEC-J2, occurrence data, trichothecene, biosynthetic pathway, acetyltransferase, deacetylase, deoxynivalenol, 3-acetyldeoxynivalenol, isotrichodermol, isotrichodermin, differentiated Caco-2 cells, cell apoptosis, transcriptome analysis, hepatocyte, chicken, acute toxicity, combined toxicity, cell protection, silibinin, in silico prediction, co-culture models, mycotoxin interaction, Loewe additivity, combination index, isobologram, Chou-Talalay method, MixLow, IPEC-J2 cells, RNA-seq, inflammation, MAPKs, Medicine and Nursing

File Description: application/octet-stream

Access URL: https://directory.doabooks.org/handle/20.500.12854/69068
https://mdpi.com/books/pdfview/book/2837

Synergistic effect of ursolic acid and piperine in CCl4 induced hepatotoxicity

Authors: Sayan Biswas, Amit Kar, Nanaocha Sharma, Pallab K. Haldar, Pulok K. Mukherjee

Source: Annals of Medicine, Vol 53, Iss 1, Pp 2009-2017 (2021)

Subject Terms: Hepatoprotective, isobologram, combination index, pharmacokinetics, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/0785-3890; https://doaj.org/toc/1365-2060

Access URL: https://doaj.org/article/02e07cb8ae174ec1bff192bad48314c4

Antagonistic Drug-herb Interactions between Clinacanthus nutans and Cyclophosphamide on WRL 68 Cell Line

Authors: Nurliana Abd Mutalib, Normala Abd Latip

Source: Pharmaceutical Sciences and Research, Vol 7, Iss 2, Pp 81-89 (2020)

Subject Terms: clinacanthus nutans, cyclophosphamide, drug-herb interactions, isobologram, combination index, Pharmacy and materia medica, RS1-441, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://scholarhub.ui.ac.id/psr/vol7/iss2/1/; https://doaj.org/toc/2407-2354; https://doaj.org/toc/2477-0612

Access URL: https://doaj.org/article/ee08dc0f2ac04160a3a8e182bdfe1313

Synergistic Inhibiting Effect of Phytochemicals in Rheum palmatum on Tyrosinase Based on Metabolomics and Isobologram Analyses

Authors: Yin Xiong, Hye Kyong Kim, Övgü Çelikler Özer, Bert van Duijn, Henrie A. A. J. Korthout, Lihong Zi, Ang Cai

Source: Molecules, Vol 28, Iss 3, p 944 (2023)

Subject Terms: tyrosinase inhibitory activity, Rheum palmatum, metabolomics, isobologram analysis, orthogonal partial least square-modelling, catechin, Organic chemistry, QD241-441

File Description: electronic resource

Relation: https://www.mdpi.com/1420-3049/28/3/944; https://doaj.org/toc/1420-3049

Access URL: https://doaj.org/article/c9f3c67364f540f3b3c02cb336ef2123

Direct In Vitro Comparison of the Anti-Leishmanial Activity of Different Olive Oil Total Polyphenolic Fractions and Assessment of Their Combined Effects with Miltefosine

Authors: Georgia Gogou, Olga S. Koutsoni, Panagiotis Stathopoulos, Leandros A. Skaltsounis, Maria Halabalaki, Eleni Dotsika

Source: Molecules, Vol 27, Iss 19, p 6176 (2022)

Subject Terms: leishmaniasis, natural products, total phenolic fraction, promastigotes, intracellular amastigotes, isobologram, Organic chemistry, QD241-441

File Description: electronic resource

Relation: https://www.mdpi.com/1420-3049/27/19/6176; https://doaj.org/toc/1420-3049

Access URL: https://doaj.org/article/c3fc47c0a1c1472db156a1bd3909b8d1

Positive Allosteric Modulation of CB1 Cannabinoid Receptor Signaling Enhances Morphine Antinociception and Attenuates Morphine Tolerance Without Enhancing Morphine- Induced Dependence or Reward

Authors: Richard A. Slivicki, Vishakh Iyer, Sonali S. Mali, Sumanta Garai, Ganesh A. Thakur, Jonathon D. Crystal, Andrea G. Hohmann

Source: Frontiers in Molecular Neuroscience, Vol 13 (2020)

Subject Terms: endocannabinoid, allosteric modulator, neuropathic pain, opioid, withdrawal, isobologram, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fnmol.2020.00054/full; https://doaj.org/toc/1662-5099

Access URL: https://doaj.org/article/fdca151317774c32b3e7e90819757de9

SiCoDEA: A Simple, Fast and Complete App for Analyzing the Effect of Individual Drugs and Their Combinations

Authors: Giulio Spinozzi, Valentina Tini, Alessio Ferrari, Ilaria Gionfriddo, Roberta Ranieri, Francesca Milano, Sara Pierangeli, Serena Donnini, Federica Mezzasoma, Serenella Silvestri, Brunangelo Falini, Maria Paola Martelli

Source: Biomolecules, Vol 12, Iss 7, p 904 (2022)

Subject Terms: drug screenings, bioinformatics, IC50, genomics, isobologram, combination index, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.mdpi.com/2218-273X/12/7/904; https://doaj.org/toc/2218-273X

Access URL: https://doaj.org/article/395c7133502f40cea2996ed6a40ae5d5

Experimental Designs for Mixtures of Chemicals along Fixed Ratio Rays

Authors: Meadows, Stephanie L., Gennings, Chris, Carter,, W. Hans, Bae, Dong-Soon

Source: Environmental Health Perspectives, 2002 Dec 01. 110, 979-983.

Access URL: https://www.jstor.org/stable/3455672

Looking for combination of benznidazole and Trypanosoma cruzi-triosephosphate isomerase inhibitors for Chagas disease treatment

Authors: Aguilera, Elena, Varela, Javier, Serna, Elva, Torres, Susana, Yaluff, Gloria, Bilbao, Ninfa Vera de, Cerecetto, Hugo, Alvarez, Guzmán, González, Mercedes

Source: Memórias do Instituto Oswaldo Cruz. March 2018 113(3)

Subject Terms: Chagas disease, synergism, isobologram, in vivo studies

File Description: text/html

Access URL: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762018000300153

Isobologram Analysis: A Comprehensive Review of Methodology and Current Research

Authors: Ruo-yue Huang, Linlin Pei, QuanJin Liu, Shiqi Chen, Haibo Dou, Gang Shu, Zhi-xiang Yuan, Juchun Lin, Guangneng Peng, Wei Zhang, Hualin Fu

Source: Frontiers in Pharmacology, Vol 10 (2019)

Subject Terms: drug interaction, synergy, isobologram analysis, principle, application, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fphar.2019.01222/full; https://doaj.org/toc/1663-9812

Access URL: https://doaj.org/article/ef32d3fdfa804843aee713b2b9fb46e7